| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J Brooks, C Escudero-Oñate, T Gomes, L Ferrando-Climen. An integrative biological effects assessment of a mine discharge into a Norwegian fjord using field transplanted mussels. The Science of the total environment. vol 644. 2019-03-01. PMID:30743819. |
the biomarkers used included: condition index (ci); stress on stress (sos); micronuclei formation (mn); acetylcholine esterase (ache) inhibition, lipid peroxidation (lpo) and neutral lipid (nl) accumulation. |
2019-03-01 |
2023-08-13 |
Not clear |
| Chanika Alahakoon, Tharaka L Dassanayake, Indika B Gawarammana, E Michael Sedgwick, Vajira S Weerasinghe, Ahmed Abdalla, Michael S Roberts, Nicholas A Buckle. Prediction of organophosphorus insecticide-induced intermediate syndrome with stimulated concentric needle single fibre electromyography. PloS one. vol 13. issue 9. 2019-02-25. PMID:30261032. |
ops inhibit acetylcholine esterase (ache), leading to over-activity of muscarinic and nicotinic cholinergic circuits. |
2019-02-25 |
2023-08-13 |
Not clear |
| Hans-Peter Hutter, Michael Kundi, Kathrin Lemmerer, Michael Poteser, Lisbeth Weitensfelder, Peter Wallner, Hanns Moshamme. Subjective Symptoms of Male Workers Linked to Occupational Pesticide Exposure on Coffee Plantations in the Jarabacoa Region, Dominican Republic. International journal of environmental research and public health. vol 15. issue 10. 2019-02-15. PMID:30257443. |
significantly increased symptom frequencies were related to neurotoxicity, parasympathic effects and acetylcholine esterase inhibition, with the highest differences found for excessive salivation, dizziness and stomach ache. |
2019-02-15 |
2023-08-13 |
Not clear |
| Xinhai Ye, Liwen Yang, David Stanley, Fei Li, Qi Fan. Two Bombyx mori acetylcholinesterase genes influence motor control and development in different ways. Scientific reports. vol 7. issue 1. 2019-02-01. PMID:28694460. |
among its other biological roles, acetylcholinesterase (ache, ec 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. |
2019-02-01 |
2023-08-13 |
Not clear |
| Neeraj Kumar, Kishore Kumar Krishnani, Narendra Pratap Sing. Comparative study of selenium and selenium nanoparticles with reference to acute toxicity, biochemical attributes, and histopathological response in fish. Environmental science and pollution research international. vol 25. issue 9. 2019-01-23. PMID:29332272. |
cat, sod, and gst were significantly elevated (p < 0.01) when exposed to se and se-nps, and similarly, a neurotransmitter enzyme (acetylcholine esterase (ache)) was significantly inhibited in a time- and dose-dependent manner. |
2019-01-23 |
2023-08-13 |
cat |
| Tabassum Hossain, Achintya Saha, Arup Mukherje. Exploring molecular structural requirement for AChE inhibition through multi-chemometric and dynamics simulation analyses. Journal of biomolecular structure & dynamics. vol 36. issue 5. 2019-01-21. PMID:28417668. |
acetylcholine (ach) acts through the regulation of ache activity, which can play a key role in accelerating senile amyloid β-peptide (aβ) plaque deposition. |
2019-01-21 |
2023-08-13 |
Not clear |
| N Samad, A Saleem, F Yasmin, M A Shehza. Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice. Physiological research. vol 67. issue 5. 2019-01-09. PMID:30044120. |
administration of quer decreased ache in unstressed, while levels of acetylcholine were increased in vehicle and quer treated stressed animals. |
2019-01-09 |
2023-08-13 |
mouse |
| Xin-Chen Wang, Yu-Min Xu, Hong-Ying Li, Chun-Ying Wu, Ting-Ting Xu, Na-Chuan Luo, Shi-Jie Zhang, Qi Wang, Shi-Jian Qua. Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice. BioMed research international. vol 2018. 2019-01-08. PMID:30050927. |
in addition, the activity of acetylcholinesterase (ache) was effectively decreased; the activity of choline acetyltransferase (chat) and concentration of acetylcholine (ach) were improved after jtw treatment in both hippocampus and cortex of scop-treated mice. |
2019-01-08 |
2023-08-13 |
mouse |
| Hoda E Mohamed, Dina M Abo-ELmatty, Noha M Mesbah, Samy M Saleh, Abdel-Moniem A Ali, Amr T Sak. Raspberry ketone preserved cholinergic activity and antioxidant defense in obesity induced Alzheimer disease in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-03. PMID:30257330. |
it inhibited acetylcholinesterase enzyme (ache) and hence increased acetylcholine level (ach) in brain tissues of o-ad rats. |
2019-01-03 |
2023-08-13 |
rat |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Yasser El-Nahhal, Raed Lubba. Acute and single repeated dose effects of low concentrations of chlorpyrifos, diuron, and their combination on chicken. Environmental science and pollution research international. vol 25. issue 11. 2018-12-11. PMID:29397503. |
the effects were determined as biological response (chicken behavior); physiological response (body weight, gaining weight); and biochemical response such as reduction of acetylcholine esterase activity (ache), changes in liver biomarkers, such as (1) alkaline phosphatase (alp), (2) aspartate aminotransferase (ast), and (3) alanine aminotransferase (alp), and effects on kidney biomarkers such as total protein, creatinine, uric acid, and urea. |
2018-12-11 |
2023-08-13 |
chicken |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| M Ender Avci, Ayse Gokce Keskus, Seniye Targen, M Efe Isilak, Mehmet Ozturk, Rengul Cetin Atalay, Michelle M Adams, Ozlen Kon. Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines. Scientific reports. vol 8. issue 1. 2018-11-26. PMID:29371671. |
acetylcholinesterase (ache), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. |
2018-11-26 |
2023-08-13 |
mouse |
| Sheemona Chowdhary, Rajasri Bhattacharyya, Dibyajyoti Banerje. 1-Naphthyl acetate: A chromogenic substrate for the detection of erythrocyte acetylcholinesterase activity. Biochimie. vol 154. 2018-11-26. PMID:30201403. |
the alternative substrates for ache were screened in terms of high goldscore and favorable tie in comparison to acetylcholine (ach)-ache complex and other relevant esterases. |
2018-11-26 |
2023-08-13 |
Not clear |
| Narayanan Gobi, Baskaralingam Vaseeharan, Ravichandran Rekha, Sekar Vijayakumar, Caterina Faggi. Bioaccumulation, cytotoxicity and oxidative stress of the acute exposure selenium in Oreochromis mossambicus. Ecotoxicology and environmental safety. vol 162. 2018-11-20. PMID:29990726. |
we also observed inhibition of acetylcholine esterase (ache) activity in brain tissue of fish exposed to se for higher concentrations. |
2018-11-20 |
2023-08-13 |
cat |
| Avigail Baruch Leshem, Sivan Isaacs, Sachin K Srivastava, Ibrahim Abdulhalim, Ariel Kushmaro, Hanna Rapapor. Quantitative assessment of paraoxon adsorption to amphiphilic β-sheet peptides presenting the catalytic triad of esterases. Journal of colloid and interface science. vol 530. 2018-11-12. PMID:29982025. |
organophosphate compounds that are used as pesticides affect the nervous system by binding irreversibly to the active site of the enzyme acetylcholine esterase (ache) and disrupting neuro-signaling nerve cells. |
2018-11-12 |
2023-08-13 |
Not clear |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
it has been recognized that the cholinergic and adenosinergic systems have an essential role in immune and inflammatory responses during bacterial fish pathogens, such as the enzymes acetylcholinesterase (ache) and adenosine deaminase (ada), which are responsible for catalysis of the anti-inflammatory molecules acetylcholine (ach) and adenosine (ado) respectively. |
2018-11-08 |
2023-08-13 |
Not clear |
| Morteza Shahriari, Arash Zibaee, Najmeh Sahebzadeh, Leila Shamakh. Effects of α-pinene, trans-anethole, and thymol as the essential oil constituents on antioxidant system and acetylcholine esterase of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae). Pesticide biochemistry and physiology. vol 150. 2018-11-01. PMID:30195386. |
the current study aimed to determine the potential effects of three essential oil constituents, α-pinene, trans-anethole, and thymol, on antioxidant system and acetylcholine esterase (ache) of ephestia kuehniella zeller. |
2018-11-01 |
2023-08-13 |
Not clear |
| Tecush Mohammadi, Yousef Ghaye. Atomic insight into designed carbamate-based derivatives as acetylcholine esterase (AChE) inhibitors: a computational study by multiple molecular docking and molecular dynamics simulation. Journal of biomolecular structure & dynamics. vol 36. issue 1. 2018-10-15. PMID:27924680. |
atomic insight into designed carbamate-based derivatives as acetylcholine esterase (ache) inhibitors: a computational study by multiple molecular docking and molecular dynamics simulation. |
2018-10-15 |
2023-08-13 |
Not clear |
| Xiaochun Guo, Shengnan Zhang, Shaoyong Lu, Binghui Zheng, Ping Xie, Jun Chen, Guangyu Li, Chunsheng Liu, Qin Wu, Houcheng Cheng, Nan San. Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). vol 241. 2018-10-05. PMID:30029309. |
additionally, the acetylcholine (ach) content as well as acetylcholinesterase (ache) activity were determined to be significantly downregulated in pfdoa treatment groups. |
2018-10-05 |
2023-08-13 |
zebrafish |