| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonise M Jaguezeski, Gessica Perin, Leandro A Rhoden, Teane M A da Silva, Ricardo E Mendes, Nathieli B Bottari, Matheus D Baldissera, Vera M Morsch, Maria Rosa C Schetinger, Lenita M Stefani, Aleksandro S da Silv. Changes on the activity of cholinesterase's in an immunomodulatory response of cattle infected by Listeria monocytogenes. Microbial pathogenesis. vol 114. 2018-08-13. PMID:29066379. |
the ache activity and acetylcholine (ach) levels were measured in the central nervous system on day 14 pi, and histopathological analyses were also performed. |
2018-08-13 |
2023-08-13 |
cattle |
| Mengshi Wang, Wenchuan Bi, Kaiyue Fan, Tongde Li, Tingxu Yan, Feng Xiao, Bosai He, Kaishun Bi, Ying Ji. Ameliorating effect of Alpinia oxyphylla-Schisandra chinensis herb pair on cognitive impairment in a mouse model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29080453. |
finally, the level of acetylcholine (ach) and muscarinic receptor (m1) receptors, the activity of choline acetyltransferase (chat) and acetyl cholinesterase (ache) were measured by commercial assay kits and elisa kit. |
2018-08-03 |
2023-08-13 |
mouse |
| Satpati Abhijit, Muthangi V V Subramanyam, Sambe Asha Dev. Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain. Neurochemical research. vol 42. issue 12. 2018-08-02. PMID:28993969. |
the aim of the present study was to assess the influence of grape seed proanthocyanidin extract (gspe) either individually or in combination with swimming training on acetylcholine esterase activity (ache) and m1 acetylcholine receptor (m1achr) on the extent of cognitive decline with aging. |
2018-08-02 |
2023-08-13 |
rat |
| Alsu R Mukhametshina, Svetlana V Fedorenko, Alexey M Petrov, Guzel F Zakyrjanova, Konstantin A Petrov, Leniz F Nurullin, Irek R Nizameev, Asiya R Mustafina, Oleg G Sinyashi. Targeted Nanoparticles for Selective Marking of Neuromuscular Junctions and ex Vivo Monitoring of Endogenous Acetylcholine Hydrolysis. ACS applied materials & interfaces. vol 10. issue 17. 2018-07-31. PMID:29652477. |
the present work for the first time introduces nanosensors for luminescent monitoring of acetylcholinesterase (ache)-catalyzed hydrolysis of endogenous acetylcholine (ach) released in neuromuscular junctions of isolated muscles. |
2018-07-31 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Yue Wang, Qing Tian, En-Jie Liu, Li Zhao, Jie Song, Xin-An Liu, Qing-Guo Ren, Xia Jiang, Juan Zeng, Yu-Tao Yang, Jian-Zhi Wan. Activation of GSK-3 disrupts cholinergic homoeostasis in nucleus basalis of Meynert and frontal cortex of rats. Journal of cellular and molecular medicine. vol 21. issue 12. 2018-07-11. PMID:28656644. |
we activated gsk-3 by lateral ventricular infusion of wortmannin (wt) and gf-109203x (gfx), the inhibitors of phosphoinositol-3 kinase (pi3-k) and protein kinase c (pkc), respectively, and significantly decreased the acetylcholine (ach) level via inhibiting choline acetyl transferase (chat) rather than regulating acetylcholinesterase (ache). |
2018-07-11 |
2023-08-13 |
rat |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Liangqia Guo, Zhihong Li, Huan Chen, Yarong Wu, Ling Chen, Zhiping Song, Tianran Li. Colorimetric biosensor for the assay of paraoxon in environmental water samples based on the iodine-starch color reaction. Analytica chimica acta. vol 967. 2018-06-15. PMID:28390486. |
in the presence of acetylcholine chloride, acetylcholinesterase (ache) and choline oxidase (cho) catalyzed the formation of h |
2018-06-15 |
2023-08-13 |
Not clear |
| Carlota Saldanha, Teresa Freitas, Ana Santos Silva-Herdad. Timolol effects on erythrocyte deformability and nitric oxide metabolism. Clinical hemorheology and microcirculation. vol 69. issue 1-2. 2018-06-15. PMID:29630536. |
in healthy human red blood cells (rbcs), timolol is an inhibitor of ache and induces no efflux and gsno efflux from that blood component in lower concentration than those obtained in presence of the natural ache substrate, acetylcholine (ach). |
2018-06-15 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (ache) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
current therapy comprises oximes to reactivate ache and atropine to antagonize effects induced by muscarinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. Toxicology letters. vol 293. 2018-06-04. PMID:29248576. |
irreversible inhibition of acetylcholinesterase (ache) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (op). |
2018-06-04 |
2023-08-13 |
human |
| Volker Strauss, Maria Cecilia Rey Moreno, Jeanette Vogt, Martina Dammann, Steffen Schneider, Sibylle Gröters, Bennard van Ravenzwaa. Acetylcholinesterase measurement in various brain regions and muscles of juvenile, adolescent, and adult rats. Toxicology mechanisms and methods. vol 27. issue 9. 2018-05-23. PMID:28671028. |
several insecticides, chemicals, and drugs are known to inhibit acetylcholinesterase (ache) activity, responsible for the cleavage of the neurotransmitter acetylcholine. |
2018-05-23 |
2023-08-13 |
rat |
| Nathalie Lécrivain, Vincent Aurenche, Nathalie Cottin, Victor Frossard, Bernard Clémen. Multi-contamination (heavy metals, polychlorinated biphenyls and polycyclic aromatic hydrocarbons) of littoral sediments and the associated ecological risk assessment in a large lake in France (Lake Bourget). The Science of the total environment. vol 619-620. 2018-05-23. PMID:29734631. |
biological analysis including both laboratory (microcosm assays) and in situ (acetylcholine esterase (ache) and glutathione s-transferase (gst) activity measurements) experiments highlighted significant differences among sites both in the field and in laboratory assays suggesting a spatial variation of the biota response to contamination. |
2018-05-23 |
2023-08-13 |
Not clear |
| Hongru Ma, Jianfeng Han, Qinchuan Don. Neuroprotective effect of Annona glabra extract against ethanol-induced apoptotic neurodegeneration in neonatal rats. Journal of photochemistry and photobiology. B, Biology. vol 181. 2018-05-14. PMID:29549803. |
the lipid peroxidation, reduced glutathione (gsh), glutathione peroxidase (gpx), superoxide dismutase (sod), catalase, and acetylcholine esterase (ache) levels were determined. |
2018-05-14 |
2023-08-13 |
rat |
| Samuel Legeay, Nicolas Clere, Grégory Hilairet, Quoc-Tuan Do, Philippe Bernard, Jean-François Quignard, Véronique Apaire-Marchais, Bruno Lapied, Sébastien Faur. The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells. Scientific reports. vol 6. 2018-05-08. PMID:27345502. |
in addition, deet inhibited ache which increased acetylcholine bioavailability and binding to m3 receptors and also strengthened proangiogenic effects by an allosteric modulation. |
2018-05-08 |
2023-08-13 |
Not clear |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Paula Rayane de Souza, Kelma Sirleide de Souza, Caio Rodrigo Dias de Assis, Marlyete Chagas de Araújo, Kaline Catiely Campos Silva, Juliett de Fátima Xavier da Silva, Andreia Cybelle Marques Ferreira, Valdir Luna da Silva, Mônica Lúcia Adam, Luiz Bezerra de Carvalho, Ranilson de Souza Bezerr. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 197. 2018-05-07. PMID:29462762. |
acetylcholinesterase (ache; ec 3.1.1.7) is an enzyme of the group of serine esterases that acts on the hydrolysis of the neurotransmitter acetylcholine allowing the intermittence of the nerve impulses responsible for the neuronal communication. |
2018-05-07 |
2023-08-13 |
Not clear |
| Taibi Ben Hadda, Oualid Talhi, Artur S M Silva, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdur Rauf, Yahia N Mabkhot, Khaldoun Bachari, Ismail Warad, Thoraya A Farghaly, Ismail I Althagafi, Mohammad S Mubara. Cholinesterase Inhibitory Activity of Some semi-Rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site. Mini reviews in medicinal chemistry. vol 18. issue 8. 2018-05-04. PMID:28714400. |
cholinesterase family consists of two sister enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) which hydrolyze acetylcholine. |
2018-05-04 |
2023-08-13 |
Not clear |
| Irini Doytchinova, Mariyana Atanasova, Iva Valkova, Georgi Stavrakov, Irena Philipova, Zvetanka Zhivkova, Dimitrina Zheleva-Dimitrova, Spiro Konstantinov, Ivan Dimitro. Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-01. PMID:29651876. |
the inhibition of the enzyme acetylcholinesterase (ache) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. |
2018-05-01 |
2023-08-13 |
Not clear |