| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
cholinomirs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache). |
2017-09-07 |
2023-08-13 |
Not clear |
| Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerqu. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28791702. |
clinical manifestations of an acute exposure of humans to op insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (ache), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ach). |
2017-09-07 |
2023-08-13 |
Not clear |
| Hugo R Arias, Federica Ravazzini, Katarzyna M Targowska-Duda, Agnieszka A Kaczor, Dominik Feuerbach, Juan C Boffi, Piotr Draczkowski, Dirk Montag, Brandon M Brown, Ana Belén Elgoyhen, Krzysztof Jozwiak, Giulia Pui. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The international journal of biochemistry & cell biology. vol 76. 2017-09-04. PMID:27129924. |
the activity of positive allosteric modulators (pams) of α7 nicotinic acetylcholine receptors (achrs), including 3-furan-2-yl-n-p-tolyl-acrylamide (pam-2), 3-furan-2-yl-n-o-tolylacrylamide (pam-3), and 3-furan-2-yl-n-phenylacrylamide (pam-4), was tested on a variety of ligand- [i.e., human (h) α7, rat (r) α9α10, hα3-containing achrs, mouse (m) 5-ht3ar, and several glutamate receptors (glurs)] and voltage-gated (i.e., sodium and potassium) ion channels, as well as on acetylcholinesterase (ache) and β-amyloid (aβ) content. |
2017-09-04 |
2023-08-13 |
mouse |
| Yong-Tao Xiao, Jun Wang, Wei Lu, Yi Cao, Wei Ca. Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE. Cell death & disease. vol 7. issue 12. 2017-08-28. PMID:27977009. |
the ache potentially negates the cholinergic anti-inflammatory signal by hydrolyzing the acetylcholine. |
2017-08-28 |
2023-08-13 |
Not clear |
| Deniz Yilmazer-Hanke, Marina Eliava, Joachim Hanke, Herbert Schwegler, Esther Asa. Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. Neuroscience letters. vol 632. 2017-08-08. PMID:27585749. |
density of acetylcholine esterase (ache) and tyrosine hydroxylase (th) containing fibers in the amygdala of roman high- and low-avoidance rats. |
2017-08-08 |
2023-08-13 |
rat |
| Deniz Yilmazer-Hanke, Marina Eliava, Joachim Hanke, Herbert Schwegler, Esther Asa. Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. Neuroscience letters. vol 632. 2017-08-08. PMID:27585749. |
in the present study, the density of acetylcholine esterase (ache)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (th-ir) fibers were analyzed in various amygdala nuclei. |
2017-08-08 |
2023-08-13 |
rat |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Physiological functions of the cholinergic system in immune cells. Journal of pharmacological sciences. vol 134. issue 1. 2017-07-13. PMID:28552584. |
this includes choline acetyltransferase (chat), muscarinic and nicotinic acetylcholine (ach) receptors (machrs and nachrs, respectively) and acetylcholinesterase (ache). |
2017-07-13 |
2023-08-13 |
Not clear |
| Bassem Sadek, Nadia Khan, Fouad H Darras, Steffen Pockes, Michael Decke. The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats. Physiology & behavior. vol 165. 2017-07-11. PMID:27568232. |
both the acetylcholine esterase (ache) and the histamine h3 receptor (h3r) are involved in the metabolism and modulation of acetylcholine release and numerous other centrally acting neurotransmitters. |
2017-07-11 |
2023-08-13 |
rat |
| Xu Rui, Li Wenfang, Cheng Jing, Chen Meng, Ding Chengcheng, Xu Jiqu, Rong Shuan. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat. Food & function. vol 8. issue 3. 2017-07-07. PMID:28256666. |
furthermore, pse improved cholinergic activities by restoring the acetylcholine (ach) content and decreasing acetylcholinesterase (ache) activity in the cerebral cortex, as well as by elevating choline acetyl transferase (chat) activity in the hippocampus and the cerebral cortex. |
2017-07-07 |
2023-08-13 |
rat |
| b' \\xc3\\x9cmide Demir \\xc3\\x96zkay, \\xc3\\x96zg\\xc3\\xbcr Devrim Can, Beg\\xc3\\xbcm Nurpelin Sa\\xc4\\x9fl\\xc4\\xb1k, Ulviye Acar \\xc3\\x87evik, Serkan Levent, Yusuf \\xc3\\x96zkay, Sinem Ilg\\xc4\\xb1n, \\xc3\\x96zlem Atl\\xc4\\xb. Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines. Bioorganic & medicinal chemistry letters. vol 26. issue 22. 2017-06-26. PMID:27789142.' |
in the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (ache) inhibitors. |
2017-06-26 |
2023-08-13 |
Not clear |
| Hengyun Wei, Zixiang Gao, Luping Zheng, Cuili Zhang, Zundong Liu, Yazong Yang, Hongming Teng, Lin Hou, Yuling Yin, Xiangyang Zo. Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice. Marine drugs. vol 15. issue 3. 2017-06-26. PMID:28300775. |
fucoidan reversed the decreased activity of acetylcholine (ach) and choline acetyl transferase (chat), as well as the increased activity of acetylcholine esterase (ache), in ad model mice induced by infusion of d-gal. |
2017-06-26 |
2023-08-13 |
mouse |
| D Rathish, S B Agampodi, M A C S Jayasumana, S H Siribaddan. From organophosphate poisoning to diabetes mellitus: The incretin effect. Medical hypotheses. vol 91. 2017-06-15. PMID:27142144. |
op poisoning leads to accumulation of acetylcholine (ach) due to the inhibition of acetylcholinesterases (ache). |
2017-06-15 |
2023-08-13 |
Not clear |
| Hee Jeong Eom, Hee Rae Kang, Ho Kyong Kim, Eun Bee Jung, Hyun Bong Park, Ki Sung Kang, Ki Hyun Ki. Bioactivity-guided isolation of antioxidant triterpenoids from Betula platyphylla var. japonica bark. Bioorganic chemistry. vol 66. 2017-06-06. PMID:27060627. |
however, no compound showed significant inhibition of acetylcholine esterase (ache). |
2017-06-06 |
2023-08-13 |
Not clear |
| Jong Min Kim, Chang Hyeon Park, Seon Kyeong Park, Tae Wan Seung, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Dae-Ok Kim, Ho Jin He. Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice. Journal of agricultural and food chemistry. vol 65. issue 13. 2017-06-05. PMID:28314104. |
g re regulated acetylcholine (ach), acetylcholinesterase (ache), malondialdehyde (mda), superoxide dismutase (sod), and oxidized glutathione (gsh)/total gsh by regulating the c-jun n-terminal protein kinase (jnk) pathway. |
2017-06-05 |
2023-08-13 |
mouse |
| Kei M Lau, Amy G W Gong, Miranda L Xu, Candy T W Lam, Laura M L Zhang, Cathy W C Bi, D Cui, Anthony W M Cheng, Tina T X Dong, Karl W K Tsim, Huangquan Li. Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis. Brain research. vol 1642. 2017-05-22. PMID:27021952. |
the expression of acetylcholinesterase (ache), an enzyme hydrolyzes neurotransmitter acetylcholine at vertebrate neuromuscular junction, is regulated during myogenesis, indicating the significance of muscle intrinsic factors in controlling the enzyme expression. |
2017-05-22 |
2023-08-13 |
mouse |
| Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua D. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules (Basel, Switzerland). vol 22. issue 3. 2017-05-18. PMID:28272324. |
further, dl0410 inhibited the ache activity and increased acetylcholine (ach) levels in a dose-dependent manner, and interacted with the active site of ache in a similar manner as donepezil. |
2017-05-18 |
2023-08-13 |
mouse |
| Neeraj Kumar, K K Krishnani, K K Meena, Sanjay Kumar Gupta, N P Sing. Oxidative and cellular metabolic stress of Oreochromis mossambicus as biomarkers indicators of trace element contaminants. Chemosphere. vol 171. 2017-05-02. PMID:28027471. |
the brain acetylcholine esterase (ache) was noticeably inhibited (p < 0.01) whereas lipid peroxide (lpo) elevated in fish collected from a few sites. |
2017-05-02 |
2023-08-13 |
cat |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
acetylcholinesterase (ache) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. |
2017-03-22 |
2023-08-13 |
Not clear |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
to combat this, ache reactivators have to be developed to remove the offending ache inhibitor, restoring acetylcholine levels to normal. |
2017-03-22 |
2023-08-13 |
Not clear |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
acheis reversibly inhibit acetylcholinesterase (ache), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. |
2017-03-10 |
2023-08-13 |
Not clear |