| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria-Letizia Campanari, Francisco Navarrete, Stephen D Ginsberg, Jorge Manzanares, Javier Sáez-Valero, María-Salud García-Aylló. Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258420. |
therefore, differential expression of ache variants in ad may reflect changes in the pathophysiological role of ache, independent of cholinergic impairment or its role in degrading acetylcholine. |
2018-01-26 |
2023-08-13 |
human |
| Adam Kostelnik, Alexander Cegan, Miroslav Pohank. Color Change of Phenol Red by Integrated Smart Phone Camera as a Tool for the Determination of Neurotoxic Compounds. Sensors (Basel, Switzerland). vol 16. issue 9. 2018-01-24. PMID:27618041. |
ache splits acetylcholine into choline and acetic acid, which changes the ph of a medium, resulting in a phenol red color change. |
2018-01-24 |
2023-08-13 |
Not clear |
| Sarumani Natarajan Suganya, Thangarajan Sumath. Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington's disease model in rats. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:27928694. |
3-np also produces striatal damage by increased the levels of lipid peroxides, nitrite, glial fibrillary acidic protein (gfap) and activity of acetylcholine esterase (ache). |
2018-01-12 |
2023-08-13 |
rat |
| Yang Jin, Jian Peng, Xiaona Wang, Dong Zhang, Tianyin Wan. Ameliorative Effect of Ginsenoside Rg1 on Lipopolysaccharide-Induced Cognitive Impairment: Role of Cholinergic System. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28078612. |
furthermore, ginsenoside rg1 treatment prevented lps-induced decrease of acetylcholine (ach) levels and increase of acetylcholinesterase (ache) activity. |
2018-01-09 |
2023-08-13 |
rat |
| Heba S Hamed, Mohsen Abdel-Tawwa. Ameliorative effect of propolis supplementation on alleviating bisphenol-A toxicity: Growth performance, biochemical variables, and oxidative stress biomarkers of Nile tilapia, Oreochromis niloticus (L.) fingerlings. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 202. 2018-01-09. PMID:28802889. |
additionally, total protein, albumin, globulin, and acetylcholine esterase (ache) decreased significantly. |
2018-01-09 |
2023-08-13 |
cat |
| Sophie Mavrikou, Kelly Flampouri, Georgia Moschopoulou, Olga Mangana, Alexandros Michaelides, Spiridon Kintzio. Assessment of Organophosphate and Carbamate Pesticide Residues in Cigarette Tobacco with a Novel Cell Biosensor. Sensors (Basel, Switzerland). vol 8. issue 4. 2018-01-04. PMID:27879851. |
the presence of pesticide residues is detected by the degree of inhibition of acetylcholine esterase (ache). |
2018-01-04 |
2023-08-13 |
Not clear |
| Ramu Venkatesan, Lalita Subedi, Eui-Ju Yeo, Sun Yeou Ki. Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27346436. |
the current study aimed to investigate the molecular mechanisms underlying scopolamine-induced cholinergic neuronal dysfunction and the neuroprotective effect of lactucopicrin, an inhibitor of acetylcholine esterase (ache). |
2018-01-03 |
2023-08-13 |
Not clear |
| Heena Tabassum, Mohammad Ashafaq, Suhel Parvez, Sheikh Raisuddi. Role of melatonin in mitigating nonylphenol-induced toxicity in frontal cortex and hippocampus of rat brain. Neurochemistry international. vol 104. 2018-01-03. PMID:28012845. |
the results showed that np significantly decreased the activity of acetylcholine esterase (ache), monoamine oxidase (mao) and na |
2018-01-03 |
2023-08-13 |
rat |
| Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Li. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29133030. |
ppd regulated cholinergic function by inhibiting scop-induced elevation of acetylcholinesterase (ache) activity, decline of choline acetyltransferase (chat) activity and decrease of acetylcholine (ach) level. |
2018-01-03 |
2023-08-13 |
mouse |
| Jong Min Kim, Seon Kyeong Park, Tian Jiao Guo, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Ho Jin He. Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27288590. |
in animal experiments using y-maze, passive avoidance and morris water maze tests, the cognitive and behavioral disorders in hfd-induced diabetic mice were considerably recovered by regulating cholinergic systems, including acetylcholine (ach) levels and acetylcholinesterase (ache) inhibition, and antioxidant systems, including superoxide dismutase (sod), glutathione (gsh), oxidized gsh, and malondialdehyde (mda) levels. |
2017-12-19 |
2023-08-13 |
mouse |
| Guozhen Qiu, Shengqiang Chen, Jialing Guo, Jie Wu, Yong-Hong Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27316341. |
to elucidate the mechanism underlying this improvement, we evaluated the expressions of various cholinergic markers, as well as acetylcholinesterase (ache) activity and acetylcholine (ach) levels, in the striatum of fmr1 ko mice. |
2017-12-13 |
2023-08-13 |
mouse |
| Dietrich E Lorke, Anka Stegmeier-Petroianu, Georg A Petroian. Biologic activity of cyclic and caged phosphates: a review. Journal of applied toxicology : JAT. vol 37. issue 1. 2017-12-04. PMID:27612208. |
cyclic compounds that inhibit acetylcholine esterase (ache), such as salithion, can be employed as pesticides. |
2017-12-04 |
2023-08-13 |
Not clear |
| Annamaria Martorana, Valentina Giacalone, Riccardo Bonsignore, Andrea Pace, Carla Gentile, Ivana Pibiri, Silvestre Buscemi, Antonino Lauria, Antonio Palumbo Piccionell. Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. Current pharmaceutical design. vol 22. issue 26. 2017-11-29. PMID:27189601. |
it has been demonstrated that both acetylcholinesterase (ache) and butyrylcholinesterase (buche) enzymes are not only responsible of acetylcholine levels, but also play an pivotal role in aβ-aggregation during the early stages of senile plaque formation. |
2017-11-29 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| Vanessa Hausherr, Nicole Schöbel, Julia Liebing, Christoph van Thrie. Assessment of neurotoxic effects of tri-cresyl phosphates (TCPs) and cresyl saligenin phosphate (CBDP) using a combination of in vitro techniques. Neurotoxicology. vol 59. 2017-11-22. PMID:27288108. |
as reported for other organophosphorus compounds (ops), the inhibition of acetylcholine esterase (ache) has also been proposed as the underlying mechanism for tcp neurotoxicity. |
2017-11-22 |
2023-08-13 |
Not clear |
| Yuehua Guo, Kaili Yang, Jiachen Sun, Jie Wu, Huangxian J. A pH-responsive colorimetric strategy for DNA detection by acetylcholinesterase catalyzed hydrolysis and cascade amplification. Biosensors & bioelectronics. vol 94. 2017-11-20. PMID:28388529. |
a ph-responsive colorimetric strategy was designed for sensitive and convenient biosensing by introducing acetylcholinesterase (ache) catalyzed hydrolysis of acetylcholine to change solution ph and phenol red as an indicator. |
2017-11-20 |
2023-08-13 |
Not clear |
| Neeraj Kumar, Kishore Kumar Krishnani, Narendra Pratap Sing. Oxidative and cellular stress as bioindicators for metal contamination in freshwater mollusk Lamellidens marginalis. Environmental science and pollution research international. vol 24. issue 19. 2017-11-20. PMID:28537033. |
aspartate amino transferase (ast), alanine amino transferase (alt), and lipid peroxidation (lpo) were significantly (p < 0.01) higher, while neurotransmitter enzymes such as acetylcholine esterase (ache) were significantly inhibited in muscle of l. marginalis (p < 0.01) collected from different sampling sites. |
2017-11-20 |
2023-08-13 |
cat |
| Zhengyu Yan, Kun Yan, Xingliang He, Yanhua Liu, Jie Zhang, Oscar Lopez Torres, Ruixin Guo, Jianqiu Che. The impact assessment of anticancer drug imatinib on the feeding behavior of rotifers with an integrated perspective: Exposure, post-exposure and re-exposure. Chemosphere. vol 185. 2017-11-16. PMID:28710991. |
the activities of acetylcholine esterase (ache) and the levels of reactive oxygen species (ros) in rotifers were also detected. |
2017-11-16 |
2023-08-13 |
Not clear |
| Mirna Ezzat Sorial, Nesrine Salah El Dine El Saye. Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 6. 2017-11-08. PMID:28188358. |
the mice also exhibited a decrease in acetylcholine (ach) and neprilysin (nep) levels accompanied by an increase in acetylcholinesterase (ache) activity. |
2017-11-08 |
2023-08-13 |
mouse |
| Mohammad Nazim, Akio Masuda, Mohammad Alinoor Rahman, Farhana Nasrin, Jun-Ichi Takeda, Kenji Ohe, Bisei Ohkawara, Mikako Ito, Kinji Ohn. Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms. Nucleic acids research. vol 45. issue 3. 2017-10-30. PMID:28180311. |
acetylcholinesterase (ache), encoded by the ache gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. |
2017-10-30 |
2023-08-13 |
human |