| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong Min Kim, Seon Kyeong Park, Tian Jiao Guo, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Ho Jin He. Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27288590. |
in animal experiments using y-maze, passive avoidance and morris water maze tests, the cognitive and behavioral disorders in hfd-induced diabetic mice were considerably recovered by regulating cholinergic systems, including acetylcholine (ach) levels and acetylcholinesterase (ache) inhibition, and antioxidant systems, including superoxide dismutase (sod), glutathione (gsh), oxidized gsh, and malondialdehyde (mda) levels. |
2017-12-19 |
2023-08-13 |
mouse |
| Guozhen Qiu, Shengqiang Chen, Jialing Guo, Jie Wu, Yong-Hong Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27316341. |
to elucidate the mechanism underlying this improvement, we evaluated the expressions of various cholinergic markers, as well as acetylcholinesterase (ache) activity and acetylcholine (ach) levels, in the striatum of fmr1 ko mice. |
2017-12-13 |
2023-08-13 |
mouse |
| Dietrich E Lorke, Anka Stegmeier-Petroianu, Georg A Petroian. Biologic activity of cyclic and caged phosphates: a review. Journal of applied toxicology : JAT. vol 37. issue 1. 2017-12-04. PMID:27612208. |
cyclic compounds that inhibit acetylcholine esterase (ache), such as salithion, can be employed as pesticides. |
2017-12-04 |
2023-08-13 |
Not clear |
| Annamaria Martorana, Valentina Giacalone, Riccardo Bonsignore, Andrea Pace, Carla Gentile, Ivana Pibiri, Silvestre Buscemi, Antonino Lauria, Antonio Palumbo Piccionell. Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. Current pharmaceutical design. vol 22. issue 26. 2017-11-29. PMID:27189601. |
it has been demonstrated that both acetylcholinesterase (ache) and butyrylcholinesterase (buche) enzymes are not only responsible of acetylcholine levels, but also play an pivotal role in aβ-aggregation during the early stages of senile plaque formation. |
2017-11-29 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| Vanessa Hausherr, Nicole Schöbel, Julia Liebing, Christoph van Thrie. Assessment of neurotoxic effects of tri-cresyl phosphates (TCPs) and cresyl saligenin phosphate (CBDP) using a combination of in vitro techniques. Neurotoxicology. vol 59. 2017-11-22. PMID:27288108. |
as reported for other organophosphorus compounds (ops), the inhibition of acetylcholine esterase (ache) has also been proposed as the underlying mechanism for tcp neurotoxicity. |
2017-11-22 |
2023-08-13 |
Not clear |
| Yuehua Guo, Kaili Yang, Jiachen Sun, Jie Wu, Huangxian J. A pH-responsive colorimetric strategy for DNA detection by acetylcholinesterase catalyzed hydrolysis and cascade amplification. Biosensors & bioelectronics. vol 94. 2017-11-20. PMID:28388529. |
a ph-responsive colorimetric strategy was designed for sensitive and convenient biosensing by introducing acetylcholinesterase (ache) catalyzed hydrolysis of acetylcholine to change solution ph and phenol red as an indicator. |
2017-11-20 |
2023-08-13 |
Not clear |
| Neeraj Kumar, Kishore Kumar Krishnani, Narendra Pratap Sing. Oxidative and cellular stress as bioindicators for metal contamination in freshwater mollusk Lamellidens marginalis. Environmental science and pollution research international. vol 24. issue 19. 2017-11-20. PMID:28537033. |
aspartate amino transferase (ast), alanine amino transferase (alt), and lipid peroxidation (lpo) were significantly (p < 0.01) higher, while neurotransmitter enzymes such as acetylcholine esterase (ache) were significantly inhibited in muscle of l. marginalis (p < 0.01) collected from different sampling sites. |
2017-11-20 |
2023-08-13 |
cat |
| Zhengyu Yan, Kun Yan, Xingliang He, Yanhua Liu, Jie Zhang, Oscar Lopez Torres, Ruixin Guo, Jianqiu Che. The impact assessment of anticancer drug imatinib on the feeding behavior of rotifers with an integrated perspective: Exposure, post-exposure and re-exposure. Chemosphere. vol 185. 2017-11-16. PMID:28710991. |
the activities of acetylcholine esterase (ache) and the levels of reactive oxygen species (ros) in rotifers were also detected. |
2017-11-16 |
2023-08-13 |
Not clear |
| Mirna Ezzat Sorial, Nesrine Salah El Dine El Saye. Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 6. 2017-11-08. PMID:28188358. |
the mice also exhibited a decrease in acetylcholine (ach) and neprilysin (nep) levels accompanied by an increase in acetylcholinesterase (ache) activity. |
2017-11-08 |
2023-08-13 |
mouse |
| Mohammad Nazim, Akio Masuda, Mohammad Alinoor Rahman, Farhana Nasrin, Jun-Ichi Takeda, Kenji Ohe, Bisei Ohkawara, Mikako Ito, Kinji Ohn. Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms. Nucleic acids research. vol 45. issue 3. 2017-10-30. PMID:28180311. |
acetylcholinesterase (ache), encoded by the ache gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. |
2017-10-30 |
2023-08-13 |
human |
| Shuaizhang Li, Ruili Huang, Samuel Solomon, Yitong Liu, Bin Zhao, Michael F Santillo, Menghang Xi. Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms. Biotechnology journal. vol 12. issue 5. 2017-10-25. PMID:28294544. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. |
2017-10-25 |
2023-08-13 |
human |
| Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frej. Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption. Toxicology. vol 390. 2017-10-23. PMID:28916328. |
this study shows that pq impaired acetylcholine levels and induced ache inhibition and increased cht expression only after 14days exposure, which suggests that acetylcholine levels alteration could be mediated by these actions. |
2017-10-23 |
2023-08-13 |
Not clear |
| Silvia Di Tommaso, Carlo Cavallotti, Antonio Malvasi, Daniele Vergara, Antonio Rizzello, Francesco De Nuccio, Andrea Tinell. A Qualitative and Quantitative Study of the Innervation of the Human Non Pregnant Uterus. Current protein & peptide science. vol 18. issue 2. 2017-10-16. PMID:27063643. |
in the present investigation, we analyzed the uterine distribution of a large set of neurotransmitters, focusing on adrenergic, noradredenergic, acetylcholine (ache) positive, dopaminergic, serotoninergic and peptidergic neurofibers; among these latter, we focused on those releasing prolattine, enkephalines (enks), vasoactive intestinal polypeptide (vip), substance p (sp) and oxytocine. |
2017-10-16 |
2023-08-13 |
human |
| Liang Peng, Zhengxing Rong, Hao Wang, Biyun Shao, Lei Kang, Hong Qi, Hongzhuan Che. A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease. Biomedical chromatography : BMC. vol 31. issue 10. 2017-10-09. PMID:28295437. |
acetycholinesterase (ache) that regulates hydrolysis of acetylcholine (ach) in the brain, is an important target for treatment of alzheimer's disease (ad), a feature of which is ach deficiency. |
2017-10-09 |
2023-08-13 |
Not clear |
| Ikunobu Muramatsu, Junsuke Uwada, Takayoshi Masuoka, Hatsumi Yoshiki, Kiyonao Sada, Kung-Shing Lee, Matomo Nishio, Takaharu Ishibashi, Takanobu Taniguch. Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission. Journal of neurochemistry. vol 143. issue 1. 2017-10-09. PMID:28700094. |
in addition to hydrolysis by acetylcholine esterase (ache), acetylcholine (ach) is also directly taken up into brain tissues. |
2017-10-09 |
2023-08-13 |
rat |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
the serine hydrolase butyrylcholinesterase (bche), like the related enzyme acetylcholinesterase (ache), co-regulates metabolism of the neurotransmitter acetylcholine. |
2017-10-02 |
2023-08-13 |
mouse |
| Melissa A Pickett, Michael K Dush, Nanette M Nascone-Yode. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development (Cambridge, England). vol 144. issue 15. 2017-10-02. PMID:28684626. |
acetylcholinesterase (ache) is crucial for degrading acetylcholine at cholinergic synapses. |
2017-10-02 |
2023-08-13 |
Not clear |
| Miranda L Xu, Cathy W C Bi, Etta Y L Liu, Tina T X Dong, Karl W K Tsi. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28607150. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. |
2017-09-26 |
2023-08-13 |
human |
| Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Dera. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology. vol 18. issue 7. 2017-09-19. PMID:28106328. |
acetylcholinesterase (ache), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. |
2017-09-19 |
2023-08-13 |
Not clear |