| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Rathish, S B Agampodi, M A C S Jayasumana, S H Siribaddan. From organophosphate poisoning to diabetes mellitus: The incretin effect. Medical hypotheses. vol 91. 2017-06-15. PMID:27142144. |
op poisoning leads to accumulation of acetylcholine (ach) due to the inhibition of acetylcholinesterases (ache). |
2017-06-15 |
2023-08-13 |
Not clear |
| Hee Jeong Eom, Hee Rae Kang, Ho Kyong Kim, Eun Bee Jung, Hyun Bong Park, Ki Sung Kang, Ki Hyun Ki. Bioactivity-guided isolation of antioxidant triterpenoids from Betula platyphylla var. japonica bark. Bioorganic chemistry. vol 66. 2017-06-06. PMID:27060627. |
however, no compound showed significant inhibition of acetylcholine esterase (ache). |
2017-06-06 |
2023-08-13 |
Not clear |
| Jong Min Kim, Chang Hyeon Park, Seon Kyeong Park, Tae Wan Seung, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Dae-Ok Kim, Ho Jin He. Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice. Journal of agricultural and food chemistry. vol 65. issue 13. 2017-06-05. PMID:28314104. |
g re regulated acetylcholine (ach), acetylcholinesterase (ache), malondialdehyde (mda), superoxide dismutase (sod), and oxidized glutathione (gsh)/total gsh by regulating the c-jun n-terminal protein kinase (jnk) pathway. |
2017-06-05 |
2023-08-13 |
mouse |
| Kei M Lau, Amy G W Gong, Miranda L Xu, Candy T W Lam, Laura M L Zhang, Cathy W C Bi, D Cui, Anthony W M Cheng, Tina T X Dong, Karl W K Tsim, Huangquan Li. Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis. Brain research. vol 1642. 2017-05-22. PMID:27021952. |
the expression of acetylcholinesterase (ache), an enzyme hydrolyzes neurotransmitter acetylcholine at vertebrate neuromuscular junction, is regulated during myogenesis, indicating the significance of muscle intrinsic factors in controlling the enzyme expression. |
2017-05-22 |
2023-08-13 |
mouse |
| Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua D. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules (Basel, Switzerland). vol 22. issue 3. 2017-05-18. PMID:28272324. |
further, dl0410 inhibited the ache activity and increased acetylcholine (ach) levels in a dose-dependent manner, and interacted with the active site of ache in a similar manner as donepezil. |
2017-05-18 |
2023-08-13 |
mouse |
| Neeraj Kumar, K K Krishnani, K K Meena, Sanjay Kumar Gupta, N P Sing. Oxidative and cellular metabolic stress of Oreochromis mossambicus as biomarkers indicators of trace element contaminants. Chemosphere. vol 171. 2017-05-02. PMID:28027471. |
the brain acetylcholine esterase (ache) was noticeably inhibited (p < 0.01) whereas lipid peroxide (lpo) elevated in fish collected from a few sites. |
2017-05-02 |
2023-08-13 |
cat |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
acetylcholinesterase (ache) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. |
2017-03-22 |
2023-08-13 |
Not clear |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
to combat this, ache reactivators have to be developed to remove the offending ache inhibitor, restoring acetylcholine levels to normal. |
2017-03-22 |
2023-08-13 |
Not clear |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
acheis reversibly inhibit acetylcholinesterase (ache), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. |
2017-03-10 |
2023-08-13 |
Not clear |
| Neeraj Kumar, Kondusamy Ambasankar, Kishore Kumar Krishnani, Shashi Bhushan, Paramjit Singh Minha. Dietary Pyridoxine Protects against Stress and Maintains Immunohaematological Status in Chanos chanos Exposed to Endosulfan. Basic & clinical pharmacology & toxicology. vol 119. issue 3. 2017-03-09. PMID:27038044. |
the effect of dietary pyridoxine supplementation was studied in terms of antioxidative enzymes (catalase, superoxide dismutase, glutathione-s-transferase), stress markers [heat-shock protein 70, caspase-3, cortisol, acetylcholine esterase (ache), blood glucose], immunohaematological parameters (total protein, albumin, globulin and a/g ratio, nitroblue tetrazolium, rbc, wbc, hb), gill histopathology and a subsequent challenge study with vibrio parahaemolyticus. |
2017-03-09 |
2023-08-13 |
Not clear |
| Catarina Duarte, Patrícia Napoleão, Teresa Freitas, Carlota Saldanh. An ex vivo study of nitric oxide efflux from human erythrocytes in both genders. Clinical hemorheology and microcirculation. vol 64. issue 4. 2017-03-09. PMID:27767976. |
it is also known that binding of acetylcholine (ach) with ache on erythrocyte membrane initiates a signal transduction mechanism that stimulates nitric oxide (no) efflux. |
2017-03-09 |
2023-08-13 |
human |
| Jean Froment, Kevin V Thomas, Knut Erik Tollefse. Automated high-throughput in vitro screening of the acetylcholine esterase inhibiting potential of environmental samples, mixtures and single compounds. Ecotoxicology and environmental safety. vol 130. 2017-03-07. PMID:27085000. |
a high-throughput and automated assay for testing the presence of acetylcholine esterase (ache) inhibiting compounds was developed, validated and applied to screen different types of environmental samples. |
2017-03-07 |
2023-08-13 |
Not clear |
| Syed Mohd Danish Rizvi, Sibhghatulla Shaikh, Deeba Naaz, Shazi Shakil, Adnan Ahmad, Mohd Haneef, Adel M Abuzenada. Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26886763. |
therefore, the present study was carried out to find whether glimepiride, an oral antidiabetic drug which is a pparγ agonist could inhibit the activity of acetylcholine esterase (ache) enzyme. |
2017-03-06 |
2023-08-13 |
Not clear |
| Syed Mohd Danish Rizvi, Sibhghatulla Shaikh, Deeba Naaz, Shazi Shakil, Adnan Ahmad, Mohd Haneef, Adel M Abuzenada. Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26886763. |
actually, ache inhibitors seize the breakdown of acetylcholine which forms the main therapeutic strategy for ad. |
2017-03-06 |
2023-08-13 |
Not clear |
| Syed Mohd Danish Rizvi, Sibhghatulla Shaikh, Deeba Naaz, Shazi Shakil, Adnan Ahmad, Mohd Haneef, Adel M Abuzenada. Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26886763. |
glimepiride was found to interact with ache enzyme at the same locus as that of substrate acetylcholine iodide (achi). |
2017-03-06 |
2023-08-13 |
Not clear |
| Nidhi Chauhan, Sheetal Chawla, C S Pundir, Utkarsh Jai. An electrochemical sensor for detection of neurotransmitter-acetylcholine using metal nanoparticles, 2D material and conducting polymer modified electrode. Biosensors & bioelectronics. vol 89. issue Pt 1. 2017-03-01. PMID:27342368. |
an essential biological sensor for acetylcholine (ach) detection is constructed by immobilizing enzymes, acetylcholinesterase (ache) and choline oxidase (cho), on the surface of iron oxide nanoparticles (fe |
2017-03-01 |
2023-08-13 |
Not clear |
| Roman Roy, Flavia Niccolini, Gennaro Pagano, Marios Politi. Cholinergic imaging in dementia spectrum disorders. European journal of nuclear medicine and molecular imaging. vol 43. issue 7. 2017-02-24. PMID:26984612. |
spect and pet studies using selective radioligands for cholinergic markers, such as [(11)c]mp4a and [(11)c]pmp pet for acetylcholinesterase (ache), [(123)i]5ia spect for the α4β2 nicotinic acetylcholine receptor and [(123)i]ibvm spect for the vesicular acetylcholine transporter, have been developed in an attempt to clarify those aspects of the diseases that remain unclear. |
2017-02-24 |
2023-08-13 |
Not clear |
| Emin Garibov, Parham Taslimi, Afsun Sujayev, Zeynebe Bingol, Songul Çetinkaya, İlhami Gulçin, Sukru Beydemir, Vagif Farzaliyev, Saleh H Alwasel, Claudiu T Supura. Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue sup3. 2017-02-23. PMID:27329935. |
these cyclic thioureas showed good inhibitory action against acetylcholine esterase (ache), butyrylcholine esterase (bche), and human (h) carbonic anhydrase (ca) isoforms i and ii. |
2017-02-23 |
2023-08-13 |
human |
| Satinderpal Singh, Atish Prakash, Shamsherjit Kaur, Long Chiau Ming, Vasudevan Mani, Abu Bakar Abdul Majee. The role of multifunctional drug therapy as an antidote to combat experimental subacute neurotoxicity induced by organophosphate pesticides. Environmental toxicology. vol 31. issue 8. 2017-02-16. PMID:25864908. |
the results showed that chronic administration of cpf significantly impaired learning and memory, along with motor coordination, and produced a marked increase in oxidative stress along with significantly reduced acetylcholine esterase (ache) activity. |
2017-02-16 |
2023-08-13 |
rat |
| Roobakkumar Amsalingam, Prabu Gajjeraman, Nisha Sam, Vattakandy Jasin Rahman, Babu Azaria. Mechanism of Fenpropathrin Resistance in Red Spider Mite, Oligonychus coffeae (Acarina: Tetranychidae), Infesting Tea [Camellia sinensis L. (O. Kuntze)]. Applied biochemistry and biotechnology. vol 181. issue 2. 2017-02-06. PMID:27604837. |
the development of acaricide (fenpropathrin) resistance has been screened in field populations (fps) of rsms from different tea-growing regions of south india and compared with a laboratory-susceptible population (sp) based on toxicity bioassay, detoxifying enzyme activities, analysis of acetylcholine esterase gene (ache, 2064 bp), and their expression pattern using semiquantitative rt-pcr. |
2017-02-06 |
2023-08-13 |
spider |