| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsade C B Piermartiri, Hongna Pan, Jun Chen, John McDonough, Neil Grunberg, James P Apland, Ann M Marin. Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. Neuromolecular medicine. vol 17. issue 3. 2016-05-20. PMID:25920465. |
exposure to organophosphorous (op) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (ache) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. |
2016-05-20 |
2023-08-13 |
Not clear |
| Zhiqing Pang, Che-Ming J Hu, Ronnie H Fang, Brian T Luk, Weiwei Gao, Fei Wang, Erdembileg Chuluun, Pavimol Angsantikul, Soracha Thamphiwatana, Weiyue Lu, Xinguo Jiang, Liangfang Zhan. Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers. ACS nano. vol 9. issue 6. 2016-05-16. PMID:26053868. |
organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (ache), leading to neuromuscular disorders via accumulation of acetylcholine in the body. |
2016-05-16 |
2023-08-13 |
mouse |
| Juliana O S Giacoppo, Tanos C C França, Kamil Kuča, Elaine F F da Cunha, Ruben Abagyan, Daiana T Mancini, Teodorico C Ramalh. Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. Journal of biomolecular structure & dynamics. vol 33. issue 9. 2016-04-19. PMID:25407587. |
nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (ache), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. |
2016-04-19 |
2023-08-13 |
Not clear |
| Tada-aki Kudo, Hiroyasu Kanetaka, Kentaro Mochizuki, Kanako Tominami, Shoko Nunome, Genji Abe, Hiroyuki Kosukegawa, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Toshiyuki Takagi, Shin-ichi Izum. Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation. PloS one. vol 10. issue 4. 2016-04-15. PMID:25879210. |
we then measured the extent of growth, neuritogenesis, or acetylcholine esterase (ache) activity (a neuronal marker). |
2016-04-15 |
2023-08-13 |
rat |
| Jian-xiang Liu, Min-ying Zhu, Ci-yuan Feng, Hai-bin Ding, Ying Zhan, Zhan Zhao, Yue-min Din. Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia. Journal of Zhejiang University. Science. B. vol 16. issue 7. 2016-04-05. PMID:26160717. |
the hippocampus of dementia model rats showed reduced levels of acetylcholine (ach), epinephrine (e), norepinephrine (ne), and dopamine (da), and increased activities of acetylcholine esterase (ache) and monoamine oxidase (mao). |
2016-04-05 |
2023-08-13 |
rat |
| Hayate Javed, Kumar Vaibhav, M Ejaz Ahmed, Andleeb Khan, Rizwana Tabassum, Farah Islam, Mohammed M Safhi, Fakhrul Isla. Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice. Journal of the neurological sciences. vol 348. issue 1-2. 2016-04-04. PMID:25434716. |
hesperidin pretreatment improved memory consolidation process as tested by morris water maze possibly through modulation of acetylcholine esterase activity (ache). |
2016-04-04 |
2023-08-13 |
mouse |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| I V Zueva, V E Semenov, M A Mukhamedyarov, S V Lushchekina, A D Kharlamova, E O Petukhova, A S Mikhailov, S N Podyachev, L F Saifina, K A Petrov, O A Minnekhanova, V V Zobov, E E Nikolsky, P Masson, V S Rezni. 6-Methyluracil derivatives as acetylcholinesterase inhibitors for treatment of Alzheimer's disease. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639718. |
these approaches mainly focus on the inhibition of brain acetyl-cholinesterase (ache) to increase lifetime of cerebral acetylcholine [3]. |
2016-03-15 |
2023-08-13 |
mouse |
| Farhana Mazhar, Raisa Khanum, Muhammad Ajaib, Muhammad Jahangi. Potent AChE enzyme inhibition activity of Zizyphus oxyphylla: A new source of antioxidant compounds. Pakistan journal of pharmaceutical sciences. vol 28. issue 6. 2016-03-10. PMID:26639499. |
the fractions were also studied for acetylcholine esterase enzyme (ache) enzyme inhibition activity and n-butanol soluble fraction exhibited maximum inhibition (95.5 ± 0.13 mg/ml with ic50 =9.58 ± 0.08 mg/ml relative to galanthamine (13.26 ± 0.73 mg/ml), while n- hexane soluble fraction (165.15 ± 0.94 mg/ml) showed non-significant. |
2016-03-10 |
2023-08-13 |
Not clear |
| Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Zhi-Xiu Li. Honokiol improves learning and memory impairments induced by scopolamine in mice. European journal of pharmacology. vol 760. 2016-03-08. PMID:25912802. |
in addition, treatment with honokiol significantly decreased the protein and mrna levels of interleukin (il)-1β and the activity of acetylcholinesterase (ache), while significantly increased the protein and mrna levels of il-10, and the level of acetylcholine (ach) in the brain of the scop-treated mice. |
2016-03-08 |
2023-08-13 |
mouse |
| Akın Akıncıoğlu, Hülya Akıncıoğlu, İlhami Gülçin, Serdar Durdagi, Claudiu T Supuran, Süleyman Göks. Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-29. PMID:25921269. |
in this study, several novel sulfamides were synthesized and evaluated for their acetylcholine esterase (ache) and human carbonic anhydrase i, and ii isoenzymes (hca i and ii) inhibition profiles. |
2016-02-29 |
2023-08-13 |
human |
| Fen Liu, Yong Li, Rong Jiang, Cheng Nie, Zhenguo Zeng, Ning Zhao, Caixue Huang, Qiang Shao, Chengzhi Ding, Cheng Qing, Liang Xia, Erming Zeng, Kejian Qia. miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway. Experimental lung research. vol 41. issue 5. 2016-02-26. PMID:26052826. |
we hypothesized that mir-132 attenuated lipopolysaccharide (lps)-induced inflammation of alveolar macrophages by targeting acetylcholinesterase (ache) and enhancing the acetylcholine (ach)-mediated cholinergic anti-inflammatory response. |
2016-02-26 |
2023-08-13 |
Not clear |
| Chun-Li Liu, Hong Chen, Yong Jiang, Peng-Fei Tu, Ming Zhong, Jing-Yi Ma, Hui Ding, Wan-Xin Zhang, Xiao-Min Ji. [Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 5. 2016-01-25. PMID:23888706. |
the content of acetylcholine (ach) and choline (ch) of microdialysate extracellular of hippocampus and striatum was determined by hplc-imer-ecd and the ache activity in the hippocampus was measured. |
2016-01-25 |
2023-08-12 |
rat |
| Xue-Qin Hou, Lei Zhang, Cong Yang, Cui-Ping Rong, Wen-Qing He, Chun-Xia Zhang, Shi Li, Ru-Yu Su, Xiang Chang, Ji-Huan Qin, Yun-Bo Chen, Shao-Xiang Xian, Qi Wan. Alleviating effects of Bushen-Yizhi formula on ibotenic acid-induced cholinergic impairments in rat. Rejuvenation research. vol 18. issue 2. 2016-01-22. PMID:25482164. |
additionally, bsyz reversed ibo-induced disorders of acetylcholine (ach) levels, chat, and cholinesterase (che) in the cortex, which was consistent with the changes in mrna levels of chat and acetylcholinesterase (ache). |
2016-01-22 |
2023-08-13 |
rat |
| Elvis A F Martis, Rakesh C Chandarana, Mushtaque S Shaikh, Premlata K Ambre, Jacinta S D'Souza, Krishna R Iyer, Evans C Coutinho, Santosh R Nandan, Raghuvir R S Pissurlenka. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 33. issue 5. 2016-01-15. PMID:24905476. |
there is a need for continued development of acetylcholinesterase (ache) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
| K Szigeti, M U Hafee. Exploring the role of donepezil in dementia with Lewy bodies. Drugs of today (Barcelona, Spain : 1998). vol 51. issue 10. 2016-01-07. PMID:26583300. |
these drugs, by reversibly blocking the hydrolytic activity of ache, increase the availability of synaptic acetylcholine. |
2016-01-07 |
2023-08-13 |
Not clear |
| J O Hollnagel, R Ul Haq, C J Behrens, A Maslarova, I Mody, U Heineman. No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro. Neuroscience. vol 284. 2016-01-04. PMID:25453770. |
acetylcholine (ach) is well known to induce persistent γ-oscillations in the hippocampus when applied together with physostigmine, an inhibitor of the ach degrading enzyme acetylcholinesterase (ache). |
2016-01-04 |
2023-08-13 |
rat |
| Maleeha Waqar, Sidra Batoo. In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer's disease. Journal of theoretical biology. vol 372. 2015-12-31. PMID:25747777. |
acetylcholinesterases (ache) are enzymes that function in hydrolyzing the neurotransmitter acetylcholine. |
2015-12-31 |
2023-08-13 |
Not clear |
| Rafał Sokołowski, Tadeusz Płus. [Today's threat of use of organophosphorus compounds]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 39. issue 231. 2015-12-31. PMID:26449583. |
inhibition of ache activity leads to the accumulation of large amounts of acetylcholine and hyperactivity of the cholinergic system by stimulating acetylcholine receptors - muscarinic and nicotinic. |
2015-12-31 |
2023-08-13 |
Not clear |
| Sihua Qian, Hengwei Li. Colorimetric sensor array for detection and identification of organophosphorus and carbamate pesticides. Analytical chemistry. vol 87. issue 10. 2015-12-23. PMID:25913282. |
the sensing mechanism of this array is based on the irreversible inhibition capability of ops and carbamates to the activity of acetylcholinesterase (ache), preventing production of thiocholine and h2o2 from s-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and h2o2 sensitive indicators. |
2015-12-23 |
2023-08-13 |
Not clear |