| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Liu, Carey Pop. The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. Neurotoxicology. vol 46. 2015-11-12. PMID:25447325. |
organophosphorus anticholinesterases (ops) elicit acute toxicity by inhibiting acetylcholinesterase (ache), leading to acetylcholine accumulation and overstimulation of cholinergic receptors. |
2015-11-12 |
2023-08-13 |
rat |
| Chunjiang Li, Qingwei Wang, Lanlan Li, Yun Liu, Hongwei Dia. Arachidonic acid attenuates learning and memory dysfunction induced by repeated isoflurane anesthesia in rats. International journal of clinical and experimental medicine. vol 8. issue 8. 2015-11-09. PMID:26550146. |
additionally, ara increased the activities of choline acetyl transferase (chat), superoxide dismutase (sod), glutathione peroxidase (gsh-px) and the levels of acetycholine (ach) and γ-amino-butyric acid (gaba), whereas decreased the activity of acetylcholine esterase (ache), the content of glutamate (glu) and malondialdehyde (mda), and the radio of glu/gaba. |
2015-11-09 |
2023-08-13 |
rat |
| Yi Xie, Binbin Wang, Fanchi Li, Lie Ma, Min Ni, Weide Shen, Fashui Hong, Bing L. Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971466. |
the treatments also relieved the phoxim-induced increases in the contents of acetylcholine (ach), glutamate (glu) and nitric oxide (no) and the phoxim-induced decreases in the contents of norepinephrine (ne), dopamine (da), and 5-hydroxytryptamine (5-ht), and reduced the inhibition of acetylcholinesterase (ache), na+/k+-atpase, ca2+-atpase, and ca2+/mg2+-atpase activities and the activation of total nitric oxide synthase (tnos) in the brain. |
2015-10-28 |
2023-08-13 |
Not clear |
| Young Hun Lee, Min Cheol Shin, Yong Don Yun, Seo Young Shin, Jong Min Kim, Jeong Moo Seo, Nam-Jung Kim, Jong Hoon Ryu, Yong Sup Le. Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25468034. |
to date, the successful therapeutic strategy to treat ad is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (ache). |
2015-10-22 |
2023-08-13 |
mouse |
| Fátima Husein Abdalla, Andréia Machado Cardoso, Roberta Schmatz, Jamile Fabbrin Gonçalves, Jucimara Baldissarelli, Caroline Curry Martins, Daniela Zanini, Lizielle Souza de Oliveira, Pauline da Costa, Victor Camera Pimentel, Luciane Belmonte Pereira, Cibele Lima Lhamas, Maria Rosa Chitolina Schetinger, Vera Maria Morsch, Cinthia Melazzo Andrade Mazzant. Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium. Molecular and cellular biochemistry. vol 396. issue 1-2. 2015-10-06. PMID:25064450. |
thus, we can suggest that the quercetin is able to modulate ntpdase, ada, ache, and mpo activities and contribute to maintain the levels of atp, adenosine, and acetylcholine normal, respectively, exhibiting potent pro-inflammatory and anti-inflammatory actions. |
2015-10-06 |
2023-08-13 |
rat |
| Li Tao, Jianmei Xie, Yuting Wang, Shi Wang, Shuangchan Wu, Qiman Wang, Hong Din. Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells. Bioorganic & medicinal chemistry letters. vol 24. issue 23. 2015-10-06. PMID:25453793. |
after behavioral testing, the mice were sacrificed and their hippocampi were removed for biochemical assays (superoxide dismutase (sod), glutathione peroxidase (gpx), malondialdehyde (mda), ache and acetylcholine (ach)). |
2015-10-06 |
2023-08-13 |
mouse |
| An Zhou, Hongfei Wu, Jian Pan, Xuncui Wang, Jiaming Li, Zeyu Wu, Ailing Hu. Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Molecules (Basel, Switzerland). vol 20. issue 1. 2015-10-02. PMID:25594344. |
taking into account the key pathological features of ad, such as low levels of acetylcholine, beta-amyloid (aβ) aggregation, oxidative stress and dyshomeostasis of biometals, a new series of paeonol derivatives 5a-5d merging three different functions, i.e., antioxidant, anti-acetylcholinesterase (ache) activity, metal chelating agents for ad treatment have been synthesized and characterized. |
2015-10-02 |
2023-08-13 |
Not clear |
| Ying Li, Shan Hai, Yan Zhou, Bi Rong Don. Cholinesterase inhibitors for rarer dementias associated with neurological conditions. The Cochrane database of systematic reviews. issue 3. 2015-10-02. PMID:25734590. |
cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (ache) which breaks down the neurotransmitter acetylcholine. |
2015-10-02 |
2023-08-13 |
Not clear |
| Sujuan Zhao, Guangyu Li, Jun Che. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring. Journal of proteomics. vol 114. 2015-10-01. PMID:25479203. |
mclr accumulation, the levels of malondialdehyde (mda) and acetylcholine esterase (ache) activity were detected. |
2015-10-01 |
2023-08-13 |
rat |
| Lewis Gazzard, Karen Williams, Huifen Chen, Lorraine Axford, Elizabeth Blackwood, Brenda Burton, Kerry Chapman, Peter Crackett, Joy Drobnick, Charles Ellwood, Jennifer Epler, Michael Flagella, Emanuela Gancia, Matthew Gill, Simon Goodacre, Jason Halladay, Joanne Hewitt, Hazel Hunt, Samuel Kintz, Joseph Lyssikatos, Calum Macleod, Sarah Major, Guillaume Médard, Raman Narukulla, Judi Ramiscal, Stephen Schmidt, Eileen Seward, Christian Wiesmann, Ping Wu, Sharon Yee, Ivana Yen, Shiva Male. Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. Journal of medicinal chemistry. vol 58. issue 12. 2015-09-14. PMID:25988399. |
lead compound 1 (gne-783), the prototype of the 1,7-diazacarbazole class of chk1 inhibitors, was found to be a highly potent inhibitor of acetylcholine esterase (ache) and unsuitable for development. |
2015-09-14 |
2023-08-13 |
mouse |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
there is evidence that ebselen inhibits acetylcholinesterase (ache) activity, an enzyme that plays a key role in the cholinergic system by hydrolyzing acetylcholine (ach), in vitro and ex vivo. |
2015-09-11 |
2023-08-13 |
Not clear |
| Benjamín Pérez-Aguilar, Cecilio J Vidal, Guillermina Palomec, Fernando García-Dolores, María Concepción Gutiérrez-Ruiz, Leticia Bucio, José Luis Gómez-Olivares, Luis Enrique Gómez-Quiro. Acetylcholinesterase is associated with a decrease in cell proliferation of hepatocellular carcinoma cells. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25869328. |
acetylcholinesterase (ache), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. |
2015-08-27 |
2023-08-13 |
human |
| Ana Claudia Souza, Andressa Souza, Liciane Fernandes Medeiros, Carla De Oliveira, Vanessa Leal Scarabelot, Rosane Souza Da Silva, Mauricio Reis Bogo, Katiucia Marques Capiotti, Luiza Wilges Kist, Carla D Bonan, Wolnei Caumo, Iraci L S Torre. Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring. Brain research. vol 1595. 2015-08-21. PMID:25451122. |
the objective of this study was to evaluate the effects of maternal caffeine intake on the neuromotor development of rat offspring and on acetylcholine degradation and acetylcholinesterase (ache) expression in the hippocampus of 14-day-old infant rats. |
2015-08-21 |
2023-08-13 |
rat |
| Mohamed A Elnasharty, Ahmed Sayed-Ahme. Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25239149. |
cholinergic innervation of the rat adrenal gland has been analyzed previously using cholinergic markers including acetylcholinesterase (ache), choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht). |
2015-08-20 |
2023-08-13 |
rat |
| Ran-Ran Zhao, Fei Xu, Xiao-Chen Xu, Guo-Jun Tan, Liang-Min Liu, Ning Wu, Wen-Zhong Zhang, Ji-Xiang Li. Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia. Neuroscience letters. vol 587. 2015-08-10. PMID:25534501. |
additionally, alpha-lipoic acid raised the level of acetylcholine (ach) and choline acetyltransferase (chat) and decreased the activity of acetycholinesterase (ache) in the hippocampus. |
2015-08-10 |
2023-08-13 |
rat |
| Fen Wang, Xianzhong Zeng, Yangbo Zhu, Dan Ning, Junxia Liu, Chunlei Liu, Xuemei Jia, Defa Zh. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25371181. |
the present study has investigated the effect of t4 and donepezil (don; an acetylcholinesterase (ache) inhibitor) treatment on the hypothyroidism-induced alterations of acetylcholine (ach) content and ache activity. |
2015-07-30 |
2023-08-13 |
rat |
| Armando Méndez-Garrido, Maricarmen Hernández-Rodríguez, Rafael Zamorano-Ulloa, José Correa-Basurto, Jessica Elena Mendieta-Wejebe, Daniel Ramírez-Rosales, Martha Cecilia Rosales-Hernánde. In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25096900. |
it is well known that the principal biomolecules involved in alzheimer's disease (ad) are acetylcholinesterase (ache), acetylcholine (ach) and the amyloid beta peptide of 42 amino acid residues (aβ42). |
2015-07-29 |
2023-08-13 |
Not clear |
| Jin Wuk Lee, Bo-Mi Kim, Chang-Bum Jeong, Eun-Ji Won, Jae-Sung Rhee, Jae-Seong Le. Inhibitory effects of biocides on transcription and protein activity of acetylcholinesterase in the intertidal copepod Tigriopus japonicus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 167. 2015-07-21. PMID:25468639. |
acetlycholinesterase (ache) is a serine esterase that plays an important role in the hydrolytic degradation of acetylcholine. |
2015-07-21 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Saida Haider, Sadia Saleem, Tahira Perveen, Saiqa Tabassum, Zehra Batool, Sadia Sadir, Laraib Liaquat, Syeda Madih. Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system. Age (Dordrecht, Netherlands). vol 36. issue 3. 2015-07-15. PMID:24771014. |
to investigate the relationship between the oxidative stress and memory decline during aging, we have determined the level of lipid peroxidation, activities of antioxidant enzymes, and activity of acetylcholine esterase (ache) in brain and plasma as well as biogenic amine levels in brain from albino-wistar rats at age of 4 and 24 months. |
2015-07-15 |
2023-08-13 |
rat |