| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Wang, Chonglei Li, Wei Liu, Yihe Ji. Potential mechanisms of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose VOCs. Inhalation toxicology. vol 26. issue 4. 2014-10-14. PMID:24568580. |
the levels of reactive oxygen species (ros), malondialdehyde (mda) and glutamic acid (glu) were significantly increased, while the acetylcholinesterase (ache), choline acetyltransferase (chat) and acetylcholine (ach) levels, and the expression of nmda receptor were significantly decreased in vocs exposed groups. |
2014-10-14 |
2023-08-12 |
mouse |
| Seung Ok Nam, Dong Hyun Park, Young Hun Lee, Jong Hoon Ryu, Yong Sup Le. Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 22. issue 4. 2014-09-29. PMID:24485122. |
to date, the successful therapeutic strategy to treat ad is maintaining levels of acetylcholine by inhibiting acetylcholinesterase (ache). |
2014-09-29 |
2023-08-12 |
mouse |
| Ji Zhou, Kaifu Xiao, Baoyang Wei, Zhi Wang, Yun Tian, Yixing Tian, Qisheng Son. Bioaccumulation of Cry1Ab protein from an herbivore reduces anti-oxidant enzyme activities in two spider species. PloS one. vol 9. issue 1. 2014-09-18. PMID:24454741. |
we also show that the activities of three key metabolic enzymes, acetylcholine esterase (ache), glutathione peroxidase (gsh-px), and superoxide dismutase (sod) were significantly influenced in the spiders after feeding on cry1ab-containing fruit flies. |
2014-09-18 |
2023-08-12 |
drosophila_melanogaster |
| Eduardo Luis Konrath, Carolina dos Santos Passos, Luiz Carlos Klein, Amélia T Henrique. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24236981. |
the inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for alzheimer's disease (ad). |
2014-09-05 |
2023-08-12 |
Not clear |
| Yinhui Yi, Gangbing Zhu, Chang Liu, Yan Huang, Youyu Zhang, Haitao Li, Jiangna Zhao, Shouzhuo Ya. A label-free silicon quantum dots-based photoluminescence sensor for ultrasensitive detection of pesticides. Analytical chemistry. vol 85. issue 23. 2014-08-28. PMID:24160846. |
this sensing strategy involves the reaction of acetylcholine chloride (ach) with acetylcholinesterase (ache) to form choline that is in turn catalytically oxidized by choline oxidase (chox) to produce betaine and h2o2 which can quench the photoluminescence (pl) of siqds. |
2014-08-28 |
2023-08-12 |
Not clear |
| Antoine-Scott Badin, John Eraifej, Susan Greenfiel. High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases. Neuropharmacology. vol 73. 2014-08-13. PMID:23711548. |
a 14 amino acid peptide fragment ('t14'), deriving from the c-terminus of ache: this peptide has been shown to be bioactive in a range of preparations and to act at an allosteric site on α₇ nicotinic acetylcholine receptors (α₇-nachrs). |
2014-08-13 |
2023-08-12 |
rat |
| Athina A Strilakou, Stylianos T Tsakiris, Konstantinos G Kalafatakis, Aikaterini T Stylianaki, Petros L Karkalousos, Andreas V Koulouris, Iordanis S Mourouzis, Charis A Liap. Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats. Canadian journal of physiology and pharmacology. vol 92. issue 1. 2014-07-25. PMID:24383876. |
choline is also the precursor of acetylcholine (cholinergic component of the heart's autonomic nervous system), whose levels are regulated by acetylcholinesterase (ache). |
2014-07-25 |
2023-08-12 |
rat |
| Donghoon Kwon, Jinmyoung Joo, Sanghee Lee, Sangmin Jeo. Facile and sensitive method for detecting cardiac markers using ubiquitous pH meters. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24229314. |
these complexes were subsequently conjugated to polyclonal antibody-functionalized acetylcholinesterase (ache) and dispersed in acetylcholine (ach) solution. |
2014-07-15 |
2023-08-12 |
human |
| Akın Akıncıoğlu, Meryem Topal, Ilhami Gülçin, Süleyman Göks. Novel sulphamides and sulphonamides incorporating the tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors. Archiv der Pharmazie. vol 347. issue 1. 2014-07-15. PMID:24243403. |
inhibition of human (h) carbonic anhydrase (ca) isoenzymes (hca i, hca ii) and acetylcholine esterase (ache) was investigated with the synthesized compounds. |
2014-07-15 |
2023-08-12 |
human |
| Wei-Wei Zhao, Shu Shan, Zheng-Yuan Ma, Lin-Na Wan, Jing-Juan Xu, Hong-Yuan Che. Acetylcholine esterase antibodies on BiOI nanoflakes/TiO2 nanoparticles electrode: a case of application for general photoelectrochemical enzymatic analysis. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24289192. |
specifically, we first prepared a bioi nanoflakes (nfs)/tio2 nanoparticles (nps) p-n heterojunction as the photoelectrode, on the basis of which acetylcholine esterase (ache) antibody was introduced via the bridging of protein a. |
2014-07-15 |
2023-08-12 |
Not clear |
| Eyal Golub, Ronit Freeman, Itamar Willne. Hemin/G-quadruplex-catalyzed aerobic oxidation of thiols to disulfides: application of the process for the development of sensors and aptasensors and for probing acetylcholine esterase activity. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24299064. |
finally, the hemin/g-quadruplex dnazyme/amplex red system was used to follow the activity of acetylcholine esterase, ache, and to probe its inhibition. |
2014-07-15 |
2023-08-12 |
Not clear |
| Aisa Ozawa, Erina Kadowaki, Yosuke Haga, Hitomi Sekiguchi, Natsuko Hemmi, Takuya Kaneko, Takehiro Maki, Kou Sakabe, Shuntaro Hara, Masako Yamamoto, Kazuyoshi Arishima, Motoharu Sakau. Acetylcholine esterase is a regulator of GFAP expression and a target of dichlorvos in astrocytic differentiation of rat glioma C6 cells. Brain research. vol 1537. 2014-06-25. PMID:24001591. |
the known potential targets of ddvp are acetylcholine esterase (ache), fatty acid amide hydrolase and methyl guanine methyl transferase. |
2014-06-25 |
2023-08-12 |
rat |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Sengottayan Senthil-Natha. Physiological and biochemical effect of neem and other Meliaceae plants secondary metabolites against Lepidopteran insects. Frontiers in physiology. vol 4. 2014-06-24. PMID:24391591. |
acethylcholine esterase (ache) is a key enzyme that terminates nerve impulses by catalyzing the hydrolysis of neurotransmitter, acetylcholine, in the nervous system of various organisms. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jennifer L Carey, Courtney Dunn, Romolo J Gaspar. Central respiratory failure during acute organophosphate poisoning. Respiratory physiology & neurobiology. vol 189. issue 2. 2014-06-02. PMID:23933009. |
ops affect neuronal signaling through acetylcholine (ach) neurotransmission via inhibition of acetylcholinesterase (ache), leading to accumulation of ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. |
2014-06-02 |
2023-08-12 |
Not clear |
| Clément Chéhensse, Stéphane Bahrami, Pierre Denys, Pierre Clément, Jacques Bernabé, François Giulian. The spinal control of ejaculation revisited: a systematic review and meta-analysis of anejaculation in spinal cord injured patients. Human reproduction update. vol 19. issue 5. 2014-05-01. PMID:23820516. |
masturbation or coïtus, penile vibratory stimulation (pvs) or acetylcholine esterase (ache) inhibitors prior to masturbation. |
2014-05-01 |
2023-08-12 |
rat |
| Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willne. Cysteine-mediated aggregation of Au nanoparticles: the development of a H2O2 sensor and oxidase-based biosensors. ACS nano. vol 7. issue 8. 2014-05-01. PMID:23829431. |
the cysteine-stimulated aggregation of au nanoparticles (au nps) is used as an auxiliary reporting system for the optical detection of h2o2, for optical probing of the glucose oxidase (gox) and the catalyzed oxidation of glucose, for probing the biocatalytic cascade composed of acetylcholine esterase/choline oxidase (ache/chox), and for following the inhibition of ache. |
2014-05-01 |
2023-08-12 |
Not clear |
| Alicja Tomaszek, Liliana Kiczak, Jacek Bania, Paweł Krupa, Urszula Pasławska, Maciej Zacharski, Adrian Janiszewski, Tadeusz Stefaniak, Dorota Zyśko, Hossein Ardehali, Ewa A Jankowska, Piotr Ponikowsk. Changes in parasympathetic system in medulla oblongata in male pigs in the course of tachycardia-induced cardiomyopathy. Autonomic neuroscience : basic & clinical. vol 177. issue 2. 2014-04-29. PMID:23891249. |
α7 nicotinic acetylcholine receptor (α7nachr) and enzymes metabolizing acetylcholine (acetylcholinesterase, ache, choline acetyltransferase, chat) in medulla oblongata (mo) of male pigs with chronic tachycardia-induced cardiomyopathy. |
2014-04-29 |
2023-08-12 |
Not clear |
| Karyn G Robinson, Janet L Mendonca, Jaimee L Militar, Mary C Theroux, Kirk W Dabney, Suken A Shah, Freeman Miller, Robert E Akin. Disruption of basal lamina components in neuromotor synapses of children with spastic quadriplegic cerebral palsy. PloS one. vol 8. issue 8. 2014-04-08. PMID:23976945. |
the localization of synaptic acetylcholine esterase (ache) relative to postsynaptic acetylcholine receptor (achr), synaptic laminin β2, and presynaptic vesicle protein 2 (sv2) appeared mismatched in the cp samples; whereas, no significant disruption was found between achr and sv2. |
2014-04-08 |
2023-08-12 |
Not clear |
| Roger B Varela, Samira S Valvassori, Jéssica Lopes-Borges, Daiane B Fraga, Wilson R Resende, Camila O Arent, Alexandra I Zugno, João Queved. Evaluation of acetylcholinesterase in an animal model of mania induced by D-amphetamine. Psychiatry research. vol 209. issue 2. 2014-04-02. PMID:23245536. |
our findings further support the notion that the mechanisms of mood stabilizers also involve changes in ache activity, thus reinforcing the need for more studies to better characterize the role of acetylcholine in bipolar disorder. |
2014-04-02 |
2023-08-12 |
rat |