| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
in brain, acetylcholine (ach) is produced by cholinergic neurons and released in extracellular space where it is cleaved by ache anchored by protein prima. |
2014-02-03 |
2023-08-12 |
mouse |
| Xing Lin, Renbin Huang, Shijun Zhang, Ling Wei, Lang Zhuo, Xiaoyan Wu, Aicun Tang, Quanfang Huan. Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice. Fitoterapia. vol 87. 2014-01-16. PMID:23562630. |
furthermore, ahs increased the levels of acetylcholine (ach), but decreased cholinesterase (ache) activity. |
2014-01-16 |
2023-08-12 |
mouse |
| Hanaa H Ahmed, Selim F Estefan, Ehab M Mohamd, Abd El-Razik H Farrag, Rania S Sala. Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model? Indian journal of clinical biochemistry : IJCB. vol 28. issue 4. 2014-01-15. PMID:24426241. |
hydrogen peroxide (h2o2), malondialdehyde (mda), total antioxidant capacity (tac), superoxide dismutase (sod), catalase (cat), b cell lymphoma 2 (bcl-2), brain derived neurotrophic factor (bdnf), acetylcholinesterase (ache) and acetylcholine (ach) were estimated in the brain tissues of the different groups. |
2014-01-15 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
the involvement of brain nicotinic acetylcholine receptors (nachrs) in the neurotoxicological effects of soman, a potent acetylcholinesterase (ache) inhibitor and a chemical warfare agent, is not clear. |
2014-01-13 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
to test the hypothesis that ache inhibition builds sufficient acetylcholine (ach) in the brain and facilitates nachr-dependent glutamate transmission, we used whole-cell patch-clamp technique to record spontaneous glutamate excitatory postsynaptic currents (epscs) from ca1 stratum radiatum interneurons (sri) in hippocampal slices. |
2014-01-13 |
2023-08-12 |
rat |
| Liang Guo, Xin Wang, Jin-yan Li, Hua-shan Liang, Yong Jiang, Shan-shan Chang, Yu-jing Song, Li Cheng, Jin-ping Zhen. [Effects of subchronic benzo[a]pyrene exposure on hippocampal cholinergic system in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 31. issue 2. 2014-01-09. PMID:23433211. |
to observe the effects of subchronic benzo[a]pyrene (b[a]p) exposure on the neurobehavior and hippocampal acetylcholine (ach) level, acetylcholinesterase (ache) activity, and mrna and protein expression of nicotinic acetylcholine receptor α7 subtype (nachr α7) in rats, and to investigate the neurotoxic mechanism of b[a]p. |
2014-01-09 |
2023-08-12 |
rat |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |
| Ilkay Erdogan Orha. Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381529. |
acetylcholinesterase (ache) (ec 3.1.1.7) is an important enzyme that breaks down of acetylcholine in synaptic cleft in neuronal junctions. |
2014-01-01 |
2023-08-12 |
Not clear |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
the fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme ache, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with alzheimer's disease and alleviating the symptoms of this neurological disorder. |
2014-01-01 |
2023-08-12 |
Not clear |
| Xianwei Meng, Jianfei Wei, Xiangling Ren, Jun Ren, Fangqiong Tan. A simple and sensitive fluorescence biosensor for detection of organophosphorus pesticides using H2O2-sensitive quantum dots/bi-enzyme. Biosensors & bioelectronics. vol 47. 2013-12-31. PMID:23612061. |
the biosensor is composed of enzymes (ache and chox (choline oxidase)), qds and acetylcholine (ach), without any complex process of assembly for biosensor. |
2013-12-31 |
2023-08-12 |
Not clear |
| Vija Klusa, Ruta Muceniece, Sergejs Isajevs, Darja Isajeva, Ulrika Beitnere, Ilona Mandrika, Jolanta Pupure, Juris Rumaks, Baiba Jansone, Ivars Kalvinsh, Harry V Vinter. Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Pharmacology, biochemistry, and behavior. vol 106. 2013-12-26. PMID:23537732. |
these biomarkers included glutamic acid decarboxylase 65/67 (gad65/67), acetylcholine esterase (ache), growth-associated protein-43 (gap-43) and the transcription factor c-jun/activator protein-1 (ap-1). |
2013-12-26 |
2023-08-12 |
mouse |
| Yu-Qin Zhang, Ji-Qi Liu, Xiang-Shu Guo, Zhen-Qiang Tang, Xu-Dong Zhao, Rui-Min Zhou, Qi Zha. [Resistance of Anopheles sinensis to insecticides in Huaibin County of Henan Province]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. vol 30. issue 6. 2013-12-12. PMID:23484266. |
the activity of acetylcholine esterase (ache) of larvae and adult mosquitoes was measured by colorimetric method before and after the respective addition of the 3 insecticides. |
2013-12-12 |
2023-08-12 |
Not clear |
| Hanaa H Ahmed, Ahmed M Salem, Gilane M Sabry, Ahmed A Husein, Soheir E Koto. Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's disease-induced rats. Journal of medicinal food. vol 16. issue 5. 2013-12-12. PMID:23631499. |
levels of brain acetylcholine (ach), serum and brain acetylcholinesterase (ache) activity, c-reactive protein (crp), total nuclear factor kappa-b (nf-κb), and monocyte chemoattractant protein-1 (mcp-1) were estimated. |
2013-12-12 |
2023-08-12 |
rat |
| Veena Beri, Scott A Wildman, Kazuro Shiomi, Ziyad F Al-Rashid, Jonah Cheung, Terrone L Rosenberr. The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry. vol 52. issue 42. 2013-12-12. PMID:24040835. |
cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (ache). |
2013-12-12 |
2023-08-12 |
Not clear |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the acetylcholinesterase (ache), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. |
2013-12-09 |
2023-08-12 |
human |
| Mehlika D Altintop, Ahmet Özdemir, Zafer A Kaplancikli, Gülhan Turan-Zitouni, Halide E Temel, Gülşen A Çiftç. Synthesis and biological evaluation of some pyrazoline derivatives bearing a dithiocarbamate moiety as new cholinesterase inhibitors. Archiv der Pharmazie. vol 346. issue 3. 2013-12-02. PMID:23389781. |
compounds effective on ache carry the 2-dimethylaminoethyl moiety, which resembles the trimethylammonium group and the ethylene bridge of acetylcholine. |
2013-12-02 |
2023-08-12 |
Not clear |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c and (18)f-labeled acetylcholine analogues. |
2013-11-26 |
2023-08-12 |
rat |
| Minmin Liang, Kelong Fan, Yong Pan, Hui Jiang, Fei Wang, Dongling Yang, Di Lu, Jing Feng, Jianjun Zhao, Liu Yang, Xiyun Ya. Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent. Analytical chemistry. vol 85. issue 1. 2013-11-13. PMID:23153113. |
the enzymes ache and cho catalyze the formation of h(2)o(2) in the presence of acetylcholine, which then activates mnps to catalyze the oxidation of colorimetric substrates to produce a color reaction. |
2013-11-13 |
2023-08-12 |
Not clear |
| Anthony J Veloso, Devjani Dhar, Ari M Chow, Biao Zhang, Derek W F Tang, Hashwin V S Ganesh, Svetlana Mikhaylichenko, Ian R Brown, Kagan Kerma. sym-Triazines for directed multitarget modulation of cholinesterases and amyloid-β in Alzheimer's disease. ACS chemical neuroscience. vol 4. issue 2. 2013-10-29. PMID:23421685. |
rational targeting of ache was achieved by the incorporation of acetylcholine substrate analogues into a sym-triazine core in either a mono-, di-, or trisubstituted regime. |
2013-10-29 |
2023-08-12 |
human |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |