| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Márcio M Costa, Aleksandro S da Silva, Francine C Paim, Raqueli França, Guilherme L Dornelles, Gustavo R Thomé, Jonas D S Serres, Roberta Schmatz, Rosélia M Spanevello, Jamile F Gonçalves, Maria Rosa C Schetinger, Cinthia M A Mazzanti, Sonia T A Lopes, Silvia G Monteir. Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits. Anais da Academia Brasileira de Ciencias. vol 84. issue 4. 2013-07-11. PMID:23011112. |
the increased activities of ache and bche probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. |
2013-07-11 |
2023-08-12 |
rat |
| Ahmad Mohammadi-Farani, Aram Ahmadi, Hamid Nadri, Alireza Aliabad. Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 21. issue 1. 2013-07-09. PMID:23758724. |
in recent years, acetylcholinesterase (ache) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with alzheimer's disease. |
2013-07-09 |
2023-08-12 |
Not clear |
| Tada-aki Kudo, Hiroyasu Kanetaka, Yoshinaka Shimizu, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Eizaburo Suzuki, Toshiyuki Takagi, Shin-ichi Izum. Induction of neuritogenesis in PC12 cells by a pulsed electromagnetic field via MEK-ERK1/2 signaling. Cell structure and function. vol 38. issue 1. 2013-07-04. PMID:23318214. |
plated pc12 cells were exposed to a single pemf (central magnetic flux density, 700 mt; frequency, 0.172 hz) for up to 12 h per day and were then evaluated for extent of neuritogenesis or acetylcholine esterase (ache) activity. |
2013-07-04 |
2023-08-12 |
rat |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
acetylcholinesterase (ache) is an enzyme that hydrolyses the neurotransmitter acetylcholine, thereby limiting spillover and duration of action. |
2013-06-27 |
2023-08-12 |
rat |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
this suggests that endogenous glutamate, released into the synaptic cleft as a co-mediator of acetylcholine, is capable of triggering the nmda receptor/no synthase-mediated pathway that modulates synaptic ache activity. |
2013-06-27 |
2023-08-12 |
rat |
| b' Milan Jokanovi\\xc4\\x8. Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data. Current topics in medicinal chemistry. vol 12. issue 16. 2013-06-04. PMID:23030612.' |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. |
2013-06-04 |
2023-08-12 |
human |
| A S Silva-Herdade, C Saldanh. Effects of acetylcholine on an animal mode of inflammation. Clinical hemorheology and microcirculation. vol 53. issue 1-2. 2013-05-29. PMID:23187452. |
in this study we performed intravenous administrations of velnacrine (vln) and acetylcholine (ach), respectively, ache inhibitor and substrate, in an animal model of lipopolysaccharide (lps)-induced inflammation in wistar rats. |
2013-05-29 |
2023-08-12 |
rat |
| John E Casida, Kathleen A Durki. Anticholinesterase insecticide retrospective. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22926007. |
in both insects and mammals, ache inhibition and acetylcholine accumulation leads to excitation and death. |
2013-05-28 |
2023-08-12 |
human |
| Jun-Ying Wang, Fan-Ying Meng, Shu-Ping Chen, Yong-Hui Gao, Jun-Ling Li. Analysis on interrelation between electroacupuncture-induced cumulative analgesic effect and hypothalamic cholinergic activities in chronic neuropathic pain rats. Chinese journal of integrative medicine. vol 18. issue 9. 2013-05-28. PMID:22936324. |
to observe the effects of repeated electroacupuncture (ea) of zusanli (st36)- yanglingquan (gb34) on hypothalamic acetylcholinesterase (ache) and vesicular acetylcholine (ach) transporter (vacht) activities and choline acetyltransferase (chat) mrna and muscarinic m1 receptor (m1r) mrna expression in chronic constrictive injury (cci) and/or ovariectomy (ovx) rats so as to reveal its underlying mechanism in cumulative analgesia. |
2013-05-28 |
2023-08-12 |
rat |
| Zrinka Kovarik, Nikolina Maček, Rakesh K Sit, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22960624. |
organophosphates (op) inhibit acetylcholinesterase (ache, ec 3.1.1.7), both in peripheral tissues and central nervous system (cns), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ach). |
2013-05-28 |
2023-08-12 |
Not clear |
| Kevin B Temeyer, Alexander P Tuckow, Danett K Brake, Andrew Y Li, Adalberto A Pérez de Leó. Acetylcholinesterases of blood-feeding flies and ticks. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23036311. |
ache hydrolyzes the neurotransmitter, acetylcholine, but may have additional roles in physiology and development. |
2013-05-28 |
2023-08-12 |
human |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Veena Beri, Jeffrey T Auletta, Ghulam M Maharvi, Juanita F Wood, Abdul H Fauq, Terrone L Rosenberr. Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047027. |
hydrolysis of acetylcholine by acetylcholinesterase (ache) is extremely rapid, with a second-order hydrolysis rate constant k(e) (often denoted k(cat)/k(m)) that approaches 10(8) m(-1) s(-1). |
2013-05-28 |
2023-08-12 |
cat |
| Elizabeth N Schock, Windsor C Ford, Kirsten J Midgley, Joseph G Fader, Michael N Giavasis, Michelle L McWhorte. The effects of carbaryl on the development of zebrafish (Danio rerio) embryos. Zebrafish. vol 9. issue 4. 2013-05-28. PMID:23094693. |
the active ingredient in sevin(™), carbaryl (1-napthyl-n-methylcarbamate), is a known acetylcholinesterase (ache) inhibitor that prevents the breakdown of acetylcholine to acetate and choline at the synapse. |
2013-05-28 |
2023-08-12 |
zebrafish |
| Pran Kishore Deb, Anuradha Sharma, Poonam Piplani, Raghuram Rao Akkinepall. Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors. Molecular diversity. vol 16. issue 4. 2013-05-16. PMID:22996404. |
the reversible inhibition of acetylcholinesterase (ache) has become a promising target for the treatment of alzheimer's disease (ad) which is mainly associated with low in vivo levels of acetylcholine (ach). |
2013-05-16 |
2023-08-12 |
Not clear |
| F Aura Kullmann, Grace I Wells, David G McKenna, Karl B Tho. Exogenous activation of muscarinic receptors decreases subsequent non-muscarinic bladder contractions in vivo in the female rat. Life sciences. vol 92. issue 12. 2013-05-07. PMID:23399698. |
our second aim was to determine if elevation of endogenous acetylcholine (ach) with distigmine, an acetylcholine esterase (ache) inhibitor, could also inhibit non-cholinergic component of reflexogenic bladder contractions. |
2013-05-07 |
2023-08-12 |
rat |
| Ravindra M Ghodke, Nagesh Tour, Kshama Dev. Effects of statins and cholesterol on memory functions in mice. Metabolic brain disease. vol 27. issue 4. 2013-05-03. PMID:23065075. |
memory performance was evaluated with two different behavioral tests and various biochemical parameters such as serum cholesterol, whole brain cholesterol, brain 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) activity and brain acetylcholine esterase (ache) activity. |
2013-05-03 |
2023-08-12 |
mouse |
| Yann S Mineur, Adetokunbo Obayemi, Mattis B Wigestrand, Gianna M Fote, Cali A Calarco, Alice M Li, Marina R Picciott. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401542. |
symptoms of depression can be induced in humans through blockade of acetylcholinesterase (ache) whereas antidepressant-like effects can be produced in animal models and some clinical trials by limiting activity of acetylcholine (ach) receptors. |
2013-05-02 |
2023-08-12 |
mouse |
| G Lou, Q Zhang, F Xiao, Q Xiang, Z Su, L Zhang, P Yang, Y Yang, Q Zheng, Y Huan. Intranasal administration of TAT-haFGF(₁₄₋₁₅₄) attenuates disease progression in a mouse model of Alzheimer's disease. Neuroscience. vol 223. 2013-05-01. PMID:22885230. |
importantly, tat-hafgf(14-154) improved the learning and memory abilities of samp8 mice in the behavioral test, and promoted the function of cholinergic system by measuring the relevant biomarkers (acetylcholine (ach) level, acetylcholinesterase (ache) and choline acetyltransferase (chat) activities). |
2013-05-01 |
2023-08-12 |
mouse |
| Abdelfatteh El Omri, Junkyu Han, Kiyokazu Kawada, Manef Ben Abdrabbah, Hiroko Isod. Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways. Brain research. vol 1437. 2013-04-30. PMID:22226506. |
our findings showed that luteolin treatment significantly induced neurite outgrowth extension, enhanced acetylcholinesterase (ache) activity, known as neuronal differentiation marker, and increased the level of total choline and acetylcholine in pc12 cells. |
2013-04-30 |
2023-08-12 |
Not clear |