| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Vera Lucia Sardá Ribeiro, Cláudia Vanzella, Felipe dos Santos Moysés, Jaqueline Campiol Dos Santos, João Ricardo Souza Martins, Gilsane Lino von Poser, Ionara Rodrigues Siqueir. Effect of Calea serrata Less. n-hexane extract on acetylcholinesterase of larvae ticks and brain Wistar rats. Veterinary parasitology. vol 189. issue 2-4. 2013-01-24. PMID:22608349. |
acetylcholinesterase (ache), an enzyme that hydrolyses acetylcholine (ach) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. |
2013-01-24 |
2023-08-12 |
rat |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Rômulo Pillon Barcelos, Rafael de Lima Portella, Thiago Henrique Lugokenski, Edovando José Flores da Rosa, Guilherme Pires Amaral, Luiz Filipe Machado Garcia, Leandro Bresolin, Vanessa Carratu, Félix Alexandre Antunes Soares, Nilda Berenice de Vargas Barbos. Isatin-3-N4-benzilthiosemicarbazone, a non-toxic thiosemicarbazone derivative, protects and reactivates rat and human cholinesterases inhibited by methamidophos in vitro and in silico. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22542756. |
the inactivation of ache results in the accumulation of acetylcholine at cholinergic receptor sites, causing a cholinergic crisis that can lead to death. |
2013-01-04 |
2023-08-12 |
mouse |
| Lev Pavlovsky, Yifat Bitan, Hadar Shalev, Yonatan Serlin, Alon Friedma. Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus. Brain research. vol 1472. 2013-01-02. PMID:22796599. |
stress-related behavioral modulation via central cholinergic pathways was enhanced by the central ache inhibitor, physostigmine, thus further supporting the notion that stress is associated with long lasting hypersensitivity to acetylcholine. |
2013-01-02 |
2023-08-12 |
mouse |
| Dong-Young Choi, Young-Jung Lee, Sun Young Lee, Yoot Mo Lee, Hyun Hee Lee, Im Seop Choi, Ki-Wan Oh, Sang Bae Han, Sang-Yoon Nam, Jin Tae Hon. Attenuation of scopolamine-induced cognitive dysfunction by obovatol. Archives of pharmacal research. vol 35. issue 7. 2012-12-18. PMID:22864751. |
the disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (ache) activity in the affected regions. |
2012-12-18 |
2023-08-12 |
Not clear |
| Pradeep Kumar Kamat, Santoshkumar Tota, Shivika Rai, Rakesh Shukla, Shakir Ali, Abul Kalam Najmi, Chandishwar Nat. Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats. European journal of pharmacology. vol 690. issue 1-3. 2012-12-17. PMID:22749976. |
in the present study, we investigated effect of oka (i.c.v) on cholinergic function by observing acetylcholine level (ach), acetylcholinestrase (ache) activity, and mrna expression of acetylcholinestrase and α7nicotinic receptor (α7-nachr) as a cholinergic markers in brain areas (cerebellum, striatum cortex and hippocampus). |
2012-12-17 |
2023-08-12 |
rat |
| Hanaa H Ahme. Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 6. 2012-12-14. PMID:21183322. |
our results revealed that brain acetylcholine esterase (ache) activity and thcy levels were significantly increased in ad model. |
2012-12-14 |
2023-08-12 |
rat |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
depending on the sensitivity of the analytical method applied for measuring acetylcholine levels in brain dialysates, acetylcholinesterase (ache) inhibitors are often used to increase the basal acetylcholine level up to a detectable magnitude. |
2012-11-30 |
2023-08-12 |
rat |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
here we performed a meta-analysis on published datasets of in vivo microdialysis measurements to assess the concentration-dependent effects of various ache inhibitors on acetylcholine levels within the prefrontal cortex, nucleus accumbens, caudate putamen, and hippocampus in adult rats. |
2012-11-30 |
2023-08-12 |
rat |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
we conclude that although the presynaptic action of ache inhibitors is well understood the nonphysiological and concentration-independent augmentation of the acetylcholine system requires the use of a standard protocol in order to produce replicable and comparable results. |
2012-11-30 |
2023-08-12 |
rat |
| Cathleen Haense, Elke Kalbe, Karl Herholz, Christoph Hohmann, Bernd Neumaier, Roman Krais, Wolf-Dieter Heis. Cholinergic system function and cognition in mild cognitive impairment. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:20961662. |
we examined whether cortical acetylcholine esterase (ache) activity is reduced at this stage and correlated with cognitive function. |
2012-11-23 |
2023-08-12 |
Not clear |
| Hwa-Jeong Yeom, Jae Soon Kang, Gil-Hah Kim, Il-Kwon Par. Insecticidal and acetylcholine esterase inhibition activity of Apiaceae plant essential oils and their constituents against adults of German cockroach (Blattella germanica). Journal of agricultural and food chemistry. vol 60. issue 29. 2012-11-21. PMID:22746406. |
we evaluated the insecticidal and acetylcholine esterase (ache) inhibition activity of 11 apiaceae plant essential oils and their constituents in adult male and female blattella germanica. |
2012-11-21 |
2023-08-12 |
Not clear |
| Carmen C Garcia, Joseph G Potian, Kormakur Hognason, Baskaran Thyagarajan, Lester G Sultatos, Nizar Souayah, Vanessa H Routh, Joseph J McArdl. Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy. American journal of physiology. Endocrinology and metabolism. vol 303. issue 4. 2012-11-19. PMID:22739110. |
prolongation of mepcs was not due to expression of the embryonic acetylcholine receptor but to reduced muscle expression of acetylcholine esterase (ache). |
2012-11-19 |
2023-08-12 |
mouse |
| Jiří Lindovský, Konstantin Petrov, Jan Krůšek, Vladimir S Reznik, Eugeny E Nikolsky, František Vyskoči. Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22634638. |
the c-547 is the most effective muscle and tissue-specific anticholinesterase among alkylammonium derivatives of 6-methyluracil (adems) acting in nanomolar concentrations on locomotor muscles but not on respiratory muscles, smooth muscles and heart and brain acetylcholine esterases (ache). |
2012-11-16 |
2023-08-12 |
rat |
| Jiří Lindovský, Konstantin Petrov, Jan Krůšek, Vladimir S Reznik, Eugeny E Nikolsky, František Vyskoči. Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22634638. |
these observations show that c-547 can be considered for symptomatic treatment of myasthenia gravis and other congenital myasthenic syndromes as an inhibitor of ache in leg muscles at concentrations much lower than those inhibiting muscle and ganglion types of acetylcholine receptors. |
2012-11-16 |
2023-08-12 |
rat |
| Sahitya C Pandanaboina, Sangeetha L A Rajbanshi, Pavan N V Kunala, Saritha Pandanaboina, Murali M Pandanaboina, Visweswari Gopalreddy, Rajendra Wudayagir. Tramadol safety--cholinergic system of rat brain without nociception. Acta poloniae pharmaceutica. vol 69. issue 5. 2012-11-06. PMID:23061278. |
in the present investigation, changes in the levels of acetylcholinesterase (ache) activity, acetylcholine (ach) content, and the activity levels of plasma (pche) and erythrocyte (eche) cholinesterases as representatives of pseudocholinesterases were examined in different areas of the rat brain during the administration of the synthetic opioid analgesic drug tramadol (ultram) without induction of pain. |
2012-11-06 |
2023-08-12 |
rat |
| Mary Popov, Sarina Grinberg, Charles Linder, Tal Waner, Bosmat Levi-Hevroni, Richard J Deckelbaum, Eliahu Heldma. Site-directed decapsulation of bolaamphiphilic vesicles with enzymatic cleavable surface groups. Journal of controlled release : official journal of the Controlled Release Society. vol 160. issue 2. 2012-11-05. PMID:22226780. |
both types of bolaamphiphiles competed with acetylthiocholine for binding to acetylcholine esterase (ache), yet, only the choline ester head groups bound to the alkyl chain via the nitrogen atom of the choline moiety were hydrolyzed by the enzyme. |
2012-11-05 |
2023-08-12 |
mouse |
| Vladimir Farar, Franziska Mohr, Marie Legrand, Boris Lamotte d'Incamps, Jan Cendelin, Jacqueline Leroy, Marc Abitbol, Veronique Bernard, Frédéric Baud, Vincent Fournet, Pascal Houze, Jochen Klein, Benoit Plaud, Jan Tuma, Martina Zimmermann, Philippe Ascher, Anna Hrabovska, Jaromir Myslivecek, Eric Krejc. Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase. Journal of neurochemistry. vol 122. issue 5. 2012-10-31. PMID:22747514. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine. |
2012-10-31 |
2023-08-12 |
mouse |