| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanne Knowle. Donepezil in Alzheimer's disease: an evidence-based review of its impact on clinical and economic outcomes. Core evidence. vol 1. issue 3. 2012-10-02. PMID:22500154. |
it is a specific and reversible inhibitor of acetylcholinesterase (ache); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Oto Pavlis, Hana Svobodova, Jiri Pikul. Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice. Interdisciplinary toxicology. vol 5. issue 1. 2012-10-02. PMID:22783145. |
the present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (ache) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ach). |
2012-10-02 |
2023-08-12 |
mouse |
| María-Ximena Silveyra, María-Salud García-Ayllón, Elena Gómez de Barreda, David H Small, Salvador Martínez, Jesús Avila, Javier Sáez-Valer. Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21530001. |
all major molecular forms of ache were increased in the tg-vlw mice, including tetrameric ache, which is the major species involved in hydrolysis of acetylcholine in the brain. |
2012-09-28 |
2023-08-12 |
mouse |
| Santoshkumar Tota, Chandishwar Nath, Abul Kalam Najmi, Rakesh Shukla, Kashif Hani. Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22460064. |
scopolamine caused impairment in memory which was associated with reduced cbf, acetylcholine (ach) level and elevated acetylcholinesterase (ache) activity and malondialdehyde (mda) level. |
2012-09-27 |
2023-08-12 |
mouse |
| Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean, Pierre-Yves Renar. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of chemical research. vol 45. issue 5. 2012-09-20. PMID:22360473. |
ache breaks down the neurotransmitter acetylcholine at neuronal synapses and neuromuscular junctions. |
2012-09-20 |
2023-08-12 |
Not clear |
| D Chand Basha, M Usha Rani, C Bhuvaneswari Devi, M Ram Kumar, G Rajarami Redd. Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co-administration. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 4. 2012-09-13. PMID:22326442. |
in this study, we examined the alterations in synaptosomal acetylcholine (ach), epinephrine, dopamine, acetylcholinesterase (ache), and mitochondrial monoamine oxidase (mao) in the cerebellum and hippocampus of perinatally pb-exposed rats. |
2012-09-13 |
2023-08-12 |
rat |
| S Anne Boettger, James B McClintoc. Acetyl cholinesterase activity and muscle contraction in the sea urchin Lytechinus variegatus (Lamarck) following chronic phosphate exposure. Environmental toxicology. vol 27. issue 4. 2012-08-14. PMID:20607821. |
nonetheless, chronic exposure to low, medium, and high-sublethal concentrations of organic phosphate inhibits the muscle enzyme acetyl cholinesterase (ache), responsible for the break down of the neurotransmitter acetylcholine, as well as inhibiting contractions in the muscles associated with the aristotle's lantern. |
2012-08-14 |
2023-08-12 |
Not clear |
| Katja S Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbroc. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245562. |
it aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (ache) and thus increases the concentration of extracellular acetylcholine. |
2012-07-23 |
2023-08-12 |
rat |
| Jose M Pizarro, Wenling E Chang, Mariama J Bah, Linnzi K M Wright, George A Saviolakis, Arun Alagappan, Christopher L Robison, Jinesh D Shah, James L Meyerhoff, Douglas M Cerasoli, Eric G Midboe, Lucille A Lumle. Repeated exposure to sublethal doses of the organophosphorus compound VX activates BDNF expression in mouse brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 126. issue 2. 2012-07-16. PMID:22240983. |
prolonged inhibition of ache increases endogenous levels of acetylcholine and is toxic at nerve synapses and neuromuscular junctions. |
2012-07-16 |
2023-08-12 |
mouse |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
other neurotransmitter is a classical neurotransmitter acetylcholine (ach), regulated by enzyme acetylcholinesterase (ache) that hydrolyses the acetylcholine after its releasing. |
2012-06-21 |
2023-08-12 |
rat |
| Shihua Hou, Zhongmin Ou, Qiang Chen, Baoyan W. Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Biosensors & bioelectronics. vol 33. issue 1. 2012-06-21. PMID:22230694. |
a novel acetylcholinesterase (ache)/choline oxidase (chox) bienzyme amperometric acetylcholine biosensor based on gold nanoparticles (aunps) and multi-walled carbon nanotubes (mwcnts) has been successfully developed by self-assembly process in combination of sol-gel technique. |
2012-06-21 |
2023-08-12 |
Not clear |
| Yonglin Gao, Chunmei Li, Jungang Yin, Jingyu Shen, Hongtao Wang, Yuzhen Wu, Haizhu Ji. Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats. Environmental toxicology and pharmacology. vol 33. issue 2. 2012-06-12. PMID:22301160. |
furthermore, fucoidan reversed the decreased activity of choline acetyl transferase (chat), superoxide dismutase (sod), glutathione peroxidase (gsh-px) and content of acetylcholine (ach), as well as the increased activity of acetylcholine esterase (ache) and content of malondialdehyde (mda) in hippocampal tissue of aβ-injected rats. |
2012-06-12 |
2023-08-12 |
rat |
| Amy C Halliday, Susan A Greenfiel. From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933122. |
acetylcholinesterase (ache), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ach). |
2012-06-08 |
2023-08-12 |
Not clear |
| T F Holth, K E Tollefse. Acetylcholine esterase inhibitors in effluents from oil production platforms in the North Sea. Aquatic toxicology (Amsterdam, Netherlands). vol 112-113. 2012-06-08. PMID:22115844. |
inhibition of acetylcholine esterase (ache) activity is a biomarker for the exposure to neurotoxic compounds such as organophosphates and is intimately associated with the toxicity of several pesticides. |
2012-06-08 |
2023-08-12 |
Not clear |
| Haley E Speed, Cory A Blaiss, Ahleum Kim, Michael E Haws, Neal R Melvin, Michael Jennings, Amelia J Eisch, Craig M Powel. Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 1. 2012-06-06. PMID:21948870. |
agricultural and household organophosphorus (op) pesticides inhibit acetylcholinesterase (ache), resulting in increased acetylcholine (ach) in the central nervous system. |
2012-06-06 |
2023-08-12 |
mouse |
| Mauricio Valenzuela-Harrington, Irene Castillo, Corín Díaz, Inés Alés, Antonio Rodríguez-Moren. Dimethoate accelerates the extinction of eyeblink conditioning in mice. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22182529. |
these compounds decrease acetylcholine esterase (ache) activity, thereby provoking an accumulation of the neurotransmitter acetylcholine at synapses and resulting in the over-stimulation of acetylcholine receptors. |
2012-06-04 |
2023-08-12 |
mouse |
| Guiling He, Yang Sun, Fei L. RNA interference of two acetylcholinesterase genes in Plutella xylostella reveals their different functions. Archives of insect biochemistry and physiology. vol 79. issue 2. 2012-05-29. PMID:22392769. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme with a typical function of degrading the neurotransmitter acetylcholine. |
2012-05-29 |
2023-08-12 |
Not clear |
| Ying-hua Shu, Hong-hui Ma, Yan Du, Jian-wu Wan. [Effects of Bt corn straw insecticidal proteins on enzyme activities of Eisenia fetida]. Ying yong sheng tai xue bao = The journal of applied ecology. vol 22. issue 8. 2012-05-24. PMID:22097378. |
in this study, the straws of bt corn and its near-isogenic non-bt line were added into soil with an application rate of 5% and 7.5% to breed eisenia fetida, and the total protein content and the activities of acetylcholine esterase (ache), glutathione peroxidase (gsh-px), catalase (cat), and superoxide dismutase (sod) in e. fetida were determined after 7 and 14 days. |
2012-05-24 |
2023-08-12 |
cat |
| A Sherin, J Anu, K T Peeyush, S Smijin, M Anitha, B T Roshni, C S Paulos. Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. vol 202. 2012-05-18. PMID:22155651. |
expression of cholinergic enzymes; acetylcholine esterase (ache) and choline acetyltransferase (chat) upregulated and downregulated, respectively, in diabetic group, which was further exacerbated by hypoglycemia. |
2012-05-18 |
2023-08-12 |
rat |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Shinji Sato, Kam Ming Ko, Tetsuya Konish. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free radical research. vol 45. issue 8. 2012-05-16. PMID:21615274. |
at the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (pat) and morris water maze (mwm) with concomitant increase of acetylcholinesterase (ache) activity and decreased acetylcholine levels. |
2012-05-16 |
2023-08-12 |
mouse |