| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
here we performed a meta-analysis on published datasets of in vivo microdialysis measurements to assess the concentration-dependent effects of various ache inhibitors on acetylcholine levels within the prefrontal cortex, nucleus accumbens, caudate putamen, and hippocampus in adult rats. |
2012-11-30 |
2023-08-12 |
rat |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
we conclude that although the presynaptic action of ache inhibitors is well understood the nonphysiological and concentration-independent augmentation of the acetylcholine system requires the use of a standard protocol in order to produce replicable and comparable results. |
2012-11-30 |
2023-08-12 |
rat |
| Cathleen Haense, Elke Kalbe, Karl Herholz, Christoph Hohmann, Bernd Neumaier, Roman Krais, Wolf-Dieter Heis. Cholinergic system function and cognition in mild cognitive impairment. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:20961662. |
we examined whether cortical acetylcholine esterase (ache) activity is reduced at this stage and correlated with cognitive function. |
2012-11-23 |
2023-08-12 |
Not clear |
| Hwa-Jeong Yeom, Jae Soon Kang, Gil-Hah Kim, Il-Kwon Par. Insecticidal and acetylcholine esterase inhibition activity of Apiaceae plant essential oils and their constituents against adults of German cockroach (Blattella germanica). Journal of agricultural and food chemistry. vol 60. issue 29. 2012-11-21. PMID:22746406. |
we evaluated the insecticidal and acetylcholine esterase (ache) inhibition activity of 11 apiaceae plant essential oils and their constituents in adult male and female blattella germanica. |
2012-11-21 |
2023-08-12 |
Not clear |
| Carmen C Garcia, Joseph G Potian, Kormakur Hognason, Baskaran Thyagarajan, Lester G Sultatos, Nizar Souayah, Vanessa H Routh, Joseph J McArdl. Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy. American journal of physiology. Endocrinology and metabolism. vol 303. issue 4. 2012-11-19. PMID:22739110. |
prolongation of mepcs was not due to expression of the embryonic acetylcholine receptor but to reduced muscle expression of acetylcholine esterase (ache). |
2012-11-19 |
2023-08-12 |
mouse |
| Jiří Lindovský, Konstantin Petrov, Jan Krůšek, Vladimir S Reznik, Eugeny E Nikolsky, František Vyskoči. Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22634638. |
the c-547 is the most effective muscle and tissue-specific anticholinesterase among alkylammonium derivatives of 6-methyluracil (adems) acting in nanomolar concentrations on locomotor muscles but not on respiratory muscles, smooth muscles and heart and brain acetylcholine esterases (ache). |
2012-11-16 |
2023-08-12 |
rat |
| Jiří Lindovský, Konstantin Petrov, Jan Krůšek, Vladimir S Reznik, Eugeny E Nikolsky, František Vyskoči. Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22634638. |
these observations show that c-547 can be considered for symptomatic treatment of myasthenia gravis and other congenital myasthenic syndromes as an inhibitor of ache in leg muscles at concentrations much lower than those inhibiting muscle and ganglion types of acetylcholine receptors. |
2012-11-16 |
2023-08-12 |
rat |
| Sahitya C Pandanaboina, Sangeetha L A Rajbanshi, Pavan N V Kunala, Saritha Pandanaboina, Murali M Pandanaboina, Visweswari Gopalreddy, Rajendra Wudayagir. Tramadol safety--cholinergic system of rat brain without nociception. Acta poloniae pharmaceutica. vol 69. issue 5. 2012-11-06. PMID:23061278. |
in the present investigation, changes in the levels of acetylcholinesterase (ache) activity, acetylcholine (ach) content, and the activity levels of plasma (pche) and erythrocyte (eche) cholinesterases as representatives of pseudocholinesterases were examined in different areas of the rat brain during the administration of the synthetic opioid analgesic drug tramadol (ultram) without induction of pain. |
2012-11-06 |
2023-08-12 |
rat |
| Mary Popov, Sarina Grinberg, Charles Linder, Tal Waner, Bosmat Levi-Hevroni, Richard J Deckelbaum, Eliahu Heldma. Site-directed decapsulation of bolaamphiphilic vesicles with enzymatic cleavable surface groups. Journal of controlled release : official journal of the Controlled Release Society. vol 160. issue 2. 2012-11-05. PMID:22226780. |
both types of bolaamphiphiles competed with acetylthiocholine for binding to acetylcholine esterase (ache), yet, only the choline ester head groups bound to the alkyl chain via the nitrogen atom of the choline moiety were hydrolyzed by the enzyme. |
2012-11-05 |
2023-08-12 |
mouse |
| Vladimir Farar, Franziska Mohr, Marie Legrand, Boris Lamotte d'Incamps, Jan Cendelin, Jacqueline Leroy, Marc Abitbol, Veronique Bernard, Frédéric Baud, Vincent Fournet, Pascal Houze, Jochen Klein, Benoit Plaud, Jan Tuma, Martina Zimmermann, Philippe Ascher, Anna Hrabovska, Jaromir Myslivecek, Eric Krejc. Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase. Journal of neurochemistry. vol 122. issue 5. 2012-10-31. PMID:22747514. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine. |
2012-10-31 |
2023-08-12 |
mouse |
| Naheed Banu, Kashif R Zaidi, Ghazala Mehdi, Tariq Mansoo. Neurohumoral alterations and their role in amoebiasis. Indian journal of clinical biochemistry : IJCB. vol 20. issue 2. 2012-10-30. PMID:23105547. |
in the patients of amoebiasis the circulating acetylcholine (ach), histamine, histaminase, cortisol, 5-hydroxy tryptamine (serotonin) levels were significnatly enhanced with no change in the dopamine-beta-hydroxylase (dbh) activity, while the activities of erythrocyte aceytylcholinesterase (ache) and plasma monoamine oxidase (mao) were found decreased in comparison to normal healthy controls. |
2012-10-30 |
2023-08-12 |
Not clear |
| Xue Gao, Guangchao Tang, Xingguang S. Optical detection of organophosphorus compounds based on Mn-doped ZnSe d-dot enzymatic catalytic sensor. Biosensors & bioelectronics. vol 36. issue 1. 2012-10-25. PMID:22534106. |
acetylcholine esterase (ache) can hydrolyze acetylcholine (ach) to choline. |
2012-10-25 |
2023-08-12 |
Not clear |
| Anshu Jain, S J S Flor. Dose related effects of nicotine on oxidative injury in young, adult and old rats. Journal of environmental biology. vol 33. issue 2. 2012-10-25. PMID:23033686. |
acetylcholine esterase (ache) activity decreased in a dose dependent manner in adult and old rats. |
2012-10-25 |
2023-08-12 |
rat |
| I Erdogan Orha. Current concepts on selected plant secondary metabolites with promising inhibitory effects against enzymes linked to Alzheimer's disease. Current medicinal chemistry. vol 19. issue 14. 2012-10-18. PMID:22414107. |
shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) that break down acetylcholine and butyrylcholine has become a standard approach for ad treatment. |
2012-10-18 |
2023-08-12 |
human |
| D Qujeq, T Roushan, A Norouzy, M Habibi-Rezaei, M Mehdinejad-Shan. Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:21937528. |
acetylcholinesterase (ache) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. |
2012-10-17 |
2023-08-12 |
Not clear |
| George D Geromichalos, Fotini N Lamari, Magdalini A Papandreou, Dimitrios T Trafalis, Marigoula Margarity, Athanasios Papageorgiou, Zacharias Sinako. Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. Journal of agricultural and food chemistry. vol 60. issue 24. 2012-10-10. PMID:22655699. |
inhibitors of acetylcholine breakdown by acetylcholinesterase (ache) constitute the main therapeutic modality for alzheimer's disease. |
2012-10-10 |
2023-08-12 |
Not clear |
| Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, Oksana Lockridge, Pierre-Yves Renard, Florian Nacho. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. The FEBS journal. vol 279. issue 16. 2012-10-09. PMID:22726956. |
it can accommodate larger substrates or inhibitors than acetylcholinesterase (ache), the enzyme responsible for hydrolysis of the neurotransmitter acetylcholine in the central nervous system and neuromuscular junctions. |
2012-10-09 |
2023-08-12 |
human |
| C I Fernández, J Bergado, K De La Cuétara, N Nunez, O Castellanos, O González, A Torres, R Macías, L Alvarez, H Molin. Brain aging and neurotransplantation. II. Effects of septal cell suspension grafts to hippocampus of aged rodents on learning and memory impairments. Archives of gerontology and geriatrics. vol 19 Suppl 1. 2012-10-02. PMID:18649844. |
acetylcholine esterase (ache) histochemistry demonstrated the survival of cholinergic cells within the transplant. |
2012-10-02 |
2023-08-12 |
human |
| Francis C M Wong, Musa Ahmad, Lee Yook Heng, Lim Boon Pen. An optical biosensor for dichlovos using stacked sol-gel films containing acetylcholinesterase and a lipophilic chromoionophore. Talanta. vol 69. issue 4. 2012-10-02. PMID:18970653. |
the cm layer is ph sensitive and detects the ph changes of the acetylcholine chloride (achcl) substrate when hydrolyzed by ache layer deposited above. |
2012-10-02 |
2023-08-12 |
Not clear |
| H Isoda, H Shinmoto, M Matsumura, T Nakahar. The neurite-initiating effect of microbial extracellular glycolipids in PC12 cells. Cytotechnology. vol 31. issue 1-2. 2012-10-02. PMID:19003137. |
mel-a increased acetylcholine esterase (ache) activity to an extent similar to nerve growth factor (ngf). |
2012-10-02 |
2023-08-12 |
Not clear |