| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Éva M Szegő, Tiago F Outeiro, Pawel Kermer, Jörg B Schul. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22579457. |
clinical studies report positive effects of acetylcholine esterase (ache) inhibitors in pdd and dementia with lewy bodies. |
2013-04-29 |
2023-08-12 |
mouse |
| Vasudevan Mani, Kalavathy Ramasamy, Aliya Ahmad, Siti Norshazwani Wahab, Siti Murnirah Jaafar, Teh Lay Kek, Mohd Zaki Salleh, Abu Bakar Abdul Majee. Effects of the total alkaloidal extract of Murraya koenigii leaf on oxidative stress and cholinergic transmission in aged mice. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22447662. |
interestingly, significant progress was noted with the supplementation of mka by an improvement of the acetylcholine (ach) levels and a reduction in the acetylcholinesterase (ache) activity in aged mouse brain. |
2013-04-26 |
2023-08-12 |
mouse |
| Jamie K Lau, Kathleen C Brown, Brent A Thornhill, Clayton M Crabtree, Aaron M Dom, Theodore R Witte, W Elaine Hardman, Christopher A McNees, Cody A Stover, A Betts Carpenter, Haitao Luo, Yi C Chen, Brandon S Shiflett, Piyali Dasgupt. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23222296. |
in this study, we show that human bacs produce acetylcholine (ach) and contain several cholinergic factors including acetylcholinesterase (ache), choline acetyltransferase (chat), choline transporter 1 (cht1, slc5a7), vesicular acetylcholine transporter (vacht, slc18a3), and nach receptors (achrs, chrnas). |
2013-04-15 |
2023-08-12 |
mouse |
| Andleeb Khan, Kumar Vaibhav, Hayate Javed, Mohd Moshahid Khan, Rizwana Tabassum, Md Ejaz Ahmed, Pallavi Srivastava, Gulrana Khuwaja, Farah Islam, Mohd Saeed Siddiqui, Mohammed M Safhi, Mohammed M Shafi, Fakhrul Isla. Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Molecular and cellular biochemistry. vol 369. issue 1-2. 2013-04-10. PMID:22752387. |
in addition, a significant elevation in the tbars content and nitric oxide (no) and activity of acetylcholine esterase (ache) was observed which was restored significantly by tq pretreatment. |
2013-04-10 |
2023-08-12 |
rat |
| Mohammd Moshiri, Emadodin Darchini-Maragheh, Mahdi Balali-Moo. Advances in toxicology and medical treatment of chemical warfare nerve agents. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 20. issue 1. 2013-03-28. PMID:23351280. |
the main mechanism of action is irreversible inhibition of acetyl choline esterase (ache) resulting in accumulation of toxic levels of acetylcholine (ach) at the synaptic junctions and thus induces muscarinic and nicotinic receptors stimulation. |
2013-03-28 |
2023-08-12 |
Not clear |
| Gopenath Thangaraj, Alexander Greif, Gesine Bachmann, Paul G Laye. Intricate paths of cells and networks becoming "Cholinergic" in the embryonic chicken retina. The Journal of comparative neurology. vol 520. issue 14. 2013-03-08. PMID:22886733. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) are the decisive enzymatic activities regulating the availability of acetylcholine (ach) at a given synaptic or nonsynaptic locus. |
2013-03-08 |
2023-08-12 |
chicken |
| Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Angliste. Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. The European journal of neuroscience. vol 36. issue 8. 2013-03-06. PMID:22805122. |
controlled regulation of synaptic nicotinic acetylcholine receptors (achrs) and acetylcholinesterase (ache), together with maintenance of a dynamic balance between them, is a requirement for proper function of cholinergic synapses. |
2013-03-06 |
2023-08-12 |
rat |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Wei-Wei Zhang, Qi-Xin Sun, Yin-Hui Liu, Wei Gao, Yan-Hai Li, Kun Lu, Zhuo Wan. Chronic administration of Liu Wei Dihuang protects rat's brain against D-galactose-induced impairment of cholinergic system. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 3. 2013-02-21. PMID:21681343. |
acetylcholine (ach) content, activities of choline acetyltransferase (chat) and acetylcholinesterase (ache) in visual cortex were assayed. |
2013-02-21 |
2023-08-12 |
rat |
| Alexander Ciji, N P Sahu, A K Pal, S Dasgupta, M S Akhta. Alterations in serum electrolytes, antioxidative enzymes and haematological parameters of Labeo rohita on short-term exposure to sublethal dose of nitrite. Fish physiology and biochemistry. vol 38. issue 5. 2013-02-12. PMID:22388937. |
activities of antioxidative enzymes (catalase and superoxide dismutase), acetylcholine esterase (ache) and methaemoglobin reductase, serum electrolytes (sodium, potassium and chloride), haematological parameters and blood glucose level significantly varied (p < 0.05) in a dose-dependent manner. |
2013-02-12 |
2023-08-12 |
Not clear |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Vera Lucia Sardá Ribeiro, Cláudia Vanzella, Felipe dos Santos Moysés, Jaqueline Campiol Dos Santos, João Ricardo Souza Martins, Gilsane Lino von Poser, Ionara Rodrigues Siqueir. Effect of Calea serrata Less. n-hexane extract on acetylcholinesterase of larvae ticks and brain Wistar rats. Veterinary parasitology. vol 189. issue 2-4. 2013-01-24. PMID:22608349. |
acetylcholinesterase (ache), an enzyme that hydrolyses acetylcholine (ach) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. |
2013-01-24 |
2023-08-12 |
rat |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Rômulo Pillon Barcelos, Rafael de Lima Portella, Thiago Henrique Lugokenski, Edovando José Flores da Rosa, Guilherme Pires Amaral, Luiz Filipe Machado Garcia, Leandro Bresolin, Vanessa Carratu, Félix Alexandre Antunes Soares, Nilda Berenice de Vargas Barbos. Isatin-3-N4-benzilthiosemicarbazone, a non-toxic thiosemicarbazone derivative, protects and reactivates rat and human cholinesterases inhibited by methamidophos in vitro and in silico. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22542756. |
the inactivation of ache results in the accumulation of acetylcholine at cholinergic receptor sites, causing a cholinergic crisis that can lead to death. |
2013-01-04 |
2023-08-12 |
mouse |
| Lev Pavlovsky, Yifat Bitan, Hadar Shalev, Yonatan Serlin, Alon Friedma. Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus. Brain research. vol 1472. 2013-01-02. PMID:22796599. |
stress-related behavioral modulation via central cholinergic pathways was enhanced by the central ache inhibitor, physostigmine, thus further supporting the notion that stress is associated with long lasting hypersensitivity to acetylcholine. |
2013-01-02 |
2023-08-12 |
mouse |
| Dong-Young Choi, Young-Jung Lee, Sun Young Lee, Yoot Mo Lee, Hyun Hee Lee, Im Seop Choi, Ki-Wan Oh, Sang Bae Han, Sang-Yoon Nam, Jin Tae Hon. Attenuation of scopolamine-induced cognitive dysfunction by obovatol. Archives of pharmacal research. vol 35. issue 7. 2012-12-18. PMID:22864751. |
the disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (ache) activity in the affected regions. |
2012-12-18 |
2023-08-12 |
Not clear |
| Pradeep Kumar Kamat, Santoshkumar Tota, Shivika Rai, Rakesh Shukla, Shakir Ali, Abul Kalam Najmi, Chandishwar Nat. Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats. European journal of pharmacology. vol 690. issue 1-3. 2012-12-17. PMID:22749976. |
in the present study, we investigated effect of oka (i.c.v) on cholinergic function by observing acetylcholine level (ach), acetylcholinestrase (ache) activity, and mrna expression of acetylcholinestrase and α7nicotinic receptor (α7-nachr) as a cholinergic markers in brain areas (cerebellum, striatum cortex and hippocampus). |
2012-12-17 |
2023-08-12 |
rat |
| Hanaa H Ahme. Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 6. 2012-12-14. PMID:21183322. |
our results revealed that brain acetylcholine esterase (ache) activity and thcy levels were significantly increased in ad model. |
2012-12-14 |
2023-08-12 |
rat |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
depending on the sensitivity of the analytical method applied for measuring acetylcholine levels in brain dialysates, acetylcholinesterase (ache) inhibitors are often used to increase the basal acetylcholine level up to a detectable magnitude. |
2012-11-30 |
2023-08-12 |
rat |