| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naheed Banu, Kashif R Zaidi, Ghazala Mehdi, Tariq Mansoo. Neurohumoral alterations and their role in amoebiasis. Indian journal of clinical biochemistry : IJCB. vol 20. issue 2. 2012-10-30. PMID:23105547. |
in the patients of amoebiasis the circulating acetylcholine (ach), histamine, histaminase, cortisol, 5-hydroxy tryptamine (serotonin) levels were significnatly enhanced with no change in the dopamine-beta-hydroxylase (dbh) activity, while the activities of erythrocyte aceytylcholinesterase (ache) and plasma monoamine oxidase (mao) were found decreased in comparison to normal healthy controls. |
2012-10-30 |
2023-08-12 |
Not clear |
| Xue Gao, Guangchao Tang, Xingguang S. Optical detection of organophosphorus compounds based on Mn-doped ZnSe d-dot enzymatic catalytic sensor. Biosensors & bioelectronics. vol 36. issue 1. 2012-10-25. PMID:22534106. |
acetylcholine esterase (ache) can hydrolyze acetylcholine (ach) to choline. |
2012-10-25 |
2023-08-12 |
Not clear |
| Anshu Jain, S J S Flor. Dose related effects of nicotine on oxidative injury in young, adult and old rats. Journal of environmental biology. vol 33. issue 2. 2012-10-25. PMID:23033686. |
acetylcholine esterase (ache) activity decreased in a dose dependent manner in adult and old rats. |
2012-10-25 |
2023-08-12 |
rat |
| I Erdogan Orha. Current concepts on selected plant secondary metabolites with promising inhibitory effects against enzymes linked to Alzheimer's disease. Current medicinal chemistry. vol 19. issue 14. 2012-10-18. PMID:22414107. |
shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) that break down acetylcholine and butyrylcholine has become a standard approach for ad treatment. |
2012-10-18 |
2023-08-12 |
human |
| D Qujeq, T Roushan, A Norouzy, M Habibi-Rezaei, M Mehdinejad-Shan. Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:21937528. |
acetylcholinesterase (ache) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. |
2012-10-17 |
2023-08-12 |
Not clear |
| George D Geromichalos, Fotini N Lamari, Magdalini A Papandreou, Dimitrios T Trafalis, Marigoula Margarity, Athanasios Papageorgiou, Zacharias Sinako. Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. Journal of agricultural and food chemistry. vol 60. issue 24. 2012-10-10. PMID:22655699. |
inhibitors of acetylcholine breakdown by acetylcholinesterase (ache) constitute the main therapeutic modality for alzheimer's disease. |
2012-10-10 |
2023-08-12 |
Not clear |
| Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, Oksana Lockridge, Pierre-Yves Renard, Florian Nacho. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. The FEBS journal. vol 279. issue 16. 2012-10-09. PMID:22726956. |
it can accommodate larger substrates or inhibitors than acetylcholinesterase (ache), the enzyme responsible for hydrolysis of the neurotransmitter acetylcholine in the central nervous system and neuromuscular junctions. |
2012-10-09 |
2023-08-12 |
human |
| C I Fernández, J Bergado, K De La Cuétara, N Nunez, O Castellanos, O González, A Torres, R Macías, L Alvarez, H Molin. Brain aging and neurotransplantation. II. Effects of septal cell suspension grafts to hippocampus of aged rodents on learning and memory impairments. Archives of gerontology and geriatrics. vol 19 Suppl 1. 2012-10-02. PMID:18649844. |
acetylcholine esterase (ache) histochemistry demonstrated the survival of cholinergic cells within the transplant. |
2012-10-02 |
2023-08-12 |
human |
| Francis C M Wong, Musa Ahmad, Lee Yook Heng, Lim Boon Pen. An optical biosensor for dichlovos using stacked sol-gel films containing acetylcholinesterase and a lipophilic chromoionophore. Talanta. vol 69. issue 4. 2012-10-02. PMID:18970653. |
the cm layer is ph sensitive and detects the ph changes of the acetylcholine chloride (achcl) substrate when hydrolyzed by ache layer deposited above. |
2012-10-02 |
2023-08-12 |
Not clear |
| H Isoda, H Shinmoto, M Matsumura, T Nakahar. The neurite-initiating effect of microbial extracellular glycolipids in PC12 cells. Cytotechnology. vol 31. issue 1-2. 2012-10-02. PMID:19003137. |
mel-a increased acetylcholine esterase (ache) activity to an extent similar to nerve growth factor (ngf). |
2012-10-02 |
2023-08-12 |
Not clear |
| Kosuke Yamamoto, Yoshie S Momonok. Subcellular localization of overexpressed maize AChE gene in rice plant. Plant signaling & behavior. vol 3. issue 8. 2012-10-02. PMID:19704473. |
the ach-mediated system consisting of acetylcholine (ach), acetylcholine receptor (achr) and acetylcholinesterase (ache) is fundamental for nervous system function in animals and insects. |
2012-10-02 |
2023-08-12 |
Not clear |
| Takafumi Tezuka, Isamu Akita, Natsuko Yoshin. Self-incompatibility involved in the level of acetylcholine and cAMP. Plant signaling & behavior. vol 2. issue 6. 2012-10-02. PMID:19704589. |
a potent inhibitor (neostigmine) of acetylcholinesterase (ache) as well as acetylcholine also promoted the elongation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Pardeep Sidhu, Bimla Nehr. Protective effects of selenium to placental lead neurotoxicity in rat pups. Toxicology mechanisms and methods. vol 15. issue 6. 2012-10-02. PMID:20021065. |
activities of succinic dehydrogenase (sdh), acetylcholine estrase (ache), and na(+)/k(+)-atpase were studied in the cerebrum and cerebellum of the rat pups at 4 weeks of age. |
2012-10-02 |
2023-08-12 |
rat |
| M Muramatsu, I Arai, J Tamaki, H Hirose, A Fujita, H Aihar. Central regulation of gastric acetylcholine metabolism and acid output Analysis using stress and 2-deoxy-d-glucose administration in rats. Neurochemistry international. vol 8. issue 4. 2012-10-02. PMID:20493088. |
the stress of immobilization in water caused a significant increase in the activity of choline acetyltransferase (cat) and acetylcholinesterase (ache), acetylcholine (ach) content in the stomach and gastric acid secretion, but a decrease of choline content in rats. |
2012-10-02 |
2023-08-12 |
rat |
| P E Potter, S Nitta, I Chaudhry, I Lalezari, P Goldiner, F F Folde. Effects of LF-14, THA and physostigmine in rat hippocampus and cerebral cortex. Neurochemistry international. vol 14. issue 4. 2012-10-02. PMID:20504446. |
the effects of physostigmine, tetrahydroaminoacridine (tha) and lf-14 [3,3-dimethyl-1(4- amino-3-pyridyl)urea], a 3,4-diaminopyridine derivative, were compared on inhibition of acetyl- cholinesterase (ache) activity, and release of [(3)h]acetylcholine (ach) from rat brain cortical and hippocampal slices. |
2012-10-02 |
2023-08-12 |
rat |
| A Szabó, J Nemcsók, P Kása, K Guly. Muscarinic cholinergic components in the carp brain. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504527. |
the activity of the muscarinic cholinergic system (acetylcholine, ach; acetylcholinesterase, ache; choline acetyltransferase, chat; muscarinic acetylcholine receptors) was studied in the carp brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| C N Pope, J Li. Age-related differences in sensitivity to organophosphorus pesticides. Environmental toxicology and pharmacology. vol 4. issue 3-4. 2012-10-02. PMID:21781839. |
extensive inhibition of ache leads to accumulation of acetylcholine in the synapse, disruption of normal impulse flow and subsequent signs of toxicity, including autonomic dysfunction, involuntary movements, muscle fasciculations and a host of others. |
2012-10-02 |
2023-08-12 |
rat |
| Carey Pope, Subramanya Karanth, Jing Li. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783509. |
under normal conditions, however, extensive inhibition of ache leads to excess synaptic acetylcholine levels, over-stimulation of cholinergic receptors, alteration of postsynaptic cell function and consequent signs of cholinergic toxicity. |
2012-10-02 |
2023-08-12 |
human |
| Oksana Lockridge, Ellen G Duysen, Troy Voelker, Charles M Thompson, Lawrence M Schopfe. Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783513. |
this implied that the mechanism of toxicity of a lethal dose of op in ache-/- mice was the same as in mice that had ache, namely accumulation of excess acetylcholine followed by overstimulation of receptors. |
2012-10-02 |
2023-08-12 |
mouse |
| Manjeet Singh, Sushma Rish. Plasma acetylcholinesterase as a biomarker of triazophos neurotoxicity in young and adult rats. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783514. |
besides inactivating acetylcholine at synaptic terminals ache also plays an important role in neuronal growth and differentiation. |
2012-10-02 |
2023-08-12 |
rat |