| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (ache) which hydrolyses acetylcholine. |
2013-10-25 |
2023-08-12 |
Not clear |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
therefore, ache and buche inhibition have been documented as critical targets for the effective management of ad by an increase in the availability of acetylcholine in the brain regions and decrease in the aβ deposition. |
2013-10-25 |
2023-08-12 |
Not clear |
| C F Höhmann, P T Carroll, F F Ebne. Acetylcholine levels and choline acetyltransferase activity in turtle cortex. Brain research. vol 258. issue 1. 2013-10-22. PMID:24010173. |
histochemical localization of acetylcholine esterase (ache) shows that the reaction product is in the outer half of the molecular layer of dorsal cortex of the turtle pseudemys. |
2013-10-22 |
2023-08-12 |
Not clear |
| Ganiyu Oboh, Odunayo M Agunloye, Ayodele J Akinyemi, Adedayo O Ademiluyi, Stephen A Adefegh. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats' brain-in vitro. Neurochemical research. vol 38. issue 2. 2013-10-17. PMID:23184188. |
inhibition of ache and bche activities slows down acetylcholine and butyrylcholine breakdown in the brain. |
2013-10-17 |
2023-08-12 |
rat |
| Jia Zhang, Yan-feng Zhen, Pu-Bu-Ci-Ren, Li-gang Song, Wei-na Kong, Tie-mei Shao, Xue Li, Xi-qing Cha. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behavioural brain research. vol 244. 2013-09-30. PMID:23396166. |
after behavioral testing, the rats were sacrificed and hippocampi were removed for biochemical assays (reactive oxygen species (ros), superoxide dismutase (sod), glutathione peroxidase (gpx), malondialdehyde (mda), acetylcholinesterase (ache), acetylcholine (ach)) and molecular biological analysis (cu/zn-sod, mn-sod, gpx, nicotinamide adenine dinucleotide phosphate (nadph) oxidase, nuclear factor κb (nf-κb), inhibitor of κb-alpha (iκbα), cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), receptor for advanced glycation end products (rage)). |
2013-09-30 |
2023-08-12 |
rat |
| Girish Beedessee, Avin Ramanjooloo, Rashmee Surnam-Boodhun, Rob W M van Soest, Daniel E P Mari. Acetylcholinesterase-inhibitory activities of the extracts from sponges collected in mauritius waters. Chemistry & biodiversity. vol 10. issue 3. 2013-09-17. PMID:23495160. |
the use of acetylcholinesterase (ache) inhibitors to retard the hydrolysis of acetylcholine has been suggested as a promising strategy for ad treatment. |
2013-09-17 |
2023-08-12 |
Not clear |
| Si-Juan Chu, Lan Zhang, Gang Liu, Wen-Xia Zhou, Lin L. [Effects of cornel iridoid glycoside on activity of cholinesterases in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 9. 2013-09-17. PMID:23944063. |
the biochemical methods were used to detect the activity of acetylcholine esterase (ache) and butyryl cholinesterase (buche) to investigate the influence of cig on cholinesterases. |
2013-09-17 |
2023-08-12 |
human |
| Dharmalingam Prakash, Kulasekaran Gopinath, Ganapasam Sudhandira. Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity. Neuromolecular medicine. vol 15. issue 1. 2013-08-29. PMID:23315010. |
administration of alcl3 developed behavioral deficits, triggered lipid peroxidation (lpo), compromised acetylcholine esterase (ache) activity, and reduced the levels of superoxide dismutase (sod), catalase (cat), glutathione-s-transferase (gst), and reduced glutathione (gsh), and caused histologic aberrations. |
2013-08-29 |
2023-08-12 |
mouse |
| William C Motel, Andrew Coop, Christopher W Cunningha. Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease. Mini reviews in medicinal chemistry. vol 13. issue 3. 2013-08-12. PMID:22931533. |
galantamine is a reversible, competitive acetylcholinesterase (ache) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nachr-apl) that shares many common structural elements with morphinan-based opioids. |
2013-08-12 |
2023-08-12 |
Not clear |
| Lei An, Zhuo Yang, Tao Zhan. Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiology of learning and memory. vol 100. 2013-07-23. PMID:23231966. |
water maze behavior and long-term depression (ltd) in hippocampal ca3-ca1 pathway were measured, followed by enzyme linked immunosorbent assay (elisa), by which acetylcholine (ach) level and acetylcholinesterase (ache) activity were determined. |
2013-07-23 |
2023-08-12 |
rat |
| Márcio M Costa, Aleksandro S da Silva, Francine C Paim, Raqueli França, Guilherme L Dornelles, Gustavo R Thomé, Jonas D S Serres, Roberta Schmatz, Rosélia M Spanevello, Jamile F Gonçalves, Maria Rosa C Schetinger, Cinthia M A Mazzanti, Sonia T A Lopes, Silvia G Monteir. Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits. Anais da Academia Brasileira de Ciencias. vol 84. issue 4. 2013-07-11. PMID:23011112. |
the increased activities of ache and bche probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. |
2013-07-11 |
2023-08-12 |
rat |
| Ahmad Mohammadi-Farani, Aram Ahmadi, Hamid Nadri, Alireza Aliabad. Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 21. issue 1. 2013-07-09. PMID:23758724. |
in recent years, acetylcholinesterase (ache) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with alzheimer's disease. |
2013-07-09 |
2023-08-12 |
Not clear |
| Tada-aki Kudo, Hiroyasu Kanetaka, Yoshinaka Shimizu, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Eizaburo Suzuki, Toshiyuki Takagi, Shin-ichi Izum. Induction of neuritogenesis in PC12 cells by a pulsed electromagnetic field via MEK-ERK1/2 signaling. Cell structure and function. vol 38. issue 1. 2013-07-04. PMID:23318214. |
plated pc12 cells were exposed to a single pemf (central magnetic flux density, 700 mt; frequency, 0.172 hz) for up to 12 h per day and were then evaluated for extent of neuritogenesis or acetylcholine esterase (ache) activity. |
2013-07-04 |
2023-08-12 |
rat |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
acetylcholinesterase (ache) is an enzyme that hydrolyses the neurotransmitter acetylcholine, thereby limiting spillover and duration of action. |
2013-06-27 |
2023-08-12 |
rat |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
this suggests that endogenous glutamate, released into the synaptic cleft as a co-mediator of acetylcholine, is capable of triggering the nmda receptor/no synthase-mediated pathway that modulates synaptic ache activity. |
2013-06-27 |
2023-08-12 |
rat |
| b' Milan Jokanovi\\xc4\\x8. Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data. Current topics in medicinal chemistry. vol 12. issue 16. 2013-06-04. PMID:23030612.' |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. |
2013-06-04 |
2023-08-12 |
human |
| A S Silva-Herdade, C Saldanh. Effects of acetylcholine on an animal mode of inflammation. Clinical hemorheology and microcirculation. vol 53. issue 1-2. 2013-05-29. PMID:23187452. |
in this study we performed intravenous administrations of velnacrine (vln) and acetylcholine (ach), respectively, ache inhibitor and substrate, in an animal model of lipopolysaccharide (lps)-induced inflammation in wistar rats. |
2013-05-29 |
2023-08-12 |
rat |
| John E Casida, Kathleen A Durki. Anticholinesterase insecticide retrospective. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22926007. |
in both insects and mammals, ache inhibition and acetylcholine accumulation leads to excitation and death. |
2013-05-28 |
2023-08-12 |
human |
| Jun-Ying Wang, Fan-Ying Meng, Shu-Ping Chen, Yong-Hui Gao, Jun-Ling Li. Analysis on interrelation between electroacupuncture-induced cumulative analgesic effect and hypothalamic cholinergic activities in chronic neuropathic pain rats. Chinese journal of integrative medicine. vol 18. issue 9. 2013-05-28. PMID:22936324. |
to observe the effects of repeated electroacupuncture (ea) of zusanli (st36)- yanglingquan (gb34) on hypothalamic acetylcholinesterase (ache) and vesicular acetylcholine (ach) transporter (vacht) activities and choline acetyltransferase (chat) mrna and muscarinic m1 receptor (m1r) mrna expression in chronic constrictive injury (cci) and/or ovariectomy (ovx) rats so as to reveal its underlying mechanism in cumulative analgesia. |
2013-05-28 |
2023-08-12 |
rat |
| Zrinka Kovarik, Nikolina Maček, Rakesh K Sit, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22960624. |
organophosphates (op) inhibit acetylcholinesterase (ache, ec 3.1.1.7), both in peripheral tissues and central nervous system (cns), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ach). |
2013-05-28 |
2023-08-12 |
Not clear |