| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Zovko, Kristina Viktorsson, Rolf Lewensohn, Katja Kološa, Metka Filipič, Hong Xing, William R Kem, Laura Paleari, Tom Tur. APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma. Marine drugs. vol 11. issue 7. 2014-04-01. PMID:23880932. |
aps8, an analog of poly-aps with defined alkyl chain length and molecular size, non-competitively inhibits α7 nicotinic acetylcholine receptors (nachrs) at nanomolar concentrations that are too low to be acetylcholinesterase (ache) inhibitory or generally cytotoxic. |
2014-04-01 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the main target of ops is the inhibition of acetylcholinesterase (ache), an enzyme necessary for the control of the neurotransmitter acetylcholine (ach). |
2014-03-26 |
2023-08-12 |
Not clear |
| Philippe Lestaevel, Hélène Bensoussan, Bernadette Dhieux, Olivia Delissen, Claire-Marie Vacher, Isabelle Dublineau, Philippe Voisin, Mohammed Taoui. Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium. The Journal of toxicological sciences. vol 38. issue 5. 2014-03-25. PMID:24067729. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were evaluated in the entorhinal cortex and hippocampus. |
2014-03-25 |
2023-08-12 |
rat |
| Ling Huang, Tao Su, Xingshu L. Natural products as sources of new lead compounds for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931437. |
one possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache) with reversible inhibitors. |
2014-03-10 |
2023-08-12 |
Not clear |
| K V Niessen, T Seeger, J E H Tattersall, C M Timperley, M Bird, C Green, H Thiermann, F Wore. Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length. Chemico-biological interactions. vol 206. issue 3. 2014-03-10. PMID:24157926. |
the toxicity of organophosphorus nerve agents or pesticides arises from accumulation of acetylcholine and overstimulation of both muscarinic and nicotinic acetylcholine receptors (machrs and nachrs) due to inhibition of acetylcholinesterase (ache). |
2014-03-10 |
2023-08-12 |
human |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Saif M Al-Ghai. Acetylcholinesterase, glutathione and hepatosomatic index as potential biomarkers of sewage pollution and depuration in fish. Marine pollution bulletin. vol 74. issue 1. 2014-02-20. PMID:23911202. |
cellular biomarkers, cholinesterase activity using acetylcholine as a substrate (acetylcholinesterase ache) and reduced glutathione (gsh) and hepatosomatic index (hsi) were investigated in fresh water fish, tilapia, raised in a fish farm (group i/clean, as control), treated sewage water/tsw (group ii/sewage) and thereafter exposed to fresh water in an aquarium for 6 weeks (group iii/depurated) for depuration. |
2014-02-20 |
2023-08-12 |
Not clear |
| Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-Ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Ki. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389690. |
cholinergic parameters (ie, acetylcholine (ach), choline acetyltransferase (chat), and acetylcholinesterase (ache)) and nmdar-dependent long-term potentiation (ltp) were significantly impaired in klotho mutant mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Michaela Prinz, Sülünay Parlar, Gülşah Bayraktar, Vildan Alptüzün, Ercin Erciyas, Adyary Fallarero, Daniela Karlsson, Pia Vuorela, Malgorzata Burek, Carola Förster, Ezgi Turunc, Guliz Armagan, Ayfer Yalcin, Carola Schiller, Kristina Leuner, Manuel Krug, Christoph A Sotriffer, Ulrike Holzgrab. 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 49. issue 4. 2014-02-11. PMID:23643737. |
here, following the cholinergic hypothesis, we aimed to inhibit both acetyl- and butyrylcholinesterase (ache and buche) in order to increase the concentration of acetylcholine in the synaptic cleft. |
2014-02-11 |
2023-08-12 |
Not clear |
| Joana Osswald, António Paulo Carvalho, Laura Guimarães, Lúcia Guilhermin. Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23648421. |
the results indicated a significant increasing trend for ache activity with the dose of anatoxin-a, possibly representing an attempt to cope with overstimulation of muscle activity by the toxin, which competes with acetylcholine for nicotinic receptors binding. |
2014-02-05 |
2023-08-12 |
Not clear |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
in brain, acetylcholine (ach) is produced by cholinergic neurons and released in extracellular space where it is cleaved by ache anchored by protein prima. |
2014-02-03 |
2023-08-12 |
mouse |
| Xing Lin, Renbin Huang, Shijun Zhang, Ling Wei, Lang Zhuo, Xiaoyan Wu, Aicun Tang, Quanfang Huan. Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice. Fitoterapia. vol 87. 2014-01-16. PMID:23562630. |
furthermore, ahs increased the levels of acetylcholine (ach), but decreased cholinesterase (ache) activity. |
2014-01-16 |
2023-08-12 |
mouse |
| Hanaa H Ahmed, Selim F Estefan, Ehab M Mohamd, Abd El-Razik H Farrag, Rania S Sala. Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model? Indian journal of clinical biochemistry : IJCB. vol 28. issue 4. 2014-01-15. PMID:24426241. |
hydrogen peroxide (h2o2), malondialdehyde (mda), total antioxidant capacity (tac), superoxide dismutase (sod), catalase (cat), b cell lymphoma 2 (bcl-2), brain derived neurotrophic factor (bdnf), acetylcholinesterase (ache) and acetylcholine (ach) were estimated in the brain tissues of the different groups. |
2014-01-15 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
the involvement of brain nicotinic acetylcholine receptors (nachrs) in the neurotoxicological effects of soman, a potent acetylcholinesterase (ache) inhibitor and a chemical warfare agent, is not clear. |
2014-01-13 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
to test the hypothesis that ache inhibition builds sufficient acetylcholine (ach) in the brain and facilitates nachr-dependent glutamate transmission, we used whole-cell patch-clamp technique to record spontaneous glutamate excitatory postsynaptic currents (epscs) from ca1 stratum radiatum interneurons (sri) in hippocampal slices. |
2014-01-13 |
2023-08-12 |
rat |
| Liang Guo, Xin Wang, Jin-yan Li, Hua-shan Liang, Yong Jiang, Shan-shan Chang, Yu-jing Song, Li Cheng, Jin-ping Zhen. [Effects of subchronic benzo[a]pyrene exposure on hippocampal cholinergic system in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 31. issue 2. 2014-01-09. PMID:23433211. |
to observe the effects of subchronic benzo[a]pyrene (b[a]p) exposure on the neurobehavior and hippocampal acetylcholine (ach) level, acetylcholinesterase (ache) activity, and mrna and protein expression of nicotinic acetylcholine receptor α7 subtype (nachr α7) in rats, and to investigate the neurotoxic mechanism of b[a]p. |
2014-01-09 |
2023-08-12 |
rat |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |
| Ilkay Erdogan Orha. Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381529. |
acetylcholinesterase (ache) (ec 3.1.1.7) is an important enzyme that breaks down of acetylcholine in synaptic cleft in neuronal junctions. |
2014-01-01 |
2023-08-12 |
Not clear |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
the fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme ache, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with alzheimer's disease and alleviating the symptoms of this neurological disorder. |
2014-01-01 |
2023-08-12 |
Not clear |
| Xianwei Meng, Jianfei Wei, Xiangling Ren, Jun Ren, Fangqiong Tan. A simple and sensitive fluorescence biosensor for detection of organophosphorus pesticides using H2O2-sensitive quantum dots/bi-enzyme. Biosensors & bioelectronics. vol 47. 2013-12-31. PMID:23612061. |
the biosensor is composed of enzymes (ache and chox (choline oxidase)), qds and acetylcholine (ach), without any complex process of assembly for biosensor. |
2013-12-31 |
2023-08-12 |
Not clear |