| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eyal Golub, Ronit Freeman, Itamar Willne. Hemin/G-quadruplex-catalyzed aerobic oxidation of thiols to disulfides: application of the process for the development of sensors and aptasensors and for probing acetylcholine esterase activity. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24299064. |
finally, the hemin/g-quadruplex dnazyme/amplex red system was used to follow the activity of acetylcholine esterase, ache, and to probe its inhibition. |
2014-07-15 |
2023-08-12 |
Not clear |
| Aisa Ozawa, Erina Kadowaki, Yosuke Haga, Hitomi Sekiguchi, Natsuko Hemmi, Takuya Kaneko, Takehiro Maki, Kou Sakabe, Shuntaro Hara, Masako Yamamoto, Kazuyoshi Arishima, Motoharu Sakau. Acetylcholine esterase is a regulator of GFAP expression and a target of dichlorvos in astrocytic differentiation of rat glioma C6 cells. Brain research. vol 1537. 2014-06-25. PMID:24001591. |
the known potential targets of ddvp are acetylcholine esterase (ache), fatty acid amide hydrolase and methyl guanine methyl transferase. |
2014-06-25 |
2023-08-12 |
rat |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Sengottayan Senthil-Natha. Physiological and biochemical effect of neem and other Meliaceae plants secondary metabolites against Lepidopteran insects. Frontiers in physiology. vol 4. 2014-06-24. PMID:24391591. |
acethylcholine esterase (ache) is a key enzyme that terminates nerve impulses by catalyzing the hydrolysis of neurotransmitter, acetylcholine, in the nervous system of various organisms. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jennifer L Carey, Courtney Dunn, Romolo J Gaspar. Central respiratory failure during acute organophosphate poisoning. Respiratory physiology & neurobiology. vol 189. issue 2. 2014-06-02. PMID:23933009. |
ops affect neuronal signaling through acetylcholine (ach) neurotransmission via inhibition of acetylcholinesterase (ache), leading to accumulation of ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. |
2014-06-02 |
2023-08-12 |
Not clear |
| Clément Chéhensse, Stéphane Bahrami, Pierre Denys, Pierre Clément, Jacques Bernabé, François Giulian. The spinal control of ejaculation revisited: a systematic review and meta-analysis of anejaculation in spinal cord injured patients. Human reproduction update. vol 19. issue 5. 2014-05-01. PMID:23820516. |
masturbation or coïtus, penile vibratory stimulation (pvs) or acetylcholine esterase (ache) inhibitors prior to masturbation. |
2014-05-01 |
2023-08-12 |
rat |
| Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willne. Cysteine-mediated aggregation of Au nanoparticles: the development of a H2O2 sensor and oxidase-based biosensors. ACS nano. vol 7. issue 8. 2014-05-01. PMID:23829431. |
the cysteine-stimulated aggregation of au nanoparticles (au nps) is used as an auxiliary reporting system for the optical detection of h2o2, for optical probing of the glucose oxidase (gox) and the catalyzed oxidation of glucose, for probing the biocatalytic cascade composed of acetylcholine esterase/choline oxidase (ache/chox), and for following the inhibition of ache. |
2014-05-01 |
2023-08-12 |
Not clear |
| Alicja Tomaszek, Liliana Kiczak, Jacek Bania, Paweł Krupa, Urszula Pasławska, Maciej Zacharski, Adrian Janiszewski, Tadeusz Stefaniak, Dorota Zyśko, Hossein Ardehali, Ewa A Jankowska, Piotr Ponikowsk. Changes in parasympathetic system in medulla oblongata in male pigs in the course of tachycardia-induced cardiomyopathy. Autonomic neuroscience : basic & clinical. vol 177. issue 2. 2014-04-29. PMID:23891249. |
α7 nicotinic acetylcholine receptor (α7nachr) and enzymes metabolizing acetylcholine (acetylcholinesterase, ache, choline acetyltransferase, chat) in medulla oblongata (mo) of male pigs with chronic tachycardia-induced cardiomyopathy. |
2014-04-29 |
2023-08-12 |
Not clear |
| Karyn G Robinson, Janet L Mendonca, Jaimee L Militar, Mary C Theroux, Kirk W Dabney, Suken A Shah, Freeman Miller, Robert E Akin. Disruption of basal lamina components in neuromotor synapses of children with spastic quadriplegic cerebral palsy. PloS one. vol 8. issue 8. 2014-04-08. PMID:23976945. |
the localization of synaptic acetylcholine esterase (ache) relative to postsynaptic acetylcholine receptor (achr), synaptic laminin β2, and presynaptic vesicle protein 2 (sv2) appeared mismatched in the cp samples; whereas, no significant disruption was found between achr and sv2. |
2014-04-08 |
2023-08-12 |
Not clear |
| Roger B Varela, Samira S Valvassori, Jéssica Lopes-Borges, Daiane B Fraga, Wilson R Resende, Camila O Arent, Alexandra I Zugno, João Queved. Evaluation of acetylcholinesterase in an animal model of mania induced by D-amphetamine. Psychiatry research. vol 209. issue 2. 2014-04-02. PMID:23245536. |
our findings further support the notion that the mechanisms of mood stabilizers also involve changes in ache activity, thus reinforcing the need for more studies to better characterize the role of acetylcholine in bipolar disorder. |
2014-04-02 |
2023-08-12 |
rat |
| Ana Zovko, Kristina Viktorsson, Rolf Lewensohn, Katja Kološa, Metka Filipič, Hong Xing, William R Kem, Laura Paleari, Tom Tur. APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma. Marine drugs. vol 11. issue 7. 2014-04-01. PMID:23880932. |
aps8, an analog of poly-aps with defined alkyl chain length and molecular size, non-competitively inhibits α7 nicotinic acetylcholine receptors (nachrs) at nanomolar concentrations that are too low to be acetylcholinesterase (ache) inhibitory or generally cytotoxic. |
2014-04-01 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the main target of ops is the inhibition of acetylcholinesterase (ache), an enzyme necessary for the control of the neurotransmitter acetylcholine (ach). |
2014-03-26 |
2023-08-12 |
Not clear |
| Philippe Lestaevel, Hélène Bensoussan, Bernadette Dhieux, Olivia Delissen, Claire-Marie Vacher, Isabelle Dublineau, Philippe Voisin, Mohammed Taoui. Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium. The Journal of toxicological sciences. vol 38. issue 5. 2014-03-25. PMID:24067729. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were evaluated in the entorhinal cortex and hippocampus. |
2014-03-25 |
2023-08-12 |
rat |
| Ling Huang, Tao Su, Xingshu L. Natural products as sources of new lead compounds for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931437. |
one possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache) with reversible inhibitors. |
2014-03-10 |
2023-08-12 |
Not clear |
| K V Niessen, T Seeger, J E H Tattersall, C M Timperley, M Bird, C Green, H Thiermann, F Wore. Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length. Chemico-biological interactions. vol 206. issue 3. 2014-03-10. PMID:24157926. |
the toxicity of organophosphorus nerve agents or pesticides arises from accumulation of acetylcholine and overstimulation of both muscarinic and nicotinic acetylcholine receptors (machrs and nachrs) due to inhibition of acetylcholinesterase (ache). |
2014-03-10 |
2023-08-12 |
human |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Saif M Al-Ghai. Acetylcholinesterase, glutathione and hepatosomatic index as potential biomarkers of sewage pollution and depuration in fish. Marine pollution bulletin. vol 74. issue 1. 2014-02-20. PMID:23911202. |
cellular biomarkers, cholinesterase activity using acetylcholine as a substrate (acetylcholinesterase ache) and reduced glutathione (gsh) and hepatosomatic index (hsi) were investigated in fresh water fish, tilapia, raised in a fish farm (group i/clean, as control), treated sewage water/tsw (group ii/sewage) and thereafter exposed to fresh water in an aquarium for 6 weeks (group iii/depurated) for depuration. |
2014-02-20 |
2023-08-12 |
Not clear |
| Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-Ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Ki. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389690. |
cholinergic parameters (ie, acetylcholine (ach), choline acetyltransferase (chat), and acetylcholinesterase (ache)) and nmdar-dependent long-term potentiation (ltp) were significantly impaired in klotho mutant mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Michaela Prinz, Sülünay Parlar, Gülşah Bayraktar, Vildan Alptüzün, Ercin Erciyas, Adyary Fallarero, Daniela Karlsson, Pia Vuorela, Malgorzata Burek, Carola Förster, Ezgi Turunc, Guliz Armagan, Ayfer Yalcin, Carola Schiller, Kristina Leuner, Manuel Krug, Christoph A Sotriffer, Ulrike Holzgrab. 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 49. issue 4. 2014-02-11. PMID:23643737. |
here, following the cholinergic hypothesis, we aimed to inhibit both acetyl- and butyrylcholinesterase (ache and buche) in order to increase the concentration of acetylcholine in the synaptic cleft. |
2014-02-11 |
2023-08-12 |
Not clear |
| Joana Osswald, António Paulo Carvalho, Laura Guimarães, Lúcia Guilhermin. Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23648421. |
the results indicated a significant increasing trend for ache activity with the dose of anatoxin-a, possibly representing an attempt to cope with overstimulation of muscle activity by the toxin, which competes with acetylcholine for nicotinic receptors binding. |
2014-02-05 |
2023-08-12 |
Not clear |