| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nidhi Chauhan, C S Pundi. Amperometric determination of acetylcholine-A neurotransmitter, by chitosan/gold-coated ferric oxide nanoparticles modified gold electrode. Biosensors & bioelectronics. vol 61. 2015-02-20. PMID:24836212. |
the biosensor is based on electrochemical measurement of h2o2 generated from oxidation of choline by immobilized cho, which in turn is produced from hydrolysis of acetylcholine by immobilized ache. |
2015-02-20 |
2023-08-13 |
Not clear |
| Miguel Larguinho, Ana Cordeiro, Mário S Diniz, Pedro M Costa, Pedro V Baptist. Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide. Environmental research. vol 135. 2015-02-09. PMID:25262075. |
in addition, no neurotoxic effects could be determined through acetylcholine esterase (ache) activity. |
2015-02-09 |
2023-08-13 |
human |
| Michael Allgaier, Clemens Allgaie. An update on drug treatment options of Alzheimer's disease. Frontiers in bioscience (Landmark edition). vol 19. 2015-02-07. PMID:24896354. |
hence, rebalancing the cholinergic input to improve the cognitive symptoms of ad by inhibition of acetylcholine esterase (ache) is still the only mechanistic target in addition to n-methyl-d-aspartate (nmda) receptor blockade by memantine that can be addressed by currently approved medications. |
2015-02-07 |
2023-08-13 |
Not clear |
| Katarina Nikolic, Slavica Filipic, Danica Agbaba, Holger Star. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS neuroscience & therapeutics. vol 20. issue 7. 2015-02-06. PMID:24836924. |
dual target drugs displaying h3 r antagonism/inverse agonism with inhibition of acetylcholine esterase (ache), histamine n-methyltransferase (hmt), or serotonin transporter (sert) are novel class of procognitive agents. |
2015-02-06 |
2023-08-13 |
Not clear |
| Ericka C Holmstrand, David Lund, Ajeesh Koshy Cherian, Jane Wright, Rolicia F Martin, Elizabeth A Ennis, Gregg D Stanwood, Martin Sarter, Randy D Blakel. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochemistry international. vol 73. 2015-02-02. PMID:24274995. |
the hemicholinium-3 (hc-3) sensitive, high-affinity choline transporter (cht) sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary sources or from acetylcholinesterase (ache)-mediated hydrolysis of acetylcholine (ach). |
2015-02-02 |
2023-08-12 |
mouse |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex, as indicated by a decreased acetylcholine (ach) level and an increased acetylcholinesterase (ache) activity. |
2015-01-27 |
2023-08-13 |
mouse |
| Andrew M King, Cynthia K Aaro. Organophosphate and carbamate poisoning. Emergency medicine clinics of North America. vol 33. issue 1. 2015-01-26. PMID:25455666. |
both classes inhibit acetylcholinesterase (ache) enzymes, leading to excess acetylcholine accumulation at nerve terminals. |
2015-01-26 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Martina Hrabinova, Kamil Kuca, Jean-Pierre Simonat. Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method. International journal of molecular sciences. vol 12. issue 4. 2015-01-22. PMID:21731462. |
we calculated michaelis constant km (2.06 × 10(-4) mol/l for acetylthiocholine and 3.21 × 10(-3) mol/l for indoxylacetate) maximum reaction velocity v(max) (4.97 × 10(-7) kat for acetylcholine and 7.71 × 10(-8) kat for indoxylacetate) for electric eel ache. |
2015-01-22 |
2023-08-12 |
Not clear |
| Rodrigo Rodrigues, Gabriela Debom, Fabiano Soares, Caroline Machado, Jéssica Pureza, William Peres, Gilberto de Lima Garcias, Marta Frescura Duarte, Maria Rosa Chitolina Schetinger, Francieli Stefanello, Elizandra Braganhol, Roselia Spanevell. Alterations of ectonucleotidases and acetylcholinesterase activities in lymphocytes of Down syndrome subjects: relation with inflammatory parameters. Clinica chimica acta; international journal of clinical chemistry. vol 433. 2015-01-15. PMID:24631131. |
atp, adenosine, and acetylcholine contribute to the immune response regulation, and ntpdase, adenosine deaminase (ada) and acetylcholinesterase (ache) are important enzymes in the control of the extracellular levels of these molecules. |
2015-01-15 |
2023-08-12 |
human |
| Sibhghatulla Shaikh, Anupriya Verma, Saimeen Siddiqui, Syed S Ahmad, Syed M D Rizvi, Shazi Shakil, Deboshree Biswas, Divya Singh, Mohmmad H Siddiqui, Shahnawaz Shakil, Shams Tabrez, Mohammad A Kama. Current acetylcholinesterase-inhibitors: a neuroinformatics perspective. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059296. |
ache is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. |
2015-01-07 |
2023-08-12 |
Not clear |
| M Merad, W Soufi, S Ghalem, F Boukli, M H Baig, K Ahmad, Mohammad A Kama. Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059305. |
acetylcholinesterase (ache) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". |
2015-01-07 |
2023-08-12 |
Not clear |
| Stéphanie Bélanger Jasmin, Vanessa Pearson, Daphnée Lalonde, Dorothée Domenger, Louise Théroux, Judes Poirie. Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatment. Brain research. vol 1562. 2014-12-08. PMID:24661912. |
ecl induced a time-dependent up-regulation of abca1, but not g1, that coincided with a significant increase in acetylcholine esterase (ache) activity in the ipsilateral hippocampus. |
2014-12-08 |
2023-08-12 |
mouse |
| Fouad H Darras, Steffen Pockes, Guozheng Huang, Sarah Wehle, Andrea Strasser, Hans-Joachim Wittmann, Martin Nimczick, Christoph A Sotriffer, Michael Decke. Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS chemical neuroscience. vol 5. issue 3. 2014-12-03. PMID:24422467. |
however, whereas ache inhibitors prevent hydrolysis of acetylcholine also peripherally, histamine h3 antagonists will raise acetylcholine levels mostly in the brain due to predominant occurrence of the receptor in the central nervous system. |
2014-12-03 |
2023-08-12 |
Not clear |
| Helen M Campanha, Félix Carvalho, Paul M Schlosse. Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line. Toxicology letters. vol 230. issue 2. 2014-11-25. PMID:24680925. |
the classical enzymatic role of acetylcholinesterase (ache) is to terminate impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine (ach). |
2014-11-25 |
2023-08-12 |
mouse |
| Satoru Yoshikawa, Takeya Kitta, Minoru Miyazato, Yasuhiro Sumino, Naoki Yoshimur. Inhibitory role of the spinal cholinergic system in the control of urethral continence reflex during sneezing in rats. Neurourology and urodynamics. vol 33. issue 4. 2014-11-24. PMID:23754327. |
we therefore investigated the effect of intrathecal administration of an acetylcholine esterase (ache) inhibitor, which increases ach in synaptic terminals, and anti-cholinergic agents on the sneeze-induced urethral reflex in rats. |
2014-11-24 |
2023-08-12 |
rat |
| Ali Afrasiabi, Gholam Hossein Riazi, Shayan Abbasi, Ali Dadras, Behafarid Ghalandari, Hossein Seidkhani, Seyed Mohamad Sadegh Modaresi, Neda Masoudian, Amir Amani, Shahin Ahmadia. Synaptosomal acetylcholinesterase activity variation pattern in the presence of electromagnetic fields. International journal of biological macromolecules. vol 65. 2014-11-24. PMID:24418344. |
acetylcholinesterase (ache) is the enzyme that controls the acetylcholine (ach) concentrations in cholinergic synaptic clefts by hydrolyzing ach to choline and acetate. |
2014-11-24 |
2023-08-12 |
Not clear |
| Guijie Li, Qiang Wang, Yu Qian, Yalin Zhou, Rui Wang, Xin Zha. Component analysis of Pu-erh and its anti-constipation effects. Molecular medicine reports. vol 9. issue 5. 2014-11-18. PMID:24604453. |
serum levels of motilin (mtl), gastrin (gas), endothelin (et), acetylcholine enzyme (ache), substance p (sp) and vasoactive intestinal peptide (vip) were significantly increased and somatostatin (ss) was decreased when the mice were treated with different concentrations of pu-erh tea compared with the untreated control mice. |
2014-11-18 |
2023-08-12 |
mouse |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
these results demonstrate that ache inhibition facilitated fasting-induced tg accumulation with up regulation of the hepatic l-fabp and srebp-1 in mice, at least in part via the activation of muscarinic acetylcholine receptors. |
2014-11-10 |
2023-08-13 |
mouse |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |
| Ibtissem Ben Amara, Mediha Sefi, Afef Troudi, Nejla Soudani, Tahia Boudawara, Najiba Zegha. Fenthion, an organophosphorus pesticide, induces alterations in oxidant/antioxidant status and histopathological disorders in cerebrum and cerebellum of suckling rats. Indian journal of biochemistry & biophysics. vol 51. issue 4. 2014-10-23. PMID:25296500. |
acetylcholine esterase (ache) activity was inhibited in both the cerebrum and cerebellum of suckling rats whose mothers were treated with fen. |
2014-10-23 |
2023-08-13 |
rat |