| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shun Shimoham. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291871. |
rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both ache and butyrylcholinesterase. |
2015-04-13 |
2023-08-12 |
Not clear |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
aβf also influenced the levels of ache, buche and chat in favour of a low level of acetylcholine. |
2015-04-13 |
2023-08-13 |
human |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| María-Letizia Campanari, María-Salud García-Ayllón, Lidia Blazquez-Llorca, Wilson K W Luk, Karl Tsim, Javier Sáez-Valer. Acetylcholinesterase protein level is preserved in the Alzheimer's brain. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24318838. |
moreover, alternative functions of ache unrelated with the hydrolysis of acetylcholine are suspected. |
2015-04-06 |
2023-08-12 |
Not clear |
| Karina Silvia Matos, Elaine F F da Cunha, Ruben Abagyan, Teodorico C Ramalh. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial chemistry & high throughput screening. vol 17. issue 6. 2015-04-06. PMID:24344993. |
acetylcholinesterase (ache) is responsible for hydrolysis of acetylcholine (ach), a function, which if disrupted, leads to cholinergic syndrome. |
2015-04-06 |
2023-08-12 |
human |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
acetylcholinesterase (ache) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2015-04-06 |
2023-08-12 |
human |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
we are exploring a strategy to design compounds that bind tightly at or near a peripheral or p-site near the mouth of the ache active site gorge and exclude ops from the active site while interfering minimally with the passage of acetylcholine. |
2015-04-06 |
2023-08-12 |
human |
| Qi Sun, Da-Yong Peng, Sheng-Gang Yang, Xiao-Lei Zhu, Wen-Chao Yang, Guang-Fu Yan. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase. Bioorganic & medicinal chemistry. vol 22. issue 17. 2015-04-06. PMID:25088549. |
exploring small-molecule acetylcholinesterase (ache) inhibitors to slow the breakdown of acetylcholine (ach) represents the mainstream direction for alzheimer's disease (ad) therapy. |
2015-04-06 |
2023-08-13 |
human |
| Andrew G Cairns, Hans Martin Senn, Michael P Murphy, Richard C Hartle. Expanding the palette of phenanthridinium cations. Chemistry (Weinheim an der Bergstrasse, Germany). vol 20. issue 13. 2015-03-12. PMID:24677631. |
some properties rely on phenanthridiniums intercalating into dna, but the use of these cations as exomarkers for the reactive oxygen species (ros), superoxide, and as inhibitors of acetylcholine esterase (ache) do not require intercalation. |
2015-03-12 |
2023-08-12 |
Not clear |
| Shuang Yu, Ling Chen, Xing-hui Cai, Xiao-ge Song, Yue Zhang, Yang Zhang, Rui Song, Yi-fang L. [Effect of manual acupuncture stimulation of "Baihui" (GV 20) and "Dazhui" (GV 14) on contents of 5-HT, dopamine and ACh and expression of 5-HT mRNA, DA mRNA and AChE mRNA in the hippocampus in methamphetamine addiction rats]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 5. 2015-03-12. PMID:25518108. |
to observe the effect of manual acupuncture stimulation on changes of hippocampal monoamine neurotransmitter levels and expression of 5-hydorxytryptamine (5-ht) mrna, dopamine (da) mrna and acetylcholine esterase (ache) mrna in methamphetamine addiction rats, so as to explore its mechanism underlying improvement of drug addiction. |
2015-03-12 |
2023-08-13 |
rat |
| Gauresh Somani, Chinmay Kulkarni, Prashant Shinde, Rupesh Shelke, Kirti Laddha, Sadhana Sathay. In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies. Journal of pharmacy & bioallied sciences. vol 7. issue 1. 2015-02-24. PMID:25709334. |
inhibitors of acetylcholinesterase (ache) leading to inhibition of acetylcholine breakdown constitute the main therapeutic strategy for ad. |
2015-02-24 |
2023-08-13 |
Not clear |
| Nidhi Chauhan, C S Pundi. Amperometric determination of acetylcholine-A neurotransmitter, by chitosan/gold-coated ferric oxide nanoparticles modified gold electrode. Biosensors & bioelectronics. vol 61. 2015-02-20. PMID:24836212. |
an amperometric acetylcholine biosensor was constructed by co-immobilizing covalently, a mixture of acetylcholinesterase (ache) and choline oxidase (cho) onto nanocomposite of chitosan (chit)/gold-coated ferric oxide nanoparticles (fe@aunps) electrodeposited onto surface of a au electrode and using it as a working electrode, ag/agcl as reference electrode and pt wire as auxiliary electrode connected through potentiostat. |
2015-02-20 |
2023-08-13 |
Not clear |
| Nidhi Chauhan, C S Pundi. Amperometric determination of acetylcholine-A neurotransmitter, by chitosan/gold-coated ferric oxide nanoparticles modified gold electrode. Biosensors & bioelectronics. vol 61. 2015-02-20. PMID:24836212. |
the biosensor is based on electrochemical measurement of h2o2 generated from oxidation of choline by immobilized cho, which in turn is produced from hydrolysis of acetylcholine by immobilized ache. |
2015-02-20 |
2023-08-13 |
Not clear |
| Miguel Larguinho, Ana Cordeiro, Mário S Diniz, Pedro M Costa, Pedro V Baptist. Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide. Environmental research. vol 135. 2015-02-09. PMID:25262075. |
in addition, no neurotoxic effects could be determined through acetylcholine esterase (ache) activity. |
2015-02-09 |
2023-08-13 |
human |
| Michael Allgaier, Clemens Allgaie. An update on drug treatment options of Alzheimer's disease. Frontiers in bioscience (Landmark edition). vol 19. 2015-02-07. PMID:24896354. |
hence, rebalancing the cholinergic input to improve the cognitive symptoms of ad by inhibition of acetylcholine esterase (ache) is still the only mechanistic target in addition to n-methyl-d-aspartate (nmda) receptor blockade by memantine that can be addressed by currently approved medications. |
2015-02-07 |
2023-08-13 |
Not clear |
| Katarina Nikolic, Slavica Filipic, Danica Agbaba, Holger Star. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS neuroscience & therapeutics. vol 20. issue 7. 2015-02-06. PMID:24836924. |
dual target drugs displaying h3 r antagonism/inverse agonism with inhibition of acetylcholine esterase (ache), histamine n-methyltransferase (hmt), or serotonin transporter (sert) are novel class of procognitive agents. |
2015-02-06 |
2023-08-13 |
Not clear |
| Ericka C Holmstrand, David Lund, Ajeesh Koshy Cherian, Jane Wright, Rolicia F Martin, Elizabeth A Ennis, Gregg D Stanwood, Martin Sarter, Randy D Blakel. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochemistry international. vol 73. 2015-02-02. PMID:24274995. |
the hemicholinium-3 (hc-3) sensitive, high-affinity choline transporter (cht) sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary sources or from acetylcholinesterase (ache)-mediated hydrolysis of acetylcholine (ach). |
2015-02-02 |
2023-08-12 |
mouse |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex, as indicated by a decreased acetylcholine (ach) level and an increased acetylcholinesterase (ache) activity. |
2015-01-27 |
2023-08-13 |
mouse |
| Andrew M King, Cynthia K Aaro. Organophosphate and carbamate poisoning. Emergency medicine clinics of North America. vol 33. issue 1. 2015-01-26. PMID:25455666. |
both classes inhibit acetylcholinesterase (ache) enzymes, leading to excess acetylcholine accumulation at nerve terminals. |
2015-01-26 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Martina Hrabinova, Kamil Kuca, Jean-Pierre Simonat. Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method. International journal of molecular sciences. vol 12. issue 4. 2015-01-22. PMID:21731462. |
we calculated michaelis constant km (2.06 × 10(-4) mol/l for acetylthiocholine and 3.21 × 10(-3) mol/l for indoxylacetate) maximum reaction velocity v(max) (4.97 × 10(-7) kat for acetylcholine and 7.71 × 10(-8) kat for indoxylacetate) for electric eel ache. |
2015-01-22 |
2023-08-12 |
Not clear |