| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
there is evidence that ebselen inhibits acetylcholinesterase (ache) activity, an enzyme that plays a key role in the cholinergic system by hydrolyzing acetylcholine (ach), in vitro and ex vivo. |
2015-09-11 |
2023-08-13 |
Not clear |
| Benjamín Pérez-Aguilar, Cecilio J Vidal, Guillermina Palomec, Fernando García-Dolores, María Concepción Gutiérrez-Ruiz, Leticia Bucio, José Luis Gómez-Olivares, Luis Enrique Gómez-Quiro. Acetylcholinesterase is associated with a decrease in cell proliferation of hepatocellular carcinoma cells. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25869328. |
acetylcholinesterase (ache), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. |
2015-08-27 |
2023-08-13 |
human |
| Ana Claudia Souza, Andressa Souza, Liciane Fernandes Medeiros, Carla De Oliveira, Vanessa Leal Scarabelot, Rosane Souza Da Silva, Mauricio Reis Bogo, Katiucia Marques Capiotti, Luiza Wilges Kist, Carla D Bonan, Wolnei Caumo, Iraci L S Torre. Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring. Brain research. vol 1595. 2015-08-21. PMID:25451122. |
the objective of this study was to evaluate the effects of maternal caffeine intake on the neuromotor development of rat offspring and on acetylcholine degradation and acetylcholinesterase (ache) expression in the hippocampus of 14-day-old infant rats. |
2015-08-21 |
2023-08-13 |
rat |
| Mohamed A Elnasharty, Ahmed Sayed-Ahme. Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25239149. |
cholinergic innervation of the rat adrenal gland has been analyzed previously using cholinergic markers including acetylcholinesterase (ache), choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht). |
2015-08-20 |
2023-08-13 |
rat |
| Ran-Ran Zhao, Fei Xu, Xiao-Chen Xu, Guo-Jun Tan, Liang-Min Liu, Ning Wu, Wen-Zhong Zhang, Ji-Xiang Li. Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia. Neuroscience letters. vol 587. 2015-08-10. PMID:25534501. |
additionally, alpha-lipoic acid raised the level of acetylcholine (ach) and choline acetyltransferase (chat) and decreased the activity of acetycholinesterase (ache) in the hippocampus. |
2015-08-10 |
2023-08-13 |
rat |
| Fen Wang, Xianzhong Zeng, Yangbo Zhu, Dan Ning, Junxia Liu, Chunlei Liu, Xuemei Jia, Defa Zh. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25371181. |
the present study has investigated the effect of t4 and donepezil (don; an acetylcholinesterase (ache) inhibitor) treatment on the hypothyroidism-induced alterations of acetylcholine (ach) content and ache activity. |
2015-07-30 |
2023-08-13 |
rat |
| Armando Méndez-Garrido, Maricarmen Hernández-Rodríguez, Rafael Zamorano-Ulloa, José Correa-Basurto, Jessica Elena Mendieta-Wejebe, Daniel Ramírez-Rosales, Martha Cecilia Rosales-Hernánde. In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25096900. |
it is well known that the principal biomolecules involved in alzheimer's disease (ad) are acetylcholinesterase (ache), acetylcholine (ach) and the amyloid beta peptide of 42 amino acid residues (aβ42). |
2015-07-29 |
2023-08-13 |
Not clear |
| Jin Wuk Lee, Bo-Mi Kim, Chang-Bum Jeong, Eun-Ji Won, Jae-Sung Rhee, Jae-Seong Le. Inhibitory effects of biocides on transcription and protein activity of acetylcholinesterase in the intertidal copepod Tigriopus japonicus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 167. 2015-07-21. PMID:25468639. |
acetlycholinesterase (ache) is a serine esterase that plays an important role in the hydrolytic degradation of acetylcholine. |
2015-07-21 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Saida Haider, Sadia Saleem, Tahira Perveen, Saiqa Tabassum, Zehra Batool, Sadia Sadir, Laraib Liaquat, Syeda Madih. Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system. Age (Dordrecht, Netherlands). vol 36. issue 3. 2015-07-15. PMID:24771014. |
to investigate the relationship between the oxidative stress and memory decline during aging, we have determined the level of lipid peroxidation, activities of antioxidant enzymes, and activity of acetylcholine esterase (ache) in brain and plasma as well as biogenic amine levels in brain from albino-wistar rats at age of 4 and 24 months. |
2015-07-15 |
2023-08-13 |
rat |
| Jacqueline D Keighron, Sebastian Åkesson, Ann-Sofie Can. Coimmobilization of acetylcholinesterase and choline oxidase on gold nanoparticles: stoichiometry, activity, and reaction efficiency. Langmuir : the ACS journal of surfaces and colloids. vol 30. issue 38. 2015-07-02. PMID:25167196. |
here we show that characterization of a two-enzyme:gold nanoparticle (aunp) conjugate stoichiometry and activity can be used to gauge the effectiveness of acetylcholine detection by acetylcholine esterase (ache) and choline oxidase (cho). |
2015-07-02 |
2023-08-13 |
Not clear |
| Jacqueline D Keighron, Sebastian Åkesson, Ann-Sofie Can. Coimmobilization of acetylcholinesterase and choline oxidase on gold nanoparticles: stoichiometry, activity, and reaction efficiency. Langmuir : the ACS journal of surfaces and colloids. vol 30. issue 38. 2015-07-02. PMID:25167196. |
we here show that the knowledge of the conjugate stoichiometry and retained enzyme activity can lead to more efficient detection of acetylcholine by controlling the ache:cho ratio bound to the gold nanoparticle material. |
2015-07-02 |
2023-08-13 |
Not clear |
| Vendula Sepsova, Jana Z Karasova, Gunnar Tobin, Daniel Jun, Jan Korabecny, Pavla Cabelova, Katerina Janska, Jan Krusek, Kristyna Skrenkova, Kamil Kuca, Ondrej Souku. Cholinergic properties of new 7-methoxytacrine-donepezil derivatives. General physiology and biophysics. vol 34. issue 2. 2015-06-18. PMID:25504063. |
organophosphorus nerve agents inhibit acetylcholinesterase (ache) which causes the breakdown of the transmitter acetylcholine (ach) in the synaptic cleft. |
2015-06-18 |
2023-08-13 |
Not clear |
| Gulseher Sarah Sirin, Yingkai Zhan. How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study. The journal of physical chemistry. A. vol 118. issue 39. 2015-06-16. PMID:24786171. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ach) and terminates synaptic signals by reducing the effective concentration of ach in the synaptic clefts. |
2015-06-16 |
2023-08-13 |
Not clear |
| Mohd Afroz Ahmad, Abul Kalam Najmi, Mohd Mujeeb, Mohd Akhta. Neuroprotective effect of guggulipid alone and in combination with aspirin on middle cerebral artery occlusion (MCAO) model of focal cerebral ischemia in rats. Toxicology mechanisms and methods. vol 24. issue 6. 2015-05-12. PMID:24965906. |
an elevation of nitrite, thiobarbituric acid reactive substance (tbars), acetylcholine esterase activity (ache) and reduction in antioxidant enzymes like superoxide dismutase (sod), glutathione (gsh) and catalase were observed following mcao. |
2015-05-12 |
2023-08-13 |
rat |
| Avital Stern, Matteo Guidotti, Eleonora Shaubi, Mary Popov, Charles Linder, Eliahu Heldman, Sarina Grinber. Steric environment around acetylcholine head groups of bolaamphiphilic nanovesicles influences the release rate of encapsulated compounds. International journal of nanomedicine. vol 9. 2015-05-11. PMID:24531296. |
two bolaamphiphilic compounds with identical acetylcholine (ach) head groups, but with different lengths of an alkyl chain pendant adjacent to the head group, as well as differences between their hydrophobic skeleton, were investigated for their ability to self-assemble into vesicles that release their encapsulated content upon hydrolysis of their head groups by acetylcholinesterase (ache). |
2015-05-11 |
2023-08-12 |
Not clear |
| Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu, Liang Ch. Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect. BMC cancer. vol 14. 2015-04-20. PMID:25220382. |
acetylcholinesterase (ache) mainly functions as an efficient terminator for acetylcholine signaling transmission. |
2015-04-20 |
2023-08-13 |
Not clear |
| Marieke Meijer, Timo Hamers, Remco H S Westerin. Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for (sub)micromolar concentrations of organophosphate insecticides. Neurotoxicology. vol 43. 2015-04-17. PMID:24495583. |
organophosphates (ops) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (ache) and subsequent overexcitation. |
2015-04-17 |
2023-08-12 |
Not clear |
| Shun Shimoham. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291871. |
rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both ache and butyrylcholinesterase. |
2015-04-13 |
2023-08-12 |
Not clear |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
aβf also influenced the levels of ache, buche and chat in favour of a low level of acetylcholine. |
2015-04-13 |
2023-08-13 |
human |