| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akın Akıncıoğlu, Hülya Akıncıoğlu, İlhami Gülçin, Serdar Durdagi, Claudiu T Supuran, Süleyman Göks. Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-29. PMID:25921269. |
in this study, several novel sulfamides were synthesized and evaluated for their acetylcholine esterase (ache) and human carbonic anhydrase i, and ii isoenzymes (hca i and ii) inhibition profiles. |
2016-02-29 |
2023-08-13 |
human |
| Fen Liu, Yong Li, Rong Jiang, Cheng Nie, Zhenguo Zeng, Ning Zhao, Caixue Huang, Qiang Shao, Chengzhi Ding, Cheng Qing, Liang Xia, Erming Zeng, Kejian Qia. miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway. Experimental lung research. vol 41. issue 5. 2016-02-26. PMID:26052826. |
we hypothesized that mir-132 attenuated lipopolysaccharide (lps)-induced inflammation of alveolar macrophages by targeting acetylcholinesterase (ache) and enhancing the acetylcholine (ach)-mediated cholinergic anti-inflammatory response. |
2016-02-26 |
2023-08-13 |
Not clear |
| Chun-Li Liu, Hong Chen, Yong Jiang, Peng-Fei Tu, Ming Zhong, Jing-Yi Ma, Hui Ding, Wan-Xin Zhang, Xiao-Min Ji. [Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 5. 2016-01-25. PMID:23888706. |
the content of acetylcholine (ach) and choline (ch) of microdialysate extracellular of hippocampus and striatum was determined by hplc-imer-ecd and the ache activity in the hippocampus was measured. |
2016-01-25 |
2023-08-12 |
rat |
| Xue-Qin Hou, Lei Zhang, Cong Yang, Cui-Ping Rong, Wen-Qing He, Chun-Xia Zhang, Shi Li, Ru-Yu Su, Xiang Chang, Ji-Huan Qin, Yun-Bo Chen, Shao-Xiang Xian, Qi Wan. Alleviating effects of Bushen-Yizhi formula on ibotenic acid-induced cholinergic impairments in rat. Rejuvenation research. vol 18. issue 2. 2016-01-22. PMID:25482164. |
additionally, bsyz reversed ibo-induced disorders of acetylcholine (ach) levels, chat, and cholinesterase (che) in the cortex, which was consistent with the changes in mrna levels of chat and acetylcholinesterase (ache). |
2016-01-22 |
2023-08-13 |
rat |
| Elvis A F Martis, Rakesh C Chandarana, Mushtaque S Shaikh, Premlata K Ambre, Jacinta S D'Souza, Krishna R Iyer, Evans C Coutinho, Santosh R Nandan, Raghuvir R S Pissurlenka. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 33. issue 5. 2016-01-15. PMID:24905476. |
there is a need for continued development of acetylcholinesterase (ache) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
| K Szigeti, M U Hafee. Exploring the role of donepezil in dementia with Lewy bodies. Drugs of today (Barcelona, Spain : 1998). vol 51. issue 10. 2016-01-07. PMID:26583300. |
these drugs, by reversibly blocking the hydrolytic activity of ache, increase the availability of synaptic acetylcholine. |
2016-01-07 |
2023-08-13 |
Not clear |
| J O Hollnagel, R Ul Haq, C J Behrens, A Maslarova, I Mody, U Heineman. No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro. Neuroscience. vol 284. 2016-01-04. PMID:25453770. |
acetylcholine (ach) is well known to induce persistent γ-oscillations in the hippocampus when applied together with physostigmine, an inhibitor of the ach degrading enzyme acetylcholinesterase (ache). |
2016-01-04 |
2023-08-13 |
rat |
| Maleeha Waqar, Sidra Batoo. In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer's disease. Journal of theoretical biology. vol 372. 2015-12-31. PMID:25747777. |
acetylcholinesterases (ache) are enzymes that function in hydrolyzing the neurotransmitter acetylcholine. |
2015-12-31 |
2023-08-13 |
Not clear |
| Rafał Sokołowski, Tadeusz Płus. [Today's threat of use of organophosphorus compounds]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 39. issue 231. 2015-12-31. PMID:26449583. |
inhibition of ache activity leads to the accumulation of large amounts of acetylcholine and hyperactivity of the cholinergic system by stimulating acetylcholine receptors - muscarinic and nicotinic. |
2015-12-31 |
2023-08-13 |
Not clear |
| Sihua Qian, Hengwei Li. Colorimetric sensor array for detection and identification of organophosphorus and carbamate pesticides. Analytical chemistry. vol 87. issue 10. 2015-12-23. PMID:25913282. |
the sensing mechanism of this array is based on the irreversible inhibition capability of ops and carbamates to the activity of acetylcholinesterase (ache), preventing production of thiocholine and h2o2 from s-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and h2o2 sensitive indicators. |
2015-12-23 |
2023-08-13 |
Not clear |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| Pedro Teixeira, Nuno Duro, Patrícia Napoleão, Carlota Saldanh. Acetylcholinesterase conformational states influence nitric oxide mobilization in the erythrocyte. The Journal of membrane biology. vol 248. issue 2. 2015-12-17. PMID:25652185. |
in addition, the present study shows evidence that conformational changes in ache promoted by incubation with n-19 and c-16 antibodies alter the enzyme's functional connection to acetylcholine (ach) (ache-ach complex) in an irreversible manner, resulting in impaired gsno concentration and no efflux from the erythrocyte. |
2015-12-17 |
2023-08-13 |
human |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
this study shows that cpf impaired cholinergic transmission, induced ache inhibition and, only after long-term exposure, increased cht expression, which suggests that acetylcholine levels alteration could be mediated by these actions. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
moreover, cpf induces, after acute and long-term exposure, cell death in cholinergic neurons in the basal forebrain and this effect is independent of ache inhibition and acetylcholine alteration, but was mediated partially by ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Harriëtte Riese, Loretto M Muñoz, Catharina A Hartman, Xiuhua Ding, Shaoyong Su, Albertine J Oldehinkel, Arie M van Roon, Peter J van der Most, Joop Lefrandt, Ron T Gansevoort, Pim van der Harst, Niek Verweij, Carmilla M M Licht, Dorret I Boomsma, Jouke-Jan Hottenga, Gonneke Willemsen, Brenda W J H Penninx, Ilja M Nolte, Eco J C de Geus, Xiaoling Wang, Harold Sniede. Identifying genetic variants for heart rate variability in the acetylcholine pathway. PloS one. vol 9. issue 11. 2015-12-14. PMID:25384021. |
we assessed whether 443 genotyped and imputed common genetic variants in eight key genes (chat, slc18a3, slc5a7, chrnb4, chrna3, chrna, chrm2 and ache) of the acetylcholine pathway were associated with variation in an established measure of heart rate variability reflecting parasympathetic control of the heart rhythm, the root mean square of successive differences (rmssd) of normal rr intervals. |
2015-12-14 |
2023-08-13 |
Not clear |
| Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S Momonok. Overexpression of acetylcholinesterase gene in rice results in enhancement of shoot gravitropism. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277389. |
acetylcholine (ach), a known neurotransmitter in animals and acetylcholinesterase (ache) exists widely in plants, although its role in plant signal transduction is unclear. |
2015-11-27 |
2023-08-13 |
Not clear |
| Amira Mira, Shuntaro Yamashita, Yoshinori Katakura, Kuniyoshi Shimiz. In vitro neuroprotective activities of compounds from Angelica shikokiana Makino. Molecules (Basel, Switzerland). vol 20. issue 3. 2015-11-23. PMID:25786165. |
quercetin showed the strongest ache inhibition (ic50 value = 35.5 µm) through binding to his-440 and tyr-70 residues at the catalytic and anionic sites of acetylcholine esterase, respectively. |
2015-11-23 |
2023-08-13 |
Not clear |
| Doaa A Ghareeb, Sofia Khalil, Hani S Hafez, Jürgen Bajorath, Hany E A Ahmed, Eman Sarhan, Eiman Elwakeel, Maha A El-Demellaw. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-11-20. PMID:26576191. |
also, our results showed a significant increase in the expression of the acetylcholine esterase (ache) and amyloid beta precursor protein (aβpp). |
2015-11-20 |
2023-08-13 |
rat |
| Tiziana Cappello, Maria Maisano, Alessia Giannetto, Vincenzo Parrino, Angela Mauceri, Salvatore Fasul. Neurotoxicological effects on marine mussel Mytilus galloprovincialis caged at petrochemical contaminated areas (eastern Sicily, Italy): ¹H NMR and immunohistochemical assays. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 169. 2015-11-17. PMID:25572855. |
acetylcholine, acetylcholinesterase, ache, and choline acetyltransferase, chat), and dopaminergic systems (i.e. |
2015-11-17 |
2023-08-13 |
Not clear |
| Da Xiao, Yan-Hui Lu, Qing-Li Shang, Dun-Lun Song, Xi-Wu Ga. Gene silencing of two acetylcholinesterases reveals their cholinergic and non-cholinergic functions in Rhopalosiphum padi and Sitobion avenae. Pest management science. vol 71. issue 4. 2015-11-16. PMID:24729410. |
the function of acetylcholinesterase (ache) is to terminate synaptic transmission by hydrolysing the neurotransmitter acetylcholine (ach) in the synaptic cleft, and thus it is an effective target for organophosphate (op) and carbamate (cb) insecticides. |
2015-11-16 |
2023-08-13 |
Not clear |