| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of ache can have therapeutic applications (e.g., drugs for alzheimer's disease) or neurotoxic consequences (e.g., pesticides). |
2016-09-12 |
2023-08-13 |
human |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
therefore, an alternative assay was developed, in which ache activity was determined by measuring fluorescence of resorufin produced from coupled enzyme reactions involving acetylcholine and amplex red (10-acetyl-3,7-dihydroxyphenoxazine). |
2016-09-12 |
2023-08-13 |
human |
| Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenama. Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking. PeerJ. vol 4. 2016-09-07. PMID:27602288. |
acetylcholinesterase (ache) is an enzyme that catalyzes the breakdown of the neurotransmitter acetylcholine that is essential for cognition and memory. |
2016-09-07 |
2023-08-13 |
human |
| Heng-Wen Chen, Xuan-Hui He, Rong Yuan, Ben-Jun Wei, Zhong Chen, Jun-Xing Dong, Jie Wan. Sesquiterpenes and a monoterpenoid with acetylcholinesterase (AchE) inhibitory activity from Valeriana officinalis var. latiofolia in vitro and in vivo. Fitoterapia. vol 110. 2016-09-06. PMID:26976216. |
the contents of acetylcholine (ach), acetylcholine transferase (chat) and ache in mice brains were determined by colorimetry. |
2016-09-06 |
2023-08-13 |
mouse |
| Allister Vale, Marcello Lott. Organophosphorus and carbamate insecticide poisoning. Handbook of clinical neurology. vol 131. 2016-08-18. PMID:26563788. |
both organophosphorus (op) and carbamate insecticides inhibit acetylcholinesterase (ache), which results in accumulation of acetylcholine (ach) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. |
2016-08-18 |
2023-08-13 |
human |
| Sehan Lee, Mace G Barro. Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 1. 2016-08-16. PMID:26202430. |
acetylcholinesterase (ache), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. |
2016-08-16 |
2023-08-13 |
Not clear |
| Huan Qu, Min Lv, Xiang Yu, Xihong Lian, Hui X. Discovery of Some Piperine-Based Phenylsulfonylhydrazone Derivatives as Potent Botanically Narcotic Agents. Scientific reports. vol 5. 2016-08-08. PMID:26268805. |
more importantly, 6c selectively displayed the inhibition activity on acetylcholine esterase (ache) of m. separata. |
2016-08-08 |
2023-08-13 |
Not clear |
| Chand D Basha, Rajarami G Redd. Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement. Interdisciplinary toxicology. vol 8. issue 4. 2016-08-03. PMID:27486377. |
biochemical analysis showed decrease in synaptosomal acetylcholinesterase (ache) activity and an increase in acetylcholine (ach) levels in the cortex, cerebellum and hippocampus on pnd 14, pnd 21, pnd 28 and in the four-month age group of rats following pb exposure. |
2016-08-03 |
2023-08-13 |
rat |
| K V Niessen, S Muschik, F Langguth, S Rappenglück, T Seeger, H Thiermann, F Wore. Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology. Toxicology letters. vol 247. 2016-07-25. PMID:26851639. |
inhibited ache results in accumulation of acetylcholine in the synaptic cleft and thus the desensitisation of the nicotinic acetylcholine receptor (nachr) in the postsynaptic membrane is provoked. |
2016-07-25 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
in the present study, we immobilized acetylcholinesterase (ache) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. |
2016-07-19 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
first, the polymers were produced with acetylcholine, substrate of ache, by dispersion polymerization. |
2016-07-19 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
then, the enzyme was immobilized onto the polymers by using two different methods: in the first method (method a), acetylcholine was removed from the polymer, and then ache was immobilized onto this polymer (acetylcholine removed imprinted polymer). |
2016-07-19 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
in the second method (method b), ache was immobilized onto acetylcholine containing polymer by affinity. |
2016-07-19 |
2023-08-13 |
Not clear |
| Hyeon-Joong Kim, Eun-Joo Shin, Byung-Hwan Lee, Sun-Hye Choi, Seok-Won Jung, Ik-Hyun Cho, Sung-Hee Hwang, Joon Yong Kim, Jung-Soo Han, ChiHye Chung, Choon-Gon Jang, Hyewon Rhim, Hyoung-Chun Kim, Seung-Yeol Na. Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer's Disease. Molecules and cells. vol 38. issue 9. 2016-07-19. PMID:26255830. |
oral administration of gintonin (25 or 50 mg/kg, 2 weeks) also significantly attenuated amyloid-β protein (aβ)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (chat) activity and immunoreactivity, and increased acetylcholine esterase (ache) activity. |
2016-07-19 |
2023-08-13 |
mouse |
| Ying Jiang, Jiandong Chen, Yue Wu, Qiang Wang, Huixin L. Sublethal Toxicity Endpoints of Heavy Metals to the Nematode Caenorhabditis elegans. PloS one. vol 11. issue 1. 2016-07-07. PMID:26824831. |
two physiological endpoints (growth and reproduction), three behavioral endpoints (head thrash frequency, body bend frequency and feeding) and two enzymatic endpoints (acetylcholine esterase [ache] and superoxide dismutase [sod]) were selected for the assessment of heavy metal toxicity. |
2016-07-07 |
2023-08-13 |
caenorhabditis_elegans |
| Hammad Saleem, Irshad Ahmad, Muhammad Nabeel Shahid, Muhammad Shoaib Ali Gill, Muhammad Faisal Nadeem, Waqas Mahmood, Imran Rashi. IN VITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY POTENTIALS OF JATROPHA GOSSYPIFOLIA PLANT EXTRACTS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180434. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of alzheimer's disease (ad). |
2016-06-20 |
2023-08-13 |
Not clear |
| Kalyani Chaubey, M Kameshwar Rao, S Imteyaz Alam, Chandrakant Waghmare, Bijoy K Bhattachary. Increased expression of immune modulator proteins and decreased expression of apolipoprotein A-1 and haptoglobin in blood plasma of sarin exposed rats. Chemico-biological interactions. vol 246. 2016-06-14. PMID:26778279. |
inhibition of ache causes large accumulation of acetylcholine at synaptic cleft leading to hyper activation of nicotinic and muscarinic acetylcholine receptors, causing excessive secretions, muscle fasciculation, nausea, vomiting, respiratory distress and neurological effects. |
2016-06-14 |
2023-08-13 |
rat |
| Tian-Xia Yu, Peng Zhang, Yan Guan, Min Wang, Ming-Qing Zhe. Protective effects of luteolin against cognitive impairment induced by infusion of Aβ peptide in rats. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-06-10. PMID:26261557. |
luteolin also reversed the increased activity of acetylcholine esterase (ache). |
2016-06-10 |
2023-08-13 |
rat |
| Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klei. Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. PloS one. vol 10. issue 10. 2016-06-10. PMID:26506622. |
activation of the m2 receptor limits acetylcholine (ach) release, especially when ach levels are increased because acetylcholinesterase (ache) activity is acutely inhibited. |
2016-06-10 |
2023-08-13 |
mouse |
| Mikako Warren, Ajay Kaul, Kevin E Bov. Calretinin-Immunoreactive Hypoinnervation in Down Syndrome (DS): Report of an Infant with Very Short-Segment Hirschsprung Disease and Comparison to Biopsy Findings in 20 Normal Infants and 11 Infants with DS and Chronic Constipation. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 19. issue 2. 2016-06-07. PMID:26230373. |
we report a case of unequivocal very short-segment hd (vshd) in an infant with ds who had aganglionosis with abnormal acetylcholine esterase (ache) activity in 3 rsbs. |
2016-06-07 |
2023-08-13 |
Not clear |