| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kitlangki Suchiang, Ramesh Sharm. Age-dependent modulation of fasting and long-term dietary restriction on acetylcholinesterase in non-neuronal tissues of mice. Molecular and cellular biochemistry. vol 419. issue 1-2. 2017-02-01. PMID:27379505. |
acetylcholinesterase (ache), a thoroughly studied enzyme better known for hydrolyzing acetylcholine (ach) in neuronal tissues, has recently been linked with multiple unrelated biological functions in different non-neuronal tissues. |
2017-02-01 |
2023-08-13 |
mouse |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Dae Cheol Nam, Yu Mi Ha, Min Kyu Park, Sung Kweon Ch. The rs662 polymorphism of paraoxonase 1 affects the difference in the inhibition of butyrylcholinesterase activity by organophosphorus pesticides in human blood. International journal of clinical pharmacology and therapeutics. vol 54. issue 8. 2017-01-27. PMID:27087156. |
ops inhibit acetylcholinesterase (ache) at nerve endings and accumulate acetylcholine (ach) at these sites. |
2017-01-27 |
2023-08-13 |
human |
| Cho Rong Kim, Soo Jung Choi, Yoon Kyung Kwon, Jae Kyeom Kim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shi. Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice. Biological & pharmaceutical bulletin. vol 39. issue 7. 2017-01-27. PMID:27374288. |
the pathogenesis of alzheimer's disease (ad) has been linked to the deficiency of neurotransmitter acetylcholine (ach) in the brain, and the main treatment strategy for improving ad symptoms is the inhibition of acetylcholinesterase (ache) activity. |
2017-01-27 |
2023-08-13 |
mouse |
| Masatoshi Inden, Kazuyuki Takata, Daijiro Yanagisawa, Eishi Ashihara, Ikuo Tooyama, Shun Shimohama, Yoshihisa Kitamur. α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. Neurochemistry international. vol 94. 2017-01-19. PMID:26911419. |
galantamine, an acetylcholine esterase (ache) inhibitor used to treat dementia symptoms, also acts as an allosteric potentiating ligand (apl) at nicotinic acetylcholine receptors (nachrs). |
2017-01-19 |
2023-08-13 |
rat |
| Katsuyoshi Mizukami, Hiroyasu Akatsu, Eric E Abrahamson, Zhiping Mi, Milos D Ikonomovi. Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26293308. |
studies of acetylcholine degrading enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) in alzheimer's disease (ad) have suggested their potential role in the development of fibrillar amyloid-β (aβ) plaques (amyloid plaques). |
2017-01-09 |
2023-08-13 |
Not clear |
| Peng Li, Ya-Ling Yin, Mo-Li Zhu, Guo-Pin Pan, Fan-Rong Zhao, Jun-Xiu Lu, Zhan Liu, Shuang-Xi Wang, Chang-Ping H. Chronic administration of isocarbophos induces vascular cognitive impairment in rats. Journal of cellular and molecular medicine. vol 20. issue 4. 2017-01-06. PMID:26818681. |
long-term administration of isocarbophos reduced the hippocampal acetylcholinesterase (ache) activity and acetylcholine (ach) content but did not alter the plasma ache activity, and significantly damaged the functions of learning and memory. |
2017-01-06 |
2023-08-13 |
rat |
| Souksanh Nouanthavong, Duangjai Nacapricha, Charles S Henry, Yupaporn Sameeno. Pesticide analysis using nanoceria-coated paper-based devices as a detection platform. The Analyst. vol 141. issue 5. 2017-01-04. PMID:26842266. |
in the presence of acetylcholine, ache and chox catalyze the formation of h2o2, which is detected colorimetrically by a nanoceria-coated device resulting in the formation of a yellow color. |
2017-01-04 |
2023-08-13 |
Not clear |
| Juan Zou, Pei-Shan Cai, Chao-Mei Xiong, Jin-Lan Rua. Neuroprotective effect of peptides extracted from walnut (Juglans Sigilata Dode) proteins on Aβ25-35-induced memory impairment in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838735. |
to further explore the underlying mechanisms of the neuroprotectivity of walnut peptides, the activities of superoxide dismutase (sod), glutathione (gsh), acetylcholine esterase (ache), and the content of malondialdehyde (mda) as well as the level of nitric oxide (no) in the hippocampus of mice were measured by spectrophotometric method. |
2016-12-30 |
2023-08-13 |
mouse |
| Meegle S Mathew, Ananya Baksi, T Pradeep, Kuruvilla Josep. Choline-induced selective fluorescence quenching of acetylcholinesterase conjugated Au@BSA clusters. Biosensors & bioelectronics. vol 81. 2016-12-28. PMID:26921554. |
the gold quantum clusters (auqc@bsa) synthesized using bovine serum albumin and conjugated with acetylcholinesterase (ache), an enzyme specific for acetylcholine, resulting in auqc@bsa-ache. |
2016-12-28 |
2023-08-13 |
cattle |
| Meegle S Mathew, Ananya Baksi, T Pradeep, Kuruvilla Josep. Choline-induced selective fluorescence quenching of acetylcholinesterase conjugated Au@BSA clusters. Biosensors & bioelectronics. vol 81. 2016-12-28. PMID:26921554. |
the enzyme, ache hydrolyzes acetylcholine (ach) to choline (ch) which in turn interacts with auqc@bsa-ache and quenches its fluorescence, enabling sensing. |
2016-12-28 |
2023-08-13 |
cattle |
| Adel El-Terras, Mohamed Mohamed Soliman, Adel Alkhedaide, Hossam Fouad Attia, Abdullah Alharthy, Abdel Elah Banaj. Carbonated soft drinks induce oxidative stress and alter the expression of certain genes in the brains of Wistar rats. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26936207. |
rats administered carbonated soft drinks also exhibited decreased monoamine oxidase a (mao‑a) and acetylcholine esterase (ache) serum and mrna levels in the brain. |
2016-12-28 |
2023-08-13 |
rat |
| Pedro Teixeira, Patrícia Napoleão, Carlota Saldanh. S-nitrosoglutathione efflux in the erythrocyte. Clinical hemorheology and microcirculation. vol 60. issue 4. 2016-12-19. PMID:24958331. |
gsno has been regarded as a store and transporter of no, with significant interest as a potential therapeutic agent, acting as an no donor.no metabolism inside the erythrocyte generates several derivatives, which can be altered by external and internal stimuli such as acetylcholine (ach), a natural substrate of acetylcholinesterase (ache). |
2016-12-19 |
2023-08-13 |
Not clear |
| Samanta Oliveira Loureiro, Daniele Susana Volkart Sidegum, Helena Biasibetti, Mery Stefani Leivas Pereira, Diogo Losch de Oliveira, Regina Pessoa-Pureur, Angela T S Wys. Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25579384. |
we also evidenced misregulation of cholinergic anti-inflammatory system with increased acetylcholinesterase (ache) activity and decreased acetylcholine (ach) levels, contributing to the inflammatory status in pro-treated astrocytes. |
2016-12-13 |
2023-08-13 |
rat |
| Jean Froment, Katherine Langford, Knut Erik Tollefsen, Inger Lise N Bråte, Steven J Brooks, Kevin V Thoma. Identification of petrogenic produced water components as acetylcholine esterase inhibitors. Environmental pollution (Barking, Essex : 1987). vol 215. 2016-12-13. PMID:27176761. |
effect-directed analysis (eda) was applied to identify acetylcholine esterase (ache) inhibitors in produced water. |
2016-12-13 |
2023-08-13 |
Not clear |
| Susimaire P Mantoani, Talita P C Chierrito, Adriana F L Vilela, Carmen L Cardoso, Ana Martínez, Ivone Carvalh. Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 21. issue 2. 2016-11-07. PMID:26861273. |
currently, the only strategy for palliative treatment of ad is to inhibit acetylcholinesterase (ache) in order to increase the concentration of acetylcholine in the synaptic cleft. |
2016-11-07 |
2023-08-13 |
Not clear |
| Susimaire P Mantoani, Talita P C Chierrito, Adriana F L Vilela, Carmen L Cardoso, Ana Martínez, Ivone Carvalh. Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 21. issue 2. 2016-11-07. PMID:26861273. |
it is known that ache has two binding sites: the peripheral site, responsible for the interactions with aβ, and the catalytic site, related with acetylcholine hydrolysis. |
2016-11-07 |
2023-08-13 |
Not clear |
| Jie-Qiong Ma, Rong-Zhen Luo, Hai-Xia Jiang, Chan-Min Li. Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation. Food & function. vol 7. issue 1. 2016-10-19. PMID:26510118. |
quercitrin also prevented ccl4 induced cerebral function disorders associated with its ability to inhibit the activities of monoamine oxidase (mao), acetylcholine esterase (ache) and the n-methyl-d-aspartate receptor 2b subunit (nr2b). |
2016-10-19 |
2023-08-13 |
mouse |
| Cui Ye, Min-Qiang Wang, Xia Zhong, Shihong Chen, Yaqin Chai, Ruo Yua. Highly sensitive electrochemiluminescenc assay of acetylcholinesterase activity based on dual biomarkers using Pd-Au nanowires as immobilization platform. Biosensors & bioelectronics. vol 79. 2016-10-19. PMID:26686921. |
in the presence of ache and choline oxidase (chox), acetylcholine (atcl) is hydrolyzed by ache to generate thiocholine, then thiocholine is catalyzed by chox to produce h2o2 in situ, which serves as the coreactant to effectively enhance the ecl intensity in luminol-ecl system. |
2016-10-19 |
2023-08-13 |
Not clear |
| Parham Taslimi, Ilhami Gulcin, Bunyamin Ozgeris, Suleyman Goksu, Ferhan Tumer, Saleh H Alwasel, Claudiu T Supura. The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 1. 2016-10-06. PMID:25697270. |
acetylcholine esterase (ache. |
2016-10-06 |
2023-08-13 |
human |