| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
first, the polymers were produced with acetylcholine, substrate of ache, by dispersion polymerization. |
2016-07-19 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
then, the enzyme was immobilized onto the polymers by using two different methods: in the first method (method a), acetylcholine was removed from the polymer, and then ache was immobilized onto this polymer (acetylcholine removed imprinted polymer). |
2016-07-19 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
in the second method (method b), ache was immobilized onto acetylcholine containing polymer by affinity. |
2016-07-19 |
2023-08-13 |
Not clear |
| Hyeon-Joong Kim, Eun-Joo Shin, Byung-Hwan Lee, Sun-Hye Choi, Seok-Won Jung, Ik-Hyun Cho, Sung-Hee Hwang, Joon Yong Kim, Jung-Soo Han, ChiHye Chung, Choon-Gon Jang, Hyewon Rhim, Hyoung-Chun Kim, Seung-Yeol Na. Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer's Disease. Molecules and cells. vol 38. issue 9. 2016-07-19. PMID:26255830. |
oral administration of gintonin (25 or 50 mg/kg, 2 weeks) also significantly attenuated amyloid-β protein (aβ)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (chat) activity and immunoreactivity, and increased acetylcholine esterase (ache) activity. |
2016-07-19 |
2023-08-13 |
mouse |
| Ying Jiang, Jiandong Chen, Yue Wu, Qiang Wang, Huixin L. Sublethal Toxicity Endpoints of Heavy Metals to the Nematode Caenorhabditis elegans. PloS one. vol 11. issue 1. 2016-07-07. PMID:26824831. |
two physiological endpoints (growth and reproduction), three behavioral endpoints (head thrash frequency, body bend frequency and feeding) and two enzymatic endpoints (acetylcholine esterase [ache] and superoxide dismutase [sod]) were selected for the assessment of heavy metal toxicity. |
2016-07-07 |
2023-08-13 |
caenorhabditis_elegans |
| Hammad Saleem, Irshad Ahmad, Muhammad Nabeel Shahid, Muhammad Shoaib Ali Gill, Muhammad Faisal Nadeem, Waqas Mahmood, Imran Rashi. IN VITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY POTENTIALS OF JATROPHA GOSSYPIFOLIA PLANT EXTRACTS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180434. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of alzheimer's disease (ad). |
2016-06-20 |
2023-08-13 |
Not clear |
| Kalyani Chaubey, M Kameshwar Rao, S Imteyaz Alam, Chandrakant Waghmare, Bijoy K Bhattachary. Increased expression of immune modulator proteins and decreased expression of apolipoprotein A-1 and haptoglobin in blood plasma of sarin exposed rats. Chemico-biological interactions. vol 246. 2016-06-14. PMID:26778279. |
inhibition of ache causes large accumulation of acetylcholine at synaptic cleft leading to hyper activation of nicotinic and muscarinic acetylcholine receptors, causing excessive secretions, muscle fasciculation, nausea, vomiting, respiratory distress and neurological effects. |
2016-06-14 |
2023-08-13 |
rat |
| Tian-Xia Yu, Peng Zhang, Yan Guan, Min Wang, Ming-Qing Zhe. Protective effects of luteolin against cognitive impairment induced by infusion of Aβ peptide in rats. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-06-10. PMID:26261557. |
luteolin also reversed the increased activity of acetylcholine esterase (ache). |
2016-06-10 |
2023-08-13 |
rat |
| Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klei. Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. PloS one. vol 10. issue 10. 2016-06-10. PMID:26506622. |
activation of the m2 receptor limits acetylcholine (ach) release, especially when ach levels are increased because acetylcholinesterase (ache) activity is acutely inhibited. |
2016-06-10 |
2023-08-13 |
mouse |
| Mikako Warren, Ajay Kaul, Kevin E Bov. Calretinin-Immunoreactive Hypoinnervation in Down Syndrome (DS): Report of an Infant with Very Short-Segment Hirschsprung Disease and Comparison to Biopsy Findings in 20 Normal Infants and 11 Infants with DS and Chronic Constipation. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 19. issue 2. 2016-06-07. PMID:26230373. |
we report a case of unequivocal very short-segment hd (vshd) in an infant with ds who had aganglionosis with abnormal acetylcholine esterase (ache) activity in 3 rsbs. |
2016-06-07 |
2023-08-13 |
Not clear |
| Tetsade C B Piermartiri, Hongna Pan, Jun Chen, John McDonough, Neil Grunberg, James P Apland, Ann M Marin. Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. Neuromolecular medicine. vol 17. issue 3. 2016-05-20. PMID:25920465. |
exposure to organophosphorous (op) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (ache) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. |
2016-05-20 |
2023-08-13 |
Not clear |
| Zhiqing Pang, Che-Ming J Hu, Ronnie H Fang, Brian T Luk, Weiwei Gao, Fei Wang, Erdembileg Chuluun, Pavimol Angsantikul, Soracha Thamphiwatana, Weiyue Lu, Xinguo Jiang, Liangfang Zhan. Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers. ACS nano. vol 9. issue 6. 2016-05-16. PMID:26053868. |
organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (ache), leading to neuromuscular disorders via accumulation of acetylcholine in the body. |
2016-05-16 |
2023-08-13 |
mouse |
| Juliana O S Giacoppo, Tanos C C França, Kamil Kuča, Elaine F F da Cunha, Ruben Abagyan, Daiana T Mancini, Teodorico C Ramalh. Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. Journal of biomolecular structure & dynamics. vol 33. issue 9. 2016-04-19. PMID:25407587. |
nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (ache), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. |
2016-04-19 |
2023-08-13 |
Not clear |
| Tada-aki Kudo, Hiroyasu Kanetaka, Kentaro Mochizuki, Kanako Tominami, Shoko Nunome, Genji Abe, Hiroyuki Kosukegawa, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Toshiyuki Takagi, Shin-ichi Izum. Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation. PloS one. vol 10. issue 4. 2016-04-15. PMID:25879210. |
we then measured the extent of growth, neuritogenesis, or acetylcholine esterase (ache) activity (a neuronal marker). |
2016-04-15 |
2023-08-13 |
rat |
| Jian-xiang Liu, Min-ying Zhu, Ci-yuan Feng, Hai-bin Ding, Ying Zhan, Zhan Zhao, Yue-min Din. Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia. Journal of Zhejiang University. Science. B. vol 16. issue 7. 2016-04-05. PMID:26160717. |
the hippocampus of dementia model rats showed reduced levels of acetylcholine (ach), epinephrine (e), norepinephrine (ne), and dopamine (da), and increased activities of acetylcholine esterase (ache) and monoamine oxidase (mao). |
2016-04-05 |
2023-08-13 |
rat |
| Hayate Javed, Kumar Vaibhav, M Ejaz Ahmed, Andleeb Khan, Rizwana Tabassum, Farah Islam, Mohammed M Safhi, Fakhrul Isla. Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice. Journal of the neurological sciences. vol 348. issue 1-2. 2016-04-04. PMID:25434716. |
hesperidin pretreatment improved memory consolidation process as tested by morris water maze possibly through modulation of acetylcholine esterase activity (ache). |
2016-04-04 |
2023-08-13 |
mouse |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| I V Zueva, V E Semenov, M A Mukhamedyarov, S V Lushchekina, A D Kharlamova, E O Petukhova, A S Mikhailov, S N Podyachev, L F Saifina, K A Petrov, O A Minnekhanova, V V Zobov, E E Nikolsky, P Masson, V S Rezni. 6-Methyluracil derivatives as acetylcholinesterase inhibitors for treatment of Alzheimer's disease. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639718. |
these approaches mainly focus on the inhibition of brain acetyl-cholinesterase (ache) to increase lifetime of cerebral acetylcholine [3]. |
2016-03-15 |
2023-08-13 |
mouse |
| Farhana Mazhar, Raisa Khanum, Muhammad Ajaib, Muhammad Jahangi. Potent AChE enzyme inhibition activity of Zizyphus oxyphylla: A new source of antioxidant compounds. Pakistan journal of pharmaceutical sciences. vol 28. issue 6. 2016-03-10. PMID:26639499. |
the fractions were also studied for acetylcholine esterase enzyme (ache) enzyme inhibition activity and n-butanol soluble fraction exhibited maximum inhibition (95.5 ± 0.13 mg/ml with ic50 =9.58 ± 0.08 mg/ml relative to galanthamine (13.26 ± 0.73 mg/ml), while n- hexane soluble fraction (165.15 ± 0.94 mg/ml) showed non-significant. |
2016-03-10 |
2023-08-13 |
Not clear |
| Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Zhi-Xiu Li. Honokiol improves learning and memory impairments induced by scopolamine in mice. European journal of pharmacology. vol 760. 2016-03-08. PMID:25912802. |
in addition, treatment with honokiol significantly decreased the protein and mrna levels of interleukin (il)-1β and the activity of acetylcholinesterase (ache), while significantly increased the protein and mrna levels of il-10, and the level of acetylcholine (ach) in the brain of the scop-treated mice. |
2016-03-08 |
2023-08-13 |
mouse |