| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| Pedro Teixeira, Nuno Duro, Patrícia Napoleão, Carlota Saldanh. Acetylcholinesterase conformational states influence nitric oxide mobilization in the erythrocyte. The Journal of membrane biology. vol 248. issue 2. 2015-12-17. PMID:25652185. |
in addition, the present study shows evidence that conformational changes in ache promoted by incubation with n-19 and c-16 antibodies alter the enzyme's functional connection to acetylcholine (ach) (ache-ach complex) in an irreversible manner, resulting in impaired gsno concentration and no efflux from the erythrocyte. |
2015-12-17 |
2023-08-13 |
human |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
this study shows that cpf impaired cholinergic transmission, induced ache inhibition and, only after long-term exposure, increased cht expression, which suggests that acetylcholine levels alteration could be mediated by these actions. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
moreover, cpf induces, after acute and long-term exposure, cell death in cholinergic neurons in the basal forebrain and this effect is independent of ache inhibition and acetylcholine alteration, but was mediated partially by ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Harriëtte Riese, Loretto M Muñoz, Catharina A Hartman, Xiuhua Ding, Shaoyong Su, Albertine J Oldehinkel, Arie M van Roon, Peter J van der Most, Joop Lefrandt, Ron T Gansevoort, Pim van der Harst, Niek Verweij, Carmilla M M Licht, Dorret I Boomsma, Jouke-Jan Hottenga, Gonneke Willemsen, Brenda W J H Penninx, Ilja M Nolte, Eco J C de Geus, Xiaoling Wang, Harold Sniede. Identifying genetic variants for heart rate variability in the acetylcholine pathway. PloS one. vol 9. issue 11. 2015-12-14. PMID:25384021. |
we assessed whether 443 genotyped and imputed common genetic variants in eight key genes (chat, slc18a3, slc5a7, chrnb4, chrna3, chrna, chrm2 and ache) of the acetylcholine pathway were associated with variation in an established measure of heart rate variability reflecting parasympathetic control of the heart rhythm, the root mean square of successive differences (rmssd) of normal rr intervals. |
2015-12-14 |
2023-08-13 |
Not clear |
| Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S Momonok. Overexpression of acetylcholinesterase gene in rice results in enhancement of shoot gravitropism. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277389. |
acetylcholine (ach), a known neurotransmitter in animals and acetylcholinesterase (ache) exists widely in plants, although its role in plant signal transduction is unclear. |
2015-11-27 |
2023-08-13 |
Not clear |
| Amira Mira, Shuntaro Yamashita, Yoshinori Katakura, Kuniyoshi Shimiz. In vitro neuroprotective activities of compounds from Angelica shikokiana Makino. Molecules (Basel, Switzerland). vol 20. issue 3. 2015-11-23. PMID:25786165. |
quercetin showed the strongest ache inhibition (ic50 value = 35.5 µm) through binding to his-440 and tyr-70 residues at the catalytic and anionic sites of acetylcholine esterase, respectively. |
2015-11-23 |
2023-08-13 |
Not clear |
| Doaa A Ghareeb, Sofia Khalil, Hani S Hafez, Jürgen Bajorath, Hany E A Ahmed, Eman Sarhan, Eiman Elwakeel, Maha A El-Demellaw. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-11-20. PMID:26576191. |
also, our results showed a significant increase in the expression of the acetylcholine esterase (ache) and amyloid beta precursor protein (aβpp). |
2015-11-20 |
2023-08-13 |
rat |
| Tiziana Cappello, Maria Maisano, Alessia Giannetto, Vincenzo Parrino, Angela Mauceri, Salvatore Fasul. Neurotoxicological effects on marine mussel Mytilus galloprovincialis caged at petrochemical contaminated areas (eastern Sicily, Italy): ¹H NMR and immunohistochemical assays. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 169. 2015-11-17. PMID:25572855. |
acetylcholine, acetylcholinesterase, ache, and choline acetyltransferase, chat), and dopaminergic systems (i.e. |
2015-11-17 |
2023-08-13 |
Not clear |
| Da Xiao, Yan-Hui Lu, Qing-Li Shang, Dun-Lun Song, Xi-Wu Ga. Gene silencing of two acetylcholinesterases reveals their cholinergic and non-cholinergic functions in Rhopalosiphum padi and Sitobion avenae. Pest management science. vol 71. issue 4. 2015-11-16. PMID:24729410. |
the function of acetylcholinesterase (ache) is to terminate synaptic transmission by hydrolysing the neurotransmitter acetylcholine (ach) in the synaptic cleft, and thus it is an effective target for organophosphate (op) and carbamate (cb) insecticides. |
2015-11-16 |
2023-08-13 |
Not clear |
| Jing Liu, Carey Pop. The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. Neurotoxicology. vol 46. 2015-11-12. PMID:25447325. |
organophosphorus anticholinesterases (ops) elicit acute toxicity by inhibiting acetylcholinesterase (ache), leading to acetylcholine accumulation and overstimulation of cholinergic receptors. |
2015-11-12 |
2023-08-13 |
rat |
| Chunjiang Li, Qingwei Wang, Lanlan Li, Yun Liu, Hongwei Dia. Arachidonic acid attenuates learning and memory dysfunction induced by repeated isoflurane anesthesia in rats. International journal of clinical and experimental medicine. vol 8. issue 8. 2015-11-09. PMID:26550146. |
additionally, ara increased the activities of choline acetyl transferase (chat), superoxide dismutase (sod), glutathione peroxidase (gsh-px) and the levels of acetycholine (ach) and γ-amino-butyric acid (gaba), whereas decreased the activity of acetylcholine esterase (ache), the content of glutamate (glu) and malondialdehyde (mda), and the radio of glu/gaba. |
2015-11-09 |
2023-08-13 |
rat |
| Yi Xie, Binbin Wang, Fanchi Li, Lie Ma, Min Ni, Weide Shen, Fashui Hong, Bing L. Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971466. |
the treatments also relieved the phoxim-induced increases in the contents of acetylcholine (ach), glutamate (glu) and nitric oxide (no) and the phoxim-induced decreases in the contents of norepinephrine (ne), dopamine (da), and 5-hydroxytryptamine (5-ht), and reduced the inhibition of acetylcholinesterase (ache), na+/k+-atpase, ca2+-atpase, and ca2+/mg2+-atpase activities and the activation of total nitric oxide synthase (tnos) in the brain. |
2015-10-28 |
2023-08-13 |
Not clear |
| Young Hun Lee, Min Cheol Shin, Yong Don Yun, Seo Young Shin, Jong Min Kim, Jeong Moo Seo, Nam-Jung Kim, Jong Hoon Ryu, Yong Sup Le. Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25468034. |
to date, the successful therapeutic strategy to treat ad is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (ache). |
2015-10-22 |
2023-08-13 |
mouse |
| Fátima Husein Abdalla, Andréia Machado Cardoso, Roberta Schmatz, Jamile Fabbrin Gonçalves, Jucimara Baldissarelli, Caroline Curry Martins, Daniela Zanini, Lizielle Souza de Oliveira, Pauline da Costa, Victor Camera Pimentel, Luciane Belmonte Pereira, Cibele Lima Lhamas, Maria Rosa Chitolina Schetinger, Vera Maria Morsch, Cinthia Melazzo Andrade Mazzant. Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium. Molecular and cellular biochemistry. vol 396. issue 1-2. 2015-10-06. PMID:25064450. |
thus, we can suggest that the quercetin is able to modulate ntpdase, ada, ache, and mpo activities and contribute to maintain the levels of atp, adenosine, and acetylcholine normal, respectively, exhibiting potent pro-inflammatory and anti-inflammatory actions. |
2015-10-06 |
2023-08-13 |
rat |
| Li Tao, Jianmei Xie, Yuting Wang, Shi Wang, Shuangchan Wu, Qiman Wang, Hong Din. Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells. Bioorganic & medicinal chemistry letters. vol 24. issue 23. 2015-10-06. PMID:25453793. |
after behavioral testing, the mice were sacrificed and their hippocampi were removed for biochemical assays (superoxide dismutase (sod), glutathione peroxidase (gpx), malondialdehyde (mda), ache and acetylcholine (ach)). |
2015-10-06 |
2023-08-13 |
mouse |
| An Zhou, Hongfei Wu, Jian Pan, Xuncui Wang, Jiaming Li, Zeyu Wu, Ailing Hu. Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Molecules (Basel, Switzerland). vol 20. issue 1. 2015-10-02. PMID:25594344. |
taking into account the key pathological features of ad, such as low levels of acetylcholine, beta-amyloid (aβ) aggregation, oxidative stress and dyshomeostasis of biometals, a new series of paeonol derivatives 5a-5d merging three different functions, i.e., antioxidant, anti-acetylcholinesterase (ache) activity, metal chelating agents for ad treatment have been synthesized and characterized. |
2015-10-02 |
2023-08-13 |
Not clear |
| Ying Li, Shan Hai, Yan Zhou, Bi Rong Don. Cholinesterase inhibitors for rarer dementias associated with neurological conditions. The Cochrane database of systematic reviews. issue 3. 2015-10-02. PMID:25734590. |
cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (ache) which breaks down the neurotransmitter acetylcholine. |
2015-10-02 |
2023-08-13 |
Not clear |
| Sujuan Zhao, Guangyu Li, Jun Che. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring. Journal of proteomics. vol 114. 2015-10-01. PMID:25479203. |
mclr accumulation, the levels of malondialdehyde (mda) and acetylcholine esterase (ache) activity were detected. |
2015-10-01 |
2023-08-13 |
rat |
| Lewis Gazzard, Karen Williams, Huifen Chen, Lorraine Axford, Elizabeth Blackwood, Brenda Burton, Kerry Chapman, Peter Crackett, Joy Drobnick, Charles Ellwood, Jennifer Epler, Michael Flagella, Emanuela Gancia, Matthew Gill, Simon Goodacre, Jason Halladay, Joanne Hewitt, Hazel Hunt, Samuel Kintz, Joseph Lyssikatos, Calum Macleod, Sarah Major, Guillaume Médard, Raman Narukulla, Judi Ramiscal, Stephen Schmidt, Eileen Seward, Christian Wiesmann, Ping Wu, Sharon Yee, Ivana Yen, Shiva Male. Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. Journal of medicinal chemistry. vol 58. issue 12. 2015-09-14. PMID:25988399. |
lead compound 1 (gne-783), the prototype of the 1,7-diazacarbazole class of chk1 inhibitors, was found to be a highly potent inhibitor of acetylcholine esterase (ache) and unsuitable for development. |
2015-09-14 |
2023-08-13 |
mouse |