| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacqueline D Keighron, Sebastian Åkesson, Ann-Sofie Can. Coimmobilization of acetylcholinesterase and choline oxidase on gold nanoparticles: stoichiometry, activity, and reaction efficiency. Langmuir : the ACS journal of surfaces and colloids. vol 30. issue 38. 2015-07-02. PMID:25167196. |
here we show that characterization of a two-enzyme:gold nanoparticle (aunp) conjugate stoichiometry and activity can be used to gauge the effectiveness of acetylcholine detection by acetylcholine esterase (ache) and choline oxidase (cho). |
2015-07-02 |
2023-08-13 |
Not clear |
| Jacqueline D Keighron, Sebastian Åkesson, Ann-Sofie Can. Coimmobilization of acetylcholinesterase and choline oxidase on gold nanoparticles: stoichiometry, activity, and reaction efficiency. Langmuir : the ACS journal of surfaces and colloids. vol 30. issue 38. 2015-07-02. PMID:25167196. |
we here show that the knowledge of the conjugate stoichiometry and retained enzyme activity can lead to more efficient detection of acetylcholine by controlling the ache:cho ratio bound to the gold nanoparticle material. |
2015-07-02 |
2023-08-13 |
Not clear |
| Vendula Sepsova, Jana Z Karasova, Gunnar Tobin, Daniel Jun, Jan Korabecny, Pavla Cabelova, Katerina Janska, Jan Krusek, Kristyna Skrenkova, Kamil Kuca, Ondrej Souku. Cholinergic properties of new 7-methoxytacrine-donepezil derivatives. General physiology and biophysics. vol 34. issue 2. 2015-06-18. PMID:25504063. |
organophosphorus nerve agents inhibit acetylcholinesterase (ache) which causes the breakdown of the transmitter acetylcholine (ach) in the synaptic cleft. |
2015-06-18 |
2023-08-13 |
Not clear |
| Gulseher Sarah Sirin, Yingkai Zhan. How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study. The journal of physical chemistry. A. vol 118. issue 39. 2015-06-16. PMID:24786171. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ach) and terminates synaptic signals by reducing the effective concentration of ach in the synaptic clefts. |
2015-06-16 |
2023-08-13 |
Not clear |
| Mohd Afroz Ahmad, Abul Kalam Najmi, Mohd Mujeeb, Mohd Akhta. Neuroprotective effect of guggulipid alone and in combination with aspirin on middle cerebral artery occlusion (MCAO) model of focal cerebral ischemia in rats. Toxicology mechanisms and methods. vol 24. issue 6. 2015-05-12. PMID:24965906. |
an elevation of nitrite, thiobarbituric acid reactive substance (tbars), acetylcholine esterase activity (ache) and reduction in antioxidant enzymes like superoxide dismutase (sod), glutathione (gsh) and catalase were observed following mcao. |
2015-05-12 |
2023-08-13 |
rat |
| Avital Stern, Matteo Guidotti, Eleonora Shaubi, Mary Popov, Charles Linder, Eliahu Heldman, Sarina Grinber. Steric environment around acetylcholine head groups of bolaamphiphilic nanovesicles influences the release rate of encapsulated compounds. International journal of nanomedicine. vol 9. 2015-05-11. PMID:24531296. |
two bolaamphiphilic compounds with identical acetylcholine (ach) head groups, but with different lengths of an alkyl chain pendant adjacent to the head group, as well as differences between their hydrophobic skeleton, were investigated for their ability to self-assemble into vesicles that release their encapsulated content upon hydrolysis of their head groups by acetylcholinesterase (ache). |
2015-05-11 |
2023-08-12 |
Not clear |
| Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu, Liang Ch. Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect. BMC cancer. vol 14. 2015-04-20. PMID:25220382. |
acetylcholinesterase (ache) mainly functions as an efficient terminator for acetylcholine signaling transmission. |
2015-04-20 |
2023-08-13 |
Not clear |
| Marieke Meijer, Timo Hamers, Remco H S Westerin. Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for (sub)micromolar concentrations of organophosphate insecticides. Neurotoxicology. vol 43. 2015-04-17. PMID:24495583. |
organophosphates (ops) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (ache) and subsequent overexcitation. |
2015-04-17 |
2023-08-12 |
Not clear |
| Shun Shimoham. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291871. |
rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both ache and butyrylcholinesterase. |
2015-04-13 |
2023-08-12 |
Not clear |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
aβf also influenced the levels of ache, buche and chat in favour of a low level of acetylcholine. |
2015-04-13 |
2023-08-13 |
human |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| María-Letizia Campanari, María-Salud García-Ayllón, Lidia Blazquez-Llorca, Wilson K W Luk, Karl Tsim, Javier Sáez-Valer. Acetylcholinesterase protein level is preserved in the Alzheimer's brain. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24318838. |
moreover, alternative functions of ache unrelated with the hydrolysis of acetylcholine are suspected. |
2015-04-06 |
2023-08-12 |
Not clear |
| Karina Silvia Matos, Elaine F F da Cunha, Ruben Abagyan, Teodorico C Ramalh. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial chemistry & high throughput screening. vol 17. issue 6. 2015-04-06. PMID:24344993. |
acetylcholinesterase (ache) is responsible for hydrolysis of acetylcholine (ach), a function, which if disrupted, leads to cholinergic syndrome. |
2015-04-06 |
2023-08-12 |
human |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
acetylcholinesterase (ache) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2015-04-06 |
2023-08-12 |
human |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
we are exploring a strategy to design compounds that bind tightly at or near a peripheral or p-site near the mouth of the ache active site gorge and exclude ops from the active site while interfering minimally with the passage of acetylcholine. |
2015-04-06 |
2023-08-12 |
human |
| Qi Sun, Da-Yong Peng, Sheng-Gang Yang, Xiao-Lei Zhu, Wen-Chao Yang, Guang-Fu Yan. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase. Bioorganic & medicinal chemistry. vol 22. issue 17. 2015-04-06. PMID:25088549. |
exploring small-molecule acetylcholinesterase (ache) inhibitors to slow the breakdown of acetylcholine (ach) represents the mainstream direction for alzheimer's disease (ad) therapy. |
2015-04-06 |
2023-08-13 |
human |
| Andrew G Cairns, Hans Martin Senn, Michael P Murphy, Richard C Hartle. Expanding the palette of phenanthridinium cations. Chemistry (Weinheim an der Bergstrasse, Germany). vol 20. issue 13. 2015-03-12. PMID:24677631. |
some properties rely on phenanthridiniums intercalating into dna, but the use of these cations as exomarkers for the reactive oxygen species (ros), superoxide, and as inhibitors of acetylcholine esterase (ache) do not require intercalation. |
2015-03-12 |
2023-08-12 |
Not clear |
| Shuang Yu, Ling Chen, Xing-hui Cai, Xiao-ge Song, Yue Zhang, Yang Zhang, Rui Song, Yi-fang L. [Effect of manual acupuncture stimulation of "Baihui" (GV 20) and "Dazhui" (GV 14) on contents of 5-HT, dopamine and ACh and expression of 5-HT mRNA, DA mRNA and AChE mRNA in the hippocampus in methamphetamine addiction rats]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 5. 2015-03-12. PMID:25518108. |
to observe the effect of manual acupuncture stimulation on changes of hippocampal monoamine neurotransmitter levels and expression of 5-hydorxytryptamine (5-ht) mrna, dopamine (da) mrna and acetylcholine esterase (ache) mrna in methamphetamine addiction rats, so as to explore its mechanism underlying improvement of drug addiction. |
2015-03-12 |
2023-08-13 |
rat |
| Gauresh Somani, Chinmay Kulkarni, Prashant Shinde, Rupesh Shelke, Kirti Laddha, Sadhana Sathay. In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies. Journal of pharmacy & bioallied sciences. vol 7. issue 1. 2015-02-24. PMID:25709334. |
inhibitors of acetylcholinesterase (ache) leading to inhibition of acetylcholine breakdown constitute the main therapeutic strategy for ad. |
2015-02-24 |
2023-08-13 |
Not clear |
| Nidhi Chauhan, C S Pundi. Amperometric determination of acetylcholine-A neurotransmitter, by chitosan/gold-coated ferric oxide nanoparticles modified gold electrode. Biosensors & bioelectronics. vol 61. 2015-02-20. PMID:24836212. |
an amperometric acetylcholine biosensor was constructed by co-immobilizing covalently, a mixture of acetylcholinesterase (ache) and choline oxidase (cho) onto nanocomposite of chitosan (chit)/gold-coated ferric oxide nanoparticles (fe@aunps) electrodeposited onto surface of a au electrode and using it as a working electrode, ag/agcl as reference electrode and pt wire as auxiliary electrode connected through potentiostat. |
2015-02-20 |
2023-08-13 |
Not clear |