| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Merad, W Soufi, S Ghalem, F Boukli, M H Baig, K Ahmad, Mohammad A Kama. Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059305. |
acetylcholinesterase (ache) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". |
2015-01-07 |
2023-08-12 |
Not clear |
| Stéphanie Bélanger Jasmin, Vanessa Pearson, Daphnée Lalonde, Dorothée Domenger, Louise Théroux, Judes Poirie. Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatment. Brain research. vol 1562. 2014-12-08. PMID:24661912. |
ecl induced a time-dependent up-regulation of abca1, but not g1, that coincided with a significant increase in acetylcholine esterase (ache) activity in the ipsilateral hippocampus. |
2014-12-08 |
2023-08-12 |
mouse |
| Fouad H Darras, Steffen Pockes, Guozheng Huang, Sarah Wehle, Andrea Strasser, Hans-Joachim Wittmann, Martin Nimczick, Christoph A Sotriffer, Michael Decke. Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS chemical neuroscience. vol 5. issue 3. 2014-12-03. PMID:24422467. |
however, whereas ache inhibitors prevent hydrolysis of acetylcholine also peripherally, histamine h3 antagonists will raise acetylcholine levels mostly in the brain due to predominant occurrence of the receptor in the central nervous system. |
2014-12-03 |
2023-08-12 |
Not clear |
| Helen M Campanha, Félix Carvalho, Paul M Schlosse. Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line. Toxicology letters. vol 230. issue 2. 2014-11-25. PMID:24680925. |
the classical enzymatic role of acetylcholinesterase (ache) is to terminate impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine (ach). |
2014-11-25 |
2023-08-12 |
mouse |
| Satoru Yoshikawa, Takeya Kitta, Minoru Miyazato, Yasuhiro Sumino, Naoki Yoshimur. Inhibitory role of the spinal cholinergic system in the control of urethral continence reflex during sneezing in rats. Neurourology and urodynamics. vol 33. issue 4. 2014-11-24. PMID:23754327. |
we therefore investigated the effect of intrathecal administration of an acetylcholine esterase (ache) inhibitor, which increases ach in synaptic terminals, and anti-cholinergic agents on the sneeze-induced urethral reflex in rats. |
2014-11-24 |
2023-08-12 |
rat |
| Ali Afrasiabi, Gholam Hossein Riazi, Shayan Abbasi, Ali Dadras, Behafarid Ghalandari, Hossein Seidkhani, Seyed Mohamad Sadegh Modaresi, Neda Masoudian, Amir Amani, Shahin Ahmadia. Synaptosomal acetylcholinesterase activity variation pattern in the presence of electromagnetic fields. International journal of biological macromolecules. vol 65. 2014-11-24. PMID:24418344. |
acetylcholinesterase (ache) is the enzyme that controls the acetylcholine (ach) concentrations in cholinergic synaptic clefts by hydrolyzing ach to choline and acetate. |
2014-11-24 |
2023-08-12 |
Not clear |
| Guijie Li, Qiang Wang, Yu Qian, Yalin Zhou, Rui Wang, Xin Zha. Component analysis of Pu-erh and its anti-constipation effects. Molecular medicine reports. vol 9. issue 5. 2014-11-18. PMID:24604453. |
serum levels of motilin (mtl), gastrin (gas), endothelin (et), acetylcholine enzyme (ache), substance p (sp) and vasoactive intestinal peptide (vip) were significantly increased and somatostatin (ss) was decreased when the mice were treated with different concentrations of pu-erh tea compared with the untreated control mice. |
2014-11-18 |
2023-08-12 |
mouse |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
these results demonstrate that ache inhibition facilitated fasting-induced tg accumulation with up regulation of the hepatic l-fabp and srebp-1 in mice, at least in part via the activation of muscarinic acetylcholine receptors. |
2014-11-10 |
2023-08-13 |
mouse |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |
| Ibtissem Ben Amara, Mediha Sefi, Afef Troudi, Nejla Soudani, Tahia Boudawara, Najiba Zegha. Fenthion, an organophosphorus pesticide, induces alterations in oxidant/antioxidant status and histopathological disorders in cerebrum and cerebellum of suckling rats. Indian journal of biochemistry & biophysics. vol 51. issue 4. 2014-10-23. PMID:25296500. |
acetylcholine esterase (ache) activity was inhibited in both the cerebrum and cerebellum of suckling rats whose mothers were treated with fen. |
2014-10-23 |
2023-08-13 |
rat |
| Fan Wang, Chonglei Li, Wei Liu, Yihe Ji. Potential mechanisms of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose VOCs. Inhalation toxicology. vol 26. issue 4. 2014-10-14. PMID:24568580. |
the levels of reactive oxygen species (ros), malondialdehyde (mda) and glutamic acid (glu) were significantly increased, while the acetylcholinesterase (ache), choline acetyltransferase (chat) and acetylcholine (ach) levels, and the expression of nmda receptor were significantly decreased in vocs exposed groups. |
2014-10-14 |
2023-08-12 |
mouse |
| Seung Ok Nam, Dong Hyun Park, Young Hun Lee, Jong Hoon Ryu, Yong Sup Le. Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 22. issue 4. 2014-09-29. PMID:24485122. |
to date, the successful therapeutic strategy to treat ad is maintaining levels of acetylcholine by inhibiting acetylcholinesterase (ache). |
2014-09-29 |
2023-08-12 |
mouse |
| Ji Zhou, Kaifu Xiao, Baoyang Wei, Zhi Wang, Yun Tian, Yixing Tian, Qisheng Son. Bioaccumulation of Cry1Ab protein from an herbivore reduces anti-oxidant enzyme activities in two spider species. PloS one. vol 9. issue 1. 2014-09-18. PMID:24454741. |
we also show that the activities of three key metabolic enzymes, acetylcholine esterase (ache), glutathione peroxidase (gsh-px), and superoxide dismutase (sod) were significantly influenced in the spiders after feeding on cry1ab-containing fruit flies. |
2014-09-18 |
2023-08-12 |
drosophila_melanogaster |
| Eduardo Luis Konrath, Carolina dos Santos Passos, Luiz Carlos Klein, Amélia T Henrique. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24236981. |
the inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for alzheimer's disease (ad). |
2014-09-05 |
2023-08-12 |
Not clear |
| Yinhui Yi, Gangbing Zhu, Chang Liu, Yan Huang, Youyu Zhang, Haitao Li, Jiangna Zhao, Shouzhuo Ya. A label-free silicon quantum dots-based photoluminescence sensor for ultrasensitive detection of pesticides. Analytical chemistry. vol 85. issue 23. 2014-08-28. PMID:24160846. |
this sensing strategy involves the reaction of acetylcholine chloride (ach) with acetylcholinesterase (ache) to form choline that is in turn catalytically oxidized by choline oxidase (chox) to produce betaine and h2o2 which can quench the photoluminescence (pl) of siqds. |
2014-08-28 |
2023-08-12 |
Not clear |
| Antoine-Scott Badin, John Eraifej, Susan Greenfiel. High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases. Neuropharmacology. vol 73. 2014-08-13. PMID:23711548. |
a 14 amino acid peptide fragment ('t14'), deriving from the c-terminus of ache: this peptide has been shown to be bioactive in a range of preparations and to act at an allosteric site on α₇ nicotinic acetylcholine receptors (α₇-nachrs). |
2014-08-13 |
2023-08-12 |
rat |
| Athina A Strilakou, Stylianos T Tsakiris, Konstantinos G Kalafatakis, Aikaterini T Stylianaki, Petros L Karkalousos, Andreas V Koulouris, Iordanis S Mourouzis, Charis A Liap. Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats. Canadian journal of physiology and pharmacology. vol 92. issue 1. 2014-07-25. PMID:24383876. |
choline is also the precursor of acetylcholine (cholinergic component of the heart's autonomic nervous system), whose levels are regulated by acetylcholinesterase (ache). |
2014-07-25 |
2023-08-12 |
rat |
| Donghoon Kwon, Jinmyoung Joo, Sanghee Lee, Sangmin Jeo. Facile and sensitive method for detecting cardiac markers using ubiquitous pH meters. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24229314. |
these complexes were subsequently conjugated to polyclonal antibody-functionalized acetylcholinesterase (ache) and dispersed in acetylcholine (ach) solution. |
2014-07-15 |
2023-08-12 |
human |
| Akın Akıncıoğlu, Meryem Topal, Ilhami Gülçin, Süleyman Göks. Novel sulphamides and sulphonamides incorporating the tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors. Archiv der Pharmazie. vol 347. issue 1. 2014-07-15. PMID:24243403. |
inhibition of human (h) carbonic anhydrase (ca) isoenzymes (hca i, hca ii) and acetylcholine esterase (ache) was investigated with the synthesized compounds. |
2014-07-15 |
2023-08-12 |
human |
| Wei-Wei Zhao, Shu Shan, Zheng-Yuan Ma, Lin-Na Wan, Jing-Juan Xu, Hong-Yuan Che. Acetylcholine esterase antibodies on BiOI nanoflakes/TiO2 nanoparticles electrode: a case of application for general photoelectrochemical enzymatic analysis. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24289192. |
specifically, we first prepared a bioi nanoflakes (nfs)/tio2 nanoparticles (nps) p-n heterojunction as the photoelectrode, on the basis of which acetylcholine esterase (ache) antibody was introduced via the bridging of protein a. |
2014-07-15 |
2023-08-12 |
Not clear |