| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuaizhang Li, Ruili Huang, Samuel Solomon, Yitong Liu, Bin Zhao, Michael F Santillo, Menghang Xi. Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms. Biotechnology journal. vol 12. issue 5. 2017-10-25. PMID:28294544. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. |
2017-10-25 |
2023-08-13 |
human |
| Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frej. Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption. Toxicology. vol 390. 2017-10-23. PMID:28916328. |
this study shows that pq impaired acetylcholine levels and induced ache inhibition and increased cht expression only after 14days exposure, which suggests that acetylcholine levels alteration could be mediated by these actions. |
2017-10-23 |
2023-08-13 |
Not clear |
| Silvia Di Tommaso, Carlo Cavallotti, Antonio Malvasi, Daniele Vergara, Antonio Rizzello, Francesco De Nuccio, Andrea Tinell. A Qualitative and Quantitative Study of the Innervation of the Human Non Pregnant Uterus. Current protein & peptide science. vol 18. issue 2. 2017-10-16. PMID:27063643. |
in the present investigation, we analyzed the uterine distribution of a large set of neurotransmitters, focusing on adrenergic, noradredenergic, acetylcholine (ache) positive, dopaminergic, serotoninergic and peptidergic neurofibers; among these latter, we focused on those releasing prolattine, enkephalines (enks), vasoactive intestinal polypeptide (vip), substance p (sp) and oxytocine. |
2017-10-16 |
2023-08-13 |
human |
| Liang Peng, Zhengxing Rong, Hao Wang, Biyun Shao, Lei Kang, Hong Qi, Hongzhuan Che. A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease. Biomedical chromatography : BMC. vol 31. issue 10. 2017-10-09. PMID:28295437. |
acetycholinesterase (ache) that regulates hydrolysis of acetylcholine (ach) in the brain, is an important target for treatment of alzheimer's disease (ad), a feature of which is ach deficiency. |
2017-10-09 |
2023-08-13 |
Not clear |
| Ikunobu Muramatsu, Junsuke Uwada, Takayoshi Masuoka, Hatsumi Yoshiki, Kiyonao Sada, Kung-Shing Lee, Matomo Nishio, Takaharu Ishibashi, Takanobu Taniguch. Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission. Journal of neurochemistry. vol 143. issue 1. 2017-10-09. PMID:28700094. |
in addition to hydrolysis by acetylcholine esterase (ache), acetylcholine (ach) is also directly taken up into brain tissues. |
2017-10-09 |
2023-08-13 |
rat |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
the serine hydrolase butyrylcholinesterase (bche), like the related enzyme acetylcholinesterase (ache), co-regulates metabolism of the neurotransmitter acetylcholine. |
2017-10-02 |
2023-08-13 |
mouse |
| Melissa A Pickett, Michael K Dush, Nanette M Nascone-Yode. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development (Cambridge, England). vol 144. issue 15. 2017-10-02. PMID:28684626. |
acetylcholinesterase (ache) is crucial for degrading acetylcholine at cholinergic synapses. |
2017-10-02 |
2023-08-13 |
Not clear |
| Miranda L Xu, Cathy W C Bi, Etta Y L Liu, Tina T X Dong, Karl W K Tsi. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28607150. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. |
2017-09-26 |
2023-08-13 |
human |
| Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Dera. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology. vol 18. issue 7. 2017-09-19. PMID:28106328. |
acetylcholinesterase (ache), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. |
2017-09-19 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
cholinomirs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache). |
2017-09-07 |
2023-08-13 |
Not clear |
| Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerqu. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28791702. |
clinical manifestations of an acute exposure of humans to op insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (ache), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ach). |
2017-09-07 |
2023-08-13 |
Not clear |
| Hugo R Arias, Federica Ravazzini, Katarzyna M Targowska-Duda, Agnieszka A Kaczor, Dominik Feuerbach, Juan C Boffi, Piotr Draczkowski, Dirk Montag, Brandon M Brown, Ana Belén Elgoyhen, Krzysztof Jozwiak, Giulia Pui. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The international journal of biochemistry & cell biology. vol 76. 2017-09-04. PMID:27129924. |
the activity of positive allosteric modulators (pams) of α7 nicotinic acetylcholine receptors (achrs), including 3-furan-2-yl-n-p-tolyl-acrylamide (pam-2), 3-furan-2-yl-n-o-tolylacrylamide (pam-3), and 3-furan-2-yl-n-phenylacrylamide (pam-4), was tested on a variety of ligand- [i.e., human (h) α7, rat (r) α9α10, hα3-containing achrs, mouse (m) 5-ht3ar, and several glutamate receptors (glurs)] and voltage-gated (i.e., sodium and potassium) ion channels, as well as on acetylcholinesterase (ache) and β-amyloid (aβ) content. |
2017-09-04 |
2023-08-13 |
mouse |
| Yong-Tao Xiao, Jun Wang, Wei Lu, Yi Cao, Wei Ca. Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE. Cell death & disease. vol 7. issue 12. 2017-08-28. PMID:27977009. |
the ache potentially negates the cholinergic anti-inflammatory signal by hydrolyzing the acetylcholine. |
2017-08-28 |
2023-08-13 |
Not clear |
| Deniz Yilmazer-Hanke, Marina Eliava, Joachim Hanke, Herbert Schwegler, Esther Asa. Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. Neuroscience letters. vol 632. 2017-08-08. PMID:27585749. |
density of acetylcholine esterase (ache) and tyrosine hydroxylase (th) containing fibers in the amygdala of roman high- and low-avoidance rats. |
2017-08-08 |
2023-08-13 |
rat |
| Deniz Yilmazer-Hanke, Marina Eliava, Joachim Hanke, Herbert Schwegler, Esther Asa. Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. Neuroscience letters. vol 632. 2017-08-08. PMID:27585749. |
in the present study, the density of acetylcholine esterase (ache)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (th-ir) fibers were analyzed in various amygdala nuclei. |
2017-08-08 |
2023-08-13 |
rat |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Physiological functions of the cholinergic system in immune cells. Journal of pharmacological sciences. vol 134. issue 1. 2017-07-13. PMID:28552584. |
this includes choline acetyltransferase (chat), muscarinic and nicotinic acetylcholine (ach) receptors (machrs and nachrs, respectively) and acetylcholinesterase (ache). |
2017-07-13 |
2023-08-13 |
Not clear |
| Bassem Sadek, Nadia Khan, Fouad H Darras, Steffen Pockes, Michael Decke. The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats. Physiology & behavior. vol 165. 2017-07-11. PMID:27568232. |
both the acetylcholine esterase (ache) and the histamine h3 receptor (h3r) are involved in the metabolism and modulation of acetylcholine release and numerous other centrally acting neurotransmitters. |
2017-07-11 |
2023-08-13 |
rat |
| Xu Rui, Li Wenfang, Cheng Jing, Chen Meng, Ding Chengcheng, Xu Jiqu, Rong Shuan. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat. Food & function. vol 8. issue 3. 2017-07-07. PMID:28256666. |
furthermore, pse improved cholinergic activities by restoring the acetylcholine (ach) content and decreasing acetylcholinesterase (ache) activity in the cerebral cortex, as well as by elevating choline acetyl transferase (chat) activity in the hippocampus and the cerebral cortex. |
2017-07-07 |
2023-08-13 |
rat |
| b' \\xc3\\x9cmide Demir \\xc3\\x96zkay, \\xc3\\x96zg\\xc3\\xbcr Devrim Can, Beg\\xc3\\xbcm Nurpelin Sa\\xc4\\x9fl\\xc4\\xb1k, Ulviye Acar \\xc3\\x87evik, Serkan Levent, Yusuf \\xc3\\x96zkay, Sinem Ilg\\xc4\\xb1n, \\xc3\\x96zlem Atl\\xc4\\xb. Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines. Bioorganic & medicinal chemistry letters. vol 26. issue 22. 2017-06-26. PMID:27789142.' |
in the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (ache) inhibitors. |
2017-06-26 |
2023-08-13 |
Not clear |
| Hengyun Wei, Zixiang Gao, Luping Zheng, Cuili Zhang, Zundong Liu, Yazong Yang, Hongming Teng, Lin Hou, Yuling Yin, Xiangyang Zo. Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice. Marine drugs. vol 15. issue 3. 2017-06-26. PMID:28300775. |
fucoidan reversed the decreased activity of acetylcholine (ach) and choline acetyl transferase (chat), as well as the increased activity of acetylcholine esterase (ache), in ad model mice induced by infusion of d-gal. |
2017-06-26 |
2023-08-13 |
mouse |