| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vija Klusa, Ruta Muceniece, Sergejs Isajevs, Darja Isajeva, Ulrika Beitnere, Ilona Mandrika, Jolanta Pupure, Juris Rumaks, Baiba Jansone, Ivars Kalvinsh, Harry V Vinter. Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Pharmacology, biochemistry, and behavior. vol 106. 2013-12-26. PMID:23537732. |
these biomarkers included glutamic acid decarboxylase 65/67 (gad65/67), acetylcholine esterase (ache), growth-associated protein-43 (gap-43) and the transcription factor c-jun/activator protein-1 (ap-1). |
2013-12-26 |
2023-08-12 |
mouse |
| Yu-Qin Zhang, Ji-Qi Liu, Xiang-Shu Guo, Zhen-Qiang Tang, Xu-Dong Zhao, Rui-Min Zhou, Qi Zha. [Resistance of Anopheles sinensis to insecticides in Huaibin County of Henan Province]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. vol 30. issue 6. 2013-12-12. PMID:23484266. |
the activity of acetylcholine esterase (ache) of larvae and adult mosquitoes was measured by colorimetric method before and after the respective addition of the 3 insecticides. |
2013-12-12 |
2023-08-12 |
Not clear |
| Hanaa H Ahmed, Ahmed M Salem, Gilane M Sabry, Ahmed A Husein, Soheir E Koto. Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's disease-induced rats. Journal of medicinal food. vol 16. issue 5. 2013-12-12. PMID:23631499. |
levels of brain acetylcholine (ach), serum and brain acetylcholinesterase (ache) activity, c-reactive protein (crp), total nuclear factor kappa-b (nf-κb), and monocyte chemoattractant protein-1 (mcp-1) were estimated. |
2013-12-12 |
2023-08-12 |
rat |
| Veena Beri, Scott A Wildman, Kazuro Shiomi, Ziyad F Al-Rashid, Jonah Cheung, Terrone L Rosenberr. The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry. vol 52. issue 42. 2013-12-12. PMID:24040835. |
cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (ache). |
2013-12-12 |
2023-08-12 |
Not clear |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the acetylcholinesterase (ache), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. |
2013-12-09 |
2023-08-12 |
human |
| Mehlika D Altintop, Ahmet Özdemir, Zafer A Kaplancikli, Gülhan Turan-Zitouni, Halide E Temel, Gülşen A Çiftç. Synthesis and biological evaluation of some pyrazoline derivatives bearing a dithiocarbamate moiety as new cholinesterase inhibitors. Archiv der Pharmazie. vol 346. issue 3. 2013-12-02. PMID:23389781. |
compounds effective on ache carry the 2-dimethylaminoethyl moiety, which resembles the trimethylammonium group and the ethylene bridge of acetylcholine. |
2013-12-02 |
2023-08-12 |
Not clear |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c and (18)f-labeled acetylcholine analogues. |
2013-11-26 |
2023-08-12 |
rat |
| Minmin Liang, Kelong Fan, Yong Pan, Hui Jiang, Fei Wang, Dongling Yang, Di Lu, Jing Feng, Jianjun Zhao, Liu Yang, Xiyun Ya. Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent. Analytical chemistry. vol 85. issue 1. 2013-11-13. PMID:23153113. |
the enzymes ache and cho catalyze the formation of h(2)o(2) in the presence of acetylcholine, which then activates mnps to catalyze the oxidation of colorimetric substrates to produce a color reaction. |
2013-11-13 |
2023-08-12 |
Not clear |
| Anthony J Veloso, Devjani Dhar, Ari M Chow, Biao Zhang, Derek W F Tang, Hashwin V S Ganesh, Svetlana Mikhaylichenko, Ian R Brown, Kagan Kerma. sym-Triazines for directed multitarget modulation of cholinesterases and amyloid-β in Alzheimer's disease. ACS chemical neuroscience. vol 4. issue 2. 2013-10-29. PMID:23421685. |
rational targeting of ache was achieved by the incorporation of acetylcholine substrate analogues into a sym-triazine core in either a mono-, di-, or trisubstituted regime. |
2013-10-29 |
2023-08-12 |
human |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (ache) which hydrolyses acetylcholine. |
2013-10-25 |
2023-08-12 |
Not clear |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
therefore, ache and buche inhibition have been documented as critical targets for the effective management of ad by an increase in the availability of acetylcholine in the brain regions and decrease in the aβ deposition. |
2013-10-25 |
2023-08-12 |
Not clear |
| C F Höhmann, P T Carroll, F F Ebne. Acetylcholine levels and choline acetyltransferase activity in turtle cortex. Brain research. vol 258. issue 1. 2013-10-22. PMID:24010173. |
histochemical localization of acetylcholine esterase (ache) shows that the reaction product is in the outer half of the molecular layer of dorsal cortex of the turtle pseudemys. |
2013-10-22 |
2023-08-12 |
Not clear |
| Ganiyu Oboh, Odunayo M Agunloye, Ayodele J Akinyemi, Adedayo O Ademiluyi, Stephen A Adefegh. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats' brain-in vitro. Neurochemical research. vol 38. issue 2. 2013-10-17. PMID:23184188. |
inhibition of ache and bche activities slows down acetylcholine and butyrylcholine breakdown in the brain. |
2013-10-17 |
2023-08-12 |
rat |
| Jia Zhang, Yan-feng Zhen, Pu-Bu-Ci-Ren, Li-gang Song, Wei-na Kong, Tie-mei Shao, Xue Li, Xi-qing Cha. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behavioural brain research. vol 244. 2013-09-30. PMID:23396166. |
after behavioral testing, the rats were sacrificed and hippocampi were removed for biochemical assays (reactive oxygen species (ros), superoxide dismutase (sod), glutathione peroxidase (gpx), malondialdehyde (mda), acetylcholinesterase (ache), acetylcholine (ach)) and molecular biological analysis (cu/zn-sod, mn-sod, gpx, nicotinamide adenine dinucleotide phosphate (nadph) oxidase, nuclear factor κb (nf-κb), inhibitor of κb-alpha (iκbα), cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), receptor for advanced glycation end products (rage)). |
2013-09-30 |
2023-08-12 |
rat |
| Girish Beedessee, Avin Ramanjooloo, Rashmee Surnam-Boodhun, Rob W M van Soest, Daniel E P Mari. Acetylcholinesterase-inhibitory activities of the extracts from sponges collected in mauritius waters. Chemistry & biodiversity. vol 10. issue 3. 2013-09-17. PMID:23495160. |
the use of acetylcholinesterase (ache) inhibitors to retard the hydrolysis of acetylcholine has been suggested as a promising strategy for ad treatment. |
2013-09-17 |
2023-08-12 |
Not clear |
| Si-Juan Chu, Lan Zhang, Gang Liu, Wen-Xia Zhou, Lin L. [Effects of cornel iridoid glycoside on activity of cholinesterases in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 9. 2013-09-17. PMID:23944063. |
the biochemical methods were used to detect the activity of acetylcholine esterase (ache) and butyryl cholinesterase (buche) to investigate the influence of cig on cholinesterases. |
2013-09-17 |
2023-08-12 |
human |
| Dharmalingam Prakash, Kulasekaran Gopinath, Ganapasam Sudhandira. Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity. Neuromolecular medicine. vol 15. issue 1. 2013-08-29. PMID:23315010. |
administration of alcl3 developed behavioral deficits, triggered lipid peroxidation (lpo), compromised acetylcholine esterase (ache) activity, and reduced the levels of superoxide dismutase (sod), catalase (cat), glutathione-s-transferase (gst), and reduced glutathione (gsh), and caused histologic aberrations. |
2013-08-29 |
2023-08-12 |
mouse |
| William C Motel, Andrew Coop, Christopher W Cunningha. Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease. Mini reviews in medicinal chemistry. vol 13. issue 3. 2013-08-12. PMID:22931533. |
galantamine is a reversible, competitive acetylcholinesterase (ache) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nachr-apl) that shares many common structural elements with morphinan-based opioids. |
2013-08-12 |
2023-08-12 |
Not clear |
| Lei An, Zhuo Yang, Tao Zhan. Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiology of learning and memory. vol 100. 2013-07-23. PMID:23231966. |
water maze behavior and long-term depression (ltd) in hippocampal ca3-ca1 pathway were measured, followed by enzyme linked immunosorbent assay (elisa), by which acetylcholine (ach) level and acetylcholinesterase (ache) activity were determined. |
2013-07-23 |
2023-08-12 |
rat |