| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin B Temeyer, Alexander P Tuckow, Danett K Brake, Andrew Y Li, Adalberto A Pérez de Leó. Acetylcholinesterases of blood-feeding flies and ticks. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23036311. |
ache hydrolyzes the neurotransmitter, acetylcholine, but may have additional roles in physiology and development. |
2013-05-28 |
2023-08-12 |
human |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Veena Beri, Jeffrey T Auletta, Ghulam M Maharvi, Juanita F Wood, Abdul H Fauq, Terrone L Rosenberr. Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047027. |
hydrolysis of acetylcholine by acetylcholinesterase (ache) is extremely rapid, with a second-order hydrolysis rate constant k(e) (often denoted k(cat)/k(m)) that approaches 10(8) m(-1) s(-1). |
2013-05-28 |
2023-08-12 |
cat |
| Elizabeth N Schock, Windsor C Ford, Kirsten J Midgley, Joseph G Fader, Michael N Giavasis, Michelle L McWhorte. The effects of carbaryl on the development of zebrafish (Danio rerio) embryos. Zebrafish. vol 9. issue 4. 2013-05-28. PMID:23094693. |
the active ingredient in sevin(™), carbaryl (1-napthyl-n-methylcarbamate), is a known acetylcholinesterase (ache) inhibitor that prevents the breakdown of acetylcholine to acetate and choline at the synapse. |
2013-05-28 |
2023-08-12 |
zebrafish |
| Pran Kishore Deb, Anuradha Sharma, Poonam Piplani, Raghuram Rao Akkinepall. Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors. Molecular diversity. vol 16. issue 4. 2013-05-16. PMID:22996404. |
the reversible inhibition of acetylcholinesterase (ache) has become a promising target for the treatment of alzheimer's disease (ad) which is mainly associated with low in vivo levels of acetylcholine (ach). |
2013-05-16 |
2023-08-12 |
Not clear |
| F Aura Kullmann, Grace I Wells, David G McKenna, Karl B Tho. Exogenous activation of muscarinic receptors decreases subsequent non-muscarinic bladder contractions in vivo in the female rat. Life sciences. vol 92. issue 12. 2013-05-07. PMID:23399698. |
our second aim was to determine if elevation of endogenous acetylcholine (ach) with distigmine, an acetylcholine esterase (ache) inhibitor, could also inhibit non-cholinergic component of reflexogenic bladder contractions. |
2013-05-07 |
2023-08-12 |
rat |
| Ravindra M Ghodke, Nagesh Tour, Kshama Dev. Effects of statins and cholesterol on memory functions in mice. Metabolic brain disease. vol 27. issue 4. 2013-05-03. PMID:23065075. |
memory performance was evaluated with two different behavioral tests and various biochemical parameters such as serum cholesterol, whole brain cholesterol, brain 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) activity and brain acetylcholine esterase (ache) activity. |
2013-05-03 |
2023-08-12 |
mouse |
| Yann S Mineur, Adetokunbo Obayemi, Mattis B Wigestrand, Gianna M Fote, Cali A Calarco, Alice M Li, Marina R Picciott. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401542. |
symptoms of depression can be induced in humans through blockade of acetylcholinesterase (ache) whereas antidepressant-like effects can be produced in animal models and some clinical trials by limiting activity of acetylcholine (ach) receptors. |
2013-05-02 |
2023-08-12 |
mouse |
| G Lou, Q Zhang, F Xiao, Q Xiang, Z Su, L Zhang, P Yang, Y Yang, Q Zheng, Y Huan. Intranasal administration of TAT-haFGF(₁₄₋₁₅₄) attenuates disease progression in a mouse model of Alzheimer's disease. Neuroscience. vol 223. 2013-05-01. PMID:22885230. |
importantly, tat-hafgf(14-154) improved the learning and memory abilities of samp8 mice in the behavioral test, and promoted the function of cholinergic system by measuring the relevant biomarkers (acetylcholine (ach) level, acetylcholinesterase (ache) and choline acetyltransferase (chat) activities). |
2013-05-01 |
2023-08-12 |
mouse |
| Abdelfatteh El Omri, Junkyu Han, Kiyokazu Kawada, Manef Ben Abdrabbah, Hiroko Isod. Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways. Brain research. vol 1437. 2013-04-30. PMID:22226506. |
our findings showed that luteolin treatment significantly induced neurite outgrowth extension, enhanced acetylcholinesterase (ache) activity, known as neuronal differentiation marker, and increased the level of total choline and acetylcholine in pc12 cells. |
2013-04-30 |
2023-08-12 |
Not clear |
| Éva M Szegő, Tiago F Outeiro, Pawel Kermer, Jörg B Schul. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22579457. |
clinical studies report positive effects of acetylcholine esterase (ache) inhibitors in pdd and dementia with lewy bodies. |
2013-04-29 |
2023-08-12 |
mouse |
| Vasudevan Mani, Kalavathy Ramasamy, Aliya Ahmad, Siti Norshazwani Wahab, Siti Murnirah Jaafar, Teh Lay Kek, Mohd Zaki Salleh, Abu Bakar Abdul Majee. Effects of the total alkaloidal extract of Murraya koenigii leaf on oxidative stress and cholinergic transmission in aged mice. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22447662. |
interestingly, significant progress was noted with the supplementation of mka by an improvement of the acetylcholine (ach) levels and a reduction in the acetylcholinesterase (ache) activity in aged mouse brain. |
2013-04-26 |
2023-08-12 |
mouse |
| Jamie K Lau, Kathleen C Brown, Brent A Thornhill, Clayton M Crabtree, Aaron M Dom, Theodore R Witte, W Elaine Hardman, Christopher A McNees, Cody A Stover, A Betts Carpenter, Haitao Luo, Yi C Chen, Brandon S Shiflett, Piyali Dasgupt. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23222296. |
in this study, we show that human bacs produce acetylcholine (ach) and contain several cholinergic factors including acetylcholinesterase (ache), choline acetyltransferase (chat), choline transporter 1 (cht1, slc5a7), vesicular acetylcholine transporter (vacht, slc18a3), and nach receptors (achrs, chrnas). |
2013-04-15 |
2023-08-12 |
mouse |
| Andleeb Khan, Kumar Vaibhav, Hayate Javed, Mohd Moshahid Khan, Rizwana Tabassum, Md Ejaz Ahmed, Pallavi Srivastava, Gulrana Khuwaja, Farah Islam, Mohd Saeed Siddiqui, Mohammed M Safhi, Mohammed M Shafi, Fakhrul Isla. Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Molecular and cellular biochemistry. vol 369. issue 1-2. 2013-04-10. PMID:22752387. |
in addition, a significant elevation in the tbars content and nitric oxide (no) and activity of acetylcholine esterase (ache) was observed which was restored significantly by tq pretreatment. |
2013-04-10 |
2023-08-12 |
rat |
| Mohammd Moshiri, Emadodin Darchini-Maragheh, Mahdi Balali-Moo. Advances in toxicology and medical treatment of chemical warfare nerve agents. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 20. issue 1. 2013-03-28. PMID:23351280. |
the main mechanism of action is irreversible inhibition of acetyl choline esterase (ache) resulting in accumulation of toxic levels of acetylcholine (ach) at the synaptic junctions and thus induces muscarinic and nicotinic receptors stimulation. |
2013-03-28 |
2023-08-12 |
Not clear |
| Gopenath Thangaraj, Alexander Greif, Gesine Bachmann, Paul G Laye. Intricate paths of cells and networks becoming "Cholinergic" in the embryonic chicken retina. The Journal of comparative neurology. vol 520. issue 14. 2013-03-08. PMID:22886733. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) are the decisive enzymatic activities regulating the availability of acetylcholine (ach) at a given synaptic or nonsynaptic locus. |
2013-03-08 |
2023-08-12 |
chicken |
| Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Angliste. Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. The European journal of neuroscience. vol 36. issue 8. 2013-03-06. PMID:22805122. |
controlled regulation of synaptic nicotinic acetylcholine receptors (achrs) and acetylcholinesterase (ache), together with maintenance of a dynamic balance between them, is a requirement for proper function of cholinergic synapses. |
2013-03-06 |
2023-08-12 |
rat |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Wei-Wei Zhang, Qi-Xin Sun, Yin-Hui Liu, Wei Gao, Yan-Hai Li, Kun Lu, Zhuo Wan. Chronic administration of Liu Wei Dihuang protects rat's brain against D-galactose-induced impairment of cholinergic system. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 3. 2013-02-21. PMID:21681343. |
acetylcholine (ach) content, activities of choline acetyltransferase (chat) and acetylcholinesterase (ache) in visual cortex were assayed. |
2013-02-21 |
2023-08-12 |
rat |
| Alexander Ciji, N P Sahu, A K Pal, S Dasgupta, M S Akhta. Alterations in serum electrolytes, antioxidative enzymes and haematological parameters of Labeo rohita on short-term exposure to sublethal dose of nitrite. Fish physiology and biochemistry. vol 38. issue 5. 2013-02-12. PMID:22388937. |
activities of antioxidative enzymes (catalase and superoxide dismutase), acetylcholine esterase (ache) and methaemoglobin reductase, serum electrolytes (sodium, potassium and chloride), haematological parameters and blood glucose level significantly varied (p < 0.05) in a dose-dependent manner. |
2013-02-12 |
2023-08-12 |
Not clear |