| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kosuke Yamamoto, Yoshie S Momonok. Subcellular localization of overexpressed maize AChE gene in rice plant. Plant signaling & behavior. vol 3. issue 8. 2012-10-02. PMID:19704473. |
the ach-mediated system consisting of acetylcholine (ach), acetylcholine receptor (achr) and acetylcholinesterase (ache) is fundamental for nervous system function in animals and insects. |
2012-10-02 |
2023-08-12 |
Not clear |
| Takafumi Tezuka, Isamu Akita, Natsuko Yoshin. Self-incompatibility involved in the level of acetylcholine and cAMP. Plant signaling & behavior. vol 2. issue 6. 2012-10-02. PMID:19704589. |
a potent inhibitor (neostigmine) of acetylcholinesterase (ache) as well as acetylcholine also promoted the elongation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Pardeep Sidhu, Bimla Nehr. Protective effects of selenium to placental lead neurotoxicity in rat pups. Toxicology mechanisms and methods. vol 15. issue 6. 2012-10-02. PMID:20021065. |
activities of succinic dehydrogenase (sdh), acetylcholine estrase (ache), and na(+)/k(+)-atpase were studied in the cerebrum and cerebellum of the rat pups at 4 weeks of age. |
2012-10-02 |
2023-08-12 |
rat |
| M Muramatsu, I Arai, J Tamaki, H Hirose, A Fujita, H Aihar. Central regulation of gastric acetylcholine metabolism and acid output Analysis using stress and 2-deoxy-d-glucose administration in rats. Neurochemistry international. vol 8. issue 4. 2012-10-02. PMID:20493088. |
the stress of immobilization in water caused a significant increase in the activity of choline acetyltransferase (cat) and acetylcholinesterase (ache), acetylcholine (ach) content in the stomach and gastric acid secretion, but a decrease of choline content in rats. |
2012-10-02 |
2023-08-12 |
rat |
| P E Potter, S Nitta, I Chaudhry, I Lalezari, P Goldiner, F F Folde. Effects of LF-14, THA and physostigmine in rat hippocampus and cerebral cortex. Neurochemistry international. vol 14. issue 4. 2012-10-02. PMID:20504446. |
the effects of physostigmine, tetrahydroaminoacridine (tha) and lf-14 [3,3-dimethyl-1(4- amino-3-pyridyl)urea], a 3,4-diaminopyridine derivative, were compared on inhibition of acetyl- cholinesterase (ache) activity, and release of [(3)h]acetylcholine (ach) from rat brain cortical and hippocampal slices. |
2012-10-02 |
2023-08-12 |
rat |
| A Szabó, J Nemcsók, P Kása, K Guly. Muscarinic cholinergic components in the carp brain. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504527. |
the activity of the muscarinic cholinergic system (acetylcholine, ach; acetylcholinesterase, ache; choline acetyltransferase, chat; muscarinic acetylcholine receptors) was studied in the carp brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| C N Pope, J Li. Age-related differences in sensitivity to organophosphorus pesticides. Environmental toxicology and pharmacology. vol 4. issue 3-4. 2012-10-02. PMID:21781839. |
extensive inhibition of ache leads to accumulation of acetylcholine in the synapse, disruption of normal impulse flow and subsequent signs of toxicity, including autonomic dysfunction, involuntary movements, muscle fasciculations and a host of others. |
2012-10-02 |
2023-08-12 |
rat |
| Carey Pope, Subramanya Karanth, Jing Li. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783509. |
under normal conditions, however, extensive inhibition of ache leads to excess synaptic acetylcholine levels, over-stimulation of cholinergic receptors, alteration of postsynaptic cell function and consequent signs of cholinergic toxicity. |
2012-10-02 |
2023-08-12 |
human |
| Oksana Lockridge, Ellen G Duysen, Troy Voelker, Charles M Thompson, Lawrence M Schopfe. Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783513. |
this implied that the mechanism of toxicity of a lethal dose of op in ache-/- mice was the same as in mice that had ache, namely accumulation of excess acetylcholine followed by overstimulation of receptors. |
2012-10-02 |
2023-08-12 |
mouse |
| Manjeet Singh, Sushma Rish. Plasma acetylcholinesterase as a biomarker of triazophos neurotoxicity in young and adult rats. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783514. |
besides inactivating acetylcholine at synaptic terminals ache also plays an important role in neuronal growth and differentiation. |
2012-10-02 |
2023-08-12 |
rat |
| Joanne Knowle. Donepezil in Alzheimer's disease: an evidence-based review of its impact on clinical and economic outcomes. Core evidence. vol 1. issue 3. 2012-10-02. PMID:22500154. |
it is a specific and reversible inhibitor of acetylcholinesterase (ache); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Oto Pavlis, Hana Svobodova, Jiri Pikul. Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice. Interdisciplinary toxicology. vol 5. issue 1. 2012-10-02. PMID:22783145. |
the present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (ache) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ach). |
2012-10-02 |
2023-08-12 |
mouse |
| María-Ximena Silveyra, María-Salud García-Ayllón, Elena Gómez de Barreda, David H Small, Salvador Martínez, Jesús Avila, Javier Sáez-Valer. Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21530001. |
all major molecular forms of ache were increased in the tg-vlw mice, including tetrameric ache, which is the major species involved in hydrolysis of acetylcholine in the brain. |
2012-09-28 |
2023-08-12 |
mouse |
| Santoshkumar Tota, Chandishwar Nath, Abul Kalam Najmi, Rakesh Shukla, Kashif Hani. Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22460064. |
scopolamine caused impairment in memory which was associated with reduced cbf, acetylcholine (ach) level and elevated acetylcholinesterase (ache) activity and malondialdehyde (mda) level. |
2012-09-27 |
2023-08-12 |
mouse |
| Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean, Pierre-Yves Renar. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of chemical research. vol 45. issue 5. 2012-09-20. PMID:22360473. |
ache breaks down the neurotransmitter acetylcholine at neuronal synapses and neuromuscular junctions. |
2012-09-20 |
2023-08-12 |
Not clear |
| D Chand Basha, M Usha Rani, C Bhuvaneswari Devi, M Ram Kumar, G Rajarami Redd. Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co-administration. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 4. 2012-09-13. PMID:22326442. |
in this study, we examined the alterations in synaptosomal acetylcholine (ach), epinephrine, dopamine, acetylcholinesterase (ache), and mitochondrial monoamine oxidase (mao) in the cerebellum and hippocampus of perinatally pb-exposed rats. |
2012-09-13 |
2023-08-12 |
rat |
| S Anne Boettger, James B McClintoc. Acetyl cholinesterase activity and muscle contraction in the sea urchin Lytechinus variegatus (Lamarck) following chronic phosphate exposure. Environmental toxicology. vol 27. issue 4. 2012-08-14. PMID:20607821. |
nonetheless, chronic exposure to low, medium, and high-sublethal concentrations of organic phosphate inhibits the muscle enzyme acetyl cholinesterase (ache), responsible for the break down of the neurotransmitter acetylcholine, as well as inhibiting contractions in the muscles associated with the aristotle's lantern. |
2012-08-14 |
2023-08-12 |
Not clear |
| Katja S Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbroc. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245562. |
it aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (ache) and thus increases the concentration of extracellular acetylcholine. |
2012-07-23 |
2023-08-12 |
rat |
| Jose M Pizarro, Wenling E Chang, Mariama J Bah, Linnzi K M Wright, George A Saviolakis, Arun Alagappan, Christopher L Robison, Jinesh D Shah, James L Meyerhoff, Douglas M Cerasoli, Eric G Midboe, Lucille A Lumle. Repeated exposure to sublethal doses of the organophosphorus compound VX activates BDNF expression in mouse brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 126. issue 2. 2012-07-16. PMID:22240983. |
prolonged inhibition of ache increases endogenous levels of acetylcholine and is toxic at nerve synapses and neuromuscular junctions. |
2012-07-16 |
2023-08-12 |
mouse |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
other neurotransmitter is a classical neurotransmitter acetylcholine (ach), regulated by enzyme acetylcholinesterase (ache) that hydrolyses the acetylcholine after its releasing. |
2012-06-21 |
2023-08-12 |
rat |