| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ludise Malkova, Alan P Kozikowski, Karen Gal. The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21185313. |
huperzine a is a reversible acetylcholinesterase (ache) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. |
2012-01-18 |
2023-08-12 |
human |
| Evert-Jan Kooi, Marloes Prins, Natasha Bajic, Jeroen A M Beliën, Wouter H Gerritsen, Jack van Horssen, Eleonora Aronica, Anne-Marie van Dam, Jeroen J M Hoozemans, Paul T Francis, Paul van der Valk, Jeroen J G Geurt. Cholinergic imbalance in the multiple sclerosis hippocampus. Acta neuropathologica. vol 122. issue 3. 2012-01-10. PMID:21691765. |
in ms hippocampus, activity and protein expression of choline acetyltransferase (chat), the acetylcholine synthesizing enzyme, was decreased, while the activity and protein expression of acetylcholinesterase (ache), the acetylcholine degrading enzyme, was found to be unaltered. |
2012-01-10 |
2023-08-12 |
Not clear |
| Michael Adler, Richard E Sweeney, Tracey A Hamilton, Oksana Lockridge, Ellen G Duysen, Angela L Purcell, Sharad S Deshpand. Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice. Cellular and molecular neurobiology. vol 31. issue 6. 2011-11-30. PMID:21538119. |
electrophysiological and ultrastructural studies were performed on phrenic nerve-hemidiaphragm preparations isolated from wild-type and acetylcholinesterase (ache) knockout (ko) mice to determine the compensatory mechanisms manifested by the neuromuscular junction to excess acetylcholine (ach). |
2011-11-30 |
2023-08-12 |
mouse |
| S Asha Devi, C S Shiva Shankar Reddy, M V V Subramanya. Peroxyl-induced oxidative stress in aging erythrocytes of rat. Biogerontology. vol 12. issue 4. 2011-11-21. PMID:21359656. |
membrane integrity in terms of hemolysis was negatively related to acetylcholine esterase (ache) activity with the extent of reduction under os being higher in the old erythrocyte than in the young. |
2011-11-21 |
2023-08-12 |
rat |
| Norifumi Shioda, Yui Yamamoto, Feng Han, Shigeki Moriguchi, Kohji Fukunag. [Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 131. issue 4. 2011-11-15. PMID:21467789. |
using this attractive obx mice model, we discovered a novel cognitive enhancer, spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3h)-one (zset1446/st101), that is a new azaindolizinone derivative without inhibitory action on acetylcholine esterase (ache). |
2011-11-15 |
2023-08-12 |
mouse |
| Pamela D Moore, Anita K Patlolla, Paul B Tchounwo. Cytogenetic evaluation of malathion-induced toxicity in Sprague-Dawley rats. Mutation research. vol 725. issue 1-2. 2011-11-15. PMID:21835262. |
its toxicity has been attributed primarily to the accumulation of acetylcholine (ach) at nerve junctions, due to the inhibition of acetylcholinesterase (ache), and consequently overstimulation of the nicotinic and muscarinic receptors. |
2011-11-15 |
2023-08-12 |
rat |
| Roberta Annicchiarico, Alessia Federici, Carla Pettenati, Carlo Caltagiron. Rivastigmine in Alzheimer's disease: Cognitive function and quality of life. Therapeutics and clinical risk management. vol 3. issue 6. 2011-11-10. PMID:18516265. |
rivastigmine is a dual inhibitor of both acetylcholine esterase (ache) and butyrylcholinesterase (buche), enzymes involved in the hydrolysis of acetylcholine. |
2011-11-10 |
2023-08-12 |
Not clear |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Vicky P Chen, Wilson K W Luk, Wallace K B Chan, K Wing Leung, Ava J Y Guo, Gallant K L Chan, Sherry L Xu, Roy C Y Choi, Karl W K Tsi. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22046147. |
acetylcholinesterase (ache) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. |
2011-11-10 |
2023-08-12 |
chicken |
| Alexandre P Atkinson, Evelyne Baguet, Nicolas Galland, Jean-Yves Le Questel, Aurélien Planchat, Jérôme Grato. Structural features and hydrogen-bond properties of galanthamine and codeine: an experimental and theoretical study. Chemistry (Weinheim an der Bergstrasse, Germany). vol 17. issue 41. 2011-11-07. PMID:21887829. |
an analysis of the interactions that occur between the two ligands and acetylcholine esterase (ache) suggests significant differences with trp84, a key component of the ache catalytic active site. |
2011-11-07 |
2023-08-12 |
Not clear |
| Tanja Klein-Rodewald, Thomas Seeger, Mathias Dutschmann, Franz Worek, Michael Mörsche. Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat. Toxicology letters. vol 206. issue 1. 2011-10-28. PMID:21767620. |
the impact of organophosphorus compound (op) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (ache) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. |
2011-10-28 |
2023-08-12 |
rat |
| Vinicius Barreto da Silva, Peterson de Andrade, Daniel Fábio Kawano, Pedro Alves Bezerra Morais, Jonathan Resende de Almeida, Ivone Carvalho, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silv. In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity. Future medicinal chemistry. vol 3. issue 8. 2011-10-12. PMID:21707398. |
one pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (ache) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. |
2011-10-12 |
2023-08-12 |
Not clear |
| Csaba Nyakas, Ivica Granic, László G Halmy, Pradeep Banerjee, Paul G M Luite. The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20553766. |
the evidence pointing to cholinergic impairments come from studies that report a decline in the activity of choline acetyltransferase (chat) and acetylcholine esterase (ache), acetylcholine (ach) release and the levels of nicotinic and muscarinic receptors, and loss of cholinergic basal forebrain neurons in the ad brain. |
2011-09-09 |
2023-08-12 |
rat |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Tetsuya Konish. Effect of Shengmai-san on cognitive performance and cerebral oxidative damage in BALB/c mice. Journal of medicinal food. vol 14. issue 6. 2011-08-30. PMID:21554136. |
to elucidate the mechanism of its cognitive-enhancing activity, the effects of sms (2, 4, or 8 g/kg) on activities of acetylcholinesterase (ache) and antioxidant enzymes and levels of acetylcholine (ach) and nitrite were evaluated in brain homogenate. |
2011-08-30 |
2023-08-12 |
mouse |
| D J Pree, J L Townshend, D E Archibal. Carbamate and Organophosphorus Nematicides: Acetylcholinesterase inhibition and Effects on Dispersal. Journal of nematology. vol 21. issue 4. 2011-07-14. PMID:19287642. |
the sensitivities of acetylcholinesterases (ache) from the fungus-feeder aphelenchus avenae and the plant-parasitic species helicotylenchus dihystera and pratylenchus penetrans and the housefly, musca domestica, were compared using a radiometric assay which utilized h(3) acetylcholine as a substrate. |
2011-07-14 |
2023-08-12 |
Not clear |
| A Gholamhoseinian, M N Moradi, F Sharifi-Fa. Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in pharmaceutical sciences. vol 4. issue 2. 2011-07-14. PMID:21589805. |
acetylcholinesterase (ache) is the main enzyme for the breakdown of acetylcholine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Véronique Bernard, Emmanuelle Girard, Anna Hrabovska, Shelley Camp, Palmer Taylor, Benoit Plaud, Eric Krejc. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20883790. |
acetylcholinesterase (ache) terminates the action of acetylcholine at cholinergic synapses thereby preventing rebinding of acetylcholine to nicotinic postsynaptic receptors at the neuromuscular junction. |
2011-07-05 |
2023-08-12 |
mouse |
| Alvin V Terry, Jerry J Buccafusco, Elizabeth J Herman, Patrick M Callahan, Wayne D Beck, Samantha Warner, Leah Vandenhuerk, Kristy Bouchard, Gary M Schwarz, Jie Gao, James M Chapma. The prototypical ranitidine analog JWS-USC-75-IX improves information processing and cognitive function in animal models. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21106907. |
jws was previously found to inhibit acetylcholinesterase (ache) activity, serve as a potent ligand at muscarinic m₂ acetylcholine receptors, and elicit positive effects on spatial learning, passive avoidance, and working memory in rodents. |
2011-04-21 |
2023-08-12 |
rat |
| Antony Sherin, Kumar T Peeyush, George Naijil, Mohan Sobhana Nandhu, Sadanandan Jayanarayanan, Paul Jes, Cheramadathikudiyil Skaria Paulos. The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats. European journal of pharmacology. vol 651. issue 1-3. 2011-04-11. PMID:21126518. |
increased ache and decreased chat expression is suggested to alter cortical acetylcholine metabolism in experimental rats along with altered muscarinic receptor binding in hypo/hyperglycemic rats, impair cholinergic transmission, which subsequently lead to cholinergic dysfunction thereby causing learning and memory deficits. |
2011-04-11 |
2023-08-12 |
rat |
| S Armenta, M Blanc. Ion mobility spectrometry: a valuable tool for kinetic studies in enzymology. Analytica chimica acta. vol 685. issue 1. 2011-04-04. PMID:21168544. |
the capability of ims in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (ache) and inhibited by neostigmine and galanthamine. |
2011-04-04 |
2023-08-12 |
Not clear |