| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Csaba Nyakas, Ivica Granic, László G Halmy, Pradeep Banerjee, Paul G M Luite. The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20553766. |
the evidence pointing to cholinergic impairments come from studies that report a decline in the activity of choline acetyltransferase (chat) and acetylcholine esterase (ache), acetylcholine (ach) release and the levels of nicotinic and muscarinic receptors, and loss of cholinergic basal forebrain neurons in the ad brain. |
2011-09-09 |
2023-08-12 |
rat |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Tetsuya Konish. Effect of Shengmai-san on cognitive performance and cerebral oxidative damage in BALB/c mice. Journal of medicinal food. vol 14. issue 6. 2011-08-30. PMID:21554136. |
to elucidate the mechanism of its cognitive-enhancing activity, the effects of sms (2, 4, or 8 g/kg) on activities of acetylcholinesterase (ache) and antioxidant enzymes and levels of acetylcholine (ach) and nitrite were evaluated in brain homogenate. |
2011-08-30 |
2023-08-12 |
mouse |
| D J Pree, J L Townshend, D E Archibal. Carbamate and Organophosphorus Nematicides: Acetylcholinesterase inhibition and Effects on Dispersal. Journal of nematology. vol 21. issue 4. 2011-07-14. PMID:19287642. |
the sensitivities of acetylcholinesterases (ache) from the fungus-feeder aphelenchus avenae and the plant-parasitic species helicotylenchus dihystera and pratylenchus penetrans and the housefly, musca domestica, were compared using a radiometric assay which utilized h(3) acetylcholine as a substrate. |
2011-07-14 |
2023-08-12 |
Not clear |
| A Gholamhoseinian, M N Moradi, F Sharifi-Fa. Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in pharmaceutical sciences. vol 4. issue 2. 2011-07-14. PMID:21589805. |
acetylcholinesterase (ache) is the main enzyme for the breakdown of acetylcholine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Véronique Bernard, Emmanuelle Girard, Anna Hrabovska, Shelley Camp, Palmer Taylor, Benoit Plaud, Eric Krejc. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20883790. |
acetylcholinesterase (ache) terminates the action of acetylcholine at cholinergic synapses thereby preventing rebinding of acetylcholine to nicotinic postsynaptic receptors at the neuromuscular junction. |
2011-07-05 |
2023-08-12 |
mouse |
| Alvin V Terry, Jerry J Buccafusco, Elizabeth J Herman, Patrick M Callahan, Wayne D Beck, Samantha Warner, Leah Vandenhuerk, Kristy Bouchard, Gary M Schwarz, Jie Gao, James M Chapma. The prototypical ranitidine analog JWS-USC-75-IX improves information processing and cognitive function in animal models. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21106907. |
jws was previously found to inhibit acetylcholinesterase (ache) activity, serve as a potent ligand at muscarinic m₂ acetylcholine receptors, and elicit positive effects on spatial learning, passive avoidance, and working memory in rodents. |
2011-04-21 |
2023-08-12 |
rat |
| Antony Sherin, Kumar T Peeyush, George Naijil, Mohan Sobhana Nandhu, Sadanandan Jayanarayanan, Paul Jes, Cheramadathikudiyil Skaria Paulos. The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats. European journal of pharmacology. vol 651. issue 1-3. 2011-04-11. PMID:21126518. |
increased ache and decreased chat expression is suggested to alter cortical acetylcholine metabolism in experimental rats along with altered muscarinic receptor binding in hypo/hyperglycemic rats, impair cholinergic transmission, which subsequently lead to cholinergic dysfunction thereby causing learning and memory deficits. |
2011-04-11 |
2023-08-12 |
rat |
| S Armenta, M Blanc. Ion mobility spectrometry: a valuable tool for kinetic studies in enzymology. Analytica chimica acta. vol 685. issue 1. 2011-04-04. PMID:21168544. |
the capability of ims in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (ache) and inhibited by neostigmine and galanthamine. |
2011-04-04 |
2023-08-12 |
Not clear |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
we are currently probing the mechanism(s) of ache shedding, and whether this process and its apparent association with α7 nicotinic acetylcholine receptors and metabolism of the alzheimer's amyloid precursor protein is determined by its association with lipid raft domains either in normal or pathological situations. |
2011-03-30 |
2023-08-12 |
rat |
| Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-Nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshim. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20219155. |
galantamine, a drug used to treat alzheimer's disease, inhibits acetylcholinesterase (ache) and allosterically modulates nicotinic acetylcholine receptors (nachrs) resulting in stimulation of catecholamine neurotransmission. |
2011-03-18 |
2023-08-12 |
mouse |
| Yingjun Zhao, Xiaoying Wang, Tao Wang, Xin Hu, Xin Hui, Mingxia Yan, Qiang Gao, Taoyang Chen, Jinjun Li, Ming Yao, Dafang Wan, Jianren Gu, Jia Fan, Xianghuo H. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology (Baltimore, Md.). vol 53. issue 2. 2011-03-18. PMID:21274871. |
further study showed that ache suppressed cell proliferation via its enzymatic activity of acetylcholine catalysis and degradation. |
2011-03-18 |
2023-08-12 |
human |
| Shaik Firdoz, Fang Ma, Xiuli Yue, Zhifei Dai, Anil Kumar, Bin Jian. A novel amperometric biosensor based on single walled carbon nanotubes with acetylcholine esterase for the detection of carbaryl pesticide in water. Talanta. vol 83. issue 1. 2011-03-10. PMID:21035674. |
amperometric biosensor is fabricated for the detection of carbaryl based on single walled carbon nanotubes (swcnts) and acetylcholine esterase (ache). |
2011-03-10 |
2023-08-12 |
Not clear |
| F A Gbor. Brain and hypophyseal acetylcholinesterase activity of pubertal boars fed dietary fumonisin B1. Journal of animal physiology and animal nutrition. vol 94. issue 5. 2011-03-02. PMID:20546069. |
the effects of dietary fumonisin b(1) (fb(1)) on regional brain and hypophyseal activities of ache (ec 3117), the enzyme which catalyses the hydrolysis of acetylcholine, were studied using 24 male large white weanling pigs divided into four groups. |
2011-03-02 |
2023-08-12 |
Not clear |
| Qiong Wang, Li-Hua Sun, William Jia, Xin-Min Liu, Hai-Xia Dang, Wen-Li Mai, Ning Wang, Andre Steinmetz, Yu-Qin Wang, Chang-Jiang X. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564503. |
after 6 and 12 mg/kg of rg1 and rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (sd) and the morris water maze (mwm) tests, the acetylcholinesterase (ache) activity, acetylcholine (ach) content and serotonin (5-ht) level in the hippocampus were analysed after sd and mwm tests. |
2011-02-17 |
2023-08-12 |
mouse |
| Mohga M Badran, Maha Abdel Hakeem, Suzan M Abuel-Maaty, Afaf El-Malah, Rania M Abdel Sala. Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease. Archiv der Pharmazie. vol 343. issue 10. 2011-02-14. PMID:20925094. |
the newly synthesized compounds have been tested for their ability to inhibit acetylcholine esterase (ache) activity using tacrine as standard drug. |
2011-02-14 |
2023-08-12 |
Not clear |
| Carles Galdeano, Elisabet Viayna, Pau Arroyo, Axel Bidon-Chanal, J Ramón Blas, Diego Muñoz-Torrero, F Javier Luqu. Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents. Current pharmaceutical design. vol 16. issue 25. 2011-02-08. PMID:20698824. |
some dual binding site ache inhibitors take on added value a significant ability to additionally inhibit the enzymes butyrylcholinesterase and bace-1, involved in the co-regulation of the hydrolysis of the neurotransmitter acetylcholine and in aβ formation, respectively. |
2011-02-08 |
2023-08-12 |
Not clear |
| Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Chetan Bhutada, Santosh Tawari, Pankaj Dixit, Dharmendra Mundhad. Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats. Neurobiology of learning and memory. vol 94. issue 3. 2011-01-27. PMID:20620214. |
diabetes-related cognitive dysfunction is a consequence of changes within the central nervous system that are secondary to chronic hyperglycemia, oxidative stress, and cholinergic dysfunction, and probably therefore anti-diabetics, anti-oxidants, and acetylcholine esterase (ache) inhibitors were found to have beneficial effects in animal models. |
2011-01-27 |
2023-08-12 |
rat |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| M Kalogiannis, S L Grupke, P E Potter, J G Edwards, R M Chemelli, Y Y Kisanuki, M Yanagisawa, C S Leonar. Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576035. |
mrna for choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht) and the high-affinity choline transporter (cht1) but not acetylcholinesterase (ache) was significantly higher in samples from dko than wild-type (wt) mice. |
2011-01-13 |
2023-08-12 |
mouse |
| Yi Wang, Yun Tang, Ling-ling Xu, Xiao-ping Dia. [Ecotoxicolgical effects of albendazole on Eisenia fetida]. Ying yong sheng tai xue bao = The journal of applied ecology. vol 20. issue 9. 2010-12-23. PMID:20030157. |
by using artificial soil test, the effects of different concentration albendozole on eisenia foetida's growth, survival, reproduction, and activities of superoxide dismutase (sod), glutathione-sulfurtransferase (gst-s) and acetylcholine esterase (ache) were studied. |
2010-12-23 |
2023-08-12 |
Not clear |