| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Suganthy, S Karutha Pandian, K Pandima Dev. Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19897016. |
until date the only symptomatic treatment for this disease is based on the "cholinergic hypothesis" where the drugs enhance acetylcholine levels in the brain by inhibiting acetylcholinesterase (ache). |
2010-04-06 |
2023-08-12 |
Not clear |
| Iftach Shaked, Ari Meerson, Yochai Wolf, Ran Avni, David Greenberg, Adi Gilboa-Geffen, Hermona Sore. MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity. vol 31. issue 6. 2010-02-09. PMID:20005135. |
the brain, via vagal secretion of acetylcholine (ach), suppresses peripheral inflammation by intercepting cytokine production; therefore, we predicted that micrornas targeting acetylcholinesterase (ache) can attenuate inflammation. |
2010-02-09 |
2023-08-12 |
mouse |
| Can-Jun Ruan, Jian-Yong Si, Li Zhang, Di-Hua Chen, Guan-Hua Du, Lan S. Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta(25-35)-induced cognitive deficits in mice. Neuroscience letters. vol 467. issue 2. 2010-02-01. PMID:19833171. |
furthermore, superoxide dismutase (sod), choline acetyl transferase (chat) and acetylcholine esterase (ache) activity in hippocampus and cortex were analyzed by spectrophotometric method. |
2010-02-01 |
2023-08-12 |
mouse |
| Jiqu Xu, Shuang Rong, Bijun Xie, Zhida Sun, Li Zhang, Hailei Wu, Ping Yao, Xiping Zhang, Yunjian Zhang, Liegang Li. Rejuvenation of antioxidant and cholinergic systems contributes to the effect of procyanidins extracted from the lotus seedpod ameliorating memory impairment in cognitively impaired aged rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 12. 2010-01-25. PMID:19716273. |
in addition, lspc significantly restored acetylcholine (ach) contents and acetylcholinesterase (ache) activities in hippocampus and cerebral cortex of ai animals. |
2010-01-25 |
2023-08-12 |
rat |
| Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova, Kamil Kuc. Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19728005. |
the toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (ache; ec 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. |
2010-01-22 |
2023-08-12 |
rat |
| Bin Guo, Lingling Xu, Yahui Wei, Chunzhao Li. [Research advances of Huperzia serrata (Thunb.) Trev]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 34. issue 16. 2010-01-04. PMID:19938535. |
it has become known worldwide as a medicinal plant since chinese scientists discovered huperzine a from it in the 1980s, which is reversible, potent and selective acetylcholine esterase (ache) inhibitors by in vitro and in vivo pharmacological, and produce definite effects in the treatment of alzheimer's disease. |
2010-01-04 |
2023-08-12 |
Not clear |
| Eu Vian Tan, Christopher R Low. Holographic enzyme inhibition assays for drug discovery. Analytical chemistry. vol 81. issue 18. 2009-12-21. PMID:19681618. |
this report describes an enzyme inhibition-based holographic sensor as a potential label-free detection system, using acetylcholinesterase (acetylcholine acetylhydrolase; ec 3.1.1.7; abbreviated herein ache) as the model enzyme. |
2009-12-21 |
2023-08-12 |
Not clear |
| Mireille Basselin, Henry N Nguyen, Lisa Chang, Jane M Bell, Stanley I Rapopor. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363262. |
donepezil, an acetylcholinesterase (ache) inhibitor used for treating alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ach), and ach binding to cholinergic receptors. |
2009-12-16 |
2023-08-12 |
rat |
| Maria Laura Bolognesi, Manuela Bartolini, Michela Rosini, Vincenza Andrisano, Carlo Melchiorr. Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action. Bioorganic & medicinal chemistry letters. vol 19. issue 15. 2009-12-07. PMID:19505825. |
the rr stereoisomer 2 resulted more effective than 1 in reverting two important effects mediated by acetylcholinesterase (ache), that is, acetylcholine hydrolysis and ache-induced amyloid-beta aggregation. |
2009-12-07 |
2023-08-12 |
Not clear |
| Muniswamy David, Vineetkumar K Patil, Sameer G Chebbi, Shambangouda R Marigoudar, Jagadeesh B Chittaragi, Ramesh Halapp. Gas-liquid chromatography for fenvalerate residue analysis: in vivo alterations in the acetylcholinesterase activity and acetylcholine in different tissues of the fish, Labeo rohita (Hamilton). Toxicology mechanisms and methods. vol 19. issue 6-7. 2009-12-04. PMID:19778241. |
l. rohita on exposure to lethal (6 microg/l) and sub-lethal (0.75 microg/l) concentrations of fenvalerate showed time- and dose-dependent inhibition in the activity of ache, suggesting a decrease in the cholinergic transmission and consequent accumulation of acetylcholine (ach) in the tissues (brain, gill, liver, and muscle) leading to continuous nerve impulses, causing prolonged muscle contraction which, as a consequence, causes paralysis and results in death. |
2009-12-04 |
2023-08-12 |
Not clear |
| Ganesan Murali, Sugumar Dhivya, Periannan Rasappa. Role of Glutathione monoester on age-related neurochemical alterations in rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 7. 2009-12-01. PMID:19682566. |
the present study was aimed to assess the neuromodulatory role of glutathione monoester (gme) when administered intraperitoneally (12 mg/kg body weight) for 20 days on acetylcholine esterase (ache) activity, levels of neurotransmitters such as dopamine, serotonin, norepinephrine and rotorod behavioral analysis in discrete brain regions of young and aged male albino wistar rats. |
2009-12-01 |
2023-08-12 |
rat |
| Michael Shanks, Miia Kivipelto, Roger Bullock, Roger Lan. Cholinesterase inhibition: is there evidence for disease-modifying effects? Current medical research and opinion. vol 25. issue 10. 2009-11-27. PMID:19678754. |
symptomatic effects are mediated by the inhibition of acetyl- and/or butyryl-cholinesterase (ache and/or buche) - the enzymes that degrade acetylcholine (ach) in the synapse. |
2009-11-27 |
2023-08-12 |
Not clear |
| Yong Wang, Xin Ge, Xiao Fang Xu, Xiao Jing Wan. Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Medical hypotheses. vol 73. issue 4. 2009-11-16. PMID:19625132. |
these components include acetylcholine, choline acetyltransferase, acetylcholinesterase (ache) and nicotinic acetylcholine receptors. |
2009-11-16 |
2023-08-12 |
Not clear |
| A B Jolitha, M V V Subramanyam, S Asha Dev. Age-related responses of the rat cerebral cortex: influence of vitamin E and exercise on the cholinergic system. Biogerontology. vol 10. issue 1. 2009-10-15. PMID:18560990. |
acetylcholine esterase (ache) and cholineacetyl transferase (chat) activities and acetylcholine (ach) were measured in the cerebral cortex (cc) of male wistar rats of 4- (adult), 12- (middle-aged) and 18-months (old) of age. |
2009-10-15 |
2023-08-12 |
rat |
| b' Milan Jokanovi\\xc4\\x8. Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. Toxicology letters. vol 190. issue 2. 2009-09-28. PMID:19651196.' |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the nervous systems. |
2009-09-28 |
2023-08-12 |
human |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
cholinergic markers like acetylcholine (ach) and acetylcholinesterase (ache) were evaluated in hippocampus and cortex of rats. |
2009-08-31 |
2023-08-12 |
rat |
| Bomi Lee, Kangsik Jung, Dong-Hyun Ki. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacology, biochemistry, and behavior. vol 93. issue 2. 2009-08-28. PMID:19426756. |
ta3 also increased hippocampal acetylcholine levels in scopolamine-treated mice and dose-dependently inhibited acetylcholinesterase (ache) activity (ic(50) value, 35.4 microm). |
2009-08-28 |
2023-08-12 |
mouse |
| Filomena A Carvalho, José Pedro Almeida, Isabel O Fernandes, Teresa Freitas-Santos, Carlota Saldanh. Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. Clinical hemorheology and microcirculation. vol 40. issue 3. 2009-08-18. PMID:19029645. |
non-neuronal acetylcholine (ach) and acetylcholinesterase (ache) have been recognized in the past. |
2009-08-18 |
2023-08-12 |
Not clear |
| Milan Jokanović, Milica Prostra. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Current medicinal chemistry. vol 16. issue 17. 2009-08-03. PMID:19519385. |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. |
2009-08-03 |
2023-08-12 |
human |
| K Nakayama, H Katsu, K Kitazum. Effect of distigmine bromide on the central cholinergic system. Journal of psychopharmacology (Oxford, England). vol 23. issue 2. 2009-07-28. PMID:18515453. |
distigmine bromide (3, 3'-[hexamethylenebis (methyliminocarbonyloxy)] bis (1-methylpyridinium) dibromide), an acetylcholinesterase (ache) inhibitor, produced a time-dependent and dose-dependent increase in acetylcholine (ach) levels in the medial prefrontal cortex of rats. |
2009-07-28 |
2023-08-12 |
rat |