| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vineetkumar K Patil, Muniswamy Davi. Behavioral and morphological endpoints: as an early response to sublethal malathion intoxication in the freshwater fish, Labeo rohita. Drug and chemical toxicology. vol 33. issue 2. 2010-06-08. PMID:20307142. |
inhibition of ache activity results in excess accumulation of acetylcholine in cholinergic synapses, leading to hyperstimulation and cessation of neuronal transmission (i.e., paralysis). |
2010-06-08 |
2023-08-12 |
Not clear |
| Kamil Musilek, Marketa Komloova, Vlasta Zavadova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Florian Nachon, Martin Dolezal, Kamil Kuca, Young-Sik Jun. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorganic & medicinal chemistry letters. vol 20. issue 5. 2010-05-27. PMID:20138518. |
reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of myasthenia gravis (mg) to block acetylcholinesterase (ache) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. |
2010-05-27 |
2023-08-12 |
human |
| Susana Almeida, Augusto Filipe, Rita Neves, Isabelle Desjardins, Eric Shink, Araceli Castill. Bioequivalence study of two different tablet formulations of donepezil using truncated areas under the curve. A single-center, single-dose, randomized, open-label, 2-way crossover study under fasting conditions. Arzneimittel-Forschung. vol 60. issue 3. 2010-05-26. PMID:20422942. |
this is accomplished by increasing the concentration of acetylcholine (ach) through reversible inhibition of its hydrolysis by ache. |
2010-05-26 |
2023-08-12 |
Not clear |
| Balakrishnan Savitha, Binoy Joseph, T Peeyush Kumar, C S Paulos. Acetylcholine and muscarinic receptor function in cerebral cortex of diabetic young and old male Wistar rats and the role of muscarinic receptors in calcium release from pancreatic islets. Biogerontology. vol 11. issue 2. 2010-05-20. PMID:19554469. |
we investigated acetylcholine esterase (ache) activity, acetylcholine and muscarinic m1, m3 receptors kinetics in the cerebral cortex of young and old streptozotocin induced and insulin treated diabetic rats. |
2010-05-20 |
2023-08-12 |
rat |
| T Rush, X Q Liu, J Hjelmhaug, D Lobne. Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. vol 166. issue 3. 2010-05-17. PMID:20096330. |
these results strongly suggest that the organophosphorous toxicity observed in this culture system is not mediated by buildup of extracellular acetylcholine resulting from inhibition of ache. |
2010-05-17 |
2023-08-12 |
Not clear |
| Richard M van Rijn, In K Rhee, Robert Verpoort. Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii. Natural product research. vol 24. issue 3. 2010-05-07. PMID:20140801. |
therefore, one of the methods that has proven successful in the treatment of ad is the use of inhibitors of acetylcholinesterase (ache) to supplement the acetylcholine level. |
2010-05-07 |
2023-08-12 |
Not clear |
| Denis V Abramochkin, Leniz F Nurullin, Anastasia A Borodinova, Nadezhda V Tarasova, Galina S Sukhova, Eugen E Nikolsky, Leonid V Rosenshtrauk. Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats. Experimental physiology. vol 95. issue 2. 2010-05-06. PMID:19767403. |
acetylcholinesterase (ache) inhibitors provoke typical cholinergic effects in the isolated right atrium of the rat due to the accumulation of acetylcholine (ach). |
2010-05-06 |
2023-08-12 |
rat |
| John C O'Donnell, John H McDonough, Tsung-Ming Shi. Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163292. |
organophosphorus nerve agents irreversibly inhibit acetylcholinesterase (ache) in the peripheral and central nervous systems, causing an increase in the concentration of acetylcholine (ach) in the synapse or neuromuscular junction and subsequent adverse effects. |
2010-04-30 |
2023-08-12 |
Not clear |
| Fang Fang, Lih-Fen Lue, Shiqiang Yan, Hongwei Xu, John S Luddy, Doris Chen, Douglas G Walker, David M Stern, Shifang Yan, Ann Marie Schmidt, John X Chen, Shirley ShiDu Ya. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 4. 2010-04-28. PMID:19906677. |
transgenic (tg) mice expressing human mutant app (mapp) in neurons and rage in microglia displayed enhanced il-1beta and tnf-alpha production, increased infiltration of microglia and astrocytes, accumulation of abeta, reduced acetylcholine esterase (ache) activity, and accelerated deterioration of spatial learning/memory. |
2010-04-28 |
2023-08-12 |
mouse |
| Kenneth Grasing, Deepan Mathur, Thomas F Newton, Cherilyn DeSouz. Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals. Drug and alcohol dependence. vol 107. issue 1. 2010-04-22. PMID:19836169. |
acetylcholinesterase (ache) inhibitors increase synaptic levels of acetylcholine (ach) by inhibiting its breakdown. |
2010-04-22 |
2023-08-12 |
human |
| Andrew G Engel, Xin-Ming Shen, Duygu Selcen, Steven M Sin. What have we learned from the congenital myasthenic syndromes. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19688192. |
for example, electrophysiologic studies in patients suffering from sudden episodes of apnea pointed to a defect in acetylcholine resynthesis and chat as the candidate gene (ohno et al., proc natl acad sci usa 98:2017-2022, 2001); refractoriness to anticholinesterase medications and partial or complete absence of acetylcholinesterase (ache) from the endplates (eps) has pointed to one of the two genes (colq and ache ( t )) encoding ache, though mutations were observed only in colq. |
2010-04-21 |
2023-08-12 |
Not clear |
| Terrone L Rosenberr. Strategies to resolve the catalytic mechanism of acetylcholinesterase. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19757206. |
acetylcholinesterase (ache) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. |
2010-04-21 |
2023-08-12 |
Not clear |
| N Suganthy, S Karutha Pandian, K Pandima Dev. Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19897016. |
until date the only symptomatic treatment for this disease is based on the "cholinergic hypothesis" where the drugs enhance acetylcholine levels in the brain by inhibiting acetylcholinesterase (ache). |
2010-04-06 |
2023-08-12 |
Not clear |
| Iftach Shaked, Ari Meerson, Yochai Wolf, Ran Avni, David Greenberg, Adi Gilboa-Geffen, Hermona Sore. MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity. vol 31. issue 6. 2010-02-09. PMID:20005135. |
the brain, via vagal secretion of acetylcholine (ach), suppresses peripheral inflammation by intercepting cytokine production; therefore, we predicted that micrornas targeting acetylcholinesterase (ache) can attenuate inflammation. |
2010-02-09 |
2023-08-12 |
mouse |
| Can-Jun Ruan, Jian-Yong Si, Li Zhang, Di-Hua Chen, Guan-Hua Du, Lan S. Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta(25-35)-induced cognitive deficits in mice. Neuroscience letters. vol 467. issue 2. 2010-02-01. PMID:19833171. |
furthermore, superoxide dismutase (sod), choline acetyl transferase (chat) and acetylcholine esterase (ache) activity in hippocampus and cortex were analyzed by spectrophotometric method. |
2010-02-01 |
2023-08-12 |
mouse |
| Jiqu Xu, Shuang Rong, Bijun Xie, Zhida Sun, Li Zhang, Hailei Wu, Ping Yao, Xiping Zhang, Yunjian Zhang, Liegang Li. Rejuvenation of antioxidant and cholinergic systems contributes to the effect of procyanidins extracted from the lotus seedpod ameliorating memory impairment in cognitively impaired aged rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 12. 2010-01-25. PMID:19716273. |
in addition, lspc significantly restored acetylcholine (ach) contents and acetylcholinesterase (ache) activities in hippocampus and cerebral cortex of ai animals. |
2010-01-25 |
2023-08-12 |
rat |
| Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova, Kamil Kuc. Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19728005. |
the toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (ache; ec 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. |
2010-01-22 |
2023-08-12 |
rat |
| Bin Guo, Lingling Xu, Yahui Wei, Chunzhao Li. [Research advances of Huperzia serrata (Thunb.) Trev]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 34. issue 16. 2010-01-04. PMID:19938535. |
it has become known worldwide as a medicinal plant since chinese scientists discovered huperzine a from it in the 1980s, which is reversible, potent and selective acetylcholine esterase (ache) inhibitors by in vitro and in vivo pharmacological, and produce definite effects in the treatment of alzheimer's disease. |
2010-01-04 |
2023-08-12 |
Not clear |
| Eu Vian Tan, Christopher R Low. Holographic enzyme inhibition assays for drug discovery. Analytical chemistry. vol 81. issue 18. 2009-12-21. PMID:19681618. |
this report describes an enzyme inhibition-based holographic sensor as a potential label-free detection system, using acetylcholinesterase (acetylcholine acetylhydrolase; ec 3.1.1.7; abbreviated herein ache) as the model enzyme. |
2009-12-21 |
2023-08-12 |
Not clear |
| Mireille Basselin, Henry N Nguyen, Lisa Chang, Jane M Bell, Stanley I Rapopor. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363262. |
donepezil, an acetylcholinesterase (ache) inhibitor used for treating alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ach), and ach binding to cholinergic receptors. |
2009-12-16 |
2023-08-12 |
rat |