| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang-Hoon Lee, Jin-Sook Park, Se-Kwon Kim, Chang-Bum Ahn, Jae-Young J. Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells. Bioorganic & medicinal chemistry letters. vol 19. issue 3. 2010-07-06. PMID:19097785. |
clinical applications of acetylcholinesterase (ache) inhibitors are widespread in alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. |
2010-07-06 |
2023-08-12 |
Not clear |
| Torsten Geissler, Wolfgang Brandt, Andrea Porzel, Dagmar Schlenzig, Astrid Kehlen, Ludger Wessjohann, Norbert Arnol. Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorganic & medicinal chemistry. vol 18. issue 6. 2010-07-06. PMID:20176490. |
inhibition of acetylcholinesterase (ache) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for alzheimer s disease (ad), today. |
2010-07-06 |
2023-08-12 |
Not clear |
| Gracielle Alves-Amaral, Marcelo Pires-Oliveira, Ana Luiza Andrade-Lopes, Tiago Chiavegatti, Rosely Oliveira Godinh. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal. Chemico-biological interactions. vol 186. issue 1. 2010-07-01. PMID:20399201. |
the role of acetylcholinesterase (ache) in the termination of the cholinergic response through acetylcholine (ach) hydrolysis and the involvement of plasma butyrylcholinesterase (buche), mainly of hepatic origin, in the metabolism of xenobiotics with ester bonds is well known. |
2010-07-01 |
2023-08-12 |
rat |
| Chawanrat Somnuek, Chuta Boonphakdee, Voravit Cheevaporn, Keiichi Tanak. Gene expression of acetylcholinesterase in hybrid catfish (Clarias gariepinus X Clarias macrocephalus) exposed to chlorpyrifos and carbaryl. Journal of environmental biology. vol 30. issue 1. 2010-06-30. PMID:20112867. |
after serving as an eurotransmitter, acetylcholine is hydrolyzed by acetylcholinesterase (ache). |
2010-06-30 |
2023-08-12 |
Not clear |
| J P Changeux, T Podleski, J C Meunie. On Some Structural Analogies between Acetylcholinesterase and the Macromolecular Receptor of Acetylcholine. The Journal of general physiology. vol 54. issue 1. 2010-06-29. PMID:19873643. |
several properties of the enzyme acetylcholinesterase (ache) isolated in vitro are compared with those of the membrane receptor(s) of acetylcholine expressed by the in vivo electrical response of the electroplax membrane. |
2010-06-29 |
2023-08-12 |
Not clear |
| Kelvin Kin-Kwan Wong, Michelle Tsz-Wan Ho, Huang Quan Lin, Kwok-Fai Lau, John A Rudd, Ronald Chi-Kit Chung, Kwok-Pui Fung, Pang-Chui Shaw, David Chi-Cheong Wa. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta medica. vol 76. issue 3. 2010-06-18. PMID:19774505. |
the current therapeutic intervention for ad is primarily based on the inhibition of brain acetylcholinesterase (ache) to restore the brain acetylcholine level. |
2010-06-18 |
2023-08-12 |
human |
| Marco Giorgetti, Jacqueline A Gibbons, Sebastián Bernales, Iván E Alfaro, Christophe Drieu La Rochelle, Thomas Cremers, C Anthony Altar, Robert Wronski, Birgit Hutter-Paier, Andrew A Protte. Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. The Journal of pharmacology and experimental therapeutics. vol 333. issue 3. 2010-06-11. PMID:20194526. |
unlike the ache inhibitors donepezil and galantamine, dimebon did not change acetylcholine levels in the hippocampus or prefrontal cortex of freely moving rats. |
2010-06-11 |
2023-08-12 |
human |
| Helena Gustafsson, Johan Runesson, Jessica Lundqvist, Heléne Lindegren, Viktoria Axelsson, Anna Forsb. Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity. Toxicology and applied pharmacology. vol 245. issue 2. 2010-06-11. PMID:20211194. |
we studied cell membrane potential (cmp), noradrenalin (na) uptake, acetylcholine esterase (ache) activity, acetylcholine receptor (achr) signalling and voltage-operated calcium channel (vocc) function in human neuroblastoma sh-sy5y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals. |
2010-06-11 |
2023-08-12 |
mouse |
| Vineetkumar K Patil, Muniswamy Davi. Behavioral and morphological endpoints: as an early response to sublethal malathion intoxication in the freshwater fish, Labeo rohita. Drug and chemical toxicology. vol 33. issue 2. 2010-06-08. PMID:20307142. |
inhibition of ache activity results in excess accumulation of acetylcholine in cholinergic synapses, leading to hyperstimulation and cessation of neuronal transmission (i.e., paralysis). |
2010-06-08 |
2023-08-12 |
Not clear |
| Kamil Musilek, Marketa Komloova, Vlasta Zavadova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Florian Nachon, Martin Dolezal, Kamil Kuca, Young-Sik Jun. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorganic & medicinal chemistry letters. vol 20. issue 5. 2010-05-27. PMID:20138518. |
reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of myasthenia gravis (mg) to block acetylcholinesterase (ache) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. |
2010-05-27 |
2023-08-12 |
human |
| Susana Almeida, Augusto Filipe, Rita Neves, Isabelle Desjardins, Eric Shink, Araceli Castill. Bioequivalence study of two different tablet formulations of donepezil using truncated areas under the curve. A single-center, single-dose, randomized, open-label, 2-way crossover study under fasting conditions. Arzneimittel-Forschung. vol 60. issue 3. 2010-05-26. PMID:20422942. |
this is accomplished by increasing the concentration of acetylcholine (ach) through reversible inhibition of its hydrolysis by ache. |
2010-05-26 |
2023-08-12 |
Not clear |
| Balakrishnan Savitha, Binoy Joseph, T Peeyush Kumar, C S Paulos. Acetylcholine and muscarinic receptor function in cerebral cortex of diabetic young and old male Wistar rats and the role of muscarinic receptors in calcium release from pancreatic islets. Biogerontology. vol 11. issue 2. 2010-05-20. PMID:19554469. |
we investigated acetylcholine esterase (ache) activity, acetylcholine and muscarinic m1, m3 receptors kinetics in the cerebral cortex of young and old streptozotocin induced and insulin treated diabetic rats. |
2010-05-20 |
2023-08-12 |
rat |
| T Rush, X Q Liu, J Hjelmhaug, D Lobne. Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. vol 166. issue 3. 2010-05-17. PMID:20096330. |
these results strongly suggest that the organophosphorous toxicity observed in this culture system is not mediated by buildup of extracellular acetylcholine resulting from inhibition of ache. |
2010-05-17 |
2023-08-12 |
Not clear |
| Richard M van Rijn, In K Rhee, Robert Verpoort. Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii. Natural product research. vol 24. issue 3. 2010-05-07. PMID:20140801. |
therefore, one of the methods that has proven successful in the treatment of ad is the use of inhibitors of acetylcholinesterase (ache) to supplement the acetylcholine level. |
2010-05-07 |
2023-08-12 |
Not clear |
| Denis V Abramochkin, Leniz F Nurullin, Anastasia A Borodinova, Nadezhda V Tarasova, Galina S Sukhova, Eugen E Nikolsky, Leonid V Rosenshtrauk. Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats. Experimental physiology. vol 95. issue 2. 2010-05-06. PMID:19767403. |
acetylcholinesterase (ache) inhibitors provoke typical cholinergic effects in the isolated right atrium of the rat due to the accumulation of acetylcholine (ach). |
2010-05-06 |
2023-08-12 |
rat |
| John C O'Donnell, John H McDonough, Tsung-Ming Shi. Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163292. |
organophosphorus nerve agents irreversibly inhibit acetylcholinesterase (ache) in the peripheral and central nervous systems, causing an increase in the concentration of acetylcholine (ach) in the synapse or neuromuscular junction and subsequent adverse effects. |
2010-04-30 |
2023-08-12 |
Not clear |
| Fang Fang, Lih-Fen Lue, Shiqiang Yan, Hongwei Xu, John S Luddy, Doris Chen, Douglas G Walker, David M Stern, Shifang Yan, Ann Marie Schmidt, John X Chen, Shirley ShiDu Ya. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 4. 2010-04-28. PMID:19906677. |
transgenic (tg) mice expressing human mutant app (mapp) in neurons and rage in microglia displayed enhanced il-1beta and tnf-alpha production, increased infiltration of microglia and astrocytes, accumulation of abeta, reduced acetylcholine esterase (ache) activity, and accelerated deterioration of spatial learning/memory. |
2010-04-28 |
2023-08-12 |
mouse |
| Kenneth Grasing, Deepan Mathur, Thomas F Newton, Cherilyn DeSouz. Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals. Drug and alcohol dependence. vol 107. issue 1. 2010-04-22. PMID:19836169. |
acetylcholinesterase (ache) inhibitors increase synaptic levels of acetylcholine (ach) by inhibiting its breakdown. |
2010-04-22 |
2023-08-12 |
human |
| Andrew G Engel, Xin-Ming Shen, Duygu Selcen, Steven M Sin. What have we learned from the congenital myasthenic syndromes. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19688192. |
for example, electrophysiologic studies in patients suffering from sudden episodes of apnea pointed to a defect in acetylcholine resynthesis and chat as the candidate gene (ohno et al., proc natl acad sci usa 98:2017-2022, 2001); refractoriness to anticholinesterase medications and partial or complete absence of acetylcholinesterase (ache) from the endplates (eps) has pointed to one of the two genes (colq and ache ( t )) encoding ache, though mutations were observed only in colq. |
2010-04-21 |
2023-08-12 |
Not clear |
| Terrone L Rosenberr. Strategies to resolve the catalytic mechanism of acetylcholinesterase. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19757206. |
acetylcholinesterase (ache) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. |
2010-04-21 |
2023-08-12 |
Not clear |