| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| C S Yadav, V Kumar, S G Suke, R S Ahmed, P K Mediratta, B D Banerje. Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera. Indian journal of biochemistry & biophysics. vol 47. issue 2. 2010-09-17. PMID:20521626. |
blood and brain acetylcholine esterase (ache) activity was also assessed. |
2010-09-17 |
2023-08-12 |
rat |
| Can-Jun Ruan, Li Zhang, Di-Hua Chen, Zhan Li, Guan-Hua Du, Lan Su. Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Abeta(25-35) both in vitro and in vivo. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20346380. |
at the same time, the decreased superoxide dismutase (sod) and choline acetyl transferase (chat) were markedly increased, and the increased acetylcholine esterase (ache) activity was significantly decreased in hippocampus and cortex. |
2010-09-13 |
2023-08-12 |
mouse |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia. Experimental brain research. vol 203. issue 3. 2010-09-03. PMID:20458473. |
cholinergic markers like acetylcholine (ach) and acetyl cholinesterase (ache) were evaluated from cortex and hippocampus. |
2010-09-03 |
2023-08-12 |
rat |
| Peter Eyer, Franz Worek, Horst Thiermann, Michael Eddlesto. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:19883634. |
it is generally accepted that inhibition of acetylcholinesterase (ache) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. |
2010-09-01 |
2023-08-12 |
mouse |
| Suzana Berend, Bozica Radić, Kamil Kuca, Ana Lucić Vrdolja. The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138854. |
inhibition of ache results in accumulation of acetylcholine (ach) at the synaptic cleft of the cholinergic neurons, leading to overstimulation of cholinergic receptors. |
2010-09-01 |
2023-08-12 |
mouse |
| Julian R Haigh, Michael Adler, James P Apland, Sharad S Deshpande, Charles B Barham, Patrick Desmond, Irwin Koplovitz, David E Lenz, Richard K Gordo. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20144889. |
organophosphate (op) chemical warfare agents such as gd exert their toxic effects by inhibiting acetylcholinesterase (ache) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). |
2010-09-01 |
2023-08-12 |
marmoset |
| Séverine M Sigoillot, Francine Bourgeois, Claire Lega. Cholinesterases regulation in the absence of ColQ. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20153305. |
one of these molecules is acetylcholinesterase (ache) that regulates acetylcholine levels. |
2010-09-01 |
2023-08-12 |
Not clear |
| Heidi Q Xie, K Wing Leung, Vicky P Chen, Gallant K L Chan, Sherry L Xu, Ava J Y Guo, Kevin Y Zhu, Ken Y Z Zheng, Cathy W Bi, Janis Y X Zhan, Wallace K P Chan, Roy C Y Choi, Karl W K Tsi. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20178777. |
acetylcholinesterase (ache), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. |
2010-09-01 |
2023-08-12 |
Not clear |
| Kelvin Kin-Kwan Wong, Jacky Chi-Ki Ngo, Sijie Liu, Huang-Quan Lin, Chun Hu, Pang-Chui Shaw, David Chi-Cheong Wa. Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20350537. |
current therapeutic intervention for ad is primarily based on the inhibition of brain acetylcholinesterase (ache) to restore the brain acetylcholine level. |
2010-09-01 |
2023-08-12 |
human |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Ramesh Halappa, Muniswamy Davi. In vivo inhibition of acetylcholinesterase activity in functionally different tissues of the freshwater fish, Cyprinus carpio, under chlorpyrifos exposure. Drug metabolism and drug interactions. vol 24. issue 2-4. 2010-07-08. PMID:20408496. |
depression of ache activity suggested decreased cholinergic transmission and consequent accumulation of acetylcholine (ach). |
2010-07-08 |
2023-08-12 |
Not clear |
| Sang-Hoon Lee, Jin-Sook Park, Se-Kwon Kim, Chang-Bum Ahn, Jae-Young J. Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells. Bioorganic & medicinal chemistry letters. vol 19. issue 3. 2010-07-06. PMID:19097785. |
clinical applications of acetylcholinesterase (ache) inhibitors are widespread in alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. |
2010-07-06 |
2023-08-12 |
Not clear |
| Torsten Geissler, Wolfgang Brandt, Andrea Porzel, Dagmar Schlenzig, Astrid Kehlen, Ludger Wessjohann, Norbert Arnol. Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorganic & medicinal chemistry. vol 18. issue 6. 2010-07-06. PMID:20176490. |
inhibition of acetylcholinesterase (ache) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for alzheimer s disease (ad), today. |
2010-07-06 |
2023-08-12 |
Not clear |
| Gracielle Alves-Amaral, Marcelo Pires-Oliveira, Ana Luiza Andrade-Lopes, Tiago Chiavegatti, Rosely Oliveira Godinh. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal. Chemico-biological interactions. vol 186. issue 1. 2010-07-01. PMID:20399201. |
the role of acetylcholinesterase (ache) in the termination of the cholinergic response through acetylcholine (ach) hydrolysis and the involvement of plasma butyrylcholinesterase (buche), mainly of hepatic origin, in the metabolism of xenobiotics with ester bonds is well known. |
2010-07-01 |
2023-08-12 |
rat |
| Chawanrat Somnuek, Chuta Boonphakdee, Voravit Cheevaporn, Keiichi Tanak. Gene expression of acetylcholinesterase in hybrid catfish (Clarias gariepinus X Clarias macrocephalus) exposed to chlorpyrifos and carbaryl. Journal of environmental biology. vol 30. issue 1. 2010-06-30. PMID:20112867. |
after serving as an eurotransmitter, acetylcholine is hydrolyzed by acetylcholinesterase (ache). |
2010-06-30 |
2023-08-12 |
Not clear |
| J P Changeux, T Podleski, J C Meunie. On Some Structural Analogies between Acetylcholinesterase and the Macromolecular Receptor of Acetylcholine. The Journal of general physiology. vol 54. issue 1. 2010-06-29. PMID:19873643. |
several properties of the enzyme acetylcholinesterase (ache) isolated in vitro are compared with those of the membrane receptor(s) of acetylcholine expressed by the in vivo electrical response of the electroplax membrane. |
2010-06-29 |
2023-08-12 |
Not clear |
| Kelvin Kin-Kwan Wong, Michelle Tsz-Wan Ho, Huang Quan Lin, Kwok-Fai Lau, John A Rudd, Ronald Chi-Kit Chung, Kwok-Pui Fung, Pang-Chui Shaw, David Chi-Cheong Wa. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta medica. vol 76. issue 3. 2010-06-18. PMID:19774505. |
the current therapeutic intervention for ad is primarily based on the inhibition of brain acetylcholinesterase (ache) to restore the brain acetylcholine level. |
2010-06-18 |
2023-08-12 |
human |
| Marco Giorgetti, Jacqueline A Gibbons, Sebastián Bernales, Iván E Alfaro, Christophe Drieu La Rochelle, Thomas Cremers, C Anthony Altar, Robert Wronski, Birgit Hutter-Paier, Andrew A Protte. Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. The Journal of pharmacology and experimental therapeutics. vol 333. issue 3. 2010-06-11. PMID:20194526. |
unlike the ache inhibitors donepezil and galantamine, dimebon did not change acetylcholine levels in the hippocampus or prefrontal cortex of freely moving rats. |
2010-06-11 |
2023-08-12 |
human |
| Helena Gustafsson, Johan Runesson, Jessica Lundqvist, Heléne Lindegren, Viktoria Axelsson, Anna Forsb. Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity. Toxicology and applied pharmacology. vol 245. issue 2. 2010-06-11. PMID:20211194. |
we studied cell membrane potential (cmp), noradrenalin (na) uptake, acetylcholine esterase (ache) activity, acetylcholine receptor (achr) signalling and voltage-operated calcium channel (vocc) function in human neuroblastoma sh-sy5y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals. |
2010-06-11 |
2023-08-12 |
mouse |