| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Laura Bolognesi, Manuela Bartolini, Michela Rosini, Vincenza Andrisano, Carlo Melchiorr. Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action. Bioorganic & medicinal chemistry letters. vol 19. issue 15. 2009-12-07. PMID:19505825. |
the rr stereoisomer 2 resulted more effective than 1 in reverting two important effects mediated by acetylcholinesterase (ache), that is, acetylcholine hydrolysis and ache-induced amyloid-beta aggregation. |
2009-12-07 |
2023-08-12 |
Not clear |
| Muniswamy David, Vineetkumar K Patil, Sameer G Chebbi, Shambangouda R Marigoudar, Jagadeesh B Chittaragi, Ramesh Halapp. Gas-liquid chromatography for fenvalerate residue analysis: in vivo alterations in the acetylcholinesterase activity and acetylcholine in different tissues of the fish, Labeo rohita (Hamilton). Toxicology mechanisms and methods. vol 19. issue 6-7. 2009-12-04. PMID:19778241. |
l. rohita on exposure to lethal (6 microg/l) and sub-lethal (0.75 microg/l) concentrations of fenvalerate showed time- and dose-dependent inhibition in the activity of ache, suggesting a decrease in the cholinergic transmission and consequent accumulation of acetylcholine (ach) in the tissues (brain, gill, liver, and muscle) leading to continuous nerve impulses, causing prolonged muscle contraction which, as a consequence, causes paralysis and results in death. |
2009-12-04 |
2023-08-12 |
Not clear |
| Ganesan Murali, Sugumar Dhivya, Periannan Rasappa. Role of Glutathione monoester on age-related neurochemical alterations in rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 7. 2009-12-01. PMID:19682566. |
the present study was aimed to assess the neuromodulatory role of glutathione monoester (gme) when administered intraperitoneally (12 mg/kg body weight) for 20 days on acetylcholine esterase (ache) activity, levels of neurotransmitters such as dopamine, serotonin, norepinephrine and rotorod behavioral analysis in discrete brain regions of young and aged male albino wistar rats. |
2009-12-01 |
2023-08-12 |
rat |
| Michael Shanks, Miia Kivipelto, Roger Bullock, Roger Lan. Cholinesterase inhibition: is there evidence for disease-modifying effects? Current medical research and opinion. vol 25. issue 10. 2009-11-27. PMID:19678754. |
symptomatic effects are mediated by the inhibition of acetyl- and/or butyryl-cholinesterase (ache and/or buche) - the enzymes that degrade acetylcholine (ach) in the synapse. |
2009-11-27 |
2023-08-12 |
Not clear |
| Yong Wang, Xin Ge, Xiao Fang Xu, Xiao Jing Wan. Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Medical hypotheses. vol 73. issue 4. 2009-11-16. PMID:19625132. |
these components include acetylcholine, choline acetyltransferase, acetylcholinesterase (ache) and nicotinic acetylcholine receptors. |
2009-11-16 |
2023-08-12 |
Not clear |
| A B Jolitha, M V V Subramanyam, S Asha Dev. Age-related responses of the rat cerebral cortex: influence of vitamin E and exercise on the cholinergic system. Biogerontology. vol 10. issue 1. 2009-10-15. PMID:18560990. |
acetylcholine esterase (ache) and cholineacetyl transferase (chat) activities and acetylcholine (ach) were measured in the cerebral cortex (cc) of male wistar rats of 4- (adult), 12- (middle-aged) and 18-months (old) of age. |
2009-10-15 |
2023-08-12 |
rat |
| b' Milan Jokanovi\\xc4\\x8. Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. Toxicology letters. vol 190. issue 2. 2009-09-28. PMID:19651196.' |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the nervous systems. |
2009-09-28 |
2023-08-12 |
human |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
cholinergic markers like acetylcholine (ach) and acetylcholinesterase (ache) were evaluated in hippocampus and cortex of rats. |
2009-08-31 |
2023-08-12 |
rat |
| Bomi Lee, Kangsik Jung, Dong-Hyun Ki. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacology, biochemistry, and behavior. vol 93. issue 2. 2009-08-28. PMID:19426756. |
ta3 also increased hippocampal acetylcholine levels in scopolamine-treated mice and dose-dependently inhibited acetylcholinesterase (ache) activity (ic(50) value, 35.4 microm). |
2009-08-28 |
2023-08-12 |
mouse |
| Filomena A Carvalho, José Pedro Almeida, Isabel O Fernandes, Teresa Freitas-Santos, Carlota Saldanh. Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. Clinical hemorheology and microcirculation. vol 40. issue 3. 2009-08-18. PMID:19029645. |
non-neuronal acetylcholine (ach) and acetylcholinesterase (ache) have been recognized in the past. |
2009-08-18 |
2023-08-12 |
Not clear |
| Milan Jokanović, Milica Prostra. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Current medicinal chemistry. vol 16. issue 17. 2009-08-03. PMID:19519385. |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. |
2009-08-03 |
2023-08-12 |
human |
| K Nakayama, H Katsu, K Kitazum. Effect of distigmine bromide on the central cholinergic system. Journal of psychopharmacology (Oxford, England). vol 23. issue 2. 2009-07-28. PMID:18515453. |
distigmine bromide (3, 3'-[hexamethylenebis (methyliminocarbonyloxy)] bis (1-methylpyridinium) dibromide), an acetylcholinesterase (ache) inhibitor, produced a time-dependent and dose-dependent increase in acetylcholine (ach) levels in the medial prefrontal cortex of rats. |
2009-07-28 |
2023-08-12 |
rat |
| G Gireesh, T Peeyush Kumar, Jobin Mathew, Cs Paulos. Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats. Journal of biomedical science. vol 16. 2009-07-09. PMID:19344500. |
in this study, we have investigated the changes of acetylcholine esterase (ache) enzyme activity, total muscarinic and muscarinic m1 receptor binding and gene expression in the corpus striatum of stz--diabetic rats and the insulin treated diabetic rats. |
2009-07-09 |
2023-08-12 |
rat |
| E Dere, Q Zheng-Fischhöfer, D Viggiano, U A Gironi Carnevale, L A Ruocco, A Zlomuzica, M Schnichels, K Willecke, J P Huston, A G Sadil. Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex. Neuroscience. vol 153. issue 2. 2009-06-29. PMID:18384970. |
we found increased levels of acetylcholine esterase (ache) and camp response element-binding protein (creb) in the striatum of cx31.1 ko mice. |
2009-06-29 |
2023-08-12 |
mouse |
| Ilya Goykhman, Nina Korbakov, Carmen Bartic, Gustaaf Borghs, Micha E Spira, Joseph Shappir, Shlomo Yitzchai. Direct detection of molecular biorecognition by dipole sensing mechanism. Journal of the American Chemical Society. vol 131. issue 13. 2009-06-29. PMID:19292449. |
it is shown for the first time that biorecognition of acetylcholine (ach) can be translated to conformational changes in the enzyme, acetylcholine-esterase (ache), which in turn induces a measurable change in surface potential. |
2009-06-29 |
2023-08-12 |
Not clear |
| F A Carvalho, J P Lopes de Almeida, T Freitas-Santos, C Saldanh. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. The Journal of membrane biology. vol 228. issue 2. 2009-06-26. PMID:19294450. |
circulating acetylcholine, substrate of membrane acetylcholinesterase (ache), is known to enhance the band 3 protein degree of phosphorylation. |
2009-06-26 |
2023-08-12 |
Not clear |
| F A Carvalho, J P Lopes de Almeida, T Freitas-Santos, C Saldanh. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. The Journal of membrane biology. vol 228. issue 2. 2009-06-26. PMID:19294450. |
from blood samples of healthy donors, erythrocyte suspensions were prepared and incubated with ache substrate (acetylcholine) and inhibitor (velnacrine), along with protein tyrosine kinase (ptk) and tyrosine phosphatase (ptp) inhibitors. |
2009-06-26 |
2023-08-12 |
Not clear |
| Savitha Balakrishnan, Jobin Mathew, Sherin Antony, Cheramadathikudyil S Paulos. Muscarinic M(1), M(3) receptors function in the brainstem of streptozotocin induced diabetic rats: their role in insulin secretion from the pancreatic islets as a function of age. European journal of pharmacology. vol 608. issue 1-3. 2009-06-24. PMID:19347982. |
in the present study, we have investigated acetylcholine esterase (ache) activity and muscarinic m(1), m(3) receptors kinetics in the brainstem of both young and old streptozotocin induced and insulin treated diabetic rats (d + i). |
2009-06-24 |
2023-08-12 |
rat |
| Anne-Marie O'Donnell, Prem Pur. Cholinergic innervation in the developing chick cloaca and colorectum. Journal of pediatric surgery. vol 44. issue 2. 2009-06-09. PMID:19231541. |
acetylcholinesterase (ache) is an enzyme involved in hydrolysing acetylcholine during its metabolism. |
2009-06-09 |
2023-08-12 |
human |
| Hiroshi Murabayashi, Hirofumi Kuramoto, Katsushi Ishikawa, Jun Iwamoto, Kiyoshi Miyakawa, Kunio Tanaka, Mitsuo Sekikawa, Motoki Sasaki, Nobuo Kitamura, Yukio Oomor. Acetylcholinesterase activity, choline acetyltransferase and vesicular acetylcholine transporter immunoreactivities in the rat adrenal gland during postnatal development. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 3. 2009-05-19. PMID:19248156. |
from postnatal-day-0 to postnatal-day-2, a few acetylcholinesterase (ache)-active and choline acetytransferase (chat)-immunoreactive nerve fibers and relatively numerous vesicular acetylcholine transporter (vacht)-immunoreactive puncta were observed in the rat adrenal medulla. |
2009-05-19 |
2023-08-12 |
rat |