| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Dutta, D Bhattacharyay, A Mukherjee, S J Setford, A P F Turner, P Sarka. Detection of pesticide by polymeric enzyme electrodes. Ecotoxicology and environmental safety. vol 69. issue 3. 2008-08-11. PMID:17328951. |
screen-printed electrodes (spes) containing immobilized acetylcholine esterase (ache) enzyme were used for the electrochemical determination of organophosphorous (op) and carbamate pesticides. |
2008-08-11 |
2023-08-12 |
Not clear |
| K Dutta, D Bhattacharyay, A Mukherjee, S J Setford, A P F Turner, P Sarka. Detection of pesticide by polymeric enzyme electrodes. Ecotoxicology and environmental safety. vol 69. issue 3. 2008-08-11. PMID:17328951. |
the extent of ache deactivation by the pesticide was determined in the presence of acetylcholine (achcl) substrate. |
2008-08-11 |
2023-08-12 |
Not clear |
| Wei Zhao, Si-Xin Sun, Jing-Juan Xu, Hong-Yuan Chen, Xiao-Jian Cao, Xiao-Hong Gua. Electrochemical identification of the property of peripheral nerve fiber based on a biocompatible polymer film via in situ incorporating gold nanoparticles. Analytical chemistry. vol 80. issue 10. 2008-08-11. PMID:18363334. |
moreover the adsorption sites of ache would not be blocked by bovine serum albumin (bsa) which provides a good platform for the quantitative amperometric determination of ache via the oxidation of the enzymatically generated h 2o 2 in the bienzyme system in the presence of acetylcholine. |
2008-08-11 |
2023-08-12 |
cattle |
| Chiara Giuliano, Vinay Parikh, Josh R Ward, Christian Chiamulera, Martin Sarte. Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites? Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18346819. |
previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (chox) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ach) and its hydrolysis by endogenous acetylcholinesterase (ache). |
2008-08-08 |
2023-08-12 |
Not clear |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
5-hydroxytryptamine (5-ht4) receptor agonists increase gastrointestinal (gi) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (ache) to inactive metabolites. |
2008-08-06 |
2023-08-12 |
human |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18023504. |
mice deficient for acetylcholinesterase (ache) have strongly increased extracellular levels of acetylcholine (ach) in the dorsal hippocampus [hartmann, j., kiewert, c., duysen, e.g., lockridge, o., greig, n.h., klein, j., 2007. |
2008-07-28 |
2023-08-12 |
mouse |
| Doaa A Ghareeb, Hend M Husse. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neuroscience letters. vol 436. issue 1. 2008-07-22. PMID:18378083. |
the alterations of both ache forms observed in diabetic state could be attributed to hyperglycemia and lipid peroxidation that triggered brain dysfunction by disturbing the neurotransmitter acetylcholine level. |
2008-07-22 |
2023-08-12 |
rat |
| Kosuke Yamamoto, Suguru Oguri, Yoshie S Momonok. Characterization of trimeric acetylcholinesterase from a legume plant, Macroptilium atropurpureum Urb. Planta. vol 227. issue 4. 2008-07-21. PMID:18046576. |
similar to electric eel ache, both plant aches hydrolyzed acetylthiocholine (or acetylcholine) and propionylthiocholine (or propionylcholine), but not butyrylthiocholine (or butyrylcholine), and their specificity constant was highest against acetylcholine. |
2008-07-21 |
2023-08-12 |
Not clear |
| A I Skorinkin, A R Shaihutdinova, F Vyskoci. Model of concentration changes across the synaptic cleft during a single quantum release. General physiology and biophysics. vol 27. issue 1. 2008-07-18. PMID:18436979. |
one outcome of the present model is that the variable part of ache activity is zero at the moment of acetylcholine (ach) release and then increases. |
2008-07-18 |
2023-08-12 |
Not clear |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Fengli Hu, Huiying Zhang, Huaqing Lin, Chunhui Deng, Xiangmin Zhan. Enzyme inhibitor screening by electrospray mass spectrometry with immobilized enzyme on magnetic silica microspheres. Journal of the American Society for Mass Spectrometry. vol 19. issue 6. 2008-07-10. PMID:18396060. |
ache activity was monitored by biochemical assay that is based on mixing of ache immobilized microspheres and model substrate acetylcholine, separating and detecting the product through esi-ms. |
2008-07-10 |
2023-08-12 |
Not clear |
| Gabriel Zimmerman, Marleisje Njunting, Sebastian Ivens, Else A Tolner, Elsa Tolner, Christoph J Behrens, Miriam Gross, Hermona Soreq, Uwe Heinemann, Alon Friedma. Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. The European journal of neuroscience. vol 27. issue 4. 2008-07-08. PMID:18333967. |
we confirmed that while the total activity of the acetylcholine (ach)-hydrolysing enzyme, acetylcholinesterase (ache) was not altered, epileptic rats showed alternative splicing of ache pre-mrna transcripts, accompanied by a shift from membrane-bound ache tetramers to soluble monomers. |
2008-07-08 |
2023-08-12 |
rat |
| Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Francesco Menichin. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Current medicinal chemistry. vol 15. issue 12. 2008-06-30. PMID:18473814. |
ad and other forms of dementia could be treated by the use of agents which restore the level of acetylcholine through inhibition of both two major forms of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2008-06-30 |
2023-08-12 |
Not clear |
| Scott D Bembenek, John M Keith, Michael A Letavic, Richard Apodaca, Ann J Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L Miller, Timothy W Lovenberg, Nicholas I Carruther. Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249544. |
however, whereas an ache inhibitor will impart its effect everywhere, a histamine h(3) antagonist will raise acetylcholine levels mostly in the brain as its mode of action will primarily be on the central nervous system. |
2008-06-13 |
2023-08-12 |
Not clear |
| Hiroaki Fukunishi, Reiji Teramoto, Jiro Shimad. Hidden active information in a random compound library: extraction using a pseudo-structure-activity relationship model. Journal of chemical information and modeling. vol 48. issue 3. 2008-06-03. PMID:18278890. |
from tests for four functionally different targets, estrogen receptor antagonist (er), thymidine kinase (tk), thrombin, and acetylcholine esterase (ache), using five scoring functions, we obtained three conclusions: (1) the psar models significantly gave higher percentages of known ligands found than random sampling, and these results are sufficient to support our hypothesis; (2) the psar models gave higher percentages of known ligands found than normal scoring by scoring function, and these results demonstrate the practical usefulness of the psar model; and (3) the psar model can assess compounds failed in the docking simulation. |
2008-06-03 |
2023-08-12 |
Not clear |
| Jere R Virta, Tuula Tolvanen, Kjell Någren, Anna Brück, Anne Roivainen, Juha O Rinn. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 3. 2008-05-16. PMID:18287260. |
the neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2008-05-16 |
2023-08-12 |
human |
| M David, H B Shivakumar, H Ramesh, S R Marigoudar, V R Nai. Hepatotoxic potential of Malathion in the freshwater teleost, Cirrhinus mrigala (Hamilton). Journal of basic and clinical physiology and pharmacology. vol 18. issue 4. 2008-05-12. PMID:18380172. |
an increase in free amino acids, protease activity, and acetylcholine (ach) levels, in contrast to decrement in total, structural, and soluble proteins, and acetylcholine esterase (ache) activity were observed at 5 and 15 days of exposure, but on day 25 of exposure, all values reached near normalcy. |
2008-05-12 |
2023-08-12 |
Not clear |
| Reiji Teramoto, Hiroaki Fukunish. Consensus scoring with feature selection for structure-based virtual screening. Journal of chemical information and modeling. vol 48. issue 2. 2008-05-05. PMID:18229906. |
we evaluated the enrichments of five scoring functions (f-score, d-score, pmf, g-score, and chemscore), fscs, and rcs (rank-by-rank consensus scoring) for four different target proteins: acetylcholine esterase (ache), thrombin (thrombin), phosphodiesterase 5 (pde5), and peroxisome proliferator-activated receptor gamma (ppargamma). |
2008-05-05 |
2023-08-12 |
Not clear |
| Sun-Ha Choi, Jong-Moon Hur, Eun-Ju Yang, Mira Jun, Hyo-Jun Park, Kyung-Bok Lee, Eunho Moon, Kyung-Sik Son. Beta-secretase (BACE1) inhibitors from Perilla frutescens var. acuta. Archives of pharmacal research. vol 31. issue 2. 2008-05-01. PMID:18365688. |
they were less inhibitory against other enzymes such as alpha-secretase (tace), acetylcholine esterase (ache), chymotrypsin, and elastase, indicating that they were relatively specific inhibitors of bace1. |
2008-05-01 |
2023-08-12 |
Not clear |
| Dongren Yang, Angela Howard, Donald Bruun, Mispa Ajua-Alemanj, Cecile Pickart, Pamela J Lei. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and applied pharmacology. vol 228. issue 1. 2008-04-28. PMID:18076960. |
a primary role of acetylcholinesterase (ache) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. |
2008-04-28 |
2023-08-12 |
mouse |