| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Gireesh, T Peeyush Kumar, Jobin Mathew, Cs Paulos. Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats. Journal of biomedical science. vol 16. 2009-07-09. PMID:19344500. |
in this study, we have investigated the changes of acetylcholine esterase (ache) enzyme activity, total muscarinic and muscarinic m1 receptor binding and gene expression in the corpus striatum of stz--diabetic rats and the insulin treated diabetic rats. |
2009-07-09 |
2023-08-12 |
rat |
| E Dere, Q Zheng-Fischhöfer, D Viggiano, U A Gironi Carnevale, L A Ruocco, A Zlomuzica, M Schnichels, K Willecke, J P Huston, A G Sadil. Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex. Neuroscience. vol 153. issue 2. 2009-06-29. PMID:18384970. |
we found increased levels of acetylcholine esterase (ache) and camp response element-binding protein (creb) in the striatum of cx31.1 ko mice. |
2009-06-29 |
2023-08-12 |
mouse |
| Ilya Goykhman, Nina Korbakov, Carmen Bartic, Gustaaf Borghs, Micha E Spira, Joseph Shappir, Shlomo Yitzchai. Direct detection of molecular biorecognition by dipole sensing mechanism. Journal of the American Chemical Society. vol 131. issue 13. 2009-06-29. PMID:19292449. |
it is shown for the first time that biorecognition of acetylcholine (ach) can be translated to conformational changes in the enzyme, acetylcholine-esterase (ache), which in turn induces a measurable change in surface potential. |
2009-06-29 |
2023-08-12 |
Not clear |
| F A Carvalho, J P Lopes de Almeida, T Freitas-Santos, C Saldanh. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. The Journal of membrane biology. vol 228. issue 2. 2009-06-26. PMID:19294450. |
circulating acetylcholine, substrate of membrane acetylcholinesterase (ache), is known to enhance the band 3 protein degree of phosphorylation. |
2009-06-26 |
2023-08-12 |
Not clear |
| F A Carvalho, J P Lopes de Almeida, T Freitas-Santos, C Saldanh. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. The Journal of membrane biology. vol 228. issue 2. 2009-06-26. PMID:19294450. |
from blood samples of healthy donors, erythrocyte suspensions were prepared and incubated with ache substrate (acetylcholine) and inhibitor (velnacrine), along with protein tyrosine kinase (ptk) and tyrosine phosphatase (ptp) inhibitors. |
2009-06-26 |
2023-08-12 |
Not clear |
| Savitha Balakrishnan, Jobin Mathew, Sherin Antony, Cheramadathikudyil S Paulos. Muscarinic M(1), M(3) receptors function in the brainstem of streptozotocin induced diabetic rats: their role in insulin secretion from the pancreatic islets as a function of age. European journal of pharmacology. vol 608. issue 1-3. 2009-06-24. PMID:19347982. |
in the present study, we have investigated acetylcholine esterase (ache) activity and muscarinic m(1), m(3) receptors kinetics in the brainstem of both young and old streptozotocin induced and insulin treated diabetic rats (d + i). |
2009-06-24 |
2023-08-12 |
rat |
| Anne-Marie O'Donnell, Prem Pur. Cholinergic innervation in the developing chick cloaca and colorectum. Journal of pediatric surgery. vol 44. issue 2. 2009-06-09. PMID:19231541. |
acetylcholinesterase (ache) is an enzyme involved in hydrolysing acetylcholine during its metabolism. |
2009-06-09 |
2023-08-12 |
human |
| Hiroshi Murabayashi, Hirofumi Kuramoto, Katsushi Ishikawa, Jun Iwamoto, Kiyoshi Miyakawa, Kunio Tanaka, Mitsuo Sekikawa, Motoki Sasaki, Nobuo Kitamura, Yukio Oomor. Acetylcholinesterase activity, choline acetyltransferase and vesicular acetylcholine transporter immunoreactivities in the rat adrenal gland during postnatal development. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 3. 2009-05-19. PMID:19248156. |
from postnatal-day-0 to postnatal-day-2, a few acetylcholinesterase (ache)-active and choline acetytransferase (chat)-immunoreactive nerve fibers and relatively numerous vesicular acetylcholine transporter (vacht)-immunoreactive puncta were observed in the rat adrenal medulla. |
2009-05-19 |
2023-08-12 |
rat |
| K Yano, K Koda, Y Ago, H Kobayashi, T Kawasaki, K Takuma, T Matsud. Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice. British journal of pharmacology. vol 156. issue 1. 2009-05-18. PMID:19133998. |
galantamine, a weak acetylcholine esterase (ache) inhibitor and allosteric potentiator of nicotinic ach receptors (nachrs), improves apomorphine-induced deficits in prepulse inhibition (ppi), sensory information-processing deficits, via a nachr-independent mechanism. |
2009-05-18 |
2023-08-12 |
mouse |
| Kazufumi Hirano, Thomas M Piers, Kirsten L Searle, Neil D Miller, A Richard Rutter, Paul F Chapma. Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease. Life sciences. vol 84. issue 15-16. 2009-05-01. PMID:19302808. |
brain microdialysis studies demonstrated that 5-ht(6) antagonists enhance not only cholinergic but also monoaminergic neurotransmission, a property that may differentiate from acetylcholine esterase (ache) inhibitors such as donepezil. |
2009-05-01 |
2023-08-12 |
rat |
| E Dere, A Zlomuzica, D Viggiano, L A Ruocco, T Watanabe, A G Sadile, J P Huston, M A De Souza-Silv. Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum. Neuroscience. vol 157. issue 3. 2009-04-14. PMID:18926883. |
in order to relate possible behavioral deficits to neurobiological changes, we examined h1r-ko and wild-type (wt) mice in terms of acetylcholine esterase (ache) activity in subregions of the hippocampus and ache and tyrosine hydroxylase (th) expression in the striatum. |
2009-04-14 |
2023-08-12 |
mouse |
| B P Paudya. Organophosphorus poisoning. JNMA; journal of the Nepal Medical Association. vol 47. issue 172. 2009-04-14. PMID:19079407. |
the toxicity of these op pesticides is due to the irreversible inhibition of acetylcholinesterase (ache) enzyme leading to accumulation of acetylcholine and subsequent over-activation of cholinergic receptors in various parts of the body. |
2009-04-14 |
2023-08-12 |
Not clear |
| Shu-Zhi Zhong, Qing-Hua Ge, Rong Qu, Qiao Li, Shi-Ping M. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. Journal of the neurological sciences. vol 277. issue 1-2. 2009-04-02. PMID:19007942. |
paeonol increased acetylcholine (ach) and glutathione (gsh) levels, restored superoxide dismutase (sod) and na(+), k(+)-adenosine triphosphatase (na(+), k(+)-atpase) activities, but decreased cholinesterase ache activity and malondialdehyde (mda) level in d-gal-treated mice. |
2009-04-02 |
2023-08-12 |
mouse |
| M J Fernandez-Cabezudo, S Azimullah, S M Nurulain, M Mechkarska, D E Lorke, M Y Hasan, G A Petroianu, B K Al-Ramad. The organophosphate paraoxon has no demonstrable effect on the murine immune system following subchronic low dose exposure. International journal of immunopathology and pharmacology. vol 21. issue 4. 2009-03-30. PMID:19144274. |
desulphuration of parathion by liver enzymes or sunlight results in the formation of paraoxon which inhibits acetylcholine esterase (ache) activity. |
2009-03-30 |
2023-08-12 |
mouse |
| Gürdal Orhan, Ilkay Orhan, Neşe Subutay-Oztekin, Fikri Ak, Bilge Sene. Contemporary anticholinesterase pharmaceuticals of natural origin and their synthetic analogues for the treatment of Alzheimer's disease. Recent patents on CNS drug discovery. vol 4. issue 1. 2009-03-17. PMID:19149713. |
therefore, the most important therapeutic approach has emerged as inhibition of acetylcholinesterase (ache), which is the key enzyme in the breakdown of acetylcholine. |
2009-03-17 |
2023-08-12 |
Not clear |
| Martina Zimmermann, Martin S Westwell, Susan A Greenfiel. Impact of detergents on the activity of acetylcholinesterase and on the effectiveness of its inhibitors. Biological chemistry. vol 390. issue 1. 2009-03-12. PMID:19007306. |
acetylcholinesterase (ache) plays a central role in the development of alzheimer's disease: ache inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. |
2009-03-12 |
2023-08-12 |
Not clear |
| H Kalonia, M Bishnoi, A Kuma. Possible mechanism involved in sleep deprivation-induced memory dysfunction. Methods and findings in experimental and clinical pharmacology. vol 30. issue 7. 2009-02-23. PMID:18985181. |
in addition, increased levels of acetylcholinesterase (ache; the enzyme responsible for the degradation of acetylcholine) and reduction in norepinephrine and dopamine levels were seen in 72-h sleep-deprived animals. |
2009-02-23 |
2023-08-12 |
rat |
| María-Salud García-Ayllón, Omar Cauli, María-Ximena Silveyra, Regina Rodrigo, Asunción Candela, Antonio Compañ, Rodrigo Jover, Miguel Pérez-Mateo, Salvador Martínez, Vicente Felipo, Javier Sáez-Valer. Brain cholinergic impairment in liver failure. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18772221. |
a selective increase of tetrameric ache, the major ache species involved in hydrolysis of acetylcholine in the brain, was detected in both cirrhotic humans and bdl rats. |
2008-12-12 |
2023-08-12 |
human |
| María-Salud García-Ayllón, Omar Cauli, María-Ximena Silveyra, Regina Rodrigo, Asunción Candela, Antonio Compañ, Rodrigo Jover, Miguel Pérez-Mateo, Salvador Martínez, Vicente Felipo, Javier Sáez-Valer. Brain cholinergic impairment in liver failure. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18772221. |
increased ache in bdl cirrhotic rats leads to a pronounced decrease (~50-60%) in the levels of acetylcholine. |
2008-12-12 |
2023-08-12 |
human |
| Jennifer M Bui, J Andrew McCammo. Intrinsic conformational flexibility of acetylcholinesterase. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18452905. |
to understand the dynamical properties of acetylcholinesterase (ache) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (md) trajectories of ache in the presence and absence of its inhibitors [j.m. |
2008-12-10 |
2023-08-12 |
Not clear |