| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junichi Kusafuka, Hiroyuki Kobayashi, Katsumi Miyahara, Geoffrey J Lane, Noriyoshi Sueyoshi, Atsuyuki Yamatak. Does abnormal expression of acetylcholine receptors in Hirschsprung's disease induce acetylcholine esterase positive nerve fibres? Asian journal of surgery. vol 30. issue 4. 2008-01-08. PMID:17962128. |
the purpose of the present study was to investigate the distribution of alpha-btx-sensitive nachr in hirschsprung's disease (hd) to understand the histopathological features of hd, especially the increase in acetylcholine esterase (ache) positive nerve fibres. |
2008-01-08 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Donia, Larry B Goldstein, Sarah Bullman, T Tu, Wasi A Khan, Ankelika M Dechkovskaia, Ali A Abdel-Rahma. Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. Journal of toxicology and environmental health. Part A. vol 71. issue 2. 2008-01-03. PMID:18080902. |
on postnatal day (pnd) 30, all male and female offspring were evaluated for (a) acetylcholinesterase (ache) and butyrylcholinesterase (buche) activity, (b) ligand binding for nicotinic acetylcholine receptors (nachr) and muscarinic acetylcholine receptors (m2 machr), (c) sensorimotor performance (inclined plane, beam-walking, and forepaw grip), and (d) pathological alterations in the brain (using cresyl violet and glial fibrillary acidic protein [gfap] immunostaining). |
2008-01-03 |
2023-08-12 |
human |
| Tatsuya Kikuchi, Toshimitsu Okamura, Kiyoshi Fukushi, Kazuhiro Takahashi, Jun Toyohara, Maki Okada, Ming-Rong Zhang, Toshiaki Iri. Cerebral acetylcholinesterase imaging: development of the radioprobes. Current topics in medicinal chemistry. vol 7. issue 18. 2007-12-18. PMID:17979787. |
the other approach is measuring cerebral ache activity with radiolabeled acetylcholine analogue substrates. |
2007-12-18 |
2023-08-12 |
Not clear |
| Ingrid Walz, Wolfgang Schwac. Cutinase inhibition by means of insecticidal organophosphates and carbamates. 3. Oxidation of phosphorothionates by chloroperoxidase from Caldariomyces fumago. Journal of agricultural and food chemistry. vol 55. issue 20. 2007-12-12. PMID:17824663. |
this type of enzymatic oxidation is easier to perform and more efficient, as compared to bromine or n-bromosuccinimide, used for acetylcholine esterase (ache) assay in water analyses, but is insufficient for complex matrices such as plant sample extracts. |
2007-12-12 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Reiji Teramoto, Hiroaki Fukunish. Supervised scoring models with docked ligand conformations for structure-based virtual screening. Journal of chemical information and modeling. vol 47. issue 5. 2007-11-06. PMID:17685604. |
we applied ssm to the flexx scoring function, that is, f-score, with five different target proteins: thymidine kinase (tk), estrogen receptor (er), acetylcholine esterase (ache), phosphodiesterase 5 (pde5), and peroxisome proliferator-activated receptor gamma (ppargamma). |
2007-11-06 |
2023-08-12 |
Not clear |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |
| Geetu Raheja, Kiran Dip Gil. Altered cholinergic metabolism and muscarinic receptor linked second messenger pathways after chronic exposure to dichlorvos in rat brain. Toxicology and industrial health. vol 23. issue 1. 2007-10-31. PMID:17722737. |
activity of the synthesizing enzyme of acetylcholine (ach) ie, choline acetyltransferase, was found to be significantly increased and the activity of hydrolyzing enzyme, acetyl cholinesterase (ache), was inhibited in all the three brain regions studied. |
2007-10-31 |
2023-08-12 |
rat |
| Yoshihito X Fujii, Ayako Tashiro, Kumiko Arimoto, Hirofumi Fujigaya, Yasuhiro Moriwaki, Hidemi Misawa, Takeshi Fujii, Minoru Matsui, Tadashi Kasahara, Koichiro Kawashim. Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice. Journal of neuroimmunology. vol 188. issue 1-2. 2007-10-19. PMID:17586055. |
immunological activation of t cells enhances synthesis of acetylcholine (ach) and transcription of choline acetyltransferase (chat), m5 muscarinic ach receptor (machr) and acetylcholinesterase (ache). |
2007-10-19 |
2023-08-12 |
mouse |
| Prabhu Venkataraman, Raju Muthuvel, Gunasekaran Krishnamoorthy, Arumugam Arunkumar, Muthusami Sridhar, Narasimhan Srinivasan, Karundevi Balasubramanian, Maria Michael Aruldhas, Jagadeesan Arunakara. PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. Neurotoxicology. vol 28. issue 3. 2007-10-18. PMID:17141323. |
hydrogen peroxide (h(2)o(2)), lipid peroxidation (lpo) and acetylcholine esterase activity (ache) were determined. |
2007-10-18 |
2023-08-12 |
rat |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
many drugs currently used for the treatment of the ad are based on the improvement of cholinergic neurotransmission achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-09-18 |
2023-08-12 |
Not clear |
| Dan Grisaru, Ran Keidar, Letizia Schreiber, Joseph B Lessing, Varda Deutsc. The effect of the readthrough acetylcholinesterase variant (AChE-R) on uterine muscle and leiomyomas. Molecular human reproduction. vol 13. issue 5. 2007-09-13. PMID:17350961. |
acetylcholine signaling and acetylcholinesterase (ache) function(s) are pivotal elements in muscle development. |
2007-09-13 |
2023-08-12 |
human |
| J B Matthews, O Lazari, A J Davidson, S Warren, M E Selkir. A tryptophan amphiphilic tetramerization domain-containing acetylcholinesterase from the bovine lungworm, Dictyocaulus viviparus. Parasitology. vol 133. issue Pt 3. 2007-09-10. PMID:16719958. |
acetylcholine (ach) is one of an array of neurotransmitters used by invertebrates and, analogous to vertebrate nervous systems, acetylcholinesterase (ache) regulates synaptic levels of this transmitter. |
2007-09-10 |
2023-08-12 |
cattle |
| b' Nevenka Kopjar, Davor Zeljezi\\xc4\\x87, Ana Luci\\xc4\\x87 Vrdoljak, Bozica Radi\\xc4\\x87, Snjezana Rami\\xc4\\x87, Mirta Mili\\xc4\\x87, Marija Gamulin, Vesna Pavlica, Aleksandra Fuci\\xc4\\x8. Irinotecan toxicity to human blood cells in vitro: relationship between various biomarkers. Basic & clinical pharmacology & toxicology. vol 100. issue 6. 2007-09-07. PMID:17516995.' |
irinotecan was found to be strong inhibitor of the acetylcholine hydrolysis and to cause a continuous decrease of catalytic activity of ache. |
2007-09-07 |
2023-08-12 |
human |
| Kamil Kuca, Jirí Cabal, Daniel Jun, Jirí Kassa, Lucie Bartosová, Gabriela Kunesová, Vlastimil Dohna. Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601804. |
nerve agent poisoning is conventionally treated using a combination of a cholinolytic drug (atropine mostly) to counteract the accumulation of acetylcholine at muscarinic receptors and ache reactivators (pralidoxime or obidoxime) to reactivate inhibited ache. |
2007-08-28 |
2023-08-12 |
Not clear |
| Haris Carageorgiou, Constantinos Pantos, Apostolos Zarros, Vasileios Stolakis, Iordanis Mourouzis, Dennis Cokkinos, Stylianos Tsakiri. Changes in acetylcholinesterase, Na+,K+-ATPase, and Mg2+-ATPase activities in the frontal cortex and the hippocampus of hyper- and hypothyroid adult rats. Metabolism: clinical and experimental. vol 56. issue 8. 2007-08-23. PMID:17618957. |
the th-reduced na+,k+-atpase activity may increase the synaptic acetylcholine release and, thus, modulate ache activity. |
2007-08-23 |
2023-08-12 |
rat |
| Gottipolu R Reddy, Bhuvaneswari C Devi, Chellu S Chett. Developmental lead neurotoxicity: alterations in brain cholinergic system. Neurotoxicology. vol 28. issue 2. 2007-08-21. PMID:16678265. |
in this study, we have further examined in detail, the alterations in ache activity and acetylcholine (ach) levels in different brain regions using histochemical and spectrophotometric methods. |
2007-08-21 |
2023-08-12 |
rat |
| Kazuaki Katakawa, Akiko Nozoe, Noriyuki Kogure, Mariko Kitajima, Masakiyo Hosokawa, Hiromitsu Takayam. Fawcettimine-related alkaloids from Lycopodium serratum. Journal of natural products. vol 70. issue 6. 2007-08-06. PMID:17503851. |
some alkaloids isolated in this and previous studies (1, 2, 5, and 10) were assayed for acetylcholine esterase (ache) inhibitory activity. |
2007-08-06 |
2023-08-12 |
Not clear |