| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daquan Gao, Chang-Guo Zha. Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases. The journal of physical chemistry. B. vol 109. issue 48. 2007-07-18. PMID:16854005. |
molecular dynamics (md) simulations and hydrogen bonding energy (hbe) calculations have been performed on the prereactive enzyme-substrate complexes (es), transition states (ts1), and intermediates (int1) for acetylcholinesterase (ache)-catalyzed hydrolysis of acetylcholine (ach), butyrylcholinesterase (bche)-catalyzed hydrolysis of ach, and bche-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. |
2007-07-18 |
2023-08-12 |
human |
| C Eggers, B Szelies, B Bauer, K Wienhard, H Schröder, K Herholz, W-D Heis. Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness. European journal of neurology. vol 14. issue 6. 2007-07-10. PMID:17539952. |
positron emission tomography with 11c-n-methyl-4-piperidyl-acetate (mp4a) was applied in eight healthy volunteers and two patients with mild alzheimer's disease (ad) to assess acetylcholine esterase (ache) activity in magnetic resonance imaging-identified brainstem nuclei. |
2007-07-10 |
2023-08-12 |
human |
| Jul Lea Shamy, Cindy A Buckmaster, David G Amaral, Michael E Calhoun, Peter R Rap. Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. The Journal of comparative neurology. vol 502. issue 2. 2007-06-26. PMID:17348008. |
alternate histological sections were processed for the visualization of somatostatin and vesicular acetylcholine transporter (vacht) immunoreactivity and acetylcholinesterase histochemistry (ache). |
2007-06-26 |
2023-08-12 |
rat |
| Hideaki Nakajima, Kenzo Uchida, Shigeru Kobayashi, Tomoo Inukai, Yukiko Horiuchi, Takafumi Yayama, Ryuichiro Sato, Hisatoshi Bab. Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene. Journal of neurotrauma. vol 24. issue 4. 2007-06-06. PMID:17439352. |
adv-bdnf transfection was associated with increased numbers of intact neurons as confirmed by nissl, cholineacetyltransferase (chat), and acetylcholine esterase (ache) staining especially from 2 weeks after injury, compared with the adv-lacz injected rats. |
2007-06-06 |
2023-08-12 |
rat |
| Pulok K Mukherjee, Venkatesan Kumar, Mainak Mal, Peter J Houghto. Acetylcholinesterase inhibitors from plants. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 14. issue 4. 2007-05-31. PMID:17346955. |
inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as alzheimer's disease, senile dementia, ataxia and myasthenia gravis. |
2007-05-31 |
2023-08-12 |
Not clear |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Kristin Huse Haug, Trond Myhrer, Frode Fonnu. The combination of donepezil and procyclidine protects against soman-induced seizures in rats. Toxicology and applied pharmacology. vol 220. issue 2. 2007-05-14. PMID:17289099. |
six hours after soman exposure cerebral ache activity and acetylcholine (ach) concentration was 5% and 188% of control, respectively. |
2007-05-14 |
2023-08-12 |
rat |
| Anatoly S Loukianov, Tatiana K Syomina, Aleksander M Korole. Conformational changes in proteins in vitro as a means of predicting the acute toxicities of chemicals. Alternatives to laboratory animals : ATLA. vol 35. issue 1. 2007-05-10. PMID:17411361. |
experimental data are presented on ovalbumin denaturation (od, ec10) and human acetylcholine esterase (ache) inhibition (ic50) in vitro, following exposure to the chemicals used in the international multicentre evaluation of in vitro cytotoxicity (meic) programme. |
2007-05-10 |
2023-08-12 |
human |
| Hiroshi Fukuda, Nobuyuki Okamur. [Introduction to and general remarks on molecular imaging]. Brain and nerve = Shinkei kenkyu no shinpo. vol 59. issue 3. 2007-05-01. PMID:17370645. |
11c-mp4p (n-methlpiperidyl-4-propionate), is a probe for the measurement of acetylcholine esterase (ache) activity in the human brain by pet. |
2007-05-01 |
2023-08-12 |
mouse |
| Timothy C Marrs, Paul Rice, J Allister Val. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicological reviews. vol 25. issue 4. 2007-04-17. PMID:17288500. |
nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (ache), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. |
2007-04-17 |
2023-08-12 |
Not clear |
| Carsten Eggers, Karl Herholz, Elke Kalbe, Wolf-Dieter Heis. Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neuroscience letters. vol 408. issue 1. 2007-04-03. PMID:16996687. |
positron emission tomography (pet) studies have demonstrated reduced acetylcholine esterase (ache) activity as an indicator of cholinergic impairment, which is a main pathogenic process in alzheimer's disease (ad). |
2007-04-03 |
2023-08-12 |
human |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Nigel H Greig, Jochen Klei. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17212694. |
we have used in vivo microdialysis to investigate the regulation of hippocampal acetylcholine (ach) levels in mice that are devoid of ache (ache-/- mice). |
2007-04-02 |
2023-08-12 |
mouse |
| Bernd Kallmünzer, Björn Sörensen, Winfried L Neuhuber, Jürgen Wör. Heterogeneity of neuromuscular junctions in striated muscle of human esophagus demonstrated by triple staining for the vesicular acetylcholine transporter, alpha-bungarotoxin, and acetylcholinesterase. Cell and tissue research. vol 324. issue 2. 2007-03-28. PMID:16437206. |
during studies on enteric co-innervation in the human esophagus, we found that not all acetylcholinesterase (ache)-positive motor endplates stained for alpha-bungarotoxin (alpha-bt) and the vesicular acetylcholine transporter (vacht), respectively. |
2007-03-28 |
2023-08-12 |
human |
| Bernd Kallmünzer, Björn Sörensen, Winfried L Neuhuber, Jürgen Wör. Heterogeneity of neuromuscular junctions in striated muscle of human esophagus demonstrated by triple staining for the vesicular acetylcholine transporter, alpha-bungarotoxin, and acetylcholinesterase. Cell and tissue research. vol 324. issue 2. 2007-03-28. PMID:16437206. |
based on these results, we suggest that, in human esophagus, (1) the most reliable method for staining motor endplates is presently ache histochemistry, (2) alpha-bt-sensitive and alpha-bt-resistant nicotinic acetylcholine receptors exist in neuromuscular junctions, and (3) different types of vacht or transport mechanisms for acetylcholine probably exist in neuromuscular junctions. |
2007-03-28 |
2023-08-12 |
human |
| Ulrike Holzgrabe, Petra Kapková, Vildan Alptüzün, Josef Scheiber, Eva Kugelman. Targeting acetylcholinesterase to treat neurodegeneration. Expert opinion on therapeutic targets. vol 11. issue 2. 2007-03-22. PMID:17227232. |
thus, the aim of many treatment regimens is to support this system either by means of muscarinic agonists or by inhibitors of acetylcholinesterase (ache), the latter being able to increase the concentration of acetylcholine. |
2007-03-22 |
2023-08-12 |
Not clear |
| Slawomir Gralewic. [Possible consequences of acetylcholinesterase inhibition in organophosphate poisoning. Discussion continued]. Medycyna pracy. vol 57. issue 3. 2007-03-20. PMID:17125036. |
numerous toxicologists still believe that the only function of acetylcholinesterase (ache) is to catalyse the hydrolysis of acetylcholine (ach), and that the toxicity of organophosphorous pesticides (op) results from their ability to switch this function off. |
2007-03-20 |
2023-08-12 |
Not clear |
| Ana-Lourdes Oropesa, Marcos Pérez-López, David Hernández, Jesús-Pablo García, Luis-Eusebio Fidalgo, Ana López-Beceiro, Francisco Sole. Acetylcholinesterase activity in seabirds affected by the Prestige oil spill on the Galician coast (NW Spain). The Science of the total environment. vol 372. issue 2-3. 2007-03-15. PMID:17113132. |
physiological levels of brain ache, expressed in nmol acetylcholine hydrolysed min(-1) mg(-1) protein were similar in non-exposed common guillemot (388.6+/-95.0) and atlantic puffin (474.0+/-60.7), however, razorbill values were higher (644.6+/-66.9). |
2007-03-15 |
2023-08-12 |
Not clear |
| Tomoko Koike, Shigeyuki Uno, Michiyasu Ishizawa, Hideo Takahashi, Kazumasa Ikeda, Shinichi Yokota, Makoto Makishim. The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells. Neuroscience letters. vol 410. issue 3. 2007-02-27. PMID:17055158. |
ngf, and not knk437, induced acetylcholine esterase (ache) activity, a functional differentiation marker, indicating that knk437 utilizes a mechanism distinct from that of ngf. |
2007-02-27 |
2023-08-12 |
rat |
| Silvia Ravera, Carla Falugi, Daniela Calzia, Isidoro M Pepe, Isabella Panfoli, Alessandro Morell. First cell cycles of sea urchin Paracentrotus lividus are dramatically impaired by exposure to extremely low-frequency electromagnetic field. Biology of reproduction. vol 75. issue 6. 2007-02-26. PMID:16957026. |
moreover, ache inhibitors seem to induce the same teratological effects as those caused by the field, while blockers of acetylcholine (ach) receptors are able to antagonize those effects. |
2007-02-26 |
2023-08-12 |
Not clear |
| Susana Nieto-Cerón, Luis F Sánchez del Campo, Encarnación Muñoz Delgado, Cecilio J Vidal, Francisco Javier Campo. Thymus acetylcholinesterase activity is reduced in mice with congenital muscular dystrophy. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192623. |
ache and bche are involved through catalytic and noncatalytic actions in multiple processes, such as hydrolysis of acetylcholine (ach), morphogenesis, hematopoiesis, and tumorigenesis (soreq and seidman, 2001). |
2007-02-23 |
2023-08-12 |
mouse |