| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Aviad Hai, Deborah Ben-Haim, Nina Korbakov, Ariel Cohen, Joseph Shappir, Ruthi Oren, Micha E Spira, Shlomo Yitzchai. Acetylcholinesterase-ISFET based system for the detection of acetylcholine and acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 22. issue 5. 2007-01-17. PMID:16529923. |
a bioelectronic hybrid system for the detection of acetylcholine esterase (ache) catalytic activity was assembled by way of immobilizing the enzyme to the gate surface of an ion-sensitive field-effect transistor (isfet). |
2007-01-17 |
2023-08-12 |
Not clear |
| Tsao-Jen Lin, Kuang-Tse Huang, Chia-Yu Li. Determination of organophosphorous pesticides by a novel biosensor based on localized surface plasmon resonance. Biosensors & bioelectronics. vol 22. issue 4. 2007-01-17. PMID:16769211. |
the underlying mechanism is that paraoxon prevents acetylcholine chloride (ach) reacting with ache by destroying the oh bond of serine in ache. |
2007-01-17 |
2023-08-12 |
Not clear |
| Martin J Hoogduijn, Zoltan Rakonczay, Paul G Geneve. The effects of anticholinergic insecticides on human mesenchymal stem cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 94. issue 2. 2007-01-09. PMID:16960032. |
organophosphate (op) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (ache). |
2007-01-09 |
2023-08-12 |
human |
| Carlos H T P da Silva, Vanessa Leiria Campo, Ivone Carvalho, Carlton A Taf. Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. Journal of molecular graphics & modelling. vol 25. issue 2. 2007-01-08. PMID:16413803. |
it is achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-01-08 |
2023-08-12 |
human |
| Patrik Danielson, Håkan Alfredson, Sture Forsgre. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microscopy research and technique. vol 69. issue 10. 2006-12-29. PMID:16830327. |
antibodies against the m(2) receptor, choline acetyltransferase (chat), and vesicular acetylcholine transporter (vacht) were applied, and staining for demonstration of activity of acetylcholinesterase (ache) was also utilized. |
2006-12-29 |
2023-08-12 |
human |
| Davut Alptekin, Hüsnü Umit Lüleyap, Levent Yilmaz, Hakan Demirhindi, Yüksel Gökel, Ayfer Pazarbaşi, Mehmet Dokur, Mülkiye Kasap, Halil Kasa. The sister-chromatid exchange and acetylcholine esterase enzyme levels among patients with insecticide intoxication in the Cukurova region, Turkey. Acta medica Okayama. vol 60. issue 2. 2006-12-28. PMID:16680189. |
acetylcholine esterase (pseudocholinesterase) enzyme (ache), sister-chromatid exchanges (sce), the mitotic index (mi), and the replication index (ri) were evaluated. |
2006-12-28 |
2023-08-12 |
Not clear |
| Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, Pascale Marcho. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16837465. |
hydrolysis of acetylcholine catalyzed by acetylcholinesterase (ache), one of the most efficient enzymes in nature, occurs at the base of a deep and narrow active center gorge. |
2006-11-27 |
2023-08-12 |
mouse |
| Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, Pascale Marcho. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16837465. |
complementary crystal structures of mouse ache and an inactive mouse ache mutant with a substituted catalytic serine (s203a), in various complexes with four substrates (acetylcholine, acetylthiocholine, succinyldicholine, and butyrylthiocholine), two non-hydrolyzable substrate analogues (m-(n,n,n-trimethylammonio)-trifluoroacetophenone and 4-ketoamyltrimethylammonium), and one reaction product (choline) were solved in the 2.05-2.65-a resolution range. |
2006-11-27 |
2023-08-12 |
mouse |
| Ai-Ling Fu, Zhao-Hui Dong, Man-Ji Su. Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16872586. |
there was also an increase in acetylcholinesterase (ache) activity and a reduction in the choline acetyltransferase (chat) activity and acetylcholine (ach) levels. |
2006-10-31 |
2023-08-12 |
mouse |
| Kamil Kuca, Daniel Jun, Jiri Cabal, Martina Hrabinova, Lucie Bartosova, Veronika Opletalov. Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent. Basic & clinical pharmacology & toxicology. vol 98. issue 4. 2006-10-26. PMID:16623863. |
oximes counteract acetylcholine increase, resulting from ache inhibition. |
2006-10-26 |
2023-08-12 |
human |
| L Gandía, R M Alvarez, J M Hernández-Guijo, J M González-Rubio, R de Pascual, J Rojo, L Tapi. [Anticholinesterases in the treatment of Alzheimer's disease]. Revista de neurologia. vol 42. issue 8. 2006-10-18. PMID:16625509. |
this led to the formulation of the so-called cholinergic theory of alzheimer, which provides the rationale behind the use of the drugs that are currently available to treat this disease, namely, acetylcholine esterase (ache) inhibitors (rivastigmine, donepezil and galanthamine). |
2006-10-18 |
2023-08-12 |
Not clear |
| Deqiang Zhang, J Andrew McCammo. The association of tetrameric acetylcholinesterase with ColQ tail: a block normal mode analysis. PLoS computational biology. vol 1. issue 6. 2006-09-29. PMID:16299589. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. |
2006-09-29 |
2023-08-12 |
mouse |
| Edson X Albuquerque, Edna F R Pereira, Yasco Aracava, William P Fawcett, Maristela Oliveira, William R Randall, Tracey A Hamilton, Robert K Kan, James A Romano, Michael Adle. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16914529. |
most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (ache), the enzyme that inactivates the neurotransmitter acetylcholine. |
2006-09-29 |
2023-08-12 |
Not clear |
| Lucie Svobodová, Jan Krůsek, Tomás Hendrych, Frantisek Vyskoci. Physostigmine modulation of acetylcholine currents in COS cells transfected with mouse muscle nicotinic receptor. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16530961. |
physostigmine (phy), a reversible inhibitor of acetylcholine (ach) esterase (ache), may also act as a low potency agonist and a modulator of the nicotinic receptor. |
2006-09-28 |
2023-08-12 |
mouse |
| T-M Shih, S W Hulet, J H McDonoug. The effects of repeated low-dose sarin exposure. Toxicology and applied pharmacology. vol 215. issue 2. 2006-09-28. PMID:16556454. |
the animals were assessed for changes in body weight, red blood cell (rbc) acetylcholinesterase (ache) levels, neurobehavioral reactions to a functional observational battery (fob), cortical electroencephalographic (eeg) power spectrum, and intrinsic acetylcholine (ach) neurotransmitter (nt) regulation over the 2 weeks of sarin exposure and for up to 12 days postinjection. |
2006-09-28 |
2023-08-12 |
Not clear |
| Agneta Nordber. Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease. Alzheimer disease and associated disorders. vol 20. issue 2 Suppl 1. 2006-09-28. PMID:16772751. |
inhibitors of the enzyme acetylcholinesterase (ache) are presently used as long-term symptomatic treatments for patients with alzheimer disease (ad), as they enhance central levels of synaptic acetylcholine. |
2006-09-28 |
2023-08-12 |
Not clear |
| K Moorthy, Umesh C S Yadav, M R Siddiqui, Anil K Mantha, Seemi F Basir, D Sharma, Sudha M Cowsik, Najma Z Baque. Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats. Biogerontology. vol 6. issue 5. 2006-09-27. PMID:16463111. |
results show decreased activity of acetylcholine esterase (ache) whereas the level of lipid peroxidation increased with age, and after the hormone treatments both ache activity and level of lipid peroxidation returned to control values. |
2006-09-27 |
2023-08-12 |
rat |
| A C da Silva, D Balz, J B D'A de Souza, V M Morsch, M C Corrêa, G D Zanetti, M P Manfron, M R C Schetinge. Inhibition of NTPDase, 5'-nucleotidase, Na+/K+-ATPase and acetylcholinesterase activities by subchronic treatment with Casearia sylvestris. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 13. issue 7. 2006-09-26. PMID:16785042. |
the rate of acetylcholine degradation was reduced, as shown by the inhibition of ache (31.65% and 26.74%, samples a and b, respectively). |
2006-09-26 |
2023-08-12 |
rat |
| Dean M Robinson, Greg L Ploske. Galantamine extended release. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863272. |
galantamine inhibits acetylcholinesterase (ache) to slow acetylcholine hydrolysis, and may also modulate presynaptic nicotinic receptor activation, thereby increasing neurotransmitter concentrations in the synaptic cleft.black triangle once-daily galantamine extended release (er) 24 mg and twice-daily galantamine immediate release (ir) 12 mg are bioequivalent in terms of the area under the plasma concentration-time curve from time 0 to 24 hours and steady-state minimum plasma concentration.black triangle primary endpoints indicated a significantly greater effect of galantamine er on cognitive performance than placebo, with efficacy similar to galantamine ir, in a randomised, double-blind trial. |
2006-09-19 |
2023-08-12 |
Not clear |