| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anil K Mantha, K Moorthy, Sudha M Cowsik, Najma Z Baque. Membrane associated functions of neurokinin B (NKB) on Abeta (25-35) induced toxicity in aging rat brain synaptosomes. Biogerontology. vol 7. issue 1. 2006-06-23. PMID:16518717. |
the effect of different concentrations (0.1-5 microm) of neurokinin b (nkb) and abeta (25-35) on acetylcholine esterase (ache), na(+)-k(+) atpase and membrane fluidity (dph anisotropy) were investigated in rat brain synaptosomes of 3, 9, 18 and 30 months old. |
2006-06-23 |
2023-08-12 |
rat |
| Xiu-ling Ji, Liu Yang, Zhe-min Shen, Jin-ping Cheng, Gui-wen Jin, Li-ya Qu, Wen-hua Wan. Neurotransmitter level changes in domestic ducks (Shaoxing duck) growing up in typical mercury contaminated area in China. Journal of environmental sciences (China). vol 17. issue 2. 2006-06-22. PMID:16295900. |
an increased content of acetylcholine (ach) in brain and blood and a decreased activity of acetylcholinesterase (ache) in blood were observed. |
2006-06-22 |
2023-08-12 |
Not clear |
| Qing Chang, Lisa M Savage, Paul E Gol. Microdialysis measures of functional increases in ACh release in the hippocampus with and without inclusion of acetylcholinesterase inhibitors in the perfusate. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16579834. |
because brain extracellular acetylcholine (ach) levels are near detection limits in microdialysis samples, an acetylcholinesterase (ache) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ach levels in the dialysate, a practice that raises concerns that the inhibitor might alter the results. |
2006-06-22 |
2023-08-12 |
Not clear |
| Eric Krejci, Isabel Martinez-Pena y Valenzuela, Rafiqa Ameziane, Mohammed Akaaboun. Acetylcholinesterase dynamics at the neuromuscular junction of live animals. The Journal of biological chemistry. vol 281. issue 15. 2006-06-05. PMID:16455662. |
furthermore, complete one-time inactivation of ache activity significantly increases the removal of postsynaptic nicotinic acetylcholine receptors (achrs). |
2006-06-05 |
2023-08-12 |
mouse |
| Kamil Kuca, Daniel Juna, Kamil Musile. Structural requirements of acetylcholinesterase reactivators. Mini reviews in medicinal chemistry. vol 6. issue 3. 2006-05-25. PMID:16515465. |
anticholinergic drugs block effects of accumulated neurotransmitter acetylcholine at nicotinic and muscarinic receptor sites, while oximes reactivate ache inhibited by opcs. |
2006-05-25 |
2023-08-12 |
Not clear |
| Kwan Ha Park, Young-Suk Kim, Ee-Yung Chung, Sun-Nam Choe, Jong-Jae Cho. Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 139. issue 4. 2006-05-08. PMID:15683842. |
the endogenous cholinergic agonist acetylcholine (ach), ache-resistant synthetic agonist carbachol, and the reversible carbamate type of ache inhibitor physostigmine, all potently depressed spontaneous cardiac contractility. |
2006-05-08 |
2023-08-12 |
Not clear |
| Rehan Baqri, Rakshita Charan, Kristina Schimmelpfeng, Swati Chavan, Krishanu Ra. Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in Drosophila. Journal of neurobiology. vol 66. issue 4. 2006-04-28. PMID:16408306. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) are involved in acetylcholine synthesis and degradation at pre- and postsynaptic compartments, respectively. |
2006-04-28 |
2023-08-12 |
drosophila_melanogaster |
| Mohammad A Kamal, Abdulaziz A Al-Jafari, Qian-Sheng Yu, Nigel H Grei. Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine. Biochimica et biophysica acta. vol 1760. issue 2. 2006-04-27. PMID:16309845. |
in contrast, however, its sister enzyme, butyrylcholinesterase (buche), that likewise cleaves acetylcholine (ach), is elevated and both ache and buche co-localize in high amounts with the classical pathological hallmarks of ad. |
2006-04-27 |
2023-08-12 |
human |
| Philip Prathipati, Anil K Saxen. Evaluation of binary QSAR models derived from LUDI and MOE scoring functions for structure based virtual screening. Journal of chemical information and modeling. vol 46. issue 1. 2006-04-14. PMID:16426038. |
estrogen receptor alphamimics (eralpha_mimics), estrogen receptor alphatoxins (eralpha_toxins), matrix metalloprotease 3 inhibitors (mmp-3), factor xa inhibitors (fxa), and acetylcholine esterase inhibitors (ache). |
2006-04-14 |
2023-08-12 |
Not clear |
| M Villarroya, A G García, J L Marc. New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544507. |
for instance, rivastigmine is a dual inhibitor of ache and butyrylcholinesterase (buche), and galanthamine is a mild inhibitor of ache and an allosteric potentiating ligand of neuronal nicotinic receptors for acetylcholine (nachrs). |
2006-04-10 |
2023-08-12 |
Not clear |
| Petra Kapková, Vildan Alptüzün, Peter Frey, Ercin Erciyas, Ulrike Holzgrab. Search for dual function inhibitors for Alzheimer's disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity. Bioorganic & medicinal chemistry. vol 14. issue 2. 2006-04-06. PMID:16198581. |
pharmacol.2003, 55, 1397] furthermore, the anti-abeta fibril formation property of ache inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels. |
2006-04-06 |
2023-08-12 |
Not clear |
| Daquan Gao, Chang-Guo Zha. Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase. Proteins. vol 62. issue 1. 2006-03-31. PMID:16288482. |
the computational results consistently reveal a unique role of the oxyanion hole (consisting of g116, g117, and a199) in bche-catalyzed hydrolysis of cocaine, compared to acetylcholinesterase (ache)-catalyzed hydrolysis of acetylcholine. |
2006-03-31 |
2023-08-12 |
human |
| David E Kuhl, Robert A Koeppe, Scott E Snyder, Satoshi Minoshima, Kirk A Frey, Michael R Kilbour. In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Annals of neurology. vol 59. issue 1. 2006-03-23. PMID:16278840. |
we tested the premise that cholinesterase inhibitor therapy should target butyrylcholinesterase (buche) in alzheimer's disease (ad), not acetylcholinesterase (ache) alone, because both enzymes hydrolyze acetylcholine, and buche is increased in ad cerebral cortex. |
2006-03-23 |
2023-08-12 |
Not clear |
| Kristin Huse Haug, Inger Lise Bogen, Harald Osmundsen, Ivar Walaas, Frode Fonnu. Effects on cholinergic markers in rat brain and blood after short and prolonged administration of donepezil. Neurochemical research. vol 30. issue 12. 2006-03-21. PMID:16362770. |
after 14 days administration (1x3 mg/kg, decapitation 4 h after the last injection) the cerebral acetylcholine level was increased by 35% and the ache activity was decreased by 66% and 32% in brain and blood, respectively. |
2006-03-21 |
2023-08-12 |
human |
| J M Rollinger, P Mocka, C Zidorn, E P Ellmerer, T Langer, H Stuppne. Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Current drug discovery technologies. vol 2. issue 3. 2006-03-10. PMID:16472227. |
because of the direct correlation of cholinergic deficit and the severity of dementia, alzheimer's disease is preferentially treated with acetylcholinesterase (ache) inhibitors to supplement the acetylcholine level. |
2006-03-10 |
2023-08-12 |
Not clear |
| Alexandre Widmer, Izabela Panek, Ulli Höger, Shannon Meisner, Andrew S French, Päivi H Torkkel. Acetylcholine receptors in spider peripheral mechanosensilla. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 192. issue 1. 2006-03-07. PMID:16184378. |
activities of acetylcholine (ach) synthesizing enzyme choline acetyltransferase (chat) and ach degrading enzyme acetylcholine esterase (ache) were previously found in some efferent fibers. |
2006-03-07 |
2023-08-12 |
spider |
| Hiroyuki Kobayashi, Atsuyuki Yamataka, Geoffrey J Lane, Takeshi Miyan. Disseminated mixed intestinal dysmotility (DMID): a new intestinal ganglion cell disorder? Pediatric surgery international. vol 21. issue 11. 2006-03-03. PMID:16133513. |
in each case, three 10 cm specimens were obtained randomly from the jejunum and ileum, and two 5 cm specimens were obtained randomly from each of the ascending colon, transverse colon, descending colon, and rectum and treated with hematoxylin and eosin (h & e) staining, acetylcholine esterase (ache) histochemistry, and protein gene product 9.5 (pgp9.5) and neural cell adhesion molecule (ncam) immunohistochemistry for histopathologic assessment. |
2006-03-03 |
2023-08-12 |
Not clear |
| Terrone L Rosenberry, Joseph L Johnson, Bernadette Cusack, Jamie L Thomas, Sujata Emani, Kunisi S Venkatasubba. Interactions between the peripheral site and the acylation site in acetylcholinesterase. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256966. |
acetylcholinesterase (ache) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. |
2006-02-24 |
2023-08-12 |
Not clear |
| Cecilio J Vida. Expression of cholinesterases in brain and non-brain tumours. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256970. |
although the involvement of cholinesterases (ches) in the removal of acetylcholine (ach) at cholinergic synapses is firmly established, there is evidence to suggest that acetylcholinesterase (ache) and butyrylcholinesterase (buche) take part in several cellular processes. |
2006-02-24 |
2023-08-12 |
Not clear |
| Richard L Rotundo, Susana G Rossi, Lewis M Kimbell, Carlos Ruiz, Emilio Marrer. Targeting acetylcholinesterase to the neuromuscular synapse. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16289417. |
while most ache clusters on quail myotubes are devoid of acetylcholine receptors, treatment of the culture with recombinant agrin results in a rapid translocation of receptors to the ache clusters in less than 4h. |
2006-02-24 |
2023-08-12 |
mouse |