| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, Pascale Marcho. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16837465. |
complementary crystal structures of mouse ache and an inactive mouse ache mutant with a substituted catalytic serine (s203a), in various complexes with four substrates (acetylcholine, acetylthiocholine, succinyldicholine, and butyrylthiocholine), two non-hydrolyzable substrate analogues (m-(n,n,n-trimethylammonio)-trifluoroacetophenone and 4-ketoamyltrimethylammonium), and one reaction product (choline) were solved in the 2.05-2.65-a resolution range. |
2006-11-27 |
2023-08-12 |
mouse |
| Ai-Ling Fu, Zhao-Hui Dong, Man-Ji Su. Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16872586. |
there was also an increase in acetylcholinesterase (ache) activity and a reduction in the choline acetyltransferase (chat) activity and acetylcholine (ach) levels. |
2006-10-31 |
2023-08-12 |
mouse |
| Kamil Kuca, Daniel Jun, Jiri Cabal, Martina Hrabinova, Lucie Bartosova, Veronika Opletalov. Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent. Basic & clinical pharmacology & toxicology. vol 98. issue 4. 2006-10-26. PMID:16623863. |
oximes counteract acetylcholine increase, resulting from ache inhibition. |
2006-10-26 |
2023-08-12 |
human |
| L Gandía, R M Alvarez, J M Hernández-Guijo, J M González-Rubio, R de Pascual, J Rojo, L Tapi. [Anticholinesterases in the treatment of Alzheimer's disease]. Revista de neurologia. vol 42. issue 8. 2006-10-18. PMID:16625509. |
this led to the formulation of the so-called cholinergic theory of alzheimer, which provides the rationale behind the use of the drugs that are currently available to treat this disease, namely, acetylcholine esterase (ache) inhibitors (rivastigmine, donepezil and galanthamine). |
2006-10-18 |
2023-08-12 |
Not clear |
| Deqiang Zhang, J Andrew McCammo. The association of tetrameric acetylcholinesterase with ColQ tail: a block normal mode analysis. PLoS computational biology. vol 1. issue 6. 2006-09-29. PMID:16299589. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. |
2006-09-29 |
2023-08-12 |
mouse |
| Edson X Albuquerque, Edna F R Pereira, Yasco Aracava, William P Fawcett, Maristela Oliveira, William R Randall, Tracey A Hamilton, Robert K Kan, James A Romano, Michael Adle. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16914529. |
most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (ache), the enzyme that inactivates the neurotransmitter acetylcholine. |
2006-09-29 |
2023-08-12 |
Not clear |
| Lucie Svobodová, Jan Krůsek, Tomás Hendrych, Frantisek Vyskoci. Physostigmine modulation of acetylcholine currents in COS cells transfected with mouse muscle nicotinic receptor. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16530961. |
physostigmine (phy), a reversible inhibitor of acetylcholine (ach) esterase (ache), may also act as a low potency agonist and a modulator of the nicotinic receptor. |
2006-09-28 |
2023-08-12 |
mouse |
| T-M Shih, S W Hulet, J H McDonoug. The effects of repeated low-dose sarin exposure. Toxicology and applied pharmacology. vol 215. issue 2. 2006-09-28. PMID:16556454. |
the animals were assessed for changes in body weight, red blood cell (rbc) acetylcholinesterase (ache) levels, neurobehavioral reactions to a functional observational battery (fob), cortical electroencephalographic (eeg) power spectrum, and intrinsic acetylcholine (ach) neurotransmitter (nt) regulation over the 2 weeks of sarin exposure and for up to 12 days postinjection. |
2006-09-28 |
2023-08-12 |
Not clear |
| Agneta Nordber. Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease. Alzheimer disease and associated disorders. vol 20. issue 2 Suppl 1. 2006-09-28. PMID:16772751. |
inhibitors of the enzyme acetylcholinesterase (ache) are presently used as long-term symptomatic treatments for patients with alzheimer disease (ad), as they enhance central levels of synaptic acetylcholine. |
2006-09-28 |
2023-08-12 |
Not clear |
| K Moorthy, Umesh C S Yadav, M R Siddiqui, Anil K Mantha, Seemi F Basir, D Sharma, Sudha M Cowsik, Najma Z Baque. Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats. Biogerontology. vol 6. issue 5. 2006-09-27. PMID:16463111. |
results show decreased activity of acetylcholine esterase (ache) whereas the level of lipid peroxidation increased with age, and after the hormone treatments both ache activity and level of lipid peroxidation returned to control values. |
2006-09-27 |
2023-08-12 |
rat |
| A C da Silva, D Balz, J B D'A de Souza, V M Morsch, M C Corrêa, G D Zanetti, M P Manfron, M R C Schetinge. Inhibition of NTPDase, 5'-nucleotidase, Na+/K+-ATPase and acetylcholinesterase activities by subchronic treatment with Casearia sylvestris. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 13. issue 7. 2006-09-26. PMID:16785042. |
the rate of acetylcholine degradation was reduced, as shown by the inhibition of ache (31.65% and 26.74%, samples a and b, respectively). |
2006-09-26 |
2023-08-12 |
rat |
| Dean M Robinson, Greg L Ploske. Galantamine extended release. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863272. |
galantamine inhibits acetylcholinesterase (ache) to slow acetylcholine hydrolysis, and may also modulate presynaptic nicotinic receptor activation, thereby increasing neurotransmitter concentrations in the synaptic cleft.black triangle once-daily galantamine extended release (er) 24 mg and twice-daily galantamine immediate release (ir) 12 mg are bioequivalent in terms of the area under the plasma concentration-time curve from time 0 to 24 hours and steady-state minimum plasma concentration.black triangle primary endpoints indicated a significantly greater effect of galantamine er on cognitive performance than placebo, with efficacy similar to galantamine ir, in a randomised, double-blind trial. |
2006-09-19 |
2023-08-12 |
Not clear |
| Annette Møller Dall, Jens Zimme. Development of DARPP-32-positive parts of fetal pig ganglionic eminence and ventral mesencephalon in organotypic slice co-cultures. Experimental neurology. vol 200. issue 1. 2006-09-05. PMID:16529743. |
the darpp-32-positive areas moreover overlapped with areas rich in acetylcholine esterase (ache) and were the preferred target areas for th-positive fibers from the co-cultured vm. |
2006-09-05 |
2023-08-12 |
Not clear |
| Carlos Mauricio R Sant'Anna, Andrea dos Santos Viana, Nailton Monteiro do Nascimento Junio. A semiempirical study of acetylcholine hydrolysis catalyzed by Drosophila melanogaster acetylcholinesterase. Bioorganic chemistry. vol 34. issue 2. 2006-08-30. PMID:16540146. |
the enzymatic mechanism of acetylcholine hydrolysis was evaluated by semiempirical molecular orbital calculations with a model constructed with the coordinates of sixteen amino acids and four water molecules from the crystallographic structure of drosophila melanogaster acetylcholinesterase (ache, entry 1qo9 in the protein data bank). |
2006-08-30 |
2023-08-12 |
drosophila_melanogaster |
| Zoraide R Ramos, Jucélia J Fortunato, Fabiano R Agostinho, Márcio R Martins, Maísa Correa, Maria Rosa C Schetinger, Felipe Dal-Pizzol, João Queved. Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test. Neurotoxicity research. vol 9. issue 4. 2006-08-23. PMID:16782587. |
classically, this toxicity is attributed mainly to the accumulation of acetylcholine (ach), due to inhibition of acetylcholinesterase (ache), and consequently overstimulation of the nicotinic and muscarinic receptors. |
2006-08-23 |
2023-08-12 |
human |
| Lucie Bartosova, Kamil Kuca, Gabriela Kunesova, Daniel Ju. The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure. Neurotoxicity research. vol 9. issue 4. 2006-08-23. PMID:16782588. |
the pharmacological action of oximes is multiple: they are able to reactivate the inhibited ache, but they affect acetylcholine release in peripheral and central cholinergic synapses, allosterically modulate the muscarinic receptors in peripheral and central synapses, and influence the nicotinic receptor-associated ion-channels. |
2006-08-23 |
2023-08-12 |
mouse |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
experimental manipulations suggest that in vivo administration of cholinergic agonists or inhibitors of acetylcholinesterase (ache) increases the concentration of acetylcholine. |
2006-06-30 |
2023-08-12 |
rat |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
our results demonstrated a direct evidence of a decrease in the activity of the ache in rat brain regions during seizure activity that could be responsible by regulation of acetylcholine levels during the establishment of se induced by pilocarpine. |
2006-06-30 |
2023-08-12 |
rat |
| Yi Xiao, Valeri Pavlov, Bella Shlyahovsky, Itamar Willne. An Os(II)--bisbipyridine--4-picolinic acid complex mediates the biocatalytic growth of au nanoparticles: optical detection of glucose and acetylcholine esterase inhibition. Chemistry (Weinheim an der Bergstrasse, Germany). vol 11. issue 9. 2006-06-27. PMID:15729675. |
in the second system, the enzyme acetylcholine esterase, ache, is assayed by the catalytic growth of the au nps. |
2006-06-27 |
2023-08-12 |
Not clear |