| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bhupendra P Doctor, Ashima Saxen. Bioscavengers for the protection of humans against organophosphate toxicity. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16293236. |
current antidotes for organophosphorus compounds (op) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (ache) from irreversible inhibition by op compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-pam chloride) to reactivate op-inhibited ache. |
2006-02-24 |
2023-08-12 |
human |
| Jennifer M Bui, J Andrew McCammo. Acetylcholinesterase: pivotal roles of its long omega loop (Cys69-Cys96) in regulating substrate binding. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429484. |
acetycholinesterase (ache) hydrolyses neuronal and non-neuronal acetylcholine (ach) very efficiently, and this possibly prevents the mitogenic action of ach. |
2006-02-24 |
2023-08-12 |
Not clear |
| Laura E Paraoanu, Paul G Laye. Mouse AChE binds in vivo to domain IV of laminin-1beta. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429555. |
functions of acetylcholinesterase (ache) other than hydrolysis of acetylcholine, e.g. |
2006-02-24 |
2023-08-12 |
mouse |
| b' A Komersov\\xc3\\xa1, K Komers, P Zdrazilov\\xc3\\xa. Kinetics of hydrolysis of acetylthiocholine and acetylcholine by cholinesterases. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16498728.' |
kinetics of hydrolysis of acetylthiocholine (atch) and acetylcholine (ach) by butyrylcholinesterase (bche) and acetylcholinesterase (ache) are studied. |
2006-02-24 |
2023-08-12 |
Not clear |
| Georg Grön, Matthias Kirstein, Axel Thielscher, Matthias W Riepe, Manfred Spitze. Cholinergic enhancement of episodic memory in healthy young adults. Psychopharmacology. vol 182. issue 1. 2006-02-22. PMID:16021483. |
acetylcholine esterase (ache) inhibitors are known to remediate symptoms of alzheimer's disease. |
2006-02-22 |
2023-08-12 |
human |
| Bryan F Curtin, Lauren M Tetz, Jaimee R Compton, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. Journal of cellular biochemistry. vol 96. issue 4. 2006-02-21. PMID:16149071. |
the biological effects of organophosphorous (op) chemical warfare nerve agents (cwnas) are exerted by inhibition of acetylcholinesterase (ache), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. |
2006-02-21 |
2023-08-12 |
human |
| Ai-Ling Fu, Xing-Mei Zhang, Man-Ji Su. Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice. Brain research. vol 1066. issue 1-2. 2006-02-15. PMID:16337925. |
the results showed that the ache activity decreased gradually along with time, initiating at 8 h and lasting 42 h. the time-effect curves of acetylcholine (ach) behaved consistency with that of ache activity. |
2006-02-15 |
2023-08-12 |
mouse |
| Tetsuya Shiraishi, Tatsuya Kikuchi, Kiyoshi Fukushi, Hitoshi Shinotoh, Shin-ichiro Nagatsuka, Noriko Tanaka, Tsuneyoshi Ota, Koichi Sato, Shigeki Hirano, Shuji Tanada, Masaomi Iyo, Toshiaki Iri. Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 12. 2006-01-24. PMID:15920507. |
the purpose of this study was to estimate in vivo plasma ic(50) of donepezil in living monkeys by measuring plasma donepezil concentration (lc/ms/ms) and brain ache activity with positron emission tomography (pet) and n-[(11)c]methylpiperidin-4-yl acetate, which is an acetylcholine analog recently developed by us for quantifying in vivo brain ache activity. |
2006-01-24 |
2023-08-12 |
monkey |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos D Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974920. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2006-01-18 |
2023-08-12 |
human |
| Yoji Umezawa, Motohiro Nishi. CH/pi hydrogen bonds as evidenced in the substrate specificity of acetylcholine esterase. Biopolymers. vol 79. issue 5. 2006-01-04. PMID:16113998. |
the crystal structure of acetylcholine esterase (ache) in complex with various inhibitors, investigated as drugs for improvement of the cognitive ability of early stage alzheimer's disease, has been analyzed with the use of our program chpi. |
2006-01-04 |
2023-08-12 |
Not clear |
| Mary C Theroux, Karyn G Oberman, Justine Lahaye, Bobbie A Boyce, David Duhadaway, Freeman Miller, Robert E Akin. Dysmorphic neuromuscular junctions associated with motor ability in cerebral palsy. Muscle & nerve. vol 32. issue 5. 2005-12-06. PMID:16025530. |
leg muscle biopsies collected from ambulatory (n = 21) or nonambulatory (n = 38) cp patients were stained in order to detect acetylcholine receptor (achr) and acetylcholine esterase (ache). |
2005-12-06 |
2023-08-12 |
Not clear |
| Horst Thiermann, Peter Eyer, Franz Worek, Ladislaus Szinic. Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicology. vol 214. issue 3. 2005-11-21. PMID:16040183. |
toxicity of organophosphates (op) is caused by inhibition of acetylcholinesterase (ache), resulting in accumulation of acetylcholine. |
2005-11-21 |
2023-08-12 |
mouse |
| Hina Mehta, Reena Haobam, Rajamma Usha, Kochupurackal P Mohanakuma. Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. Behavioural brain research. vol 163. issue 2. 2005-11-07. PMID:15990178. |
it produces tremor in animals, which is believed to be due to an increase in the brain acetylcholine level following ache inhibition. |
2005-11-07 |
2023-08-12 |
mouse |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Current opinion in pharmacology. vol 5. issue 3. 2005-09-08. PMID:15907917. |
the synaptic enzyme acetylcholinesterase (ache) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. |
2005-09-08 |
2023-08-12 |
Not clear |
| Hidekazu Tomimoto, Ryo Ohtani, Masunari Shibata, Noriko Nakamura, Masafumi Ihar. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15785029. |
the cholinergic pathway was labeled either by histochemistry for acetylcholine esterase (ache), a degradatory enzyme of ach, or by immunohistochemistry for choline acetyltransferase, its synthetic enzyme. |
2005-09-01 |
2023-08-12 |
Not clear |
| Paul A Dabisch, David C Burnett, Dennis B Miller, Edward M Jakubowski, William T Muse, Jeffry S Forster, Jacqueline A Scotto, Jill R Jarvis, Emily A Davis, Stanley W Hulet, Sharon A Reutter, Robert J Mioduszewski, Sandra A Thomso. Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 21. issue 3. 2005-08-26. PMID:15969635. |
inhibition of acetylcholinesterase (ache) by the organophosphorous compound sarin (gb) results in the accumulation of acetylcholine and excessive cholinergic stimulation. |
2005-08-26 |
2023-08-12 |
rat |
| Marcella Reale, Carla Iarlori, Francesco Gambi, Isabella Lucci, Mirella Salvatore, Domenico Gamb. Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Experimental gerontology. vol 40. issue 3. 2005-08-25. PMID:15763393. |
one strategy for treatment of ad has been to use acetylcholinesterase (ache) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. |
2005-08-25 |
2023-08-12 |
Not clear |
| Kaj Blenno. Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 1. issue 2. 2005-08-23. PMID:15717022. |
the introduction of acetylcholine esterase (ache) inhibitors as a symptomatic treatment of alzheimer's disease (ad) has made patients seek medical advice at an earlier stage of the disease. |
2005-08-23 |
2023-08-12 |
Not clear |
| Anis Alam, Laishram Indira Singha, Vinod Sing. Molecular characterization of tumor associated antigen in mice exposed to a hepatocarcinogen. Molecular and cellular biochemistry. vol 271. issue 1-2. 2005-08-23. PMID:15881669. |
carcinogenesis induction in mice was monitored by assays of y-glutamyl transpeptidase (ggt), acetylcholine esterase (ache), glutathione-s-transferase (gst) activities and the level of glutathione (gsh) in liver. |
2005-08-23 |
2023-08-12 |
mouse |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Human mutation. vol 24. issue 5. 2005-07-29. PMID:15459952. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2005-07-29 |
2023-08-12 |
human |