| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annette Møller Dall, Jens Zimme. Development of DARPP-32-positive parts of fetal pig ganglionic eminence and ventral mesencephalon in organotypic slice co-cultures. Experimental neurology. vol 200. issue 1. 2006-09-05. PMID:16529743. |
the darpp-32-positive areas moreover overlapped with areas rich in acetylcholine esterase (ache) and were the preferred target areas for th-positive fibers from the co-cultured vm. |
2006-09-05 |
2023-08-12 |
Not clear |
| Carlos Mauricio R Sant'Anna, Andrea dos Santos Viana, Nailton Monteiro do Nascimento Junio. A semiempirical study of acetylcholine hydrolysis catalyzed by Drosophila melanogaster acetylcholinesterase. Bioorganic chemistry. vol 34. issue 2. 2006-08-30. PMID:16540146. |
the enzymatic mechanism of acetylcholine hydrolysis was evaluated by semiempirical molecular orbital calculations with a model constructed with the coordinates of sixteen amino acids and four water molecules from the crystallographic structure of drosophila melanogaster acetylcholinesterase (ache, entry 1qo9 in the protein data bank). |
2006-08-30 |
2023-08-12 |
drosophila_melanogaster |
| Zoraide R Ramos, Jucélia J Fortunato, Fabiano R Agostinho, Márcio R Martins, Maísa Correa, Maria Rosa C Schetinger, Felipe Dal-Pizzol, João Queved. Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test. Neurotoxicity research. vol 9. issue 4. 2006-08-23. PMID:16782587. |
classically, this toxicity is attributed mainly to the accumulation of acetylcholine (ach), due to inhibition of acetylcholinesterase (ache), and consequently overstimulation of the nicotinic and muscarinic receptors. |
2006-08-23 |
2023-08-12 |
human |
| Lucie Bartosova, Kamil Kuca, Gabriela Kunesova, Daniel Ju. The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure. Neurotoxicity research. vol 9. issue 4. 2006-08-23. PMID:16782588. |
the pharmacological action of oximes is multiple: they are able to reactivate the inhibited ache, but they affect acetylcholine release in peripheral and central cholinergic synapses, allosterically modulate the muscarinic receptors in peripheral and central synapses, and influence the nicotinic receptor-associated ion-channels. |
2006-08-23 |
2023-08-12 |
mouse |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
experimental manipulations suggest that in vivo administration of cholinergic agonists or inhibitors of acetylcholinesterase (ache) increases the concentration of acetylcholine. |
2006-06-30 |
2023-08-12 |
rat |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
our results demonstrated a direct evidence of a decrease in the activity of the ache in rat brain regions during seizure activity that could be responsible by regulation of acetylcholine levels during the establishment of se induced by pilocarpine. |
2006-06-30 |
2023-08-12 |
rat |
| Yi Xiao, Valeri Pavlov, Bella Shlyahovsky, Itamar Willne. An Os(II)--bisbipyridine--4-picolinic acid complex mediates the biocatalytic growth of au nanoparticles: optical detection of glucose and acetylcholine esterase inhibition. Chemistry (Weinheim an der Bergstrasse, Germany). vol 11. issue 9. 2006-06-27. PMID:15729675. |
in the second system, the enzyme acetylcholine esterase, ache, is assayed by the catalytic growth of the au nps. |
2006-06-27 |
2023-08-12 |
Not clear |
| Yi Xiao, Valeri Pavlov, Bella Shlyahovsky, Itamar Willne. An Os(II)--bisbipyridine--4-picolinic acid complex mediates the biocatalytic growth of au nanoparticles: optical detection of glucose and acetylcholine esterase inhibition. Chemistry (Weinheim an der Bergstrasse, Germany). vol 11. issue 9. 2006-06-27. PMID:15729675. |
the hydrolysis of acetylcholine (2) by ache to choline is followed by the [os(bpy)(2)pyco(2)h](3+) mediated oxidation of choline to betaine and the concomitant growth of the au nps. |
2006-06-27 |
2023-08-12 |
Not clear |
| Camiel F de Jong, Rico J E Derks, Ben Bruyneel, Wilfried Niessen, Hubertus Irt. High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts. Journal of chromatography. A. vol 1112. issue 1-2. 2006-06-27. PMID:16516896. |
ache activity of sample components is monitored by a post-column biochemical assay that is based on the separate, sequential mixing of ache and acetylcholine, respectively, with the hplc eluate. |
2006-06-27 |
2023-08-12 |
Not clear |
| Anil K Mantha, K Moorthy, Sudha M Cowsik, Najma Z Baque. Membrane associated functions of neurokinin B (NKB) on Abeta (25-35) induced toxicity in aging rat brain synaptosomes. Biogerontology. vol 7. issue 1. 2006-06-23. PMID:16518717. |
the effect of different concentrations (0.1-5 microm) of neurokinin b (nkb) and abeta (25-35) on acetylcholine esterase (ache), na(+)-k(+) atpase and membrane fluidity (dph anisotropy) were investigated in rat brain synaptosomes of 3, 9, 18 and 30 months old. |
2006-06-23 |
2023-08-12 |
rat |
| Xiu-ling Ji, Liu Yang, Zhe-min Shen, Jin-ping Cheng, Gui-wen Jin, Li-ya Qu, Wen-hua Wan. Neurotransmitter level changes in domestic ducks (Shaoxing duck) growing up in typical mercury contaminated area in China. Journal of environmental sciences (China). vol 17. issue 2. 2006-06-22. PMID:16295900. |
an increased content of acetylcholine (ach) in brain and blood and a decreased activity of acetylcholinesterase (ache) in blood were observed. |
2006-06-22 |
2023-08-12 |
Not clear |
| Qing Chang, Lisa M Savage, Paul E Gol. Microdialysis measures of functional increases in ACh release in the hippocampus with and without inclusion of acetylcholinesterase inhibitors in the perfusate. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16579834. |
because brain extracellular acetylcholine (ach) levels are near detection limits in microdialysis samples, an acetylcholinesterase (ache) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ach levels in the dialysate, a practice that raises concerns that the inhibitor might alter the results. |
2006-06-22 |
2023-08-12 |
Not clear |
| Eric Krejci, Isabel Martinez-Pena y Valenzuela, Rafiqa Ameziane, Mohammed Akaaboun. Acetylcholinesterase dynamics at the neuromuscular junction of live animals. The Journal of biological chemistry. vol 281. issue 15. 2006-06-05. PMID:16455662. |
furthermore, complete one-time inactivation of ache activity significantly increases the removal of postsynaptic nicotinic acetylcholine receptors (achrs). |
2006-06-05 |
2023-08-12 |
mouse |
| Kamil Kuca, Daniel Juna, Kamil Musile. Structural requirements of acetylcholinesterase reactivators. Mini reviews in medicinal chemistry. vol 6. issue 3. 2006-05-25. PMID:16515465. |
anticholinergic drugs block effects of accumulated neurotransmitter acetylcholine at nicotinic and muscarinic receptor sites, while oximes reactivate ache inhibited by opcs. |
2006-05-25 |
2023-08-12 |
Not clear |
| Kwan Ha Park, Young-Suk Kim, Ee-Yung Chung, Sun-Nam Choe, Jong-Jae Cho. Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 139. issue 4. 2006-05-08. PMID:15683842. |
the endogenous cholinergic agonist acetylcholine (ach), ache-resistant synthetic agonist carbachol, and the reversible carbamate type of ache inhibitor physostigmine, all potently depressed spontaneous cardiac contractility. |
2006-05-08 |
2023-08-12 |
Not clear |
| Rehan Baqri, Rakshita Charan, Kristina Schimmelpfeng, Swati Chavan, Krishanu Ra. Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in Drosophila. Journal of neurobiology. vol 66. issue 4. 2006-04-28. PMID:16408306. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) are involved in acetylcholine synthesis and degradation at pre- and postsynaptic compartments, respectively. |
2006-04-28 |
2023-08-12 |
drosophila_melanogaster |
| Mohammad A Kamal, Abdulaziz A Al-Jafari, Qian-Sheng Yu, Nigel H Grei. Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine. Biochimica et biophysica acta. vol 1760. issue 2. 2006-04-27. PMID:16309845. |
in contrast, however, its sister enzyme, butyrylcholinesterase (buche), that likewise cleaves acetylcholine (ach), is elevated and both ache and buche co-localize in high amounts with the classical pathological hallmarks of ad. |
2006-04-27 |
2023-08-12 |
human |
| Philip Prathipati, Anil K Saxen. Evaluation of binary QSAR models derived from LUDI and MOE scoring functions for structure based virtual screening. Journal of chemical information and modeling. vol 46. issue 1. 2006-04-14. PMID:16426038. |
estrogen receptor alphamimics (eralpha_mimics), estrogen receptor alphatoxins (eralpha_toxins), matrix metalloprotease 3 inhibitors (mmp-3), factor xa inhibitors (fxa), and acetylcholine esterase inhibitors (ache). |
2006-04-14 |
2023-08-12 |
Not clear |
| M Villarroya, A G García, J L Marc. New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544507. |
for instance, rivastigmine is a dual inhibitor of ache and butyrylcholinesterase (buche), and galanthamine is a mild inhibitor of ache and an allosteric potentiating ligand of neuronal nicotinic receptors for acetylcholine (nachrs). |
2006-04-10 |
2023-08-12 |
Not clear |