| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petra Kapková, Vildan Alptüzün, Peter Frey, Ercin Erciyas, Ulrike Holzgrab. Search for dual function inhibitors for Alzheimer's disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity. Bioorganic & medicinal chemistry. vol 14. issue 2. 2006-04-06. PMID:16198581. |
pharmacol.2003, 55, 1397] furthermore, the anti-abeta fibril formation property of ache inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels. |
2006-04-06 |
2023-08-12 |
Not clear |
| Daquan Gao, Chang-Guo Zha. Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase. Proteins. vol 62. issue 1. 2006-03-31. PMID:16288482. |
the computational results consistently reveal a unique role of the oxyanion hole (consisting of g116, g117, and a199) in bche-catalyzed hydrolysis of cocaine, compared to acetylcholinesterase (ache)-catalyzed hydrolysis of acetylcholine. |
2006-03-31 |
2023-08-12 |
human |
| David E Kuhl, Robert A Koeppe, Scott E Snyder, Satoshi Minoshima, Kirk A Frey, Michael R Kilbour. In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Annals of neurology. vol 59. issue 1. 2006-03-23. PMID:16278840. |
we tested the premise that cholinesterase inhibitor therapy should target butyrylcholinesterase (buche) in alzheimer's disease (ad), not acetylcholinesterase (ache) alone, because both enzymes hydrolyze acetylcholine, and buche is increased in ad cerebral cortex. |
2006-03-23 |
2023-08-12 |
Not clear |
| Kristin Huse Haug, Inger Lise Bogen, Harald Osmundsen, Ivar Walaas, Frode Fonnu. Effects on cholinergic markers in rat brain and blood after short and prolonged administration of donepezil. Neurochemical research. vol 30. issue 12. 2006-03-21. PMID:16362770. |
after 14 days administration (1x3 mg/kg, decapitation 4 h after the last injection) the cerebral acetylcholine level was increased by 35% and the ache activity was decreased by 66% and 32% in brain and blood, respectively. |
2006-03-21 |
2023-08-12 |
human |
| J M Rollinger, P Mocka, C Zidorn, E P Ellmerer, T Langer, H Stuppne. Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Current drug discovery technologies. vol 2. issue 3. 2006-03-10. PMID:16472227. |
because of the direct correlation of cholinergic deficit and the severity of dementia, alzheimer's disease is preferentially treated with acetylcholinesterase (ache) inhibitors to supplement the acetylcholine level. |
2006-03-10 |
2023-08-12 |
Not clear |
| Alexandre Widmer, Izabela Panek, Ulli Höger, Shannon Meisner, Andrew S French, Päivi H Torkkel. Acetylcholine receptors in spider peripheral mechanosensilla. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 192. issue 1. 2006-03-07. PMID:16184378. |
activities of acetylcholine (ach) synthesizing enzyme choline acetyltransferase (chat) and ach degrading enzyme acetylcholine esterase (ache) were previously found in some efferent fibers. |
2006-03-07 |
2023-08-12 |
spider |
| Hiroyuki Kobayashi, Atsuyuki Yamataka, Geoffrey J Lane, Takeshi Miyan. Disseminated mixed intestinal dysmotility (DMID): a new intestinal ganglion cell disorder? Pediatric surgery international. vol 21. issue 11. 2006-03-03. PMID:16133513. |
in each case, three 10 cm specimens were obtained randomly from the jejunum and ileum, and two 5 cm specimens were obtained randomly from each of the ascending colon, transverse colon, descending colon, and rectum and treated with hematoxylin and eosin (h & e) staining, acetylcholine esterase (ache) histochemistry, and protein gene product 9.5 (pgp9.5) and neural cell adhesion molecule (ncam) immunohistochemistry for histopathologic assessment. |
2006-03-03 |
2023-08-12 |
Not clear |
| Terrone L Rosenberry, Joseph L Johnson, Bernadette Cusack, Jamie L Thomas, Sujata Emani, Kunisi S Venkatasubba. Interactions between the peripheral site and the acylation site in acetylcholinesterase. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256966. |
acetylcholinesterase (ache) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. |
2006-02-24 |
2023-08-12 |
Not clear |
| Cecilio J Vida. Expression of cholinesterases in brain and non-brain tumours. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256970. |
although the involvement of cholinesterases (ches) in the removal of acetylcholine (ach) at cholinergic synapses is firmly established, there is evidence to suggest that acetylcholinesterase (ache) and butyrylcholinesterase (buche) take part in several cellular processes. |
2006-02-24 |
2023-08-12 |
Not clear |
| Richard L Rotundo, Susana G Rossi, Lewis M Kimbell, Carlos Ruiz, Emilio Marrer. Targeting acetylcholinesterase to the neuromuscular synapse. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16289417. |
while most ache clusters on quail myotubes are devoid of acetylcholine receptors, treatment of the culture with recombinant agrin results in a rapid translocation of receptors to the ache clusters in less than 4h. |
2006-02-24 |
2023-08-12 |
mouse |
| Bhupendra P Doctor, Ashima Saxen. Bioscavengers for the protection of humans against organophosphate toxicity. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16293236. |
current antidotes for organophosphorus compounds (op) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (ache) from irreversible inhibition by op compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-pam chloride) to reactivate op-inhibited ache. |
2006-02-24 |
2023-08-12 |
human |
| Jennifer M Bui, J Andrew McCammo. Acetylcholinesterase: pivotal roles of its long omega loop (Cys69-Cys96) in regulating substrate binding. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429484. |
acetycholinesterase (ache) hydrolyses neuronal and non-neuronal acetylcholine (ach) very efficiently, and this possibly prevents the mitogenic action of ach. |
2006-02-24 |
2023-08-12 |
Not clear |
| Laura E Paraoanu, Paul G Laye. Mouse AChE binds in vivo to domain IV of laminin-1beta. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429555. |
functions of acetylcholinesterase (ache) other than hydrolysis of acetylcholine, e.g. |
2006-02-24 |
2023-08-12 |
mouse |
| b' A Komersov\\xc3\\xa1, K Komers, P Zdrazilov\\xc3\\xa. Kinetics of hydrolysis of acetylthiocholine and acetylcholine by cholinesterases. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16498728.' |
kinetics of hydrolysis of acetylthiocholine (atch) and acetylcholine (ach) by butyrylcholinesterase (bche) and acetylcholinesterase (ache) are studied. |
2006-02-24 |
2023-08-12 |
Not clear |
| Georg Grön, Matthias Kirstein, Axel Thielscher, Matthias W Riepe, Manfred Spitze. Cholinergic enhancement of episodic memory in healthy young adults. Psychopharmacology. vol 182. issue 1. 2006-02-22. PMID:16021483. |
acetylcholine esterase (ache) inhibitors are known to remediate symptoms of alzheimer's disease. |
2006-02-22 |
2023-08-12 |
human |
| Bryan F Curtin, Lauren M Tetz, Jaimee R Compton, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. Journal of cellular biochemistry. vol 96. issue 4. 2006-02-21. PMID:16149071. |
the biological effects of organophosphorous (op) chemical warfare nerve agents (cwnas) are exerted by inhibition of acetylcholinesterase (ache), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. |
2006-02-21 |
2023-08-12 |
human |
| Ai-Ling Fu, Xing-Mei Zhang, Man-Ji Su. Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice. Brain research. vol 1066. issue 1-2. 2006-02-15. PMID:16337925. |
the results showed that the ache activity decreased gradually along with time, initiating at 8 h and lasting 42 h. the time-effect curves of acetylcholine (ach) behaved consistency with that of ache activity. |
2006-02-15 |
2023-08-12 |
mouse |
| Tetsuya Shiraishi, Tatsuya Kikuchi, Kiyoshi Fukushi, Hitoshi Shinotoh, Shin-ichiro Nagatsuka, Noriko Tanaka, Tsuneyoshi Ota, Koichi Sato, Shigeki Hirano, Shuji Tanada, Masaomi Iyo, Toshiaki Iri. Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 12. 2006-01-24. PMID:15920507. |
the purpose of this study was to estimate in vivo plasma ic(50) of donepezil in living monkeys by measuring plasma donepezil concentration (lc/ms/ms) and brain ache activity with positron emission tomography (pet) and n-[(11)c]methylpiperidin-4-yl acetate, which is an acetylcholine analog recently developed by us for quantifying in vivo brain ache activity. |
2006-01-24 |
2023-08-12 |
monkey |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos D Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974920. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2006-01-18 |
2023-08-12 |
human |
| Yoji Umezawa, Motohiro Nishi. CH/pi hydrogen bonds as evidenced in the substrate specificity of acetylcholine esterase. Biopolymers. vol 79. issue 5. 2006-01-04. PMID:16113998. |
the crystal structure of acetylcholine esterase (ache) in complex with various inhibitors, investigated as drugs for improvement of the cognitive ability of early stage alzheimer's disease, has been analyzed with the use of our program chpi. |
2006-01-04 |
2023-08-12 |
Not clear |