| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroto Tachikawa, Manabu Igarashi, Jun Nishihira, Teruo Ishibash. Ab initio model study on acetylcholinesterase catalysis: potential energy surfaces of the proton transfer reactions. Journal of photochemistry and photobiology. B, Biology. vol 79. issue 1. 2005-07-29. PMID:15792875. |
ab initio molecular orbital (mo) and hybrid density functional theory (dft) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (ache), which is the nucleophiric addition of ser200 in catalytic triads to a neurotransmitter acetylcholine (ach). |
2005-07-29 |
2023-08-12 |
Not clear |
| Héric Valette, Michel Bottlaender, Frédéric Dollé, Christine Coulon, Michèle Ottaviani, André Syrot. Acute effects of physostigmine and galantamine on the binding of [18F]fluoro-A-85380: a PET study in monkeys. Synapse (New York, N.Y.). vol 56. issue 4. 2005-07-29. PMID:15803498. |
the effects of physostigmine, a more potent ache inhibitor than galantamine, could be interpreted as a desensitization of nachrs, due to a prolonged exposure to high synaptic concentration of acetylcholine or as a competition with acetylcholine. |
2005-07-29 |
2023-08-12 |
monkey |
| Hsiao-chung Tsai, Ruey-an Doon. Simultaneous determination of pH, urea, acetylcholine and heavy metals using array-based enzymatic optical biosensor. Biosensors & bioelectronics. vol 20. issue 9. 2005-06-24. PMID:15681196. |
urease and acetylcholinesterase (ache) were used as model enzymes and were co-entrapped with the sensing probe, fitc-dextran, in the sol-gel matrix to measure ph, urea, acetylcholine (ach) and heavy metals (enzyme inhibitors). |
2005-06-24 |
2023-08-12 |
Not clear |
| Valeri Pavlov, Yi Xiao, Itamar Willne. Inhibition of the acetycholine esterase-stimulated growth of Au nanoparticles: nanotechnology-based sensing of nerve gases. Nano letters. vol 5. issue 4. 2005-06-21. PMID:15826103. |
the acetylcholine esterase, ache, mediated hydrolysis of acetylthiocholine (1) yields a reducing agent thiocholine (2) that stimulates the catalytic enlargement of au np seeds in the presence of aucl(4)(-). |
2005-06-21 |
2023-08-12 |
Not clear |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| J Srinivasan, S Jayadev, D Kumaran, K F Haja Nazeer Ahamed, B Suresh, M Ramanatha. Effect of losartan and enalapril on cognitive deficit caused by Goldblatt induced hypertension. Indian journal of experimental biology. vol 43. issue 3. 2005-05-12. PMID:15816410. |
acetylcholine esterase (ache) levels in the pons medulla, hippocampus, striatum and frontal cortex were measured as a cholinergic marker of learning and memory. |
2005-05-12 |
2023-08-12 |
rat |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c-labeled acetylcholine analogues, n-[(11)c]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (pet). |
2005-05-05 |
2023-08-12 |
human |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
our aim was to develop an (18)f-labeled acetylcholine analogue useful for brain ache mapping with pet, since (18)f, with a longer half-life, has advantages over (11)c. in a preliminary study, a series of n-[(14)c]ethylpiperidin-3-yl or -4-ylmethanol esters (acetyl and propionyl esters) were newly designed and evaluated in vitro regarding the reactivity with and specificity to ache using purified human enzymes, leading to a novel (18)f-labeled acetylcholine analogue, n-[(18)f]fluoroethylpiperidin-4-ylmethyl acetate. |
2005-05-05 |
2023-08-12 |
human |
| Pamela J Lein, Allison D Frye. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological sciences : an official journal of the Society of Toxicology. vol 83. issue 1. 2005-05-02. PMID:15470232. |
we previously demonstrated that the organophosphorus (op) insecticide chlorpyrifos potentiates vagally induced bronchoconstriction independent of acetylcholinesterase (ache) inhibition by decreasing the function of neuronal m2 muscarinic receptors that normally inhibit acetylcholine release from parasympathetic nerves supplying airway smooth muscle. |
2005-05-02 |
2023-08-12 |
Not clear |
| Pamela J Lein, Allison D Frye. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological sciences : an official journal of the Society of Toxicology. vol 83. issue 1. 2005-05-02. PMID:15470232. |
none of the op treatments altered bronchoconstriction induced by iv acetylcholine or methacholine in vagotomized guinea pigs, suggesting that op-induced airway hyperreactivity is not due to altered function of muscarinic receptors on airway smooth muscle or to ache inhibition. |
2005-05-02 |
2023-08-12 |
Not clear |
| Boris Bryk, Liat BenMoyal-Segal, Erez Podoly, Oded Livnah, Arik Eisenkraft, Shai Luria, Amir Cohen, Yoav Yehezkelli, Ariel Hourvitz, Hermona Sore. Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715671. |
the 5.5 mb chromosome 7q21-22 ache/pon1 locus harbours the ache gene encoding the acetylcholine hydrolyzing, organophosphate (op)-inhibitable acetylcholinesterase protein and the paraoxonase gene pon1, yielding the op-hydrolyzing pon1 enzyme which also displays arylesterase activity. |
2005-04-28 |
2023-08-12 |
Not clear |
| C H Opperman, S Chan. Nematode acetylcholinesterases: molecular forms and their potential role in nematode behavior. Parasitology today (Personal ed.). vol 8. issue 12. 2005-04-21. PMID:15463554. |
acetylcholine activity is terminated by hydrolysis by acetylcholinesterase (ache). |
2005-04-21 |
2023-08-12 |
Not clear |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
in post-mortem frontal cortex from ad patients, acetylcholine (ach) levels, cholinacetyltransferase (chat) and acetylcholinesterase (ache) activity were all reduced compared to controls. |
2005-04-18 |
2023-08-12 |
rat |
| Michihisa Tohda, Prawpan Suwanakitch, Rattima Jeenapongsa, Hisae Hayashi, Hiroshi Watanabe, Kinzo Matsumot. Expression changes of the mRNA of Alzheimer's disease related factors in the permanent ischemic rat brain. Biological & pharmaceutical bulletin. vol 27. issue 12. 2005-04-15. PMID:15577224. |
the expression changes of amyloid precursor protein (app), secretase, alpha7 nicotinic acetylcholine receptor (alpha7nicr) and acetylcholine esterase (ache), which are involved in alzheimer's disease, were examined by quantitative rt/pcr in this model rat brain. |
2005-04-15 |
2023-08-12 |
rat |
| T K Manojkumar, Chunzhi Cui, Kwang S Ki. Theoretical insights into the mechanism of acetylcholinesterase-catalyzed acylation of acetylcholine. Journal of computational chemistry. vol 26. issue 6. 2005-04-13. PMID:15739192. |
acylation of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. |
2005-04-13 |
2023-08-12 |
Not clear |
| R Nikolo. Alzheimer's disease therapy - an update. Drug news & perspectives. vol 11. issue 4. 2005-03-30. PMID:15616667. |
the two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (ache) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. |
2005-03-30 |
2023-08-12 |
Not clear |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
ache, acetylcholine (ach) receptors and choline acetyltransferase have been reported to be expressed by t cells, suggesting that cholinergic signalling may exert some modulatory influence on t-cell function and consequently on the immune system. |
2005-03-18 |
2023-08-12 |
human |
| Vincenzo Rispoli, Domenicantonio Rotiroti, Vincenzo Carelli, Felice Liberatore, Luigi Scipione, Rosario Marra, Silvano Tortorella, Barbara Di Rienz. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301920. |
the results of the present work allow us to put forward the hypothesis that the eeg effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ach) consequent upon acetylcholinesterase (ache) inhibition by choline pivaloyl esters. |
2005-03-04 |
2023-08-12 |
rat |
| C Angelini, B Baccetti, P Piomboni, S Trombino, M G Aluigi, S Stringara, L Gallus, C Falug. Acetylcholine synthesis and possible functions during sea urchin development. European journal of histochemistry : EJH. vol 48. issue 3. 2005-03-02. PMID:15590413. |
acetylcholinesterase (ache, the lytic enzyme of acetylcholine) was also found in ovarian eggs, with a similar distribution; however, it disappeared after fertilisation. |
2005-03-02 |
2023-08-12 |
Not clear |