| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Horst Thiermann, Peter Eyer, Franz Worek, Ladislaus Szinic. Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicology. vol 214. issue 3. 2005-11-21. PMID:16040183. |
toxicity of organophosphates (op) is caused by inhibition of acetylcholinesterase (ache), resulting in accumulation of acetylcholine. |
2005-11-21 |
2023-08-12 |
mouse |
| Hina Mehta, Reena Haobam, Rajamma Usha, Kochupurackal P Mohanakuma. Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. Behavioural brain research. vol 163. issue 2. 2005-11-07. PMID:15990178. |
it produces tremor in animals, which is believed to be due to an increase in the brain acetylcholine level following ache inhibition. |
2005-11-07 |
2023-08-12 |
mouse |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Current opinion in pharmacology. vol 5. issue 3. 2005-09-08. PMID:15907917. |
the synaptic enzyme acetylcholinesterase (ache) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. |
2005-09-08 |
2023-08-12 |
Not clear |
| Hidekazu Tomimoto, Ryo Ohtani, Masunari Shibata, Noriko Nakamura, Masafumi Ihar. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15785029. |
the cholinergic pathway was labeled either by histochemistry for acetylcholine esterase (ache), a degradatory enzyme of ach, or by immunohistochemistry for choline acetyltransferase, its synthetic enzyme. |
2005-09-01 |
2023-08-12 |
Not clear |
| Paul A Dabisch, David C Burnett, Dennis B Miller, Edward M Jakubowski, William T Muse, Jeffry S Forster, Jacqueline A Scotto, Jill R Jarvis, Emily A Davis, Stanley W Hulet, Sharon A Reutter, Robert J Mioduszewski, Sandra A Thomso. Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 21. issue 3. 2005-08-26. PMID:15969635. |
inhibition of acetylcholinesterase (ache) by the organophosphorous compound sarin (gb) results in the accumulation of acetylcholine and excessive cholinergic stimulation. |
2005-08-26 |
2023-08-12 |
rat |
| Marcella Reale, Carla Iarlori, Francesco Gambi, Isabella Lucci, Mirella Salvatore, Domenico Gamb. Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Experimental gerontology. vol 40. issue 3. 2005-08-25. PMID:15763393. |
one strategy for treatment of ad has been to use acetylcholinesterase (ache) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. |
2005-08-25 |
2023-08-12 |
Not clear |
| Kaj Blenno. Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 1. issue 2. 2005-08-23. PMID:15717022. |
the introduction of acetylcholine esterase (ache) inhibitors as a symptomatic treatment of alzheimer's disease (ad) has made patients seek medical advice at an earlier stage of the disease. |
2005-08-23 |
2023-08-12 |
Not clear |
| Anis Alam, Laishram Indira Singha, Vinod Sing. Molecular characterization of tumor associated antigen in mice exposed to a hepatocarcinogen. Molecular and cellular biochemistry. vol 271. issue 1-2. 2005-08-23. PMID:15881669. |
carcinogenesis induction in mice was monitored by assays of y-glutamyl transpeptidase (ggt), acetylcholine esterase (ache), glutathione-s-transferase (gst) activities and the level of glutathione (gsh) in liver. |
2005-08-23 |
2023-08-12 |
mouse |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Human mutation. vol 24. issue 5. 2005-07-29. PMID:15459952. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2005-07-29 |
2023-08-12 |
human |
| Hiroto Tachikawa, Manabu Igarashi, Jun Nishihira, Teruo Ishibash. Ab initio model study on acetylcholinesterase catalysis: potential energy surfaces of the proton transfer reactions. Journal of photochemistry and photobiology. B, Biology. vol 79. issue 1. 2005-07-29. PMID:15792875. |
ab initio molecular orbital (mo) and hybrid density functional theory (dft) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (ache), which is the nucleophiric addition of ser200 in catalytic triads to a neurotransmitter acetylcholine (ach). |
2005-07-29 |
2023-08-12 |
Not clear |
| Héric Valette, Michel Bottlaender, Frédéric Dollé, Christine Coulon, Michèle Ottaviani, André Syrot. Acute effects of physostigmine and galantamine on the binding of [18F]fluoro-A-85380: a PET study in monkeys. Synapse (New York, N.Y.). vol 56. issue 4. 2005-07-29. PMID:15803498. |
the effects of physostigmine, a more potent ache inhibitor than galantamine, could be interpreted as a desensitization of nachrs, due to a prolonged exposure to high synaptic concentration of acetylcholine or as a competition with acetylcholine. |
2005-07-29 |
2023-08-12 |
monkey |
| Hsiao-chung Tsai, Ruey-an Doon. Simultaneous determination of pH, urea, acetylcholine and heavy metals using array-based enzymatic optical biosensor. Biosensors & bioelectronics. vol 20. issue 9. 2005-06-24. PMID:15681196. |
urease and acetylcholinesterase (ache) were used as model enzymes and were co-entrapped with the sensing probe, fitc-dextran, in the sol-gel matrix to measure ph, urea, acetylcholine (ach) and heavy metals (enzyme inhibitors). |
2005-06-24 |
2023-08-12 |
Not clear |
| Valeri Pavlov, Yi Xiao, Itamar Willne. Inhibition of the acetycholine esterase-stimulated growth of Au nanoparticles: nanotechnology-based sensing of nerve gases. Nano letters. vol 5. issue 4. 2005-06-21. PMID:15826103. |
the acetylcholine esterase, ache, mediated hydrolysis of acetylthiocholine (1) yields a reducing agent thiocholine (2) that stimulates the catalytic enlargement of au np seeds in the presence of aucl(4)(-). |
2005-06-21 |
2023-08-12 |
Not clear |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| J Srinivasan, S Jayadev, D Kumaran, K F Haja Nazeer Ahamed, B Suresh, M Ramanatha. Effect of losartan and enalapril on cognitive deficit caused by Goldblatt induced hypertension. Indian journal of experimental biology. vol 43. issue 3. 2005-05-12. PMID:15816410. |
acetylcholine esterase (ache) levels in the pons medulla, hippocampus, striatum and frontal cortex were measured as a cholinergic marker of learning and memory. |
2005-05-12 |
2023-08-12 |
rat |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c-labeled acetylcholine analogues, n-[(11)c]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (pet). |
2005-05-05 |
2023-08-12 |
human |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
our aim was to develop an (18)f-labeled acetylcholine analogue useful for brain ache mapping with pet, since (18)f, with a longer half-life, has advantages over (11)c. in a preliminary study, a series of n-[(14)c]ethylpiperidin-3-yl or -4-ylmethanol esters (acetyl and propionyl esters) were newly designed and evaluated in vitro regarding the reactivity with and specificity to ache using purified human enzymes, leading to a novel (18)f-labeled acetylcholine analogue, n-[(18)f]fluoroethylpiperidin-4-ylmethyl acetate. |
2005-05-05 |
2023-08-12 |
human |
| Pamela J Lein, Allison D Frye. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological sciences : an official journal of the Society of Toxicology. vol 83. issue 1. 2005-05-02. PMID:15470232. |
we previously demonstrated that the organophosphorus (op) insecticide chlorpyrifos potentiates vagally induced bronchoconstriction independent of acetylcholinesterase (ache) inhibition by decreasing the function of neuronal m2 muscarinic receptors that normally inhibit acetylcholine release from parasympathetic nerves supplying airway smooth muscle. |
2005-05-02 |
2023-08-12 |
Not clear |
| Pamela J Lein, Allison D Frye. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological sciences : an official journal of the Society of Toxicology. vol 83. issue 1. 2005-05-02. PMID:15470232. |
none of the op treatments altered bronchoconstriction induced by iv acetylcholine or methacholine in vagotomized guinea pigs, suggesting that op-induced airway hyperreactivity is not due to altered function of muscarinic receptors on airway smooth muscle or to ache inhibition. |
2005-05-02 |
2023-08-12 |
Not clear |