| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideo Tsukad. [Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 124. issue 3. 2005-03-01. PMID:15333988. |
ache inhibition by donepezil resulted in a dose-dependent increase in acetylcholine levels in the prefrontal cortex as measured by microdialysis. |
2005-03-01 |
2023-08-12 |
monkey |
| Ezio Giacobin. Cholinesterase inhibitors: new roles and therapeutic alternatives. Pharmacological research. vol 50. issue 4. 2005-02-04. PMID:15304240. |
within particular conditions, such as in mice nullizygote for ache or in ad patients at advanced stages of the disease, buche may replace ache in hydrolyzing brain acetylcholine. |
2005-02-04 |
2023-08-12 |
mouse |
| Xiaoqiang Ma, David R Gan. The Lycopodium alkaloids. Natural product reports. vol 21. issue 6. 2005-02-02. PMID:15565253. |
in particular, the effect of hupa and other cholinesterase inhibitors (anti-ad drugs) on acetylcholine esterase (ache) activity in the rat cortex and butylcholine esterase activity are compared. |
2005-02-02 |
2023-08-12 |
rat |
| Tsuneyoshi Ota, Hitoshi Shinotoh, Kiyoshi Fukushi, Shin-ichiro Nagatsuka, Hiroki Namba, Masaomi Iyo, Akiyo Aotsuka, Noriko Tanaka, Koichi Sato, Tetsuya Shiraishi, Shuji Tanada, Heii Arai, Toshiaki Iri. A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT. Annals of nuclear medicine. vol 18. issue 3. 2004-12-21. PMID:15233279. |
we have developed a radiolabeled lipophilic acetylcholine analogue, n-[11c]methylpiperidin-4-yl acetate ([11c]mp4a) to measure brain acetylcholinesterase (ache) activity by positron emission tomography (pet) in vivo. |
2004-12-21 |
2023-08-12 |
Not clear |
| Malahat Mousavi, Ivan Bednar, Agneta Nordber. Selective changes in expression of different nicotinic receptor subtypes in brain and adrenal glands of mice carrying human mutated gene for APP or over-expressing human acetylcholinestrase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465284. |
in this study, we investigated regulatory mechanisms and plasticity of the nicotinic acetylcholine receptors (nachrs) in the brain and adrenal glands of two transgenic mice models over-expressing human beta-amyloid precursor protein (app(swe)tg) and human ache enzyme (hache-tg), respectively. |
2004-12-15 |
2023-08-12 |
mouse |
| Laura E Paraoanu, Paul G Laye. Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta. FEBS letters. vol 576. issue 1-2. 2004-11-19. PMID:15474030. |
acetylcholinesterase (ache) is likely to have roles other than the hydrolysis of acetylcholine, e.g., related to developmental processes like neurite outgrowth, differentiation and adhesion. |
2004-11-19 |
2023-08-12 |
mouse |
| Tomie Nishizawa, Hiroyuki Tamaki, Norikatsu Kasuga, Hiroaki Takekur. Degeneration and regeneration of neuromuscular junction architecture in rat skeletal muscle fibers damaged by bupivacaine hydrochloride. Journal of muscle research and cell motility. vol 24. issue 8. 2004-11-15. PMID:14870968. |
we evaluated the degeneration and regeneration of neuromuscular junctions (nmjs) on the extensor digitorum longus muscle of fischer 344 rats between 4 h and 3 weeks after bupivacaine hydrochloride (bpvc) injection, which induces muscle fiber necrosis, using histochemical staining by acetylcholine esterase (ache)-silver and electron microscopy. |
2004-11-15 |
2023-08-12 |
rat |
| Bianca Fuhrman, Ayelet Partoush, Michael Avira. Acetylcholine esterase protects LDL against oxidation. Biochemical and biophysical research communications. vol 322. issue 3. 2004-11-01. PMID:15336559. |
acetylcholine esterase (ache) and paraoxonase 1 (pon1) are both serum ester hydrolases, which are associated with the prevalence of myocardial infarction. |
2004-11-01 |
2023-08-12 |
Not clear |
| Jiri Bajgar, Lucie Sevelová, Gabriela Krejcová, Josef Fusek, Josef Vachek, Jiri Kassa, Josef Herink, Leo P A de Jong, Hendrik P Benscho. Biochemical and behavioral effects of soman vapors in low concentrations. Inhalation toxicology. vol 16. issue 8. 2004-09-28. PMID:15204741. |
soman acts by inhibiting acetylcholinesterase (ache) both peripherally and centrally, with a subsequent accumulation of neuromediator acetylcholine and other metabolic changes. |
2004-09-28 |
2023-08-12 |
Not clear |
| E Boudinot, M J Emery, E Mouisel, A Chatonnet, J Champagnat, P Escourrou, A S Fout. Increased ventilation and CO2 chemosensitivity in acetylcholinesterase knockout mice. Respiratory physiology & neurobiology. vol 140. issue 3. 2004-09-23. PMID:15186785. |
to investigate the effects of a permanent excess of acetylcholine (ache) on respiration, breathing and chemosensitivity were analyzed from birth to adulthood in mice lacking the ache gene (ache-/-), in heterozygotes, and in control wild-type (ache+/+) littermates. |
2004-09-23 |
2023-08-12 |
mouse |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Francesco Ament. Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 26. issue 4. 2004-09-08. PMID:15195690. |
the present study has investigated the influence of two doses of the ache inhibitor rivastigmine (0.625 mg/kg/day and 2.5 mg/kg/day) on vesicular acetylcholine transporter (vacht) and on choline acetyltransferase (chat) expression in frontal cortex, hippocampus, striatum and cerebellum of normotensive and spontaneously hypertensive rats (shr). |
2004-09-08 |
2023-08-12 |
rat |
| José L Arreola, Mario H Vargas, Patricia Segura, Jaime Chávez, Bettina Sommer, Verónica Carvajal, Luis M Montañ. Possible role of substance P in the ischemia-reperfusion injury in the isolated rabbit lung. Transplantation. vol 78. issue 2. 2004-08-18. PMID:15280694. |
thus, in isolated rabbit lungs preserved over 24 hours, we evaluated the release of acetylcholine (ach) and substance p (sp), the activity of their major degrading enzymes, acetylcholinesterase (ache) and neutral endopeptidase (nep), and changes in the capillary permeability. |
2004-08-18 |
2023-08-12 |
rabbit |
| Yoon-Bok Lee, Hyong Joo Lee, Moo Ho Won, In Koo Hwang, Tae-Cheon Kang, Jae-Yong Lee, Sang-Yoon Nam, Kang-Sung Kim, Eugene Kim, Sang-Hee Cheon, Heon-Soo Soh. Soy isoflavones improve spatial delayed matching-to-place performance and reduce cholinergic neuron loss in elderly male rats. The Journal of nutrition. vol 134. issue 7. 2004-08-10. PMID:15226476. |
acetylcholine esterase (ache) activity in the iso 0.3 group was significantly inhibited in cortex, bf, and hippocampus and in the iso 1.2 group in cortex and hippocampus. |
2004-08-10 |
2023-08-12 |
rat |
| Jeremy Kua, Yingkai Zhang, Angelique C Eslami, John R Butler, J Andrew McCammo. Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach. Protein science : a publication of the Protein Society. vol 12. issue 12. 2004-07-14. PMID:14627729. |
a combined molecular dynamics simulation and multiple ligand docking approach is applied to study the roles of the anionic subsite residues (w86, e202, y337) in the binding of acetylcholine (ach) to acetylcholinesterase (ache). |
2004-07-14 |
2023-08-12 |
Not clear |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Susana Nieto-Cerón, María Teresa Moral-Naranjo, Encarnación Muñoz-Delgado, Cecilio J Vidal, Francisco J Campo. Molecular properties of acetylcholinesterase in mouse spleen. Neurochemistry international. vol 45. issue 1. 2004-06-22. PMID:15082230. |
since cholinergic stimulation modulates proliferation/maturation of lymphoid cells, ache may be important for regulating the level of acetylcholine (ach) in the neighborhood of cholinergic receptors (achr) in spleen and other lymphoid tissues. |
2004-06-22 |
2023-08-12 |
mouse |
| Peter Eye. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicological reviews. vol 22. issue 3. 2004-06-22. PMID:15181665. |
ops act primarily by inhibiting acetylcholinesterase (ache), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain cns regions. |
2004-06-22 |
2023-08-12 |
human |
| Hitoshi Shinotoh, Kiyoshi Fukushi, Shin-ichiro Nagatsuka, Toshiaki Iri. Acetylcholinesterase imaging: its use in therapy evaluation and drug design. Current pharmaceutical design. vol 10. issue 13. 2004-06-21. PMID:15134572. |
an alternative approach to map ache is the use of acetylcholine analogue substrates. |
2004-06-21 |
2023-08-12 |
human |
| Ella H Sklan, Alexander Lowenthal, Mira Korner, Ya'acov Ritov, Daniel M Landers, Tuomo Rankinen, Claude Bouchard, Arthur S Leon, Treva Rice, D C Rao, Jack H Wilmore, James S Skinner, Hermona Sore. Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 15. 2004-05-19. PMID:15060281. |
the ache protein controls the termination of the stress-enhanced acetylcholine signaling, whereas the pon protein displays peroxidase-like activity, thus protecting blood proteins from oxidative stress damages. |
2004-05-19 |
2023-08-12 |
human |
| Fernando Sánchez-Santed, Fernando Cañadas, Pilar Flores, Matilde López-Grancha, Diana Cardon. Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence. Neurotoxicology and teratology. vol 26. issue 2. 2004-05-10. PMID:15019964. |
the major mechanism of acute toxic action is the inhibition of acetylcholinesterase (ache), which is responsible for the degradation of the neurotransmitter acetylcholine. |
2004-05-10 |
2023-08-12 |
Not clear |