| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Micael Jacobsson, Per Lidén, Eva Stjernschantz, Henrik Boström, Ulf Norinde. Improving structure-based virtual screening by multivariate analysis of scoring data. Journal of medicinal chemistry. vol 46. issue 26. 2004-01-20. PMID:14667231. |
three different multivariate statistical methods, pls discriminant analysis, rule-based methods, and bayesian classification, have been applied to multidimensional scoring data from four different target proteins: estrogen receptor alpha (eralpha), matrix metalloprotease 3 (mmp3), factor xa (fxa), and acetylcholine esterase (ache). |
2004-01-20 |
2023-08-12 |
Not clear |
| M Faimali, C Falugi, L Gallus, V Piazza, G Tagliafierr. Involvement of acetyl choline in settlement of Balanus amphitrite. Biofouling. vol 19 Suppl. 2004-01-14. PMID:14618723. |
acetylcholinesterase (ache, the lythic enzyme of acetylcholine) activity was detected, for the first time, by biochemical and histoenzymological methods, in the thoracic muscles, gut wall and cement gland. |
2004-01-14 |
2023-08-12 |
Not clear |
| M Faimali, C Falugi, L Gallus, V Piazza, G Tagliafierr. Involvement of acetyl choline in settlement of Balanus amphitrite. Biofouling. vol 19 Suppl. 2004-01-14. PMID:14618723. |
an increase of available acetylcholine due to the partial inhibition of ache activity produced an increase in cyprid settlement. |
2004-01-14 |
2023-08-12 |
Not clear |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
in this study, the effects of oral administration of ppe on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated, and compared to that of tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride), a well-known and centrally acting acetylcholinesterase (ache) inhibitor, which had been developed for the treatment of alzheimer's disease. |
2003-12-29 |
2023-08-12 |
rat |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
the results suggest that oral administration of ppe and tacrine increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through ache inhibition, and that ppe has a potent and long-lasting effect on the central cholinergic system. |
2003-12-29 |
2023-08-12 |
rat |
| L M Gerstein, E L Dovedova, N S Popov. [Mechanism of nootropic digam action in hypofunction of brain dopaminergic system]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 103. issue 7. 2003-12-29. PMID:12938655. |
using microchemical methods for detection of dopamine (da), noradrenaline (na), serotonin (s) and its metabolite--5'-hydroxyindolilacetic acid (5'-hiaa) as well as the activity of neuromediator-utilising enzymes--mao a and b and enzymes of acetylcholine metabolism--cholinacetyltranspherase (chat) and acetylcholinesterase (ache), we revealed that synthetic gaba-derivative compound diagram (250 mg/kg during 10 days) normalized functioning of dopaminergic and acetylcholinergic systems in sensormotor cortex and caudate nucleus of wistar rats with haloperidol-induced (0.5 mg/kg during 30 days) bradykinesia. |
2003-12-29 |
2023-08-12 |
rat |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. |
2003-12-15 |
2023-08-12 |
mouse |
| C Ducho, J Balzarini, C Meie. Non-inhibition of acetylcholinesterase by cycloSal nucleotides. Nucleosides, nucleotides & nucleic acids. vol 22. issue 5-8. 2003-12-11. PMID:14565292. |
ache is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. |
2003-12-11 |
2023-08-12 |
human |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
acetylcholinesterase (ache) inhibitors, which increase synaptic levels of available acetylcholine (ach) by preventing its degradation, are the most extensively prescribed drugs for the treatment of alzheimer's disease. |
2003-12-10 |
2023-08-12 |
rat |
| Nilkanta Chakrabarti, Arun K Ra. Stimulation of AChE activity in relation to changes in electronmicroscopic structure of adult rat cerebrocortical synaptosomes pretreated with 3-5-3'-triiodo-L-thyronine. Neuroreport. vol 14. issue 11. 2003-11-20. PMID:12960772. |
the experiments suggest that t3 might have a role in the calcium-dependent release/co-release of acetylcholine from intact synaptosomes concomitant with the acceleration of choline uptake mechanisms that has been reported to accompany elevation of ache activity. |
2003-11-20 |
2023-08-12 |
rat |
| Kaj Blennow, Eugeen Vanmechele. CSF markers for pathogenic processes in Alzheimer's disease: diagnostic implications and use in clinical neurochemistry. Brain research bulletin. vol 61. issue 3. 2003-10-14. PMID:12909293. |
in view of current (acetylcholine esterase (ache) inhibitors) and future (e.g. |
2003-10-14 |
2023-08-12 |
Not clear |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| M Pakaski, P Kas. Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Current drug targets. CNS and neurological disorders. vol 2. issue 3. 2003-08-27. PMID:12769797. |
increasing the acetylcholine concentration in the brain by modulating acetylcholine-sterase (ache) activity is among the most promising therapeutic strategies. |
2003-08-27 |
2023-08-12 |
Not clear |
| Tirupapuliyur V Damodaran, Katherine H Jones, Anand G Patel, Mohamed B Abou-Doni. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochemical pharmacology. vol 65. issue 12. 2003-07-22. PMID:12787884. |
sarin inactivates the enzyme ache which is responsible for the breakdown of the neurotransmitter acetylcholine (ach), leading to its accumulation at ach receptors and overstimulation of the cholinergic system. |
2003-07-22 |
2023-08-12 |
rat |
| Laura A Volpicelli-Daley, Ellen G Duysen, Oksana Lockridge, Allan I Leve. Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice. Annals of neurology. vol 53. issue 6. 2003-07-09. PMID:12783426. |
stimulation of muscarinic acetylcholine receptors (machrs) by elevated levels of ach plays a role in the effects of ache inhibitors on cognition and behavior. |
2003-07-09 |
2023-08-12 |
mouse |
| Nigel H Greig, Debomoy K Lahiri, Kumar Sambamurt. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. International psychogeriatrics. vol 14 Suppl 1. 2003-07-03. PMID:12636181. |
acetylcholinesterase (ache) predominates in the healthy brain, with butyrylcholinesterase (buche) considered to play a minor role in regulating brain acetylcholine (ach) levels. |
2003-07-03 |
2023-08-12 |
Not clear |
| Ezio Giacobin. Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochemical research. vol 28. issue 3-4. 2003-06-18. PMID:12675140. |
within particular conditions, such as in mice nullizygote for ache or in ad patients at advanced stages of the disease, buche may replace ache in hydrolizing brain acetylcholine. |
2003-06-18 |
2023-08-12 |
mouse |
| Victoria Zarotsky, John J Sramek, Neal R Cutle. Galantamine hydrobromide: an agent for Alzheimer's disease. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 60. issue 5. 2003-06-03. PMID:12635450. |
galantamine acts both as a reversible competitive inhibitor of acetylcholinesterase (ache) and as an allosteric modulator of nicotinic acetylcholine receptors. |
2003-06-03 |
2023-08-12 |
Not clear |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases. Cellular and molecular neurobiology. vol 23. issue 1. 2003-05-20. PMID:12701885. |
acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (buche, ec 3.1.1.8) are serine hydrolase enzymes that catalyze the hydrolysis of acetylcholine. |
2003-05-20 |
2023-08-12 |
human |
| Qi-Huang Jin, Yu-Fang Shi, Heng-Yi He, Kelvin K W Ng, Hua Jiang, Lei Yang, Zi-Qing Jiang, Xue-Jun Zhan. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. BioTechniques. vol Suppl. 2003-04-25. PMID:12395932. |
acetylcholinesterase (ache; ec3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. |
2003-04-25 |
2023-08-12 |
human |