| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takasuke Fujimura, Haruo Kobayashi, Tadahiko Suzuki, Itaru Sato, Shigeo Har. [Neurotoxicity in sodium azide poisoning]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. vol 15. issue 3. 2002-12-24. PMID:12415870. |
measurements of the activities of acetylcholinesterase (ache) and choline acetyltransferase (chat), enzymes that hydrolyze and synthesize acetylcholine (ach) and high-affinity choline uptake (hacu), a rate-limiting step in the synthesis of ach, were determined in the presence of various concentrations of sodium azide in vitro. |
2002-12-24 |
2023-08-12 |
mouse |
| Jeffrey Sterling, Yaacov Herzig, Tamar Goren, Nina Finkelstein, David Lerner, Willy Goldenberg, Istvan Miskolczi, Sandor Molnar, Ferenc Rantal, Tivadar Tamas, Gyorgy Toth, Adela Zagyva, Andras Zekany, John Finberg, Gila Lavian, Aviva Gross, Rachel Friedman, Michal Razin, Wei Huang, Boris Krais, Michael Chorev, Moussa B Youdim, Marta Weinstoc. Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. Journal of medicinal chemistry. vol 45. issue 24. 2002-12-20. PMID:12431053. |
the respective rasagiline- and selegiline-related series were designed to combine inhibitory activities of both acetylcholine esterase (ache) and monoamine oxidase (mao) by virtue of their carbamoyl and propargylamine pharmacophores. |
2002-12-20 |
2023-08-12 |
Not clear |
| N Nunes-Tavares, A Nery da Matta, C M Batista e Silva, G M N Araújo, S R W Louro, A Hassón-Voloc. Inhibition of acetylcholinesterase from Electrophorus electricus (L.) by tricyclic antidepressants. The international journal of biochemistry & cell biology. vol 34. issue 9. 2002-12-17. PMID:12009302. |
the effects of tricyclic antidepressants drugs (tca) amitriptyline, imipramine and nortriptyline, on purified electrophorus electricus (l.) acetylcholinesterase (ache; acetylcholine hydrolase, ec 3.1.1.7) were studied using kinetic methods and specific fluorescent probe propidium. |
2002-12-17 |
2023-08-12 |
Not clear |
| Glenn D Baxter, Stephen C Barke. Analysis of the sequence and expression of a second putative acetylcholinesterase cDNA from organophosphate-susceptible and organophosphate-resistant cattle ticks. Insect biochemistry and molecular biology. vol 32. issue 7. 2002-12-03. PMID:12044498. |
certainly none of the polymorphisms correspond to sites in ache that are involved in catalysis or binding of acetylcholine in other organisms. |
2002-12-03 |
2023-08-12 |
cattle |
| Jorge Andres Rodriguez, Ana Maria Buzaleh, Mariana Fossati, Julio Azcurra, Alcira Maria Del Carmen Batll. The effects of some porphyrinogenic drugs on the brain cholinergic system. Cellular and molecular biology (Noisy-le-Grand, France). vol 48. issue 1. 2002-12-02. PMID:11929041. |
in central nervous system, acetylcholinesterase (ache) and butyrylcholinesterase (buche) hydrolyse acetylcholine. |
2002-12-02 |
2023-08-12 |
Not clear |
| Sean Lilienfel. Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS drug reviews. vol 8. issue 2. 2002-11-25. PMID:12177686. |
it is a reversible, competitive inhibitor of acetylcholinesterase (ache), and is the only drug actively marketed for the treatment of ad with proven activity as an allosteric modulator of nicotinic acetylcholine receptors (nachrs). |
2002-11-25 |
2023-08-12 |
Not clear |
| Ali Abdel-Rahman, Ashok K Shetty, Mohamed B Abou-Doni. Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. Neurobiology of disease. vol 10. issue 3. 2002-11-15. PMID:12270692. |
all animals were evaluated for: (i) the disruption of the blood-brain barrier (bbb) using intravenous horseradish peroxidase (hrp) injections and endothelial barrier antigen (eba) immunostaining; (ii) neuronal cell death using h&e staining, silver staining, and glial fibrillary acidic protein (gfap) immunostaining; and (iii) acetylcholinesterase (ache) activity and m2-muscarinic acetylcholine receptors (m2-achr). |
2002-11-15 |
2023-08-12 |
rat |
| Kazuo Isoma, Masago Ishikawa, Megumi Ohta, Yoichiro Ogawa, Hiroshi Hasegawa, Tadayuki Kohda, Junzo Kame. Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Japanese journal of pharmacology. vol 88. issue 2. 2002-11-04. PMID:11928722. |
the effects of t-82 (2-[2-(1-benzylpiperidin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1h-pyrrolo [3,4-b]quinolin-1-one hemifumarate), a new quinoline derivative, on acetylcholinesterase (ache) activity and acetylcholine (ach) release were compared with those of the well-known cholinesterase inhibitors tacrine and e2020. |
2002-11-04 |
2023-08-12 |
human |
| Ho-Jin Heo, Seong-Chan Hong, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eun-Ki Kim, Dong-Hoon Shi. Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells. Molecules and cells. vol 13. issue 1. 2002-10-10. PMID:11911460. |
acetylcholinesterase (ache) inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of the compound that is currently approved for the treatment of alzheimer's disease (ad). |
2002-10-10 |
2023-08-12 |
Not clear |
| Brandy J White, H James Harmo. Interaction of monosulfonate tetraphenyl porphyrin, a competitive inhibitor, with acetylcholinesterase. Biosensors & bioelectronics. vol 17. issue 6-7. 2002-10-10. PMID:11959466. |
the addition of acetylcholine iodide (achi) or the competitive inhibitor tetracaine to the preformed ache-tpps(1) complex results in a loss of the 442 nm absorbance band as the porphyrin is displaced from ache. |
2002-10-10 |
2023-08-12 |
Not clear |
| T Carbonell, I Masip, F Sánchez-Baeza, M Delgado, E Araya, O Llorens, F Corcho, J J Pérez, E Pérez-Payá, A Messegue. Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones. Molecular diversity. vol 5. issue 3. 2002-09-30. PMID:12197070. |
increasing the acetylcholine concentration in brain by modulating acetylcholinesterase (ache) activity is among the most promising strategies. |
2002-09-30 |
2023-08-12 |
Not clear |
| b' Jean Massouli\\xc3\\xa. The origin of the molecular diversity and functional anchoring of cholinesterases. Neuro-Signals. vol 11. issue 3. 2002-09-25. PMID:12138250.' |
vertebrates possess two cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche) which both hydrolyze acetylcholine, but differ in their specificity towards other substrates, and in their sensitivity to inhibitors. |
2002-09-25 |
2023-08-12 |
mouse |
| Jeremy Kua, Yingkai Zhang, J Andrew McCammo. Studying enzyme binding specificity in acetylcholinesterase using a combined molecular dynamics and multiple docking approach. Journal of the American Chemical Society. vol 124. issue 28. 2002-09-18. PMID:12105904. |
a combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (ache) with its natural substrate acetylcholine (ach), a family of substrate analogues, and choline. |
2002-09-18 |
2023-08-12 |
cat |
| Ivan Bednar, David Paterson, Amelia Marutle, Therese M Pham, Marie Svedberg, Ewa Hellström-Lindahl, Malahat Mousavi, Jennifer Court, Christopher Morris, Elaine Perry, Abdul Mohammed, Xiao Zhang, Agneta Nordber. Selective nicotinic receptor consequences in APP(SWE) transgenic mice. Molecular and cellular neurosciences. vol 20. issue 2. 2002-08-29. PMID:12093166. |
the nicotinic (nachrs) and muscarinic (machrs) acetylcholine receptors and acetylcholinesterase (ache) activity were studied in the brains of app(swe) transgenic mice (tg+) and age-matched nontransgenic controls (tg-) that were between 4 and 19 months of age. |
2002-08-29 |
2023-08-12 |
mouse |
| Antonella Gorini, Umberto Canosi, Elisabetta Devecchi, Diego Geroldi, Roberto Federico Vill. ATPases enzyme activities during ageing in different types of somatic and synaptic plasma membranes from rat frontal cerebral cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 1. 2002-08-20. PMID:11853124. |
the following enzymes were evaluated: na+, k+-atpase, ca2+, mg2+-atpase, mg2+-atpase and the activity of acetylcholine esterase (ache) was also evaluated. |
2002-08-20 |
2023-08-12 |
rat |
| Hengshan Zhang, Jing Liu, Carey N Pop. Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Archives of toxicology. vol 75. issue 11-12. 2002-08-13. PMID:11876500. |
a number of studies suggest that in addition to inhibiting acetylcholinesterase (ache), cpf oxon may also interact directly with m2 and/or m4 subtypes of muscarinic acetylcholine receptors (machrs). |
2002-08-13 |
2023-08-12 |
rat |
| Dongren Yang, Xinfang Lu, Weiguo Zhang, Fengsheng H. Biochemical changes in primary culture of skeletal muscle cells following dimethoate exposure. Toxicology. vol 174. issue 2. 2002-07-18. PMID:11985885. |
in order to investigate the cellular mechanism of muscular weakness in the intermediate myasthenia syndrome (ims) following acute organophosphate poisoning, we studied the cytotoxicity of dimethoate and its effects on the activity of acetylcholine esterase (ache), na+-k+-atpase, succinate dehydrogenase (sdh), and ca2+-atpase in primary cultured skeletal muscle cells. |
2002-07-18 |
2023-08-12 |
Not clear |
| D Braida, M Sal. Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. CNS drug reviews. vol 7. issue 4. 2002-06-10. PMID:11830755. |
when administered in vivo to rodents by various routes, eptastigmine inhibits cerebral acetylcholinesterases (ache) and increases acetylcholine (ach) brain levels by 2500-3000%, depending on the dose. |
2002-06-10 |
2023-08-12 |
Not clear |
| Andrea Sbarbati, Flavia Merigo, Paolo Bernardi, Caterina Crescimanno, Donatella Benati, Francesco Osculat. Ganglion cells and topographically related nerves in the vallate papilla/von Ebner gland complex. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 50. issue 5. 2002-06-10. PMID:11967282. |
small groups of acetylcholine esterase (ache)-positive/nadphd-negative cells were visible. |
2002-06-10 |
2023-08-12 |
rat |
| F R de la Torre, L Ferrari, A Salibiá. Freshwater pollution biomarker: response of brain acetylcholinesterase activity in two fish species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 131. issue 3. 2002-06-06. PMID:11912052. |
the effect of prolonged exposure at two sites along the reconquista river (argentina), a highly polluted peri-urban water body, on brain acetylcholinesterase (ache, ec 3.1.1.7, acetylcholine acetylhydrolase) of two teleosts was examined. |
2002-06-06 |
2023-08-12 |
Not clear |