| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H von der Kammer, C Demiralay, B Andresen, C Albrecht, M Mayhaus, R M Nitsc. Regulation of gene expression by muscarinic acetylcholine receptors. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447829. |
the results also suggest a feedback mechanism where up-regulated ache expression and accelerated breakdown of acetylcholine (ach) at the cholinergic synapses limits increases in cholinergic transmission. |
2001-12-14 |
2023-08-12 |
Not clear |
| J El Yazal, S N Rao, A Mehl, W Slikke. Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods. Toxicological sciences : an official journal of the Society of Toxicology. vol 63. issue 2. 2001-12-12. PMID:11568366. |
neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (ache), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. |
2001-12-12 |
2023-08-12 |
Not clear |
| K Herholz, M Lercher, K Wienhard, B Bauer, O Lenz, W D Heis. PET measurement of cerebral acetylcholine esterase activity without blood sampling. European journal of nuclear medicine. vol 28. issue 4. 2001-12-07. PMID:11357497. |
measurement of cerebral acetylcholine esterase (ache) activity is of clinical interest for the differential diagnosis of memory disorders and dementia. |
2001-12-07 |
2023-08-12 |
human |
| P K Sarkar, A K Ra. Involvement of L-triiodothyronine in acetylcholine metabolism in adult rat cerebrocortical synaptosomes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 33. issue 5. 2001-12-04. PMID:11440272. |
these results predict that t3 stimulates acetylcholine (ach) metabolism by increasing ache activity as well as uptake of the released ach through an increase in synaptosomal mg2+-atpase activity. |
2001-12-04 |
2023-08-12 |
rat |
| J Stoja. Slow detection reaction can mimic initial inhibition of an enzymic reaction. Journal of enzyme inhibition. vol 16. issue 2. 2001-10-11. PMID:11342277. |
an analysis of sigmoid-shaped progress curves in the reaction between electric eel acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7, ache) and its substrate acetylthiocholine in low concentrations at ph 7 is presented. |
2001-10-11 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology. vol 133. issue 7. 2001-10-04. PMID:11487516. |
in addition to its role in hydrolyzing the neurotransmitter acetylcholine, the synaptically enriched enzyme acetylcholinesterase (ache) has been reported to play an important role in the development and remodelling of neural processes and synapses. |
2001-10-04 |
2023-08-12 |
rat |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| K Herholz, B Bauer, K Wienhard, L Kracht, R Mielke, M O Lenz, T Strotmann, W D Heis. In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 12. 2001-08-23. PMID:11458998. |
local activity of acetylcholine esterase (ache) is an indicator of its integrity. |
2001-08-23 |
2023-08-12 |
human |
| U Krügel, V Bigl, K Eschrich, M Big. Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 3. 2001-07-19. PMID:11337195. |
the deafferentation of the hippocampus results in a degeneration of cholinergic septo-hippocampal terminals accompanied by a persistent decrease of choline acetyltransferase (chat) and acetylcholine esterase (ache) activities similar to the cholinergic malfunction in ad. |
2001-07-19 |
2023-08-12 |
human |
| L A Naves, W Van der Kloo. Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction. The Journal of physiology. vol 532. issue Pt 3. 2001-07-12. PMID:11313435. |
when the solution contained 10 microm neostigmine (neo) 3000 stimuli reduced [integral]mepcs by 60 %, because with acetylcholinesterase (ache) inhibited, [integral]mepc size is more sensitive to changes in acetylcholine (ach) content. |
2001-07-12 |
2023-08-12 |
Not clear |
| M B Abou-Donia, L B Goldstein, K H Jones, A A Abdel-Rahman, T V Damodaran, A M Dechkovskaia, S L Bullman, B E Amir, W A Kha. Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicological sciences : an official journal of the Society of Toxicology. vol 60. issue 2. 2001-06-07. PMID:11248143. |
thus, these results suggest that exposure to physiologically relevant doses of pb, deet, and permethrin, alone or in combination, leads to neurobehavioral deficits and region-specific alterations in ache and acetylcholine receptors. |
2001-06-07 |
2023-08-12 |
rat |
| T Neufeld, I Eshkenazi, E Cohen, J Rishpo. A micro flow injection electrochemical biosensor for organophosphorus pesticides. Biosensors & bioelectronics. vol 15. issue 5-6. 2001-05-17. PMID:11219744. |
the system traces very small quantities of op by monitoring the enzymatic reaction of acetylcholine esterase (ache) and its inhibition. |
2001-05-17 |
2023-08-12 |
Not clear |
| M Samochocki, M Zerlin, R Jostock, P J Groot Kormelink, W H Luyten, E X Albuquerque, A Maelick. Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261808. |
originally established as a reversible inhibitor of the acetylcholine-degrading enzyme acetylcholinesterase (ache), galantamine also acts as an allosterically potentiating ligand (apl) on nicotinic acetylcholine receptors (nachr). |
2001-05-17 |
2023-08-12 |
human |
| N H Greig, E De Micheli, H W Holloway, Q S Yu, T Utsuki, T A Perry, A Brossi, D K Ingram, J Deutsch, D K Lahiri, T T Soncran. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261809. |
to determine the time-dependent effects of phenserine on cholinergic function, ache activity, brain and plasma drug levels and brain extracellular acetylcholine (ach) concentrations were measured in rats before and after phenserine administration. |
2001-05-17 |
2023-08-12 |
rat |
| K V Sharma, C Koenigsberger, S Brimijoin, J W Bigbe. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. Journal of neuroscience research. vol 63. issue 2. 2001-04-26. PMID:11169626. |
acetylcholinesterase (ache) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. |
2001-04-26 |
2023-08-12 |
Not clear |
| D S Woodruff-Pak, R W Vogel, G L Wen. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172080. |
the allosterically potentiating ligand galantamine (gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (ache) inhibitor. |
2001-04-19 |
2023-08-12 |
Not clear |
| A Dekundy, P Blaszczak, R Kaminski, W A Tursk. On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Archives of toxicology. vol 74. issue 11. 2001-04-12. PMID:11218047. |
both organophosphate (op) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (ache) and subsequent excess of acetylcholine (ach). |
2001-04-12 |
2023-08-12 |
mouse |
| I J Enyedy, I M Kovach, A Bencsur. Molecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutants. The Biochemical journal. vol 353. issue Pt 3. 2001-04-05. PMID:11171062. |
parallel simulations were carried out with the tetrahedral intermediate formed between serine-200 ogamma of ache and acetylcholine. |
2001-04-05 |
2023-08-12 |
Not clear |
| D G Wilkinso. The pharmacology of donepezil: a new treatment of Alzheimer's disease. Expert opinion on pharmacotherapy. vol 1. issue 1. 2001-04-05. PMID:11249555. |
experimentally, donepezil inhibits ache activity in human erythrocytes and increases extracellular acetylcholine levels in the cerebral cortex and the hippocampus of the rat. |
2001-04-05 |
2023-08-12 |
human |
| A Das, M Dikshit, C Nat. Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age. Life sciences. vol 68. issue 13. 2001-03-29. PMID:11253171. |
inhibition of acetylcholinesterase (ache)-metabolizing enzyme of acetylcholine, is presently the most important therapeutic target for development of cognitive enhancers. |
2001-03-29 |
2023-08-12 |
rat |