| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W F Li. Effects of cholinesterase inhibitors on a two-component chained schedule performance in rats. Neurotoxicology and teratology. vol 22. issue 3. 2000-07-12. PMID:10840182. |
the above medical applications are based upon the neurochemical principles of elevation of transient levels of acetylcholine (ach) in brain and reversible inhibition of ache in blood and brain, respectively. |
2000-07-12 |
2023-08-12 |
rat |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| H N Nigg, J B Knaa. Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Reviews of environmental contamination and toxicology. vol 163. 2000-05-03. PMID:10771584. |
ops exert their insecticidal action by their ability to inhibit ache at the cholinergic synapse, resulting in the accumulation of acetylcholine. |
2000-05-03 |
2023-08-12 |
human |
| L Alfonta, E Katz, I Willne. Sensing of acetylcholine by a tricomponent-enzyme layered electrode using faradaic impedance spectroscopy, cyclic voltammetry, and microgravimetric quartz crystal microbalance transduction methods. Analytical chemistry. vol 72. issue 5. 2000-04-12. PMID:10739194. |
a three-enzyme layered assembly on au electrodes or au-quartz crystals, consisting of horseradish peroxidase, hrp, choline oxidase, cho, and acetylcholine esterase, ache, is used to sense acetylcholine by the hrp-mediated oxidation of 3,3',5,5'-tetramethylbenzidine, tmb (1), by h2o2, and the formation of the insoluble product (2) on the respective transducers. |
2000-04-12 |
2023-08-12 |
Not clear |
| L Alfonta, E Katz, I Willne. Sensing of acetylcholine by a tricomponent-enzyme layered electrode using faradaic impedance spectroscopy, cyclic voltammetry, and microgravimetric quartz crystal microbalance transduction methods. Analytical chemistry. vol 72. issue 5. 2000-04-12. PMID:10739194. |
the analyte-substrate, acetylcholine, is hydrolyzed by ache to choline that is oxidized by cho and o2 to yield the respective betaine and h2o2. |
2000-04-12 |
2023-08-12 |
Not clear |
| S Palmero, G Bardi, L Coniglio, C Falug. Presence and localization of molecules related to the cholinergic system in developing rat testis. European journal of histochemistry : EJH. vol 43. issue 4. 2000-03-22. PMID:10682265. |
in the present study, a contribution is given to the localization of some cholinergic-like molecules, such as acetylcholinesterase (ache), nicotinic acetylcholine and muscarinic acetylcoline (nachr and machr, respectively) receptors during postnatal development of the testis. |
2000-03-22 |
2023-08-12 |
rat |
| J Bäurle, G Brüning, M Schemann, S Nishiike, W O Guldi. Co-localization of glutamate, choline acetyltransferase and glycine in the mammalian vestibular ganglion and periphery. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619636. |
in the vestibular periphery a transmitter role for acetylcholine (ach) has been attributed chiefly to vestibular efferents (ve), however only a subset of ve neurons displays immunoreactivity (ir) for choline acetyltransferase (chat) and acetylcholine esterase (ache). |
2000-01-19 |
2023-08-12 |
mouse |
| F J Muñoz, R Aldunate, N C Inestros. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619655. |
acetylcholinesterase (ache) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. |
2000-01-19 |
2023-08-12 |
Not clear |
| H L Fernandez, G S Ross, I Nadelhaf. Neurogenic calcitonin gene-related peptide: a neurotrophic factor in the maintenance of acetylcholinesterase molecular forms in adult skeletal muscles. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536264. |
results show that: (a) cgrp is present in obturator nerve motor neurons which supply the gracilis muscle, as well as in the corresponding motor endplate regions where high levels of both ache activity and acetylcholine receptors (achrs) are detected; (b) endplate-associated cgrp declines with muscle denervation several hours before any changes in ache forms are detected; (c) a single subcutaneous injection of cgrp reversibly reduces the activities of all ache forms in endplate regions of normally innervated and otherwise untreated gracilis muscles; and (d) similar treatment with hcgrp(8-37), a potent and selective cgrp antagonist, produces the opposite effects, i.e., it reversibly elevates the activities of all ache forms. |
1999-12-10 |
2023-08-12 |
rat |
| Z Yingge, Z Delu, B Chunli, W Che. Force spectroscopy between acetylcholinesterase molecule and its natural substrate to study the effects of inhibitors and reactivators on enzyme activity. Life sciences. vol 65. issue 21. 1999-12-07. PMID:10576601. |
the force spectrum (fs) between acetylcholinesterase (ache) molecule and its natural substrates acetylcholine (ach) and the influences of ache inhibitors and reactivators have been investigated with atomic force microscopy (afm) at single molecule level in real-time. |
1999-12-07 |
2023-08-12 |
Not clear |
| L S Tonduli, G Testylier, I P Marino, G Lallemen. Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data. Journal of neuroscience research. vol 58. issue 3. 1999-11-23. PMID:10518121. |
for the same rat, we associated cortical acetylcholinesterase (ache) activity by microdialysis with both the assay of extracellular acetylcholine (ach) concentrations and electroencephalographic (eeg) recording and power spectrum analysis (gamma band). |
1999-11-23 |
2023-08-12 |
rat |
| T Kosasa, Y Kuriya, K Matsui, Y Yamanish. Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. European journal of pharmacology. vol 380. issue 2-3. 1999-11-01. PMID:10513568. |
the effects of oral administration of the centrally acting acetylcholinesterase (ache) inhibitors, donepezil hydrochloride (donepezil: e2020: (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one monohydrochloride), tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) and ena-713 (rivastigmine: (s)-n-ethyl-3-[(1-dimethyl-amino)ethyl]-n-methyl-phenylcarbamate hydrogentartrate), which have been developed for the treatment of alzheimer's disease, on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated by using a microdialysis technique without adding cholinesterase inhibitor to the perfusion solution. |
1999-11-01 |
2023-08-12 |
rat |
| T Kosasa, Y Kuriya, K Matsui, Y Yamanish. Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. European journal of pharmacology. vol 380. issue 2-3. 1999-11-01. PMID:10513568. |
these results suggest that oral administration of donepezil, tacrine and ena-713 increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through ache inhibition, and that donepezil has a more potent activity than tacrine and a longer-lasting effect than ena-713 on the central cholinergic system. |
1999-11-01 |
2023-08-12 |
rat |
| D Grisaru, M Sternfeld, A Eldor, D Glick, H Sore. Structural roles of acetylcholinesterase variants in biology and pathology. European journal of biochemistry. vol 264. issue 3. 1999-10-14. PMID:10491113. |
apart from its catalytic function in hydrolyzing acetylcholine, acetylcholinesterase (ache) affects cell proliferation, differentiation and responses to various insults, including stress. |
1999-10-14 |
2023-08-12 |
human |
| D I Mitsur. [Changes of the aluminum and silicon contents and cholinergic activity of the blood depending on the course of the gastroduodenal ulcer]. Klinichna khirurhiia. issue 5. 1999-09-08. PMID:10429395. |
in 37 patients with gastroduodenal ulcer disease were revealed the changes of concentration of aluminium and silicon in blood, of acetylcholine in erythrocytes and plasma, the cholinesterase (ache) activity depending on the disease clinical course, the ulcer size; the interconnection between the blood cholinergic activity and the contents of aluminium and silicon; the influence of aluminium and silicon ions on the ache activity of plasma and erythrocytes, what is confirmed by the correlational analysis data and gives and arguments for application of chemical compounds with aluminium and silicon in treatment and prophylaxis of an ulcer disease recurrence. |
1999-09-08 |
2023-08-12 |
Not clear |
| C A Nurse, M Zhan. Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons. Respiration physiology. vol 115. issue 2. 1999-08-27. PMID:10385033. |
recent evidence has strengthened the case for acetylcholine (ach) as a co-released transmitter: (i) cultured type 1 cells express several cholinergic markers including the vesicular ach transporter (vacht), intracellular acetylcholinesterase (ache), and occasional clear cored vesicles (approximately 50 nm diameter); (ii) the frequency of spontaneous synaptic activity, as well as the hypoxia-induced depolarization recorded in 'juxtaposed' pn in co-culture, were partially suppressed by the nicotinic ach receptor (nachr) blocker, mecamylamine (2 microm); (iii) consistent with the presence of extracellular ache, ach-mediated membrane noise in type 1 cells as well as the hypoxia-evoked pn response in co-culture were potentiated in a few cases by the ache inhibitor, eserine (100 microm). |
1999-08-27 |
2023-08-12 |
rat |
| D Kaufer, A Friedman, S Seidman, H Sore. Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission. Chemico-biological interactions. vol 119-120. 1999-08-19. PMID:10421471. |
cholinesterase inhibitors (anti-ches) include a wide range of therapeutic, agricultural and warfare agents all aimed to inhibit the catalytic activity of the acetylcholine (ach) hydrolysing enzyme acetylcholinesterase (ache). |
1999-08-19 |
2023-08-12 |
mouse |
| B D Banerjee, V Seth, A Bhattacharya, S T Pasha, A K Chakrabort. Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers. Toxicology letters. vol 107. issue 1-3. 1999-07-29. PMID:10414779. |
acetylcholine esterase (ache), gamma glutamyl transpeptidase (ggt) and gsh level were also assayed in lymphocytes. |
1999-07-29 |
2023-08-12 |
human |
| K Tuovinen, E Kaliste-Korhonen, F M Raushel, O Hännine. Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology. vol 134. issue 2-3. 1999-07-26. PMID:10403635. |
the acute toxicity of organophosphorus (op) compounds in mammals is due to their irreversible inhibition of acetylcholinesterase (ache) in the nervous system, which leads to increased synaptic acetylcholine levels. |
1999-07-26 |
2023-08-12 |
mouse |
| H B Peng, H Xie, S G Rossi, R L Rotund. Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan. The Journal of cell biology. vol 145. issue 4. 1999-07-21. PMID:10330416. |
prelabeling ache on the surface of xenopus muscle cells revealed that preexisting ache molecules could be recruited to form clusters that colocalize with acetylcholine receptors at sites of nerve-muscle contact. |
1999-07-21 |
2023-08-12 |
xenopus_laevis |