| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Shapira, C K Thompson, H Soreq, G E Robinso. Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies. Journal of molecular neuroscience : MN. vol 17. issue 1. 2002-05-10. PMID:11665858. |
because acetylcholinesterase (ache) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we searched for changes in ache expression in the brain during bee behavioral development. |
2002-05-10 |
2023-08-12 |
bee |
| Artemis Doulgeraki, Zetta Papadopoulou-Daifoti, Stylianos Tsakiri. Effects of L-phenylalanine on acetylcholinesterase and Na+,K+-ATPase activities in suckling rat frontal cortex, hippocampus and hypothalamus. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 57. issue 1-2. 2002-05-10. PMID:11926533. |
it is suggested that: a) in the frontal cortex, the improper acetylcholine (ach) release, due to ache inhibition by phe, combined with the stimulation of na+,k+-atpase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (pku). |
2002-05-10 |
2023-08-12 |
rat |
| Karl W K Tsim, Eric A Barnar. The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction. Neuro-Signals. vol 11. issue 1. 2002-05-09. PMID:11943883. |
the muscle cell surface contains a high local density of acetylcholine (ach) receptors (achrs), acetylcholinesterase (ache) and their interacting macromolecules at the nmj, forming the postsynaptic specializations. |
2002-05-09 |
2023-08-12 |
Not clear |
| E X Albuquerque, M D Santos, M Alkondon, E F Pereira, A Maelick. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669505. |
currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (ache). |
2002-03-18 |
2023-08-12 |
Not clear |
| F Coelho, J Birk. Physostigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11405996. |
the main pharmacological approach for the treatment of alzheimer's disease (ad) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (ache), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. |
2002-02-28 |
2023-08-12 |
Not clear |
| H J Harmo. Spectroscopic determination of acetylcholine esterase-inhibitor complex: determination of conformational shifts of proteins. Biosensors & bioelectronics. vol 16. issue 9-12. 2002-02-25. PMID:11679286. |
the absorbance spectrum of the soret band of tpps undergoes bathochromic shifts upon addition of local anesthetics to acetylcholine esterase (ache), suggesting that the absorbance spectrum of porphyrins can be used as a reporter of the presence of inhibitors of ache by indicating conformational changes on binding of the inhibitor. |
2002-02-25 |
2023-08-12 |
cattle |
| P Drapeau, R R Buss, D W Ali, P Legendre, R L Rotund. Limits to the development of fast neuromuscular transmission in zebrafish. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731551. |
to identify the bases for these changes we compared, in embryos and larvae, the properties and distributions of acetylcholine (ach) receptors (achrs) and acetylcholinesterase (ache) as well as the ultrastructure of the developing neuromuscular junctions (nmjs). |
2002-01-28 |
2023-08-12 |
zebrafish |
| Iain H M Smart, Colette Dehay, Pascale Giroud, Michel Berland, Henry Kenned. Unique morphological features of the proliferative zones and postmitotic compartments of the neural epithelium giving rise to striate and extrastriate cortex in the monkey. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 1. 2002-01-28. PMID:11734531. |
we examined the development of the occipital lobe in fetal monkeys between embryonic day 37 (e37) and e108 in nissl-stained and acetylcholine esterase (ache)-reacted sections. |
2002-01-28 |
2023-08-12 |
monkey |
| G L Larsen, J Loader, D D Nguyen, G N Colasurd. Mechanisms of cholinergic dysfunction in rabbits following recurrent aspiration of cow's milk. Pediatric pulmonology. vol 32. issue 6. 2002-01-10. PMID:11747243. |
segments were assessed for acetylcholine (ach) release by high-performance liquid chromatography ( hplc) with electrochemical detection or acetylcholinesterase (ache) kinetic activity by spectrophotometry. |
2002-01-10 |
2023-08-12 |
Not clear |
| F Amenta, L Parnetti, V Gallai, A Walli. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches? Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589920. |
the different approaches proposed or tested included intervention with acetylcholine (ach) precursors, stimulation of ach release, use of muscarinic or nicotinic receptor agonists and acetylcholinesterase (ache) or cholinesterase (che) inhibition. |
2001-12-31 |
2023-08-12 |
Not clear |
| Y K Chung, H J Heo, E K Kim, H K Kim, T L Huh, Y Lim, S K Kim, D H Shi. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Molecules and cells. vol 11. issue 2. 2001-12-19. PMID:11355692. |
ache inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of compound currently approved for the treatment of alzheimer's disease (ad). |
2001-12-19 |
2023-08-12 |
Not clear |
| H von der Kammer, C Demiralay, B Andresen, C Albrecht, M Mayhaus, R M Nitsc. Regulation of gene expression by muscarinic acetylcholine receptors. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447829. |
the results also suggest a feedback mechanism where up-regulated ache expression and accelerated breakdown of acetylcholine (ach) at the cholinergic synapses limits increases in cholinergic transmission. |
2001-12-14 |
2023-08-12 |
Not clear |
| J El Yazal, S N Rao, A Mehl, W Slikke. Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods. Toxicological sciences : an official journal of the Society of Toxicology. vol 63. issue 2. 2001-12-12. PMID:11568366. |
neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (ache), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. |
2001-12-12 |
2023-08-12 |
Not clear |
| K Herholz, M Lercher, K Wienhard, B Bauer, O Lenz, W D Heis. PET measurement of cerebral acetylcholine esterase activity without blood sampling. European journal of nuclear medicine. vol 28. issue 4. 2001-12-07. PMID:11357497. |
measurement of cerebral acetylcholine esterase (ache) activity is of clinical interest for the differential diagnosis of memory disorders and dementia. |
2001-12-07 |
2023-08-12 |
human |
| P K Sarkar, A K Ra. Involvement of L-triiodothyronine in acetylcholine metabolism in adult rat cerebrocortical synaptosomes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 33. issue 5. 2001-12-04. PMID:11440272. |
these results predict that t3 stimulates acetylcholine (ach) metabolism by increasing ache activity as well as uptake of the released ach through an increase in synaptosomal mg2+-atpase activity. |
2001-12-04 |
2023-08-12 |
rat |
| J Stoja. Slow detection reaction can mimic initial inhibition of an enzymic reaction. Journal of enzyme inhibition. vol 16. issue 2. 2001-10-11. PMID:11342277. |
an analysis of sigmoid-shaped progress curves in the reaction between electric eel acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7, ache) and its substrate acetylthiocholine in low concentrations at ph 7 is presented. |
2001-10-11 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology. vol 133. issue 7. 2001-10-04. PMID:11487516. |
in addition to its role in hydrolyzing the neurotransmitter acetylcholine, the synaptically enriched enzyme acetylcholinesterase (ache) has been reported to play an important role in the development and remodelling of neural processes and synapses. |
2001-10-04 |
2023-08-12 |
rat |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| K Herholz, B Bauer, K Wienhard, L Kracht, R Mielke, M O Lenz, T Strotmann, W D Heis. In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 12. 2001-08-23. PMID:11458998. |
local activity of acetylcholine esterase (ache) is an indicator of its integrity. |
2001-08-23 |
2023-08-12 |
human |
| U Krügel, V Bigl, K Eschrich, M Big. Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 3. 2001-07-19. PMID:11337195. |
the deafferentation of the hippocampus results in a degeneration of cholinergic septo-hippocampal terminals accompanied by a persistent decrease of choline acetyltransferase (chat) and acetylcholine esterase (ache) activities similar to the cholinergic malfunction in ad. |
2001-07-19 |
2023-08-12 |
human |