| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuhiro Konn. [Neurotoxicity of organophosphorus and dithiocarbamate compounds]. Nihon eiseigaku zasshi. Japanese journal of hygiene. vol 57. issue 4. 2003-04-25. PMID:12638169. |
the major neurotoxicities of ops were acute toxicity produced by the acetylcholine esterase (ache) inhibiting action of ops and delayed neurotoxicity produced by such ops as leptophos and tocp. |
2003-04-25 |
2023-08-12 |
Not clear |
| Joana Barbosa Melo, Paula Agostinho, Catarina Resende Oliveir. Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide. Neuroscience research. vol 45. issue 1. 2003-04-08. PMID:12507730. |
in this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide abeta(25-35) on the activity of ache, the degradation enzyme of acetylcholine, as well as the involvement of oxidative stress in this process. |
2003-04-08 |
2023-08-12 |
Not clear |
| Joana Barbosa Melo, Paula Agostinho, Catarina Resende Oliveir. Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide. Neuroscience research. vol 45. issue 1. 2003-04-08. PMID:12507730. |
the data obtained show that the enhancement of ache activity induced by abeta(25-35) is mediated by oxidative stress, and that vitamin e and nos inhibitors, by preventing the compromise of the enzyme activity, can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of ad patients. |
2003-04-08 |
2023-08-12 |
Not clear |
| Archana Hazarika, S N Sarkar, Sunil Hajare, Meena Kataria, J K Mali. Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology. vol 185. issue 1-2. 2003-03-11. PMID:12505439. |
toxicity of organophosphates stems mainly from the accumulation of acetylcholine due to inhibition of acetylcholinesterase (ache). |
2003-03-11 |
2023-08-12 |
rat |
| Hiroki Namba, Kiyoshi Fukushi, Shin-ichiro Nagatsuka, Masaomi Iyo, Hitoshi Shinotoh, Shuji Tanada, Toshiaki Iri. Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates. Methods (San Diego, Calif.). vol 27. issue 3. 2003-03-04. PMID:12183113. |
we tested several radiolabeled lipophilic acetylcholine analogs, e.g., n-methylpiperidyl esters, which readily entered the brain via the blood-brain barrier, were hydrolyzed selectively by ache, and were then trapped in the brain. |
2003-03-04 |
2023-08-12 |
human |
| Ray D Beck, Michael A King, Zhi Huang, John M Petitt. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419517. |
stereological cell counting and imaging techniques were used to compare c57bl/6-il-2(-/-) knockout and c57bl/6-il-2(+/+) wild-type mice for differences in choline acetyltransferase (chat)-positive somata in the medial septum and vertical limb of the diagonal band of broca (ms/vdb) and acetylcholine esterase (ache)-labeled cholinergic axons in hippocampal projection fields. |
2003-01-31 |
2023-08-12 |
mouse |
| C Flores-Flores, A Nissim, S Shochat, H Sore. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456061. |
current alzheimer's disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (ache) at cholinergic synapses. |
2003-01-10 |
2023-08-12 |
human |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
the levels of nitric oxide as marker for increased oxidative stress, and the integrity of the cholinergic system as reflected in acetylcholinesterase (ache) activity and m2 muscarinic acetylcholine receptors ligand binding, were determined. |
2003-01-08 |
2023-08-12 |
rat |
| Seyed K Tayebati, Dahuk El-Assouad, Alberto Ricci, Francesco Ament. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 132. issue 1-2. 2003-01-02. PMID:12417445. |
the totality of peripheral blood lymphocytes express acetylcholine (ach) immunoreactivity, choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular ach transporter (vacht) and m(2)-m(5) muscarinic cholinergic receptor protein immunoreactivity. |
2003-01-02 |
2023-08-12 |
human |
| Takasuke Fujimura, Haruo Kobayashi, Tadahiko Suzuki, Itaru Sato, Shigeo Har. [Neurotoxicity in sodium azide poisoning]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. vol 15. issue 3. 2002-12-24. PMID:12415870. |
measurements of the activities of acetylcholinesterase (ache) and choline acetyltransferase (chat), enzymes that hydrolyze and synthesize acetylcholine (ach) and high-affinity choline uptake (hacu), a rate-limiting step in the synthesis of ach, were determined in the presence of various concentrations of sodium azide in vitro. |
2002-12-24 |
2023-08-12 |
mouse |
| Jeffrey Sterling, Yaacov Herzig, Tamar Goren, Nina Finkelstein, David Lerner, Willy Goldenberg, Istvan Miskolczi, Sandor Molnar, Ferenc Rantal, Tivadar Tamas, Gyorgy Toth, Adela Zagyva, Andras Zekany, John Finberg, Gila Lavian, Aviva Gross, Rachel Friedman, Michal Razin, Wei Huang, Boris Krais, Michael Chorev, Moussa B Youdim, Marta Weinstoc. Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. Journal of medicinal chemistry. vol 45. issue 24. 2002-12-20. PMID:12431053. |
the respective rasagiline- and selegiline-related series were designed to combine inhibitory activities of both acetylcholine esterase (ache) and monoamine oxidase (mao) by virtue of their carbamoyl and propargylamine pharmacophores. |
2002-12-20 |
2023-08-12 |
Not clear |
| N Nunes-Tavares, A Nery da Matta, C M Batista e Silva, G M N Araújo, S R W Louro, A Hassón-Voloc. Inhibition of acetylcholinesterase from Electrophorus electricus (L.) by tricyclic antidepressants. The international journal of biochemistry & cell biology. vol 34. issue 9. 2002-12-17. PMID:12009302. |
the effects of tricyclic antidepressants drugs (tca) amitriptyline, imipramine and nortriptyline, on purified electrophorus electricus (l.) acetylcholinesterase (ache; acetylcholine hydrolase, ec 3.1.1.7) were studied using kinetic methods and specific fluorescent probe propidium. |
2002-12-17 |
2023-08-12 |
Not clear |
| Glenn D Baxter, Stephen C Barke. Analysis of the sequence and expression of a second putative acetylcholinesterase cDNA from organophosphate-susceptible and organophosphate-resistant cattle ticks. Insect biochemistry and molecular biology. vol 32. issue 7. 2002-12-03. PMID:12044498. |
certainly none of the polymorphisms correspond to sites in ache that are involved in catalysis or binding of acetylcholine in other organisms. |
2002-12-03 |
2023-08-12 |
cattle |
| Jorge Andres Rodriguez, Ana Maria Buzaleh, Mariana Fossati, Julio Azcurra, Alcira Maria Del Carmen Batll. The effects of some porphyrinogenic drugs on the brain cholinergic system. Cellular and molecular biology (Noisy-le-Grand, France). vol 48. issue 1. 2002-12-02. PMID:11929041. |
in central nervous system, acetylcholinesterase (ache) and butyrylcholinesterase (buche) hydrolyse acetylcholine. |
2002-12-02 |
2023-08-12 |
Not clear |
| Sean Lilienfel. Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS drug reviews. vol 8. issue 2. 2002-11-25. PMID:12177686. |
it is a reversible, competitive inhibitor of acetylcholinesterase (ache), and is the only drug actively marketed for the treatment of ad with proven activity as an allosteric modulator of nicotinic acetylcholine receptors (nachrs). |
2002-11-25 |
2023-08-12 |
Not clear |
| Ali Abdel-Rahman, Ashok K Shetty, Mohamed B Abou-Doni. Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. Neurobiology of disease. vol 10. issue 3. 2002-11-15. PMID:12270692. |
all animals were evaluated for: (i) the disruption of the blood-brain barrier (bbb) using intravenous horseradish peroxidase (hrp) injections and endothelial barrier antigen (eba) immunostaining; (ii) neuronal cell death using h&e staining, silver staining, and glial fibrillary acidic protein (gfap) immunostaining; and (iii) acetylcholinesterase (ache) activity and m2-muscarinic acetylcholine receptors (m2-achr). |
2002-11-15 |
2023-08-12 |
rat |
| Kazuo Isoma, Masago Ishikawa, Megumi Ohta, Yoichiro Ogawa, Hiroshi Hasegawa, Tadayuki Kohda, Junzo Kame. Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Japanese journal of pharmacology. vol 88. issue 2. 2002-11-04. PMID:11928722. |
the effects of t-82 (2-[2-(1-benzylpiperidin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1h-pyrrolo [3,4-b]quinolin-1-one hemifumarate), a new quinoline derivative, on acetylcholinesterase (ache) activity and acetylcholine (ach) release were compared with those of the well-known cholinesterase inhibitors tacrine and e2020. |
2002-11-04 |
2023-08-12 |
human |
| Ho-Jin Heo, Seong-Chan Hong, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eun-Ki Kim, Dong-Hoon Shi. Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells. Molecules and cells. vol 13. issue 1. 2002-10-10. PMID:11911460. |
acetylcholinesterase (ache) inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of the compound that is currently approved for the treatment of alzheimer's disease (ad). |
2002-10-10 |
2023-08-12 |
Not clear |
| Brandy J White, H James Harmo. Interaction of monosulfonate tetraphenyl porphyrin, a competitive inhibitor, with acetylcholinesterase. Biosensors & bioelectronics. vol 17. issue 6-7. 2002-10-10. PMID:11959466. |
the addition of acetylcholine iodide (achi) or the competitive inhibitor tetracaine to the preformed ache-tpps(1) complex results in a loss of the 442 nm absorbance band as the porphyrin is displaced from ache. |
2002-10-10 |
2023-08-12 |
Not clear |
| T Carbonell, I Masip, F Sánchez-Baeza, M Delgado, E Araya, O Llorens, F Corcho, J J Pérez, E Pérez-Payá, A Messegue. Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones. Molecular diversity. vol 5. issue 3. 2002-09-30. PMID:12197070. |
increasing the acetylcholine concentration in brain by modulating acetylcholinesterase (ache) activity is among the most promising strategies. |
2002-09-30 |
2023-08-12 |
Not clear |