| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Tsakiris, K H Schulpi. The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 55. issue 9-10. 2001-03-08. PMID:11098845. |
it is suggested that galtol as well as gal-1-p can affect acetylcholine degradation acting directly on ache molecule. |
2001-03-08 |
2023-08-12 |
rat |
| A S Torrão, F M Carmona, J Lindstrom, L R Britt. Expression of cholinergic system molecules during development of the chick nervous system. Brain research. Developmental brain research. vol 124. issue 1-2. 2001-02-01. PMID:11113515. |
there are suggestions of the participation of nicotinic acetylcholine receptors (nachrs), the acetylcholine degradation enzyme, acetylcholinesterase (ache), and the acetylcholine synthesizing enzyme, choline acetyltransferase (chat), in the development of the nervous system. |
2001-02-01 |
2023-08-12 |
chicken |
| L J Scott, K L Go. Galantamine: a review of its use in Alzheimer's disease. Drugs. vol 60. issue 5. 2001-02-01. PMID:11129124. |
in addition to inhibition of ache galantamine interacts allosterically with nicotinic acetylcholine receptors to potentiate the action of agonists at these receptors. |
2001-02-01 |
2023-08-12 |
Not clear |
| A Maelick. Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11 Suppl 1. 2000-12-28. PMID:10971047. |
the two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ach) by inhibiting acetylcholinesterase (ache), or to mimic the effects of ach (nicotinic agonists) by acting directly on nicotinic receptors. |
2000-12-28 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, M Yeluashvili, M Qui. Nitric oxide is involved in acetylcholinesterase inhibitor-induced myopathy in rats. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991996. |
excess activation of muscle nicotinic acetylcholine receptors due to genetic mutations, as seen in slow channel congenital myasthenic syndrome, or acetylcholinesterase (ache) inhibition results in muscle cell degeneration. |
2000-11-03 |
2023-08-12 |
rat |
| X Sun, X B Liu, J R Martinez, G H Zhan. Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY. Archives of oral biology. vol 45. issue 8. 2000-08-18. PMID:10869474. |
inhibition of acetylcholinesterase (ache) by ops leads to a decrease in acetylcholine (ach) breakdown that results in overstimulation of muscarinic cholinergic receptors (mchr). |
2000-08-18 |
2023-08-12 |
human |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, M Yeluashvili, M Qui. Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817586. |
tacrine, an acetylcholinesterase (ache) inhibitor that has been used in the treatment of alzheimer's disease, increases available acetylcholine (ach) levels in the synaptic cleft thereby enhancing the activity of cholinergic pathways. |
2000-07-17 |
2023-08-12 |
rat |
| G Testylier, L Tonduli, G Lallemen. Implication of gamma band in soman-induced seizures. Acta biotheoretica. vol 47. issue 3-4. 2000-07-13. PMID:10855266. |
for the same rat, we associated cortical acetylcholinesterase (ache) activity by microdialysis with both the assay of extracellular acetylcholine (ach) concentrations and electroencephalographic (eeg) recording and power spectrum analysis (gamma band). |
2000-07-13 |
2023-08-12 |
rat |
| W F Li. Effects of cholinesterase inhibitors on a two-component chained schedule performance in rats. Neurotoxicology and teratology. vol 22. issue 3. 2000-07-12. PMID:10840182. |
the above medical applications are based upon the neurochemical principles of elevation of transient levels of acetylcholine (ach) in brain and reversible inhibition of ache in blood and brain, respectively. |
2000-07-12 |
2023-08-12 |
rat |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| H N Nigg, J B Knaa. Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Reviews of environmental contamination and toxicology. vol 163. 2000-05-03. PMID:10771584. |
ops exert their insecticidal action by their ability to inhibit ache at the cholinergic synapse, resulting in the accumulation of acetylcholine. |
2000-05-03 |
2023-08-12 |
human |
| L Alfonta, E Katz, I Willne. Sensing of acetylcholine by a tricomponent-enzyme layered electrode using faradaic impedance spectroscopy, cyclic voltammetry, and microgravimetric quartz crystal microbalance transduction methods. Analytical chemistry. vol 72. issue 5. 2000-04-12. PMID:10739194. |
a three-enzyme layered assembly on au electrodes or au-quartz crystals, consisting of horseradish peroxidase, hrp, choline oxidase, cho, and acetylcholine esterase, ache, is used to sense acetylcholine by the hrp-mediated oxidation of 3,3',5,5'-tetramethylbenzidine, tmb (1), by h2o2, and the formation of the insoluble product (2) on the respective transducers. |
2000-04-12 |
2023-08-12 |
Not clear |
| L Alfonta, E Katz, I Willne. Sensing of acetylcholine by a tricomponent-enzyme layered electrode using faradaic impedance spectroscopy, cyclic voltammetry, and microgravimetric quartz crystal microbalance transduction methods. Analytical chemistry. vol 72. issue 5. 2000-04-12. PMID:10739194. |
the analyte-substrate, acetylcholine, is hydrolyzed by ache to choline that is oxidized by cho and o2 to yield the respective betaine and h2o2. |
2000-04-12 |
2023-08-12 |
Not clear |
| S Palmero, G Bardi, L Coniglio, C Falug. Presence and localization of molecules related to the cholinergic system in developing rat testis. European journal of histochemistry : EJH. vol 43. issue 4. 2000-03-22. PMID:10682265. |
in the present study, a contribution is given to the localization of some cholinergic-like molecules, such as acetylcholinesterase (ache), nicotinic acetylcholine and muscarinic acetylcoline (nachr and machr, respectively) receptors during postnatal development of the testis. |
2000-03-22 |
2023-08-12 |
rat |
| J Bäurle, G Brüning, M Schemann, S Nishiike, W O Guldi. Co-localization of glutamate, choline acetyltransferase and glycine in the mammalian vestibular ganglion and periphery. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619636. |
in the vestibular periphery a transmitter role for acetylcholine (ach) has been attributed chiefly to vestibular efferents (ve), however only a subset of ve neurons displays immunoreactivity (ir) for choline acetyltransferase (chat) and acetylcholine esterase (ache). |
2000-01-19 |
2023-08-12 |
mouse |
| F J Muñoz, R Aldunate, N C Inestros. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619655. |
acetylcholinesterase (ache) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. |
2000-01-19 |
2023-08-12 |
Not clear |
| H L Fernandez, G S Ross, I Nadelhaf. Neurogenic calcitonin gene-related peptide: a neurotrophic factor in the maintenance of acetylcholinesterase molecular forms in adult skeletal muscles. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536264. |
results show that: (a) cgrp is present in obturator nerve motor neurons which supply the gracilis muscle, as well as in the corresponding motor endplate regions where high levels of both ache activity and acetylcholine receptors (achrs) are detected; (b) endplate-associated cgrp declines with muscle denervation several hours before any changes in ache forms are detected; (c) a single subcutaneous injection of cgrp reversibly reduces the activities of all ache forms in endplate regions of normally innervated and otherwise untreated gracilis muscles; and (d) similar treatment with hcgrp(8-37), a potent and selective cgrp antagonist, produces the opposite effects, i.e., it reversibly elevates the activities of all ache forms. |
1999-12-10 |
2023-08-12 |
rat |
| Z Yingge, Z Delu, B Chunli, W Che. Force spectroscopy between acetylcholinesterase molecule and its natural substrate to study the effects of inhibitors and reactivators on enzyme activity. Life sciences. vol 65. issue 21. 1999-12-07. PMID:10576601. |
the force spectrum (fs) between acetylcholinesterase (ache) molecule and its natural substrates acetylcholine (ach) and the influences of ache inhibitors and reactivators have been investigated with atomic force microscopy (afm) at single molecule level in real-time. |
1999-12-07 |
2023-08-12 |
Not clear |
| L S Tonduli, G Testylier, I P Marino, G Lallemen. Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data. Journal of neuroscience research. vol 58. issue 3. 1999-11-23. PMID:10518121. |
for the same rat, we associated cortical acetylcholinesterase (ache) activity by microdialysis with both the assay of extracellular acetylcholine (ach) concentrations and electroencephalographic (eeg) recording and power spectrum analysis (gamma band). |
1999-11-23 |
2023-08-12 |
rat |