| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221754. |
in addition to its action at cholinergic synapses acetylcholinesterase (ache) has been proposed to modulate neuronal activity by mechanisms unrelated to the hydrolysis of acetylcholine. |
1999-07-02 |
2023-08-12 |
rat |
| G Feng, E Krejci, J Molgo, J M Cunningham, J Massoulié, J R Sane. Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. The Journal of cell biology. vol 144. issue 6. 1999-06-14. PMID:10087275. |
at the skeletal neuromuscular junction, asymmetric ache is anchored to the basal lamina of the synaptic cleft, where it hydrolyzes acetylcholine to terminate synaptic transmission. |
1999-06-14 |
2023-08-12 |
mouse |
| M Hilgert, M Nöldner, S S Chatterjee, J Klei. KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo. Neuroscience letters. vol 263. issue 2-3. 1999-06-10. PMID:10213168. |
however, when we employed the microdialysis procedure to monitor acetylcholine (ach) release from rat hippocampus, no effect of ka-672 (0.1-10 mg/kg) was found, indicating a lack of inhibition of brain ache under in vivo-conditions. |
1999-06-10 |
2023-08-12 |
rat |
| C N Pop. Organophosphorus pesticides: do they all have the same mechanism of toxicity? Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230392. |
it is concluded that all op anticholinesterases potentially have a mechanism of toxicity in common, that is, phosphorylation of ache causing accumulation of acetylcholine, overstimulation of cholinergic receptors, and consequent clinical signs of cholinergic toxicity. |
1999-05-18 |
2023-08-12 |
Not clear |
| G Testylier, N Micoud, S Martinez, G Lallemen. Simultaneous in vivo determination of acetylcholinesterase activity and acetylcholine release in the cortex of waking rat by microdialysis. Effects of VX. Journal of neuroscience methods. vol 81. issue 1-2. 1999-05-12. PMID:9696310. |
we have designed a microdialysis technique to measure acetylcholinesterase (ache) activity in the cortex of freely moving rats while simultaneously measuring the release of acetylcholine (ach). |
1999-05-12 |
2023-08-12 |
rat |
| J E Keymer, J Gaete, G Kameid, J Alvare. Acetylcholinesterase and inhibitors: effects upon normal and regenerating nerves of the rat. The European journal of neuroscience. vol 11. issue 3. 1999-04-26. PMID:10103097. |
in peripheral nerves, the function of acetylcholinesterase (ache) is not related to hydrolysis of acetylcholine. |
1999-04-26 |
2023-08-12 |
rat |
| J Dudel, M Heckman. Desensitization reduces amplitudes of quantal end-plate currents after a single preceding end-plate current in mouse muscle. Pflugers Archiv : European journal of physiology. vol 437. issue 4. 1999-04-23. PMID:10089570. |
twenty milliseconds after an epc, a subsequent qepc was reduced to 90% of control, and to 70-80% if acetylcholine esterase (ache) was blocked. |
1999-04-23 |
2023-08-12 |
mouse |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
their acute toxic effect in the central and peripheral nervous system is due to inhibition of acetylcholinesterase (ache) at nerve endings which causes accumulation of acetylcholine and consequently overstimulation of the nicotinic and muscarinic receptors. |
1999-02-25 |
2023-08-12 |
Not clear |
| T Szegletes, W D Mallender, P J Thomas, T L Rosenberr. Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Biochemistry. vol 38. issue 1. 1999-02-18. PMID:9890890. |
however, our analyses indicate that the primary physiologic role of the ache peripheral site is to accelerate the hydrolysis of acetylcholine at low substrate concentrations. |
1999-02-18 |
2023-08-12 |
Not clear |
| J McFerrin, W K Engel, V Askana. Impaired innervation of cultured human muscle overexpressing betaAPP experimentally and genetically: relevance to inclusion-body myopathies. Neuroreport. vol 9. issue 14. 1999-01-20. PMID:9831451. |
innervated normal cultured muscle fibers were continuously contracting and fully cross-striated, and they had acetylcholine receptors (achrs) and acetylcholinesterase (ache) accumulated only at the neuromuscular junctions (nmjs). |
1999-01-20 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results suggest a feedback mechanism by which the ache gene is activated by cholinergic neurotransmission, possibly leading to increased formation of ache protein and accelerated degradation of acetylcholine at cholinergic synapses. |
1999-01-13 |
2023-08-12 |
human |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
cholinergic neurotransmission plays a significant role in intrinsic cardiac ganglia with the action of acetylcholine being terminated by acetylcholinesterase (ache, ec 3.1.1.7). |
1998-12-11 |
2023-08-12 |
Not clear |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
enzyme kinetic studies demonstrated that canine ache preferentially catalyzed the hydrolysis of acetylcholine while canine buche preferentially catalyzed the hydrolysis of butyrylcholine. |
1998-12-11 |
2023-08-12 |
Not clear |
| R E Carson, D O Kiesewetter, E Jagoda, M G Der, P Herscovitch, W C Eckelma. Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 10. 1998-11-09. PMID:9778190. |
third, the sensitivity of [18f]fp-tztp binding to changes in brain acetylcholine (ach) was assessed by administering physostigmine, an acetylcholinesterase (ache) inhibitor, by intravenous infusion (100 to 200 microg x kg(-1) x h(-1)) beginning 30 minutes before tracer injection (n = 7). |
1998-11-09 |
2023-08-12 |
monkey |
| B Wiedenmann, C Riedel, M John, G Ahnert-Hilger, G Stoltenburg, J Waldschmidt, K von Deimling, E O Riecken, F Schie. Qualitative and quantitative analysis of synapses in Hirschsprung's disease. Pediatric surgery international. vol 13. issue 7. 1998-11-03. PMID:9716672. |
our data also suggest that nerve endings in hd may contain high concentrations of cholinergic vesicles, paralleling the known high amounts of acetylcholine and ache found in intestinal segments of patients with hd. |
1998-11-03 |
2023-08-12 |
Not clear |
| S De La Porte, E Chaubourt, F Fabre, K Poulas, J Chapron, B Eymard, S Tzartos, J Koeni. Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vitro neuromuscular synaptogenesis. The European journal of neuroscience. vol 10. issue 5. 1998-10-22. PMID:9751136. |
to study a step of the very complex processes of the formation of the neuromuscular junction (nmj), we have analysed the clustering of acetylcholine receptors (achr) and acetylcholinesterase (ache) in myotubes cultured in various conditions. |
1998-10-22 |
2023-08-12 |
mouse |
| F H Calderón, R von Bernhardi, G De Ferrari, S Luza, R Aldunate, N C Inestros. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672900. |
acetylcholinesterase (ache), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as alzheimer's disease. |
1998-10-08 |
2023-08-12 |
Not clear |
| G W Eagleson, R Ubink, B G Jenks, E W Roubo. Forebrain differentiation and axonogenesis in amphibians: I. Differentiation of the suprachiasmatic nucleus in relation to background adaptation behavior. Brain, behavior and evolution. vol 52. issue 1. 1998-09-28. PMID:9667806. |
whole brain acetylcholine esterase (ache) histochemistry was used to follow the early pattern of forebrain neuronal differentiation, and whole brain acetylated-tubulin immunocytochemistry was done to follow early forebrain axonogenesis. |
1998-09-28 |
2023-08-12 |
xenopus_laevis |
| H G Liu, G X Hong, F B Wang, F Che. Motoneurotrophins derived from limb buds protect the motoneurons in anterior spinal cord after nerve injury and promote nerve regeneration. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685649. |
at 1 day, 4 days, 1 week, 2 weeks, 4 weeks and 6 weeks post surgery, the content of acetylcholine esterase (ache) and acid phosphatase (acp) of the anterior spinal cord (injured side) was quantified, and the corresponding motoneuron's ultrastructure and the existant ratio were also examined. |
1998-09-04 |
2023-08-12 |
rat |
| A Marín Burgin, L Szczupa. Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site. The Journal of experimental biology. vol 201. issue Pt 12. 1998-08-24. PMID:9722429. |
the results suggest the existence of a basal level of acetylcholine (ach) release in the leech ganglion that is powerfully counteracted by endogenous ache activity. |
1998-08-24 |
2023-08-12 |
Not clear |