| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Naves, W Van der Kloo. Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction. The Journal of physiology. vol 532. issue Pt 3. 2001-07-12. PMID:11313435. |
when the solution contained 10 microm neostigmine (neo) 3000 stimuli reduced [integral]mepcs by 60 %, because with acetylcholinesterase (ache) inhibited, [integral]mepc size is more sensitive to changes in acetylcholine (ach) content. |
2001-07-12 |
2023-08-12 |
Not clear |
| M B Abou-Donia, L B Goldstein, K H Jones, A A Abdel-Rahman, T V Damodaran, A M Dechkovskaia, S L Bullman, B E Amir, W A Kha. Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicological sciences : an official journal of the Society of Toxicology. vol 60. issue 2. 2001-06-07. PMID:11248143. |
thus, these results suggest that exposure to physiologically relevant doses of pb, deet, and permethrin, alone or in combination, leads to neurobehavioral deficits and region-specific alterations in ache and acetylcholine receptors. |
2001-06-07 |
2023-08-12 |
rat |
| T Neufeld, I Eshkenazi, E Cohen, J Rishpo. A micro flow injection electrochemical biosensor for organophosphorus pesticides. Biosensors & bioelectronics. vol 15. issue 5-6. 2001-05-17. PMID:11219744. |
the system traces very small quantities of op by monitoring the enzymatic reaction of acetylcholine esterase (ache) and its inhibition. |
2001-05-17 |
2023-08-12 |
Not clear |
| M Samochocki, M Zerlin, R Jostock, P J Groot Kormelink, W H Luyten, E X Albuquerque, A Maelick. Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261808. |
originally established as a reversible inhibitor of the acetylcholine-degrading enzyme acetylcholinesterase (ache), galantamine also acts as an allosterically potentiating ligand (apl) on nicotinic acetylcholine receptors (nachr). |
2001-05-17 |
2023-08-12 |
human |
| N H Greig, E De Micheli, H W Holloway, Q S Yu, T Utsuki, T A Perry, A Brossi, D K Ingram, J Deutsch, D K Lahiri, T T Soncran. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261809. |
to determine the time-dependent effects of phenserine on cholinergic function, ache activity, brain and plasma drug levels and brain extracellular acetylcholine (ach) concentrations were measured in rats before and after phenserine administration. |
2001-05-17 |
2023-08-12 |
rat |
| K V Sharma, C Koenigsberger, S Brimijoin, J W Bigbe. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. Journal of neuroscience research. vol 63. issue 2. 2001-04-26. PMID:11169626. |
acetylcholinesterase (ache) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. |
2001-04-26 |
2023-08-12 |
Not clear |
| D S Woodruff-Pak, R W Vogel, G L Wen. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172080. |
the allosterically potentiating ligand galantamine (gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (ache) inhibitor. |
2001-04-19 |
2023-08-12 |
Not clear |
| A Dekundy, P Blaszczak, R Kaminski, W A Tursk. On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Archives of toxicology. vol 74. issue 11. 2001-04-12. PMID:11218047. |
both organophosphate (op) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (ache) and subsequent excess of acetylcholine (ach). |
2001-04-12 |
2023-08-12 |
mouse |
| I J Enyedy, I M Kovach, A Bencsur. Molecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutants. The Biochemical journal. vol 353. issue Pt 3. 2001-04-05. PMID:11171062. |
parallel simulations were carried out with the tetrahedral intermediate formed between serine-200 ogamma of ache and acetylcholine. |
2001-04-05 |
2023-08-12 |
Not clear |
| D G Wilkinso. The pharmacology of donepezil: a new treatment of Alzheimer's disease. Expert opinion on pharmacotherapy. vol 1. issue 1. 2001-04-05. PMID:11249555. |
experimentally, donepezil inhibits ache activity in human erythrocytes and increases extracellular acetylcholine levels in the cerebral cortex and the hippocampus of the rat. |
2001-04-05 |
2023-08-12 |
human |
| A Das, M Dikshit, C Nat. Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age. Life sciences. vol 68. issue 13. 2001-03-29. PMID:11253171. |
inhibition of acetylcholinesterase (ache)-metabolizing enzyme of acetylcholine, is presently the most important therapeutic target for development of cognitive enhancers. |
2001-03-29 |
2023-08-12 |
rat |
| S Tsakiris, K H Schulpi. The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 55. issue 9-10. 2001-03-08. PMID:11098845. |
it is suggested that galtol as well as gal-1-p can affect acetylcholine degradation acting directly on ache molecule. |
2001-03-08 |
2023-08-12 |
rat |
| A S Torrão, F M Carmona, J Lindstrom, L R Britt. Expression of cholinergic system molecules during development of the chick nervous system. Brain research. Developmental brain research. vol 124. issue 1-2. 2001-02-01. PMID:11113515. |
there are suggestions of the participation of nicotinic acetylcholine receptors (nachrs), the acetylcholine degradation enzyme, acetylcholinesterase (ache), and the acetylcholine synthesizing enzyme, choline acetyltransferase (chat), in the development of the nervous system. |
2001-02-01 |
2023-08-12 |
chicken |
| L J Scott, K L Go. Galantamine: a review of its use in Alzheimer's disease. Drugs. vol 60. issue 5. 2001-02-01. PMID:11129124. |
in addition to inhibition of ache galantamine interacts allosterically with nicotinic acetylcholine receptors to potentiate the action of agonists at these receptors. |
2001-02-01 |
2023-08-12 |
Not clear |
| A Maelick. Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11 Suppl 1. 2000-12-28. PMID:10971047. |
the two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ach) by inhibiting acetylcholinesterase (ache), or to mimic the effects of ach (nicotinic agonists) by acting directly on nicotinic receptors. |
2000-12-28 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, M Yeluashvili, M Qui. Nitric oxide is involved in acetylcholinesterase inhibitor-induced myopathy in rats. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991996. |
excess activation of muscle nicotinic acetylcholine receptors due to genetic mutations, as seen in slow channel congenital myasthenic syndrome, or acetylcholinesterase (ache) inhibition results in muscle cell degeneration. |
2000-11-03 |
2023-08-12 |
rat |
| X Sun, X B Liu, J R Martinez, G H Zhan. Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY. Archives of oral biology. vol 45. issue 8. 2000-08-18. PMID:10869474. |
inhibition of acetylcholinesterase (ache) by ops leads to a decrease in acetylcholine (ach) breakdown that results in overstimulation of muscarinic cholinergic receptors (mchr). |
2000-08-18 |
2023-08-12 |
human |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, M Yeluashvili, M Qui. Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817586. |
tacrine, an acetylcholinesterase (ache) inhibitor that has been used in the treatment of alzheimer's disease, increases available acetylcholine (ach) levels in the synaptic cleft thereby enhancing the activity of cholinergic pathways. |
2000-07-17 |
2023-08-12 |
rat |
| G Testylier, L Tonduli, G Lallemen. Implication of gamma band in soman-induced seizures. Acta biotheoretica. vol 47. issue 3-4. 2000-07-13. PMID:10855266. |
for the same rat, we associated cortical acetylcholinesterase (ache) activity by microdialysis with both the assay of extracellular acetylcholine (ach) concentrations and electroencephalographic (eeg) recording and power spectrum analysis (gamma band). |
2000-07-13 |
2023-08-12 |
rat |