| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Jean Massouli\\xc3\\xa. The origin of the molecular diversity and functional anchoring of cholinesterases. Neuro-Signals. vol 11. issue 3. 2002-09-25. PMID:12138250.' |
vertebrates possess two cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche) which both hydrolyze acetylcholine, but differ in their specificity towards other substrates, and in their sensitivity to inhibitors. |
2002-09-25 |
2023-08-12 |
mouse |
| Jeremy Kua, Yingkai Zhang, J Andrew McCammo. Studying enzyme binding specificity in acetylcholinesterase using a combined molecular dynamics and multiple docking approach. Journal of the American Chemical Society. vol 124. issue 28. 2002-09-18. PMID:12105904. |
a combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (ache) with its natural substrate acetylcholine (ach), a family of substrate analogues, and choline. |
2002-09-18 |
2023-08-12 |
cat |
| Ivan Bednar, David Paterson, Amelia Marutle, Therese M Pham, Marie Svedberg, Ewa Hellström-Lindahl, Malahat Mousavi, Jennifer Court, Christopher Morris, Elaine Perry, Abdul Mohammed, Xiao Zhang, Agneta Nordber. Selective nicotinic receptor consequences in APP(SWE) transgenic mice. Molecular and cellular neurosciences. vol 20. issue 2. 2002-08-29. PMID:12093166. |
the nicotinic (nachrs) and muscarinic (machrs) acetylcholine receptors and acetylcholinesterase (ache) activity were studied in the brains of app(swe) transgenic mice (tg+) and age-matched nontransgenic controls (tg-) that were between 4 and 19 months of age. |
2002-08-29 |
2023-08-12 |
mouse |
| Antonella Gorini, Umberto Canosi, Elisabetta Devecchi, Diego Geroldi, Roberto Federico Vill. ATPases enzyme activities during ageing in different types of somatic and synaptic plasma membranes from rat frontal cerebral cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 1. 2002-08-20. PMID:11853124. |
the following enzymes were evaluated: na+, k+-atpase, ca2+, mg2+-atpase, mg2+-atpase and the activity of acetylcholine esterase (ache) was also evaluated. |
2002-08-20 |
2023-08-12 |
rat |
| Hengshan Zhang, Jing Liu, Carey N Pop. Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Archives of toxicology. vol 75. issue 11-12. 2002-08-13. PMID:11876500. |
a number of studies suggest that in addition to inhibiting acetylcholinesterase (ache), cpf oxon may also interact directly with m2 and/or m4 subtypes of muscarinic acetylcholine receptors (machrs). |
2002-08-13 |
2023-08-12 |
rat |
| Dongren Yang, Xinfang Lu, Weiguo Zhang, Fengsheng H. Biochemical changes in primary culture of skeletal muscle cells following dimethoate exposure. Toxicology. vol 174. issue 2. 2002-07-18. PMID:11985885. |
in order to investigate the cellular mechanism of muscular weakness in the intermediate myasthenia syndrome (ims) following acute organophosphate poisoning, we studied the cytotoxicity of dimethoate and its effects on the activity of acetylcholine esterase (ache), na+-k+-atpase, succinate dehydrogenase (sdh), and ca2+-atpase in primary cultured skeletal muscle cells. |
2002-07-18 |
2023-08-12 |
Not clear |
| D Braida, M Sal. Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. CNS drug reviews. vol 7. issue 4. 2002-06-10. PMID:11830755. |
when administered in vivo to rodents by various routes, eptastigmine inhibits cerebral acetylcholinesterases (ache) and increases acetylcholine (ach) brain levels by 2500-3000%, depending on the dose. |
2002-06-10 |
2023-08-12 |
Not clear |
| Andrea Sbarbati, Flavia Merigo, Paolo Bernardi, Caterina Crescimanno, Donatella Benati, Francesco Osculat. Ganglion cells and topographically related nerves in the vallate papilla/von Ebner gland complex. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 50. issue 5. 2002-06-10. PMID:11967282. |
small groups of acetylcholine esterase (ache)-positive/nadphd-negative cells were visible. |
2002-06-10 |
2023-08-12 |
rat |
| F R de la Torre, L Ferrari, A Salibiá. Freshwater pollution biomarker: response of brain acetylcholinesterase activity in two fish species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 131. issue 3. 2002-06-06. PMID:11912052. |
the effect of prolonged exposure at two sites along the reconquista river (argentina), a highly polluted peri-urban water body, on brain acetylcholinesterase (ache, ec 3.1.1.7, acetylcholine acetylhydrolase) of two teleosts was examined. |
2002-06-06 |
2023-08-12 |
Not clear |
| M Shapira, C K Thompson, H Soreq, G E Robinso. Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies. Journal of molecular neuroscience : MN. vol 17. issue 1. 2002-05-10. PMID:11665858. |
because acetylcholinesterase (ache) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we searched for changes in ache expression in the brain during bee behavioral development. |
2002-05-10 |
2023-08-12 |
bee |
| Artemis Doulgeraki, Zetta Papadopoulou-Daifoti, Stylianos Tsakiri. Effects of L-phenylalanine on acetylcholinesterase and Na+,K+-ATPase activities in suckling rat frontal cortex, hippocampus and hypothalamus. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 57. issue 1-2. 2002-05-10. PMID:11926533. |
it is suggested that: a) in the frontal cortex, the improper acetylcholine (ach) release, due to ache inhibition by phe, combined with the stimulation of na+,k+-atpase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (pku). |
2002-05-10 |
2023-08-12 |
rat |
| Karl W K Tsim, Eric A Barnar. The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction. Neuro-Signals. vol 11. issue 1. 2002-05-09. PMID:11943883. |
the muscle cell surface contains a high local density of acetylcholine (ach) receptors (achrs), acetylcholinesterase (ache) and their interacting macromolecules at the nmj, forming the postsynaptic specializations. |
2002-05-09 |
2023-08-12 |
Not clear |
| E X Albuquerque, M D Santos, M Alkondon, E F Pereira, A Maelick. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669505. |
currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (ache). |
2002-03-18 |
2023-08-12 |
Not clear |
| F Coelho, J Birk. Physostigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11405996. |
the main pharmacological approach for the treatment of alzheimer's disease (ad) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (ache), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. |
2002-02-28 |
2023-08-12 |
Not clear |
| H J Harmo. Spectroscopic determination of acetylcholine esterase-inhibitor complex: determination of conformational shifts of proteins. Biosensors & bioelectronics. vol 16. issue 9-12. 2002-02-25. PMID:11679286. |
the absorbance spectrum of the soret band of tpps undergoes bathochromic shifts upon addition of local anesthetics to acetylcholine esterase (ache), suggesting that the absorbance spectrum of porphyrins can be used as a reporter of the presence of inhibitors of ache by indicating conformational changes on binding of the inhibitor. |
2002-02-25 |
2023-08-12 |
cattle |
| P Drapeau, R R Buss, D W Ali, P Legendre, R L Rotund. Limits to the development of fast neuromuscular transmission in zebrafish. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731551. |
to identify the bases for these changes we compared, in embryos and larvae, the properties and distributions of acetylcholine (ach) receptors (achrs) and acetylcholinesterase (ache) as well as the ultrastructure of the developing neuromuscular junctions (nmjs). |
2002-01-28 |
2023-08-12 |
zebrafish |
| Iain H M Smart, Colette Dehay, Pascale Giroud, Michel Berland, Henry Kenned. Unique morphological features of the proliferative zones and postmitotic compartments of the neural epithelium giving rise to striate and extrastriate cortex in the monkey. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 1. 2002-01-28. PMID:11734531. |
we examined the development of the occipital lobe in fetal monkeys between embryonic day 37 (e37) and e108 in nissl-stained and acetylcholine esterase (ache)-reacted sections. |
2002-01-28 |
2023-08-12 |
monkey |
| G L Larsen, J Loader, D D Nguyen, G N Colasurd. Mechanisms of cholinergic dysfunction in rabbits following recurrent aspiration of cow's milk. Pediatric pulmonology. vol 32. issue 6. 2002-01-10. PMID:11747243. |
segments were assessed for acetylcholine (ach) release by high-performance liquid chromatography ( hplc) with electrochemical detection or acetylcholinesterase (ache) kinetic activity by spectrophotometry. |
2002-01-10 |
2023-08-12 |
Not clear |
| F Amenta, L Parnetti, V Gallai, A Walli. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches? Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589920. |
the different approaches proposed or tested included intervention with acetylcholine (ach) precursors, stimulation of ach release, use of muscarinic or nicotinic receptor agonists and acetylcholinesterase (ache) or cholinesterase (che) inhibition. |
2001-12-31 |
2023-08-12 |
Not clear |
| Y K Chung, H J Heo, E K Kim, H K Kim, T L Huh, Y Lim, S K Kim, D H Shi. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Molecules and cells. vol 11. issue 2. 2001-12-19. PMID:11355692. |
ache inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of compound currently approved for the treatment of alzheimer's disease (ad). |
2001-12-19 |
2023-08-12 |
Not clear |