| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nilkanta Chakrabarti, Arun K Ra. Stimulation of AChE activity in relation to changes in electronmicroscopic structure of adult rat cerebrocortical synaptosomes pretreated with 3-5-3'-triiodo-L-thyronine. Neuroreport. vol 14. issue 11. 2003-11-20. PMID:12960772. |
the experiments suggest that t3 might have a role in the calcium-dependent release/co-release of acetylcholine from intact synaptosomes concomitant with the acceleration of choline uptake mechanisms that has been reported to accompany elevation of ache activity. |
2003-11-20 |
2023-08-12 |
rat |
| Kaj Blennow, Eugeen Vanmechele. CSF markers for pathogenic processes in Alzheimer's disease: diagnostic implications and use in clinical neurochemistry. Brain research bulletin. vol 61. issue 3. 2003-10-14. PMID:12909293. |
in view of current (acetylcholine esterase (ache) inhibitors) and future (e.g. |
2003-10-14 |
2023-08-12 |
Not clear |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| M Pakaski, P Kas. Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Current drug targets. CNS and neurological disorders. vol 2. issue 3. 2003-08-27. PMID:12769797. |
increasing the acetylcholine concentration in the brain by modulating acetylcholine-sterase (ache) activity is among the most promising therapeutic strategies. |
2003-08-27 |
2023-08-12 |
Not clear |
| Tirupapuliyur V Damodaran, Katherine H Jones, Anand G Patel, Mohamed B Abou-Doni. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochemical pharmacology. vol 65. issue 12. 2003-07-22. PMID:12787884. |
sarin inactivates the enzyme ache which is responsible for the breakdown of the neurotransmitter acetylcholine (ach), leading to its accumulation at ach receptors and overstimulation of the cholinergic system. |
2003-07-22 |
2023-08-12 |
rat |
| Laura A Volpicelli-Daley, Ellen G Duysen, Oksana Lockridge, Allan I Leve. Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice. Annals of neurology. vol 53. issue 6. 2003-07-09. PMID:12783426. |
stimulation of muscarinic acetylcholine receptors (machrs) by elevated levels of ach plays a role in the effects of ache inhibitors on cognition and behavior. |
2003-07-09 |
2023-08-12 |
mouse |
| Nigel H Greig, Debomoy K Lahiri, Kumar Sambamurt. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. International psychogeriatrics. vol 14 Suppl 1. 2003-07-03. PMID:12636181. |
acetylcholinesterase (ache) predominates in the healthy brain, with butyrylcholinesterase (buche) considered to play a minor role in regulating brain acetylcholine (ach) levels. |
2003-07-03 |
2023-08-12 |
Not clear |
| Ezio Giacobin. Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochemical research. vol 28. issue 3-4. 2003-06-18. PMID:12675140. |
within particular conditions, such as in mice nullizygote for ache or in ad patients at advanced stages of the disease, buche may replace ache in hydrolizing brain acetylcholine. |
2003-06-18 |
2023-08-12 |
mouse |
| Victoria Zarotsky, John J Sramek, Neal R Cutle. Galantamine hydrobromide: an agent for Alzheimer's disease. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 60. issue 5. 2003-06-03. PMID:12635450. |
galantamine acts both as a reversible competitive inhibitor of acetylcholinesterase (ache) and as an allosteric modulator of nicotinic acetylcholine receptors. |
2003-06-03 |
2023-08-12 |
Not clear |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases. Cellular and molecular neurobiology. vol 23. issue 1. 2003-05-20. PMID:12701885. |
acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (buche, ec 3.1.1.8) are serine hydrolase enzymes that catalyze the hydrolysis of acetylcholine. |
2003-05-20 |
2023-08-12 |
human |
| Qi-Huang Jin, Yu-Fang Shi, Heng-Yi He, Kelvin K W Ng, Hua Jiang, Lei Yang, Zi-Qing Jiang, Xue-Jun Zhan. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. BioTechniques. vol Suppl. 2003-04-25. PMID:12395932. |
acetylcholinesterase (ache; ec3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. |
2003-04-25 |
2023-08-12 |
human |
| Nobuhiro Konn. [Neurotoxicity of organophosphorus and dithiocarbamate compounds]. Nihon eiseigaku zasshi. Japanese journal of hygiene. vol 57. issue 4. 2003-04-25. PMID:12638169. |
the major neurotoxicities of ops were acute toxicity produced by the acetylcholine esterase (ache) inhibiting action of ops and delayed neurotoxicity produced by such ops as leptophos and tocp. |
2003-04-25 |
2023-08-12 |
Not clear |
| Joana Barbosa Melo, Paula Agostinho, Catarina Resende Oliveir. Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide. Neuroscience research. vol 45. issue 1. 2003-04-08. PMID:12507730. |
in this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide abeta(25-35) on the activity of ache, the degradation enzyme of acetylcholine, as well as the involvement of oxidative stress in this process. |
2003-04-08 |
2023-08-12 |
Not clear |
| Joana Barbosa Melo, Paula Agostinho, Catarina Resende Oliveir. Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide. Neuroscience research. vol 45. issue 1. 2003-04-08. PMID:12507730. |
the data obtained show that the enhancement of ache activity induced by abeta(25-35) is mediated by oxidative stress, and that vitamin e and nos inhibitors, by preventing the compromise of the enzyme activity, can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of ad patients. |
2003-04-08 |
2023-08-12 |
Not clear |
| Archana Hazarika, S N Sarkar, Sunil Hajare, Meena Kataria, J K Mali. Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology. vol 185. issue 1-2. 2003-03-11. PMID:12505439. |
toxicity of organophosphates stems mainly from the accumulation of acetylcholine due to inhibition of acetylcholinesterase (ache). |
2003-03-11 |
2023-08-12 |
rat |
| Hiroki Namba, Kiyoshi Fukushi, Shin-ichiro Nagatsuka, Masaomi Iyo, Hitoshi Shinotoh, Shuji Tanada, Toshiaki Iri. Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates. Methods (San Diego, Calif.). vol 27. issue 3. 2003-03-04. PMID:12183113. |
we tested several radiolabeled lipophilic acetylcholine analogs, e.g., n-methylpiperidyl esters, which readily entered the brain via the blood-brain barrier, were hydrolyzed selectively by ache, and were then trapped in the brain. |
2003-03-04 |
2023-08-12 |
human |
| Ray D Beck, Michael A King, Zhi Huang, John M Petitt. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419517. |
stereological cell counting and imaging techniques were used to compare c57bl/6-il-2(-/-) knockout and c57bl/6-il-2(+/+) wild-type mice for differences in choline acetyltransferase (chat)-positive somata in the medial septum and vertical limb of the diagonal band of broca (ms/vdb) and acetylcholine esterase (ache)-labeled cholinergic axons in hippocampal projection fields. |
2003-01-31 |
2023-08-12 |
mouse |
| C Flores-Flores, A Nissim, S Shochat, H Sore. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456061. |
current alzheimer's disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (ache) at cholinergic synapses. |
2003-01-10 |
2023-08-12 |
human |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
the levels of nitric oxide as marker for increased oxidative stress, and the integrity of the cholinergic system as reflected in acetylcholinesterase (ache) activity and m2 muscarinic acetylcholine receptors ligand binding, were determined. |
2003-01-08 |
2023-08-12 |
rat |
| Seyed K Tayebati, Dahuk El-Assouad, Alberto Ricci, Francesco Ament. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 132. issue 1-2. 2003-01-02. PMID:12417445. |
the totality of peripheral blood lymphocytes express acetylcholine (ach) immunoreactivity, choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular ach transporter (vacht) and m(2)-m(5) muscarinic cholinergic receptor protein immunoreactivity. |
2003-01-02 |
2023-08-12 |
human |