| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
ache inhibition by donepezil resulted in a dose-dependent increase in acetylcholine levels in the prefrontal cortex of young animals as measured by microdialysis. |
2004-05-07 |
2023-08-12 |
monkey |
| R Fabian, E A Seyfart. Acetylcholine and histamine are transmitter candidates in identifiable mechanosensitive neurons of the spider Cupiennius salei: an immunocytochemical study. Cell and tissue research. vol 287. issue 2. 2004-05-06. PMID:8995212. |
moreover, staining for acetylcholine esterase (ache) revealed ache activity in one neuron of each mechanoreceptor type. |
2004-05-06 |
2023-08-12 |
spider |
| R Fabian, E A Seyfart. Acetylcholine and histamine are transmitter candidates in identifiable mechanosensitive neurons of the spider Cupiennius salei: an immunocytochemical study. Cell and tissue research. vol 287. issue 2. 2004-05-06. PMID:8995212. |
the presence of chat-like immunoreactivity and ache implicates acetylcholine as a transmitter candidate in the two mechanoreceptive organs. |
2004-05-06 |
2023-08-12 |
spider |
| Tsutomu Nakahara, Yuko Kubota, Kenji Sakamoto, Kunio Ishi. The role of cholinesterases in rat urinary bladder contractility. Urological research. vol 31. issue 3. 2004-05-06. PMID:12736766. |
this study examines the effects of inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche) on acetylcholine (ach)-induced contraction in rat urinary bladder smooth muscle. |
2004-05-06 |
2023-08-12 |
rat |
| Smeeta Panda, Sanjat K Sah. Recovery of acetylcholine esterase activity of Drawida willsi (Oligochaeta) following application of three pesticides to soil. Chemosphere. vol 55. issue 2. 2004-04-09. PMID:14761699. |
the recovery of acetylcholine esterase (ache) activity of a dominant crop field earthworm (drawida willsi, michaelsen) was investigated under laboratory conditions following the application of two recommended agricultural (single and double) doses of butachlor (1.1 and 2.2 mga.i.kg(-1) dry soil), malathion (2.2 and 4.4 mga.i.kg(-1) dry soil) and carbofuran (1.1 and 2.2 mga.i.kg(-1) dry soil) to the soil. |
2004-04-09 |
2023-08-12 |
Not clear |
| Esperanza Arias, Eva Alés, Nelson H Gabilan, María F Cano-Abad, Mercedes Villarroya, Antonio G García, Manuela G Lópe. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology. vol 46. issue 1. 2004-04-05. PMID:14654102. |
galantamine is currently used to treat alzheimer's disease patients; it behaves as a mild blocker of acetylcholinesterase (ache) and has an allosteric modulating action on nicotinic acetylcholine receptors (nachrs). |
2004-04-05 |
2023-08-12 |
human |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
the effect of abeta1-42 on ache was blocked by inhibitors of alpha7 nicotinic acetylcholine receptors (alpha7 nachrs) as well as by inhibitors of l- or n-type voltage-dependent calcium channels (vdccs), whereas agonists of alpha7 nachrs (choline, nicotine) increased the level of ache. |
2004-03-30 |
2023-08-12 |
mouse |
| K M Sales, S T Kingston, K M Doyle, W M Purcel. Preliminary characterisation of an in vitro paradigm for the study of the delayed effects of organophosphorus compounds: hen embryo brain spheroids. Toxicology. vol 195. issue 2-3. 2004-03-09. PMID:14751674. |
we optimised the levels of acetylcholine esterase (ache) and neuropathy target esterase by adapting the culture technique and using chemically defined media. |
2004-03-09 |
2023-08-12 |
Not clear |
| T Day, S A Greenfiel. A peptide derived from acetylcholinesterase induces neuronal cell death: characterisation of possible mechanisms. Experimental brain research. vol 153. issue 3. 2004-02-26. PMID:13680041. |
acetylcholinesterase (ache) exhibits functions unrelated to the catalysis of acetylcholine (ach) in particular during development. |
2004-02-26 |
2023-08-12 |
rat |
| Karl Herhol. PET studies in dementia. Annals of nuclear medicine. vol 17. issue 2. 2004-02-10. PMID:12790355. |
cortical acetylcholine esterase activity (ache) activity is significantly lower in patients with ad or with dementia with lewy bodies (dlb) than in age-matched normal controls. |
2004-02-10 |
2023-08-12 |
Not clear |
| A Abdel-Rahman, Suzanne Abou-Donia, Eman El-Masry, Ashok Shetty, Mohamed Abou-Doni. Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. Journal of toxicology and environmental health. Part A. vol 67. issue 2. 2004-02-04. PMID:14675905. |
animals exposed to both stress and chemical exhibited decreased brain acetylcholinesterase (ache) activity in the midbrain, brainstem, and cerebellum and decreased m2 muscarinic acetylcholine (ach) receptor ligand binding in the midbrain and cerebellum. |
2004-02-04 |
2023-08-12 |
rat |
| Micael Jacobsson, Per Lidén, Eva Stjernschantz, Henrik Boström, Ulf Norinde. Improving structure-based virtual screening by multivariate analysis of scoring data. Journal of medicinal chemistry. vol 46. issue 26. 2004-01-20. PMID:14667231. |
three different multivariate statistical methods, pls discriminant analysis, rule-based methods, and bayesian classification, have been applied to multidimensional scoring data from four different target proteins: estrogen receptor alpha (eralpha), matrix metalloprotease 3 (mmp3), factor xa (fxa), and acetylcholine esterase (ache). |
2004-01-20 |
2023-08-12 |
Not clear |
| M Faimali, C Falugi, L Gallus, V Piazza, G Tagliafierr. Involvement of acetyl choline in settlement of Balanus amphitrite. Biofouling. vol 19 Suppl. 2004-01-14. PMID:14618723. |
acetylcholinesterase (ache, the lythic enzyme of acetylcholine) activity was detected, for the first time, by biochemical and histoenzymological methods, in the thoracic muscles, gut wall and cement gland. |
2004-01-14 |
2023-08-12 |
Not clear |
| M Faimali, C Falugi, L Gallus, V Piazza, G Tagliafierr. Involvement of acetyl choline in settlement of Balanus amphitrite. Biofouling. vol 19 Suppl. 2004-01-14. PMID:14618723. |
an increase of available acetylcholine due to the partial inhibition of ache activity produced an increase in cyprid settlement. |
2004-01-14 |
2023-08-12 |
Not clear |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
in this study, the effects of oral administration of ppe on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated, and compared to that of tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride), a well-known and centrally acting acetylcholinesterase (ache) inhibitor, which had been developed for the treatment of alzheimer's disease. |
2003-12-29 |
2023-08-12 |
rat |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
the results suggest that oral administration of ppe and tacrine increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through ache inhibition, and that ppe has a potent and long-lasting effect on the central cholinergic system. |
2003-12-29 |
2023-08-12 |
rat |
| L M Gerstein, E L Dovedova, N S Popov. [Mechanism of nootropic digam action in hypofunction of brain dopaminergic system]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 103. issue 7. 2003-12-29. PMID:12938655. |
using microchemical methods for detection of dopamine (da), noradrenaline (na), serotonin (s) and its metabolite--5'-hydroxyindolilacetic acid (5'-hiaa) as well as the activity of neuromediator-utilising enzymes--mao a and b and enzymes of acetylcholine metabolism--cholinacetyltranspherase (chat) and acetylcholinesterase (ache), we revealed that synthetic gaba-derivative compound diagram (250 mg/kg during 10 days) normalized functioning of dopaminergic and acetylcholinergic systems in sensormotor cortex and caudate nucleus of wistar rats with haloperidol-induced (0.5 mg/kg during 30 days) bradykinesia. |
2003-12-29 |
2023-08-12 |
rat |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. |
2003-12-15 |
2023-08-12 |
mouse |
| C Ducho, J Balzarini, C Meie. Non-inhibition of acetylcholinesterase by cycloSal nucleotides. Nucleosides, nucleotides & nucleic acids. vol 22. issue 5-8. 2003-12-11. PMID:14565292. |
ache is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. |
2003-12-11 |
2023-08-12 |
human |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
acetylcholinesterase (ache) inhibitors, which increase synaptic levels of available acetylcholine (ach) by preventing its degradation, are the most extensively prescribed drugs for the treatment of alzheimer's disease. |
2003-12-10 |
2023-08-12 |
rat |