| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boris Bryk, Liat BenMoyal-Segal, Erez Podoly, Oded Livnah, Arik Eisenkraft, Shai Luria, Amir Cohen, Yoav Yehezkelli, Ariel Hourvitz, Hermona Sore. Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715671. |
the 5.5 mb chromosome 7q21-22 ache/pon1 locus harbours the ache gene encoding the acetylcholine hydrolyzing, organophosphate (op)-inhibitable acetylcholinesterase protein and the paraoxonase gene pon1, yielding the op-hydrolyzing pon1 enzyme which also displays arylesterase activity. |
2005-04-28 |
2023-08-12 |
Not clear |
| C H Opperman, S Chan. Nematode acetylcholinesterases: molecular forms and their potential role in nematode behavior. Parasitology today (Personal ed.). vol 8. issue 12. 2005-04-21. PMID:15463554. |
acetylcholine activity is terminated by hydrolysis by acetylcholinesterase (ache). |
2005-04-21 |
2023-08-12 |
Not clear |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
in post-mortem frontal cortex from ad patients, acetylcholine (ach) levels, cholinacetyltransferase (chat) and acetylcholinesterase (ache) activity were all reduced compared to controls. |
2005-04-18 |
2023-08-12 |
rat |
| Michihisa Tohda, Prawpan Suwanakitch, Rattima Jeenapongsa, Hisae Hayashi, Hiroshi Watanabe, Kinzo Matsumot. Expression changes of the mRNA of Alzheimer's disease related factors in the permanent ischemic rat brain. Biological & pharmaceutical bulletin. vol 27. issue 12. 2005-04-15. PMID:15577224. |
the expression changes of amyloid precursor protein (app), secretase, alpha7 nicotinic acetylcholine receptor (alpha7nicr) and acetylcholine esterase (ache), which are involved in alzheimer's disease, were examined by quantitative rt/pcr in this model rat brain. |
2005-04-15 |
2023-08-12 |
rat |
| T K Manojkumar, Chunzhi Cui, Kwang S Ki. Theoretical insights into the mechanism of acetylcholinesterase-catalyzed acylation of acetylcholine. Journal of computational chemistry. vol 26. issue 6. 2005-04-13. PMID:15739192. |
acylation of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. |
2005-04-13 |
2023-08-12 |
Not clear |
| R Nikolo. Alzheimer's disease therapy - an update. Drug news & perspectives. vol 11. issue 4. 2005-03-30. PMID:15616667. |
the two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (ache) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. |
2005-03-30 |
2023-08-12 |
Not clear |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
ache, acetylcholine (ach) receptors and choline acetyltransferase have been reported to be expressed by t cells, suggesting that cholinergic signalling may exert some modulatory influence on t-cell function and consequently on the immune system. |
2005-03-18 |
2023-08-12 |
human |
| Vincenzo Rispoli, Domenicantonio Rotiroti, Vincenzo Carelli, Felice Liberatore, Luigi Scipione, Rosario Marra, Silvano Tortorella, Barbara Di Rienz. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301920. |
the results of the present work allow us to put forward the hypothesis that the eeg effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ach) consequent upon acetylcholinesterase (ache) inhibition by choline pivaloyl esters. |
2005-03-04 |
2023-08-12 |
rat |
| C Angelini, B Baccetti, P Piomboni, S Trombino, M G Aluigi, S Stringara, L Gallus, C Falug. Acetylcholine synthesis and possible functions during sea urchin development. European journal of histochemistry : EJH. vol 48. issue 3. 2005-03-02. PMID:15590413. |
acetylcholinesterase (ache, the lytic enzyme of acetylcholine) was also found in ovarian eggs, with a similar distribution; however, it disappeared after fertilisation. |
2005-03-02 |
2023-08-12 |
Not clear |
| Hideo Tsukad. [Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 124. issue 3. 2005-03-01. PMID:15333988. |
ache inhibition by donepezil resulted in a dose-dependent increase in acetylcholine levels in the prefrontal cortex as measured by microdialysis. |
2005-03-01 |
2023-08-12 |
monkey |
| Ezio Giacobin. Cholinesterase inhibitors: new roles and therapeutic alternatives. Pharmacological research. vol 50. issue 4. 2005-02-04. PMID:15304240. |
within particular conditions, such as in mice nullizygote for ache or in ad patients at advanced stages of the disease, buche may replace ache in hydrolyzing brain acetylcholine. |
2005-02-04 |
2023-08-12 |
mouse |
| Xiaoqiang Ma, David R Gan. The Lycopodium alkaloids. Natural product reports. vol 21. issue 6. 2005-02-02. PMID:15565253. |
in particular, the effect of hupa and other cholinesterase inhibitors (anti-ad drugs) on acetylcholine esterase (ache) activity in the rat cortex and butylcholine esterase activity are compared. |
2005-02-02 |
2023-08-12 |
rat |
| Tsuneyoshi Ota, Hitoshi Shinotoh, Kiyoshi Fukushi, Shin-ichiro Nagatsuka, Hiroki Namba, Masaomi Iyo, Akiyo Aotsuka, Noriko Tanaka, Koichi Sato, Tetsuya Shiraishi, Shuji Tanada, Heii Arai, Toshiaki Iri. A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT. Annals of nuclear medicine. vol 18. issue 3. 2004-12-21. PMID:15233279. |
we have developed a radiolabeled lipophilic acetylcholine analogue, n-[11c]methylpiperidin-4-yl acetate ([11c]mp4a) to measure brain acetylcholinesterase (ache) activity by positron emission tomography (pet) in vivo. |
2004-12-21 |
2023-08-12 |
Not clear |
| Malahat Mousavi, Ivan Bednar, Agneta Nordber. Selective changes in expression of different nicotinic receptor subtypes in brain and adrenal glands of mice carrying human mutated gene for APP or over-expressing human acetylcholinestrase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465284. |
in this study, we investigated regulatory mechanisms and plasticity of the nicotinic acetylcholine receptors (nachrs) in the brain and adrenal glands of two transgenic mice models over-expressing human beta-amyloid precursor protein (app(swe)tg) and human ache enzyme (hache-tg), respectively. |
2004-12-15 |
2023-08-12 |
mouse |
| Laura E Paraoanu, Paul G Laye. Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta. FEBS letters. vol 576. issue 1-2. 2004-11-19. PMID:15474030. |
acetylcholinesterase (ache) is likely to have roles other than the hydrolysis of acetylcholine, e.g., related to developmental processes like neurite outgrowth, differentiation and adhesion. |
2004-11-19 |
2023-08-12 |
mouse |
| Tomie Nishizawa, Hiroyuki Tamaki, Norikatsu Kasuga, Hiroaki Takekur. Degeneration and regeneration of neuromuscular junction architecture in rat skeletal muscle fibers damaged by bupivacaine hydrochloride. Journal of muscle research and cell motility. vol 24. issue 8. 2004-11-15. PMID:14870968. |
we evaluated the degeneration and regeneration of neuromuscular junctions (nmjs) on the extensor digitorum longus muscle of fischer 344 rats between 4 h and 3 weeks after bupivacaine hydrochloride (bpvc) injection, which induces muscle fiber necrosis, using histochemical staining by acetylcholine esterase (ache)-silver and electron microscopy. |
2004-11-15 |
2023-08-12 |
rat |
| Bianca Fuhrman, Ayelet Partoush, Michael Avira. Acetylcholine esterase protects LDL against oxidation. Biochemical and biophysical research communications. vol 322. issue 3. 2004-11-01. PMID:15336559. |
acetylcholine esterase (ache) and paraoxonase 1 (pon1) are both serum ester hydrolases, which are associated with the prevalence of myocardial infarction. |
2004-11-01 |
2023-08-12 |
Not clear |
| Jiri Bajgar, Lucie Sevelová, Gabriela Krejcová, Josef Fusek, Josef Vachek, Jiri Kassa, Josef Herink, Leo P A de Jong, Hendrik P Benscho. Biochemical and behavioral effects of soman vapors in low concentrations. Inhalation toxicology. vol 16. issue 8. 2004-09-28. PMID:15204741. |
soman acts by inhibiting acetylcholinesterase (ache) both peripherally and centrally, with a subsequent accumulation of neuromediator acetylcholine and other metabolic changes. |
2004-09-28 |
2023-08-12 |
Not clear |
| E Boudinot, M J Emery, E Mouisel, A Chatonnet, J Champagnat, P Escourrou, A S Fout. Increased ventilation and CO2 chemosensitivity in acetylcholinesterase knockout mice. Respiratory physiology & neurobiology. vol 140. issue 3. 2004-09-23. PMID:15186785. |
to investigate the effects of a permanent excess of acetylcholine (ache) on respiration, breathing and chemosensitivity were analyzed from birth to adulthood in mice lacking the ache gene (ache-/-), in heterozygotes, and in control wild-type (ache+/+) littermates. |
2004-09-23 |
2023-08-12 |
mouse |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Francesco Ament. Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 26. issue 4. 2004-09-08. PMID:15195690. |
the present study has investigated the influence of two doses of the ache inhibitor rivastigmine (0.625 mg/kg/day and 2.5 mg/kg/day) on vesicular acetylcholine transporter (vacht) and on choline acetyltransferase (chat) expression in frontal cortex, hippocampus, striatum and cerebellum of normotensive and spontaneously hypertensive rats (shr). |
2004-09-08 |
2023-08-12 |
rat |