| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
their acute toxic effect in the central and peripheral nervous system is due to inhibition of acetylcholinesterase (ache) at nerve endings which causes accumulation of acetylcholine and consequently overstimulation of the nicotinic and muscarinic receptors. |
1999-02-25 |
2023-08-12 |
Not clear |
| T Szegletes, W D Mallender, P J Thomas, T L Rosenberr. Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Biochemistry. vol 38. issue 1. 1999-02-18. PMID:9890890. |
however, our analyses indicate that the primary physiologic role of the ache peripheral site is to accelerate the hydrolysis of acetylcholine at low substrate concentrations. |
1999-02-18 |
2023-08-12 |
Not clear |
| J McFerrin, W K Engel, V Askana. Impaired innervation of cultured human muscle overexpressing betaAPP experimentally and genetically: relevance to inclusion-body myopathies. Neuroreport. vol 9. issue 14. 1999-01-20. PMID:9831451. |
innervated normal cultured muscle fibers were continuously contracting and fully cross-striated, and they had acetylcholine receptors (achrs) and acetylcholinesterase (ache) accumulated only at the neuromuscular junctions (nmjs). |
1999-01-20 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results suggest a feedback mechanism by which the ache gene is activated by cholinergic neurotransmission, possibly leading to increased formation of ache protein and accelerated degradation of acetylcholine at cholinergic synapses. |
1999-01-13 |
2023-08-12 |
human |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
cholinergic neurotransmission plays a significant role in intrinsic cardiac ganglia with the action of acetylcholine being terminated by acetylcholinesterase (ache, ec 3.1.1.7). |
1998-12-11 |
2023-08-12 |
Not clear |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
enzyme kinetic studies demonstrated that canine ache preferentially catalyzed the hydrolysis of acetylcholine while canine buche preferentially catalyzed the hydrolysis of butyrylcholine. |
1998-12-11 |
2023-08-12 |
Not clear |
| R E Carson, D O Kiesewetter, E Jagoda, M G Der, P Herscovitch, W C Eckelma. Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 10. 1998-11-09. PMID:9778190. |
third, the sensitivity of [18f]fp-tztp binding to changes in brain acetylcholine (ach) was assessed by administering physostigmine, an acetylcholinesterase (ache) inhibitor, by intravenous infusion (100 to 200 microg x kg(-1) x h(-1)) beginning 30 minutes before tracer injection (n = 7). |
1998-11-09 |
2023-08-12 |
monkey |
| B Wiedenmann, C Riedel, M John, G Ahnert-Hilger, G Stoltenburg, J Waldschmidt, K von Deimling, E O Riecken, F Schie. Qualitative and quantitative analysis of synapses in Hirschsprung's disease. Pediatric surgery international. vol 13. issue 7. 1998-11-03. PMID:9716672. |
our data also suggest that nerve endings in hd may contain high concentrations of cholinergic vesicles, paralleling the known high amounts of acetylcholine and ache found in intestinal segments of patients with hd. |
1998-11-03 |
2023-08-12 |
Not clear |
| S De La Porte, E Chaubourt, F Fabre, K Poulas, J Chapron, B Eymard, S Tzartos, J Koeni. Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vitro neuromuscular synaptogenesis. The European journal of neuroscience. vol 10. issue 5. 1998-10-22. PMID:9751136. |
to study a step of the very complex processes of the formation of the neuromuscular junction (nmj), we have analysed the clustering of acetylcholine receptors (achr) and acetylcholinesterase (ache) in myotubes cultured in various conditions. |
1998-10-22 |
2023-08-12 |
mouse |
| F H Calderón, R von Bernhardi, G De Ferrari, S Luza, R Aldunate, N C Inestros. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672900. |
acetylcholinesterase (ache), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as alzheimer's disease. |
1998-10-08 |
2023-08-12 |
Not clear |
| G W Eagleson, R Ubink, B G Jenks, E W Roubo. Forebrain differentiation and axonogenesis in amphibians: I. Differentiation of the suprachiasmatic nucleus in relation to background adaptation behavior. Brain, behavior and evolution. vol 52. issue 1. 1998-09-28. PMID:9667806. |
whole brain acetylcholine esterase (ache) histochemistry was used to follow the early pattern of forebrain neuronal differentiation, and whole brain acetylated-tubulin immunocytochemistry was done to follow early forebrain axonogenesis. |
1998-09-28 |
2023-08-12 |
xenopus_laevis |
| H G Liu, G X Hong, F B Wang, F Che. Motoneurotrophins derived from limb buds protect the motoneurons in anterior spinal cord after nerve injury and promote nerve regeneration. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685649. |
at 1 day, 4 days, 1 week, 2 weeks, 4 weeks and 6 weeks post surgery, the content of acetylcholine esterase (ache) and acid phosphatase (acp) of the anterior spinal cord (injured side) was quantified, and the corresponding motoneuron's ultrastructure and the existant ratio were also examined. |
1998-09-04 |
2023-08-12 |
rat |
| A Marín Burgin, L Szczupa. Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site. The Journal of experimental biology. vol 201. issue Pt 12. 1998-08-24. PMID:9722429. |
the results suggest the existence of a basal level of acetylcholine (ach) release in the leech ganglion that is powerfully counteracted by endogenous ache activity. |
1998-08-24 |
2023-08-12 |
Not clear |
| S R Pereira, G A Menezes, G C Franco, A E Costa, A M Ribeir. Chronic ethanol consumption impairs spatial remote memory in rats but does not affect cortical cholinergic parameters. Pharmacology, biochemistry, and behavior. vol 60. issue 2. 1998-08-17. PMID:9632211. |
moreover, there were no significant differences between treated and control subjects in the following biochemical brain cortical parameters: in vitro acetylcholinesterase (ache) activity, and stimulated acetylcholine (ach) release. |
1998-08-17 |
2023-08-12 |
human |
| R N Sachdev, S M Lu, R G Wiley, F F Ebne. Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity. Journal of neurophysiology. vol 79. issue 6. 1998-07-17. PMID:9636120. |
the immunotoxin reduces acetylcholine esterase (ache)-positive fibers in s1 cortex by >90% by 3 wk after injection. |
1998-07-17 |
2023-08-12 |
rat |
| B Garrone, M R Luparini, L Tolu, M Magnani, C Landolfi, C Milanes. Effect of the subchronic treatment with the acetylcholinesterase inhibitor heptastigmine on central cholinergic transmission and memory impairment in aged rats. Neuroscience letters. vol 245. issue 1. 1998-07-14. PMID:9596354. |
the effect of subchronic administration of the acetylcholinesterase (ache) inhibitor heptastigmine (hep 0.6 mg/kg s.c. daily for 15 days) was investigated on cortical extracellular acetylcholine (ach) levels and on memory function in aged male rats (26 months old at the beginning of the experiments) using microdialysis and behavioural techniques. |
1998-07-14 |
2023-08-12 |
rat |
| R C Choi, L Y Yung, T T Dong, D C Wan, Y H Wong, K W Tsi. The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP. Journal of neurochemistry. vol 71. issue 1. 1998-07-09. PMID:9648861. |
in vertebrate neuromuscular junctions, post-synaptic specialization includes aggregation of acetylcholine receptors (achrs) and acetylcholinesterase (ache). |
1998-07-09 |
2023-08-12 |
chicken |
| W Yao, D A Godfre. Immunohistochemical evaluation of cholinergic neurons in the rat superior olivary complex. Microscopy research and technique. vol 41. issue 3. 1998-07-02. PMID:9605344. |
the cholinergic system in the rat superior olivary complex (soc) was evaluated by immunohistochemistry for choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht) and histochemistry for acetylcholinesterase (ache). |
1998-07-02 |
2023-08-12 |
rat |
| L A Zimmer, M Ennis, R G Wiley, M T Shiple. Nerve gas-induced seizures: role of acetylcholine in the rapid induction of Fos and glial fibrillary acidic protein in piriform cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 10. 1998-06-01. PMID:9570817. |
this suggests that the inhibition of ache by soman leads to increased acetylcholine (ach) and neuronal excitability in pc. |
1998-06-01 |
2023-08-12 |
rat |
| M A Prendergast, A V Terry, J J Buccafusc. Effects of chronic, low-level organophosphate exposure on delayed recall, discrimination, and spatial learning in monkeys and rats. Neurotoxicology and teratology. vol 20. issue 2. 1998-05-14. PMID:9536457. |
chronic exposure to low levels of organophosphate (op) compounds impairs acetylcholine (ach) degradation by acetylcholinesterase (ache) and, in humans, may produce lasting neurotoxicity affecting cognitive function. |
1998-05-14 |
2023-08-12 |
rat |