| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Chen, E Shohami, R Bass, M Weinstoc. Cerebro-protective effects of ENA713, a novel acetylcholinesterase inhibitor, in closed head injury in the rat. Brain research. vol 784. issue 1-2. 1998-04-30. PMID:9518537. |
ischemia decreases brain acetylcholine (ach) levels and head trauma upregulates acetylcholinesterase (ache) in experimental animal models. |
1998-04-30 |
2023-08-12 |
rat |
| J Liu, C N Pop. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. Journal of toxicology and environmental health. Part A. vol 53. issue 7. 1998-04-30. PMID:9561967. |
the relative effects of either vehicle (peanut oil, 2 ml/kg, sc), cpf (280 mg/kg), or ps (6.6 mg/kg) on clinical signs of toxicity and ache activity, high-affinity choline uptake (hacu), and potassium-evoked acetylcholine (ach) release in striatum were examined for a 7-d period after exposure in adult female sprague-dawley rats. |
1998-04-30 |
2023-08-12 |
rat |
| M Alkondon, E F Pereira, W S Cortes, A Maelicke, E X Albuquerqu. Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517478. |
in the present study, we demonstrate that choline, a precursor of acetylcholine (ach) and a product of acetylcholine hydrolysis by acetylcholinesterase (ache), acts as an efficient and relatively selective agonist of alpha7-containing nicotinic acetylcholine receptors (nachr) in neurons cultured from the rat hippocampus, olfactory bulb and thalamus as well as in pc12 cells. |
1998-04-24 |
2023-08-12 |
rat |
| C Opazo, N C Inestros. Crosslinking of amyloid-beta peptide to brain acetylcholinesterase. Molecular and chemical neuropathology. vol 33. issue 1. 1998-04-21. PMID:9493175. |
acetylcholinesterase (ache) is the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine in the central nervous system. |
1998-04-21 |
2023-08-12 |
Not clear |
| O Niwa, T Horiuchi, R Kurita, K Torimits. On-line electrochemical sensor for selective continuous measurement of acetylcholine in cultured brain tissue. Analytical chemistry. vol 70. issue 6. 1998-04-15. PMID:9530003. |
carbon electrodes were modified with an acetylcholine esterase (ache), choline oxidase (chox), and osmium poly(vinylpyridine)-based redox polymer containing horseradish peroxidase (os-gel-hrp). |
1998-04-15 |
2023-08-12 |
rat |
| J Thome, K Nara, P Foley, T Michel, W Gsell, W Retz, M Rosler, P Riedere. Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin 3 (NT3) concentration in human post mortem brain tissue. Journal fur Hirnforschung. vol 38. issue 4. 1998-03-31. PMID:9476208. |
ciliary neurotrophic factor (cntf) genotypes: influence on choline acetyltransferase (chat) and acetylcholine esterase (ache) activities and neurotrophin 3 (nt3) concentration in human post mortem brain tissue. |
1998-03-31 |
2023-08-12 |
human |
| J Thome, K Nara, P Foley, T Michel, W Gsell, W Retz, M Rosler, P Riedere. Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin 3 (NT3) concentration in human post mortem brain tissue. Journal fur Hirnforschung. vol 38. issue 4. 1998-03-31. PMID:9476208. |
we therefore conducted an explorative pilot study to investigate the influence of a null mutation allele of the cntf gene on chat (choline acetyltransferase) and ache (acetylcholine esterase) activities in various regions of human post mortem brain tissue. |
1998-03-31 |
2023-08-12 |
human |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
to characterize the neurochemical mechanisms that may mediate this effect, we investigated the development of indices of the cholinergic system in the hippocampus: choline acetyltransferase (chat), acetylcholinesterase (ache), synthesis of acetylcholine (ach) from choline transported by high-affinity choline uptake (hacu), and potassium-evoked ach release. |
1998-03-31 |
2023-08-12 |
rat |
| M Brank, K Zajc-Kreft, S Kreft, R Komel, Z Grubi. Biogenesis of acetylcholinesterase is impaired, although its mRNA level remains normal, in the glucocorticoid-treated rat skeletal muscle. European journal of biochemistry. vol 251. issue 1-2. 1998-03-23. PMID:9492307. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the neuromuscular junction and other cholinergic synapses. |
1998-03-23 |
2023-08-12 |
rat |
| E Acquas, H C Fibige. Dopaminergic regulation of striatal acetylcholine release: the critical role of acetylcholinesterase inhibition. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489729. |
this study examined the effects of different levels of acetylcholinesterase (ache) inhibition on dopaminergic regulation of striatal acetylcholine (ach) release as estimated by in vivo brain microdialysis. |
1998-03-12 |
2023-08-12 |
Not clear |
| S Gralewic. [Possible consequences of AChE inhibition in organophosphate poisoning. A new approach to an old problem]. Medycyna pracy. vol 48. issue 4. 1998-02-18. PMID:9471495. |
the known function of ache is hydrolysis of the neurotransmitter, acetylcholine (ach). |
1998-02-18 |
2023-08-12 |
Not clear |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
in vivo suppression of the acetylcholine hydrolyzing activity of ache and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. |
1998-02-17 |
2023-08-12 |
human |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
phosphorylation of ache may possibly offer a rapid feedback mechanism that can compensate for impairments in cholinergic neurotransmission, modulating the hydrolytic activity of this enzyme and enabling acetylcholine hydrolysis to proceed under such challenges. |
1998-02-17 |
2023-08-12 |
human |
| S K Tayebati, M Giannella, S R Indraccolo, M Pigini, M Sabbatini, D Zaccheo, F Ament. Muscarinic cholinergic receptors and acetylcholinesterase activity in umbilical artery and vein in pregnancy-induced hypertension (pre-eclampsia). Clinical and experimental hypertension (New York, N.Y. : 1993). vol 19. issue 8. 1998-01-20. PMID:9385471. |
these findings suggest that pre-eclampsia is characterized by a loss of muscarinic cholinergic receptors in the umbilical circulation not accompanied by changes of the acetylcholine catabolizing enzyme ache. |
1998-01-20 |
2023-08-12 |
human |
| A Alvarez, C Opazo, R Alarcón, J Garrido, N C Inestros. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. Journal of molecular biology. vol 272. issue 3. 1997-10-28. PMID:9325095. |
acetylcholinesterase (ache), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of alzheimer's disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. |
1997-10-28 |
2023-08-12 |
Not clear |
| R A Giniatullin, M Talantova, F Vyskoci. Desensitization shortens the high-quantal-content endplate current time course in frog muscle with intact cholinesterase. The Journal of physiology. vol 502 ( Pt 3). 1997-10-27. PMID:9279814. |
the desensitization induced by bath-applied carbachol or acetylcholine (ach) and potentiated by proadifen (skf 525a) was studied in the frog sartorius with intact synaptic acetylcholinesterase (ache). |
1997-10-27 |
2023-08-12 |
Not clear |
| C Koenigsberger, S Chiappa, S Brimijoi. Neurite differentiation is modulated in neuroblastoma cells engineered for altered acetylcholinesterase expression. Journal of neurochemistry. vol 69. issue 4. 1997-10-27. PMID:9326267. |
previous observations from several groups suggest that acetylcholinesterase (ache) may have a role in neural morphogenesis, but not solely by virtue of its ability to hydrolyze acetylcholine. |
1997-10-27 |
2023-08-12 |
Not clear |
| C Holmes, S A Jones, T C Budd, S A Greenfiel. Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons. Journal of neuroscience research. vol 49. issue 2. 1997-10-16. PMID:9272643. |
indeed, several recent studies have already demonstrated a neurotrophic action of ache independent of hydrolysis of acetylcholine. |
1997-10-16 |
2023-08-12 |
mouse |
| T Irie, K Fukushi, Y Akimoto, H Tamagami, T Nozak. Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo. Nuclear medicine and biology. vol 21. issue 6. 1997-09-25. PMID:9234329. |
design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (ache) in vivo. |
1997-09-25 |
2023-08-12 |
mouse |
| T Irie, K Fukushi, Y Akimoto, H Tamagami, T Nozak. Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo. Nuclear medicine and biology. vol 21. issue 6. 1997-09-25. PMID:9234329. |
for mapping brain acetylcholinesterase (ache) in vivo, seven radioactive acetylcholine analogs, n-[14c]methylpiperidyl-3- and 4-acetates, propionates, isobutyrates, and 3-butyrate were newly synthesized and evaluated in mice. |
1997-09-25 |
2023-08-12 |
mouse |