| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Takahata, Y Katayama, H Oshima, T Suma, M Koshinag. Transplantation of polymer-encapsulated fetal hippocampal cells into ischemic lesions of adult rat hippocampus. Cell transplantation. vol 5. issue 5 Suppl 1. 1997-01-31. PMID:8889221. |
in addition, the cholinergic fibers originated from the host brain were examined by acetylcholine esterase (ache) histochemistry. |
1997-01-31 |
2023-08-12 |
rat |
| C A Hawkins, S A Greenfiel. Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870040. |
it has been postulated for many years that acetylcholinesterase (ache) may play a nonclassical role in the substantia nigra, unrelated to its ability to hydrolyse acetylcholine. |
1997-01-23 |
2023-08-12 |
rat |
| Y Loewenstein-Lichtenstein, D Glick, N Gluzman, M Sternfeld, H Zakut, H Sore. Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. Molecular pharmacology. vol 50. issue 6. 1997-01-23. PMID:8967962. |
to delineate the protein domains that are responsible for this phenomenon, we mutated residues within the rim of the active site gorge, the region parallel to the peripheral site in the homologous enzyme acetylcholinesterase [ache (acetylcholine acetyl hydrolase); ec 3.1.1.7], the oxyanion hole, and the choline-binding site. |
1997-01-23 |
2023-08-12 |
human |
| F M Cowan, T M Shih, D E Lenz, J M Madsen, C A Broomfiel. Hypothesis for synergistic toxicity of organophosphorus poisoning-induced cholinergic crisis and anaphylactoid reactions. Journal of applied toxicology : JAT. vol 16. issue 1. 1997-01-17. PMID:8821672. |
the neurotoxicity of organophosphorus (op) compounds involves the inhibition of acetylcholinesterase (ache), causing accumulation of acetylcholine (ach) at synapses. |
1997-01-17 |
2023-08-12 |
Not clear |
| L Y Zang, H P Misr. Inhibition of acetylcholinesterase by the neurotoxicant, 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Archives of biochemistry and biophysics. vol 336. issue 1. 1997-01-16. PMID:8951045. |
these data suggest that once mpdp+ enters the basal ganglia of the brain, it can inhibit the ache and thereby increase the acetylcholine level in the basal ganglia, leading to potential cell dysfunction. |
1997-01-16 |
2023-08-12 |
Not clear |
| V Tõugu, T Kesvater. Role of ionic interactions in cholinesterase catalysis. Biochimica et biophysica acta. vol 1298. issue 1. 1997-01-06. PMID:8948485. |
acetylcholinesterase (ache, ec 3.1.1.7) is an enzyme terminating the transmission of nerve impulse in synapses by rapid and selective hydrolysis of the neurotransmitter acetylcholine. |
1997-01-06 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholinesterase (ache) is distinguished from butyrylcholinesterase (bche) by its greater specificity for hydrolysing acetylcholine. |
1996-12-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholine has been shown to influence cell proliferation and neurite outgrowth through nicotinic and muscarinic receptor-mediated mechanisms and thus, that the expression of ache and bche at non-synaptic sites may be associated with a cholinergic function. |
1996-12-30 |
2023-08-12 |
Not clear |
| J B Mudd, P J Dawson, J R Adams, J Wingo, J Santroc. Reaction of ozone with enzymes of erythrocyte membranes. Archives of biochemistry and biophysics. vol 335. issue 1. 1996-12-24. PMID:8914845. |
ozone inactivated acetylcholine esterase (ache) both in intact washed human erythrocytes and in ghosts prepared from the erythrocytes. |
1996-12-24 |
2023-08-12 |
human |
| S Hirokawa, M Nose, A Ishige, S Amagaya, T Oyama, Y Ogihar. Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain. Journal of ethnopharmacology. vol 50. issue 2. 1996-12-13. PMID:8866727. |
the effect of hachimi-jio-gan (hj) on scopolamine induced memory impairment was studied using a radial maze performance, the effect of hj on the central cholinergic system as measured by acetylcholine (ach) content, choline acetyltransferase (cat) and acetylcholinesterase (ache) activities was also examined. |
1996-12-13 |
2023-08-12 |
rat |
| A Inoue, T Kawai, M Wakita, Y Iimura, H Sugimoto, Y Kawakam. The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses. Journal of medicinal chemistry. vol 39. issue 22. 1996-12-10. PMID:8893840. |
the simulated binding profiles of acetylcholine, ach, and the inhibitor (+/-)-2,3-dihydro-5,6- dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-on e hydrochloride (e2020), 1, and some of its analogs to acetylcholinesterase, ache, were determined using full force field energetics and allowing complete conformational flexibility in both the ligand and receptor. |
1996-12-10 |
2023-08-12 |
Not clear |
| P T Carrol. Evidence to suggest that cytosolic acetylcholine in rat hippocampal nerve terminals is not directly transferred into synaptic vesicles for release. Brain research. vol 725. issue 1. 1996-12-06. PMID:8828580. |
rat hippocampal minces were loaded with [acetyl 1-14c]acetylcholine ([14c]ach) in the presence of the "poorly penetrating" acetylcholinesterase (ec 3.1.1.7; ache) inhibitor echothiophate and the effect of high k+ depolarization determined on the subcellular storage and release of [14c]ach and its metabolites. |
1996-12-06 |
2023-08-12 |
rat |
| J J Hutsler, M S Gazzanig. Acetylcholinesterase staining in human auditory and language cortices: regional variation of structural features. Cerebral cortex (New York, N.Y. : 1991). vol 6. issue 2. 1996-11-27. PMID:8670655. |
acetylcholinesterase (ache), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers iii and v of the cerebral cortex. |
1996-11-27 |
2023-08-12 |
human |
| M Srivatsan, B Peret. Effect of acetylcholinesterase inhibition on behavior is age-dependent in freely moving Aplysia. Behavioural brain research. vol 77. issue 1-2. 1996-11-18. PMID:8762162. |
comparisons of the results of ache inhibition which would elevate acetylcholine (ach) levels with those of carbachol administration revealed that ache inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. |
1996-11-18 |
2023-08-12 |
aplysia |
| M Guenneugues, M Verdière-Sahuqué, R Amouri, D Goudou, F Riege. Mouse G2-GPI AChE is processed as a membrane-bound ectoenzyme in transfected mouse sarcoma cells but is not a homophilic adhesion molecule. Neuroscience letters. vol 210. issue 1. 1996-10-31. PMID:8762181. |
acetylcholinesterase (ache) is mainly involved in synaptic transmission by hydrolyzing acetylcholine in the synaptic cleft. |
1996-10-31 |
2023-08-12 |
mouse |
| S Sudha, M K Lakshmana, N Pradha. Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels. Pharmacology, biochemistry, and behavior. vol 54. issue 3. 1996-10-24. PMID:8743640. |
the pb levels in plasma, the acetylcholine esterase (ache) activity in the motor cortex, pyriform cortex, olfactory bulb, striatum, septum, and hippocampus and the levels of serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), dopamine (da), dihydroxyphenylacetic acid (dopac), and homovanillic acid (hva) levels in the hippocampus were measured. |
1996-10-24 |
2023-08-12 |
rat |
| M Weinstoc. The pharmacotherapy of Alzheimer's disease based on the cholinergic hypothesis: an update. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 4. 1996-10-24. PMID:8846227. |
current pharmacological strategies, aimed at increasing cholinergic activity include acetylcholinesterase (ache) inhibitors, cholinergic agonists, acetylcholine (ach) releasers and stimulants of nerve growth factors (ngf). |
1996-10-24 |
2023-08-12 |
Not clear |
| H L Fernandez, C A Hodges-Savol. Physiological regulation of G4 AChe in fast-twitch muscle: effects of exercise and CGRP. Journal of applied physiology (Bethesda, Md. : 1985). vol 80. issue 1. 1996-10-24. PMID:8847328. |
they are also consistent with the hypothesis that, in addition to acetylcholine, neurogenic cgrp participates in the regulation of g4 ache at the neuromuscular junction. |
1996-10-24 |
2023-08-12 |
rat |
| N Kishibayashi, A Karasaw. Effects of KW-5092, a novel gastroprokinetic agent, on intestinal water and electrolyte transport in rats. Biological & pharmaceutical bulletin. vol 18. issue 12. 1996-10-23. PMID:8787786. |
kw-5092 ([1-[2-[[[5-(piperidinomethyl)- 2-furanyl]methyl]amino]ethyl]-2-imidazolidinylidene]propanedini trile fumarate) enhances acetylcholine release from enteric neurons and inhibits acetylcholinesterase (ache), resulting in the enhancement of a wide range of gastrointestinal motilities. |
1996-10-23 |
2023-08-12 |
rat |
| T Irie, K Fukushi, H Namba, M Iyo, H Tamagami, S Nagatsuka, N Ikot. Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 4. 1996-08-26. PMID:8691261. |
we developed three radioactive acetylcholine analogs--n[14c]methyl-4-piperidyl acetate ([14c]mp4a), propionate ([14c]mp4p) and isobutyrate ([14c]mp4ib)--as radiotracers for measuring brain acetylcholinesterase (ache) activity in vivo. |
1996-08-26 |
2023-08-12 |
rat |