| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Niwa, T Horiuchi, R Kurita, K Torimits. On-line electrochemical sensor for selective continuous measurement of acetylcholine in cultured brain tissue. Analytical chemistry. vol 70. issue 6. 1998-04-15. PMID:9530003. |
carbon electrodes were modified with an acetylcholine esterase (ache), choline oxidase (chox), and osmium poly(vinylpyridine)-based redox polymer containing horseradish peroxidase (os-gel-hrp). |
1998-04-15 |
2023-08-12 |
rat |
| J Thome, K Nara, P Foley, T Michel, W Gsell, W Retz, M Rosler, P Riedere. Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin 3 (NT3) concentration in human post mortem brain tissue. Journal fur Hirnforschung. vol 38. issue 4. 1998-03-31. PMID:9476208. |
ciliary neurotrophic factor (cntf) genotypes: influence on choline acetyltransferase (chat) and acetylcholine esterase (ache) activities and neurotrophin 3 (nt3) concentration in human post mortem brain tissue. |
1998-03-31 |
2023-08-12 |
human |
| J Thome, K Nara, P Foley, T Michel, W Gsell, W Retz, M Rosler, P Riedere. Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin 3 (NT3) concentration in human post mortem brain tissue. Journal fur Hirnforschung. vol 38. issue 4. 1998-03-31. PMID:9476208. |
we therefore conducted an explorative pilot study to investigate the influence of a null mutation allele of the cntf gene on chat (choline acetyltransferase) and ache (acetylcholine esterase) activities in various regions of human post mortem brain tissue. |
1998-03-31 |
2023-08-12 |
human |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
to characterize the neurochemical mechanisms that may mediate this effect, we investigated the development of indices of the cholinergic system in the hippocampus: choline acetyltransferase (chat), acetylcholinesterase (ache), synthesis of acetylcholine (ach) from choline transported by high-affinity choline uptake (hacu), and potassium-evoked ach release. |
1998-03-31 |
2023-08-12 |
rat |
| M Brank, K Zajc-Kreft, S Kreft, R Komel, Z Grubi. Biogenesis of acetylcholinesterase is impaired, although its mRNA level remains normal, in the glucocorticoid-treated rat skeletal muscle. European journal of biochemistry. vol 251. issue 1-2. 1998-03-23. PMID:9492307. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the neuromuscular junction and other cholinergic synapses. |
1998-03-23 |
2023-08-12 |
rat |
| E Acquas, H C Fibige. Dopaminergic regulation of striatal acetylcholine release: the critical role of acetylcholinesterase inhibition. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489729. |
this study examined the effects of different levels of acetylcholinesterase (ache) inhibition on dopaminergic regulation of striatal acetylcholine (ach) release as estimated by in vivo brain microdialysis. |
1998-03-12 |
2023-08-12 |
Not clear |
| S Gralewic. [Possible consequences of AChE inhibition in organophosphate poisoning. A new approach to an old problem]. Medycyna pracy. vol 48. issue 4. 1998-02-18. PMID:9471495. |
the known function of ache is hydrolysis of the neurotransmitter, acetylcholine (ach). |
1998-02-18 |
2023-08-12 |
Not clear |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
in vivo suppression of the acetylcholine hydrolyzing activity of ache and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. |
1998-02-17 |
2023-08-12 |
human |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
phosphorylation of ache may possibly offer a rapid feedback mechanism that can compensate for impairments in cholinergic neurotransmission, modulating the hydrolytic activity of this enzyme and enabling acetylcholine hydrolysis to proceed under such challenges. |
1998-02-17 |
2023-08-12 |
human |
| S K Tayebati, M Giannella, S R Indraccolo, M Pigini, M Sabbatini, D Zaccheo, F Ament. Muscarinic cholinergic receptors and acetylcholinesterase activity in umbilical artery and vein in pregnancy-induced hypertension (pre-eclampsia). Clinical and experimental hypertension (New York, N.Y. : 1993). vol 19. issue 8. 1998-01-20. PMID:9385471. |
these findings suggest that pre-eclampsia is characterized by a loss of muscarinic cholinergic receptors in the umbilical circulation not accompanied by changes of the acetylcholine catabolizing enzyme ache. |
1998-01-20 |
2023-08-12 |
human |
| A Alvarez, C Opazo, R Alarcón, J Garrido, N C Inestros. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. Journal of molecular biology. vol 272. issue 3. 1997-10-28. PMID:9325095. |
acetylcholinesterase (ache), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of alzheimer's disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. |
1997-10-28 |
2023-08-12 |
Not clear |
| R A Giniatullin, M Talantova, F Vyskoci. Desensitization shortens the high-quantal-content endplate current time course in frog muscle with intact cholinesterase. The Journal of physiology. vol 502 ( Pt 3). 1997-10-27. PMID:9279814. |
the desensitization induced by bath-applied carbachol or acetylcholine (ach) and potentiated by proadifen (skf 525a) was studied in the frog sartorius with intact synaptic acetylcholinesterase (ache). |
1997-10-27 |
2023-08-12 |
Not clear |
| C Koenigsberger, S Chiappa, S Brimijoi. Neurite differentiation is modulated in neuroblastoma cells engineered for altered acetylcholinesterase expression. Journal of neurochemistry. vol 69. issue 4. 1997-10-27. PMID:9326267. |
previous observations from several groups suggest that acetylcholinesterase (ache) may have a role in neural morphogenesis, but not solely by virtue of its ability to hydrolyze acetylcholine. |
1997-10-27 |
2023-08-12 |
Not clear |
| C Holmes, S A Jones, T C Budd, S A Greenfiel. Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons. Journal of neuroscience research. vol 49. issue 2. 1997-10-16. PMID:9272643. |
indeed, several recent studies have already demonstrated a neurotrophic action of ache independent of hydrolysis of acetylcholine. |
1997-10-16 |
2023-08-12 |
mouse |
| T Irie, K Fukushi, Y Akimoto, H Tamagami, T Nozak. Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo. Nuclear medicine and biology. vol 21. issue 6. 1997-09-25. PMID:9234329. |
design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (ache) in vivo. |
1997-09-25 |
2023-08-12 |
mouse |
| T Irie, K Fukushi, Y Akimoto, H Tamagami, T Nozak. Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo. Nuclear medicine and biology. vol 21. issue 6. 1997-09-25. PMID:9234329. |
for mapping brain acetylcholinesterase (ache) in vivo, seven radioactive acetylcholine analogs, n-[14c]methylpiperidyl-3- and 4-acetates, propionates, isobutyrates, and 3-butyrate were newly synthesized and evaluated in mice. |
1997-09-25 |
2023-08-12 |
mouse |
| B Nehru, R Du. The effect of dietary selenium on lead neurotoxicity. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 16. issue 1. 1997-09-03. PMID:9256932. |
along with these, a decrease in acetylcholine esterase (ache) and monoamine oxidase (mao) was seen, thus affecting both cholinergic and adrenergic neurotransmitters. |
1997-09-03 |
2023-08-12 |
rat |
| K Matsuno, T Senda, T Kobayashi, K Okamoto, K Nakata, S Mit. SA4503, a novel cognitive enhancer, with sigma 1 receptor agonistic properties. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062689. |
on the other hand, tetrahydroaminoacridine (tha), an acetylcholinesterase (ache) inhibitor, increased the extracellular acetylcholine level in both regions. |
1997-07-09 |
2023-08-12 |
rat |
| J M Chemnitius, F Schahmirzadi, B D Gonska, H Kreuzer, R Zec. Indirect parasympathomimetic activity of the class III antiarrhythmic substance D/L-sotalol in vitro: reversible inhibition of cholinesterase isoenzymes from blood and the human central nervous system. Pharmacological research. vol 34. issue 5-6. 1997-06-16. PMID:9076843. |
non-competitive d/l-sotalol inhibition of caudate nucleus ache and the non-competitive component of erythrocyte ache inhibition cannot be overcome by increased concentrations of the cholinergic transmitter acetylcholine (ach). |
1997-06-16 |
2023-08-12 |
human |
| M J Kubek, T M Shih, J L Meyerhof. Thyrotropin-releasing hormone (TRH) is markedly increased in the rat brain following soman-induced convulsions. Brain research. vol 747. issue 2. 1997-05-27. PMID:9046010. |
soman is an organophosphorus (op) compound which irreversibly inhibits acetylcholinesterase (ache), the primary synaptic inactivator of acetylcholine. |
1997-05-27 |
2023-08-12 |
rat |