| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P T Carrol. Evidence to suggest that cytosolic acetylcholine in rat hippocampal nerve terminals is not directly transferred into synaptic vesicles for release. Brain research. vol 725. issue 1. 1996-12-06. PMID:8828580. |
rat hippocampal minces were loaded with [acetyl 1-14c]acetylcholine ([14c]ach) in the presence of the "poorly penetrating" acetylcholinesterase (ec 3.1.1.7; ache) inhibitor echothiophate and the effect of high k+ depolarization determined on the subcellular storage and release of [14c]ach and its metabolites. |
1996-12-06 |
2023-08-12 |
rat |
| J J Hutsler, M S Gazzanig. Acetylcholinesterase staining in human auditory and language cortices: regional variation of structural features. Cerebral cortex (New York, N.Y. : 1991). vol 6. issue 2. 1996-11-27. PMID:8670655. |
acetylcholinesterase (ache), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers iii and v of the cerebral cortex. |
1996-11-27 |
2023-08-12 |
human |
| M Srivatsan, B Peret. Effect of acetylcholinesterase inhibition on behavior is age-dependent in freely moving Aplysia. Behavioural brain research. vol 77. issue 1-2. 1996-11-18. PMID:8762162. |
comparisons of the results of ache inhibition which would elevate acetylcholine (ach) levels with those of carbachol administration revealed that ache inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. |
1996-11-18 |
2023-08-12 |
aplysia |
| M Guenneugues, M Verdière-Sahuqué, R Amouri, D Goudou, F Riege. Mouse G2-GPI AChE is processed as a membrane-bound ectoenzyme in transfected mouse sarcoma cells but is not a homophilic adhesion molecule. Neuroscience letters. vol 210. issue 1. 1996-10-31. PMID:8762181. |
acetylcholinesterase (ache) is mainly involved in synaptic transmission by hydrolyzing acetylcholine in the synaptic cleft. |
1996-10-31 |
2023-08-12 |
mouse |
| S Sudha, M K Lakshmana, N Pradha. Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels. Pharmacology, biochemistry, and behavior. vol 54. issue 3. 1996-10-24. PMID:8743640. |
the pb levels in plasma, the acetylcholine esterase (ache) activity in the motor cortex, pyriform cortex, olfactory bulb, striatum, septum, and hippocampus and the levels of serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), dopamine (da), dihydroxyphenylacetic acid (dopac), and homovanillic acid (hva) levels in the hippocampus were measured. |
1996-10-24 |
2023-08-12 |
rat |
| M Weinstoc. The pharmacotherapy of Alzheimer's disease based on the cholinergic hypothesis: an update. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 4. 1996-10-24. PMID:8846227. |
current pharmacological strategies, aimed at increasing cholinergic activity include acetylcholinesterase (ache) inhibitors, cholinergic agonists, acetylcholine (ach) releasers and stimulants of nerve growth factors (ngf). |
1996-10-24 |
2023-08-12 |
Not clear |
| H L Fernandez, C A Hodges-Savol. Physiological regulation of G4 AChe in fast-twitch muscle: effects of exercise and CGRP. Journal of applied physiology (Bethesda, Md. : 1985). vol 80. issue 1. 1996-10-24. PMID:8847328. |
they are also consistent with the hypothesis that, in addition to acetylcholine, neurogenic cgrp participates in the regulation of g4 ache at the neuromuscular junction. |
1996-10-24 |
2023-08-12 |
rat |
| N Kishibayashi, A Karasaw. Effects of KW-5092, a novel gastroprokinetic agent, on intestinal water and electrolyte transport in rats. Biological & pharmaceutical bulletin. vol 18. issue 12. 1996-10-23. PMID:8787786. |
kw-5092 ([1-[2-[[[5-(piperidinomethyl)- 2-furanyl]methyl]amino]ethyl]-2-imidazolidinylidene]propanedini trile fumarate) enhances acetylcholine release from enteric neurons and inhibits acetylcholinesterase (ache), resulting in the enhancement of a wide range of gastrointestinal motilities. |
1996-10-23 |
2023-08-12 |
rat |
| T Irie, K Fukushi, H Namba, M Iyo, H Tamagami, S Nagatsuka, N Ikot. Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 4. 1996-08-26. PMID:8691261. |
we developed three radioactive acetylcholine analogs--n[14c]methyl-4-piperidyl acetate ([14c]mp4a), propionate ([14c]mp4p) and isobutyrate ([14c]mp4ib)--as radiotracers for measuring brain acetylcholinesterase (ache) activity in vivo. |
1996-08-26 |
2023-08-12 |
rat |
| Z D Luo, M Pincon-Raymond, P Taylo. Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channel. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8666981. |
in contrast to ache transcripts, mrna levels of the alpha-subunit of the nicotinic acetylcholine receptors (nachrs) were increased in dysgenic skeletal muscle. |
1996-08-06 |
2023-08-12 |
mouse |
| M Marinovich, F Ghilardi, C L Gall. Effect of pesticide mixtures on in vitro nervous cells: comparison with single pesticides. Toxicology. vol 108. issue 3. 1996-07-26. PMID:8658539. |
diazinon, azinphos-methyl and pirimiphos, but not dimethoate and benomyl, inhibited acetylcholine esterase (ache) activity, whereas all the compounds inhibited protein synthesis in the following order: benomyl > azinphos > diazinon >> pirimiphos = dimethoate. |
1996-07-26 |
2023-08-12 |
human |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| D Milatovic, W D Dettbar. Modification of acetylcholinesterase during adaptation to chronic, subacute paraoxon application in rat. Toxicology and applied pharmacology. vol 136. issue 1. 1996-02-23. PMID:8560475. |
the hypothesis was tested that changes in the kinetics of reactivity of ache with its substrate acetylcholine (ach) and the inhibitor paraoxon contribute to the observed tolerance. |
1996-02-23 |
2023-08-12 |
rat |
| C A Hawkins, S A Greenfiel. Recombinant acetylcholinesterase has behavioural effects in the rat substantia nigra not attributable to its enzymatic activity. Neuroscience letters. vol 197. issue 3. 1996-02-22. PMID:8552299. |
hence ache is not exerting these actions by potentiating the neurotransmitter acetylcholine, but via some cholinergic-independent mechanism. |
1996-02-22 |
2023-08-12 |
human |
| M Camacho, A Agne. Schistosoma: rate of glucose import is altered by acetylcholine interaction with tegumental acetylcholine receptors and acetylcholinesterase. Experimental parasitology. vol 81. issue 4. 1996-02-13. PMID:8543000. |
the blood dwelling stages of schistosomes have acetylcholinesterase (ache) and nicotinic-like acetylcholine receptors (nachr) on their teguments. |
1996-02-13 |
2023-08-12 |
Not clear |
| M Camacho, A Agne. Schistosoma: rate of glucose import is altered by acetylcholine interaction with tegumental acetylcholine receptors and acetylcholinesterase. Experimental parasitology. vol 81. issue 4. 1996-02-13. PMID:8543000. |
exposure of tegumental ache and nachr to acetylcholine (ach), the natural ligand of these molecules, has a consequence for the transporting function of this membrane in some schistosome species. |
1996-02-13 |
2023-08-12 |
Not clear |
| S Sudha, M K Lakshmana, N Pradha. Chronic phenytoin induced impairment of learning and memory with associated changes in brain acetylcholine esterase activity and monoamine levels. Pharmacology, biochemistry, and behavior. vol 52. issue 1. 1996-01-16. PMID:7501653. |
the plasma dph levels, acetylcholine esterase (ache) activity in different brain regions, and the levels of monoamines in the hippocampus were measured. |
1996-01-16 |
2023-08-12 |
rat |
| A Ishiyama, I Lopez, P A Wacky. Distribution of efferent cholinergic terminals and alpha-bungarotoxin binding to putative nicotinic acetylcholine receptors in the human vestibular end-organs. The Laryngoscope. vol 105. issue 11. 1995-12-15. PMID:7475869. |
chati and ache activity was found in numerous bouton-type terminals contacting the basal area of type ii vestibular hair cells and the afferent chalices surrounding type i hair cells; alpha-bungarotoxin binding suggested the presence of nicotinic acetylcholine receptors on type ii vestibular hair cells and on the afferent chalices surrounding type i hair cells. |
1995-12-15 |
2023-08-12 |
human |
| Y Dimber. Neurochemical effects of a 20 kHz magnetic field on the central nervous system in prenatally exposed mice. Bioelectromagnetics. vol 16. issue 4. 1995-12-07. PMID:7488260. |
no significant differences were found in the weight of cortex, hippocampus, septum, or cerebellum on any of the sampling occasions, nor were any significant differences detected in protein-, dna-level, nerve growth factor (ngf), acetylcholine esterase- (ache), or 2',3'-cyclic nucleotide 3'-phosphodiesterase- (cnp; marker for oligodendrocytes) activities on pd21 in cerebellum. |
1995-12-07 |
2023-08-12 |
mouse |
| S Brecht, A Martin-Villalba, W Zuschratter, R Bravo, T Herdege. Transection of rat fimbria-fornix induces lasting expression of c-Jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitric oxide synthase. Experimental neurology. vol 134. issue 1. 1995-10-18. PMID:7545586. |
in addition, nadph-diaphorase (ndp) and acetylcholine esterase (ache) were visualized by activity assays. |
1995-10-18 |
2023-08-12 |
rat |