| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ricci, M Mancini, P Strocchi, S Bongrani, E Bronzett. Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: sensitivity to treatment with the monoamine oxidase-B inhibitor L-deprenyl. Drugs under experimental and clinical research. vol 18. issue 5. 1993-03-04. PMID:1490432. |
administration of ethylcholine mustard aziridinium (af64a) and of the monoamine oxidase (mao)-b inhibitor l-deprenyl on the acetylcholine (ach) biosynthetic enzyme choline acetyltransferase (chat), on the ach catabolic enzyme acetylcholinesterase (ache) and on the density of ach muscarinic m-1 and m-2 receptor sites. |
1993-03-04 |
2023-08-11 |
rat |
| G Lallement, P Carpentier, A Collet, D Baubichon, I Pernot-Marino, G Blanche. Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures. Neurotoxicology. vol 13. issue 3. 1993-02-03. PMID:1475060. |
extracellular acetylcholine (ach) levels were determined, by intracranial microdialysis, in medial septum, amygdala and hippocampus (ca1, ca3, dentate gyrus) of rats during seizures induced by systemic administration of soman (pinacolyl methylphosphonofluoridate), a potent inhibitor of acetylcholinesterase (ache). |
1993-02-03 |
2023-08-11 |
rat |
| R Gábriel, D Buda. Seasonal variations in acetylcholine content and the levels of cholinergic enzymes in the alimentary tract and heart of Rana esculenta L. Journal of the autonomic nervous system. vol 40. issue 3. 1993-01-12. PMID:1460236. |
seasonal variations in acetylcholine content and the levels of cholinergic enzymes in the alimentary tract and heart of rana esculenta l. the acetylcholine (ach) content and the relative levels of choline-acetyltransferase (chat) and acetylcholinesterase (ache) were measured in the stomach and intestinal musculature and in the heart muscles of frogs (rana esculenta l.) during hibernation (january-stage 1), low activity (april-stage 2) and high activity period (july-stage 3). |
1993-01-12 |
2023-08-11 |
Not clear |
| A Kinoshita, K Yamada, T Mushiroi, T Hayakaw. Cholinergic deafferentation prevents delayed neuronal death of the hippocampal CA1 pyramidal neurons after transient forebrain ischaemia. Neurological research. vol 14. issue 4. 1993-01-07. PMID:1360631. |
the relation between ca1 neurons, fimbria-fornix and cholinergic neurons of the basal forebrain was examined with the aid of acetylcholine esterase (ache) staining, woelcke's staining and immunohistochemistry of choline-acetyl transferase (chat). |
1993-01-07 |
2023-08-11 |
Not clear |
| M M el-Etri, W T Nickell, M Ennis, K A Skau, M T Shiple. Brain norepinephrine reductions in soman-intoxicated rats: association with convulsions and AChE inhibition, time course, and relation to other monoamines. Experimental neurology. vol 118. issue 2. 1992-12-22. PMID:1426125. |
although a primary cause of these symptoms is the excess of acetylcholine which follows acetylcholinesterase (ache) inhibition, centrally acting muscarinic blockers, such as atropine, alleviate, but do not block, the convulsive actions of soman. |
1992-12-22 |
2023-08-11 |
human |
| R A Giniatullin, R N Khazipov, T I Oranskai. [Non-quantal secretion of a mediator as factor determining consequences of acetylcholinesterase inhibition]. Biulleten' eksperimental'noi biologii i meditsiny. vol 114. issue 7. 1992-12-01. PMID:1421312. |
the mechanism of shortening mepc decay phase after initial prolongation due to acetylcholinesterase inhibition by armine and neostigmine was studied by use of two-electrode voltage-clamp at the mice diaphragm factors which switch off non-quantal secretion of acetylcholine from the nerve (acute denervation in vitro, ouabain, high concentration of magnesium ions) only slightly reduced the prolongation of mepc caused by ache inhibition. |
1992-12-01 |
2023-08-11 |
mouse |
| J Sirviö, P J Riekkine. Brain and cerebrospinal fluid cholinesterases in Alzheimer's disease, Parkinson's disease and aging. A critical review of clinical and experimental studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. 1992-11-17. PMID:1388703. |
acetylcholinesterase (ache), an enzyme responsible for the break-down of acetylcholine, is found both in cholinergic and non-cholinergic neurons in the central nervous system. |
1992-11-17 |
2023-08-11 |
Not clear |
| J Sirviö, P J Riekkine. Brain and cerebrospinal fluid cholinesterases in Alzheimer's disease, Parkinson's disease and aging. A critical review of clinical and experimental studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. 1992-11-17. PMID:1388703. |
in addition to its role in the catabolism of acetylcholine, ache have other functions in brain, e.g. |
1992-11-17 |
2023-08-11 |
Not clear |
| A Shafferman, B Velan, A Ordentlich, C Kronman, H Grosfeld, M Leitner, Y Flashner, S Cohen, D Barak, N Arie. Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center. The EMBO journal. vol 11. issue 10. 1992-11-02. PMID:1396557. |
we propose that binding of acetylcholine, on the surface of ache, may trigger sequence of conformational changes extending from the peripheral anionic site through w286 to d74, at the entrance of the 'gorge', and down to the catalytic center (through y341 to f338 and y337). |
1992-11-02 |
2023-08-11 |
human |
| Iu V Burov, T N Robakidze, A E Voroni. [A comparative study on the effects of amiridin on learning and memory of old rats during passive avoidance test]. Biulleten' eksperimental'noi biologii i meditsiny. vol 113. issue 1. 1992-10-30. PMID:1391861. |
the activity of acetylcholine esterase (ache) from homogenates of old rat cortex was reduced as compared with that of young rats. |
1992-10-30 |
2023-08-11 |
rat |
| E E Tyrala, S V Mathews, G S Ra. Effect of intrauterine exposure to cocaine on acetylcholinesterase in primary cultures of fetal mouse brain cells. Neurotoxicology and teratology. vol 14. issue 4. 1992-10-15. PMID:1522827. |
the effect of in utero exposure to cocaine on the developmental pattern of acetylcholinesterase (ache), a major regulator of the central nervous system neurotransmitter acetylcholine, was studied in fetal brain cell cultures collected from mice on gestational day 15 after maternal exposure to cocaine from gestational days 6-14. |
1992-10-15 |
2023-08-11 |
mouse |
| S K Dutta, K Das, B Ghosh, C F Blackma. Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation. Bioelectromagnetics. vol 13. issue 4. 1992-09-24. PMID:1510740. |
to explore the physiological importance of these findings, we have examined the impact of rfr exposure on a membrane-bound enzyme, acetylcholinesterase (ache), which is intimately involved with the acetylcholine (ach) neurotransmitter system. |
1992-09-24 |
2023-08-11 |
Not clear |
| G Ehrlich, E Viegas-Pequignot, D Ginzberg, L Sindel, H Soreq, H Zaku. Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries. Genomics. vol 13. issue 4. 1992-09-22. PMID:1380483. |
to establish the chromosomal location of the human ache gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache, acetylcholine acetylhydrolase, e.c. |
1992-09-22 |
2023-08-11 |
human |
| J M de Gandarias, J Irazusta, E Echevarría, J Gil, L Casí. [Acetylcholinesterase activity during the cortical development of the cat brain]. Archivos de neurobiologia. vol 55. issue 3. 1992-09-08. PMID:1497415. |
acetylcholinesterase (ache) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. |
1992-09-08 |
2023-08-11 |
cat |
| Y Wang, C H Che. Acetylcholine receptor-enriched membrane vesicles in response to ethanol: activity and microcalorimetric studies. Biophysical chemistry. vol 43. issue 1. 1992-08-27. PMID:1633258. |
microcalorimetric measurements revealed that the enthalpy change in acetylcholine (ach) hydrolysis reaction was 586 j/mol in association with membrane-bound ache in achr-enriched membrane vesicles, as compared to -544 j/mol with the isolated soluble ache. |
1992-08-27 |
2023-08-11 |
Not clear |
| J Kiss, A J Pate. Development of the cholinergic fibres innervating the cerebral cortex of the rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 10. issue 2. 1992-08-18. PMID:1632275. |
a striking correlation during ontogeny was observed in the cerebral cortex between the changing patterns of ache fibre network and the activity of chat, the enzyme synthesizing acetylcholine. |
1992-08-18 |
2023-08-11 |
rat |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| K J Wilson, M G McNamee, W L Peticola. The time dependent UV resonance Raman spectra, conformation, and biological activity of acetylcholine analogues upon binding to acetylcholine binding proteins. Journal of biomolecular structure & dynamics. vol 9. issue 3. 1992-06-29. PMID:1726137. |
in addition, the suitability of some of these compounds as substrates for hydrolysis by acetylcholine esterase (ache) was determined. |
1992-06-29 |
2023-08-11 |
Not clear |
| P Ghosh, S Bhattachary. In vivo and in vitro acetylcholinesterase inhibition by metacid-50 and carbaryl in Channa punctatus under natural field condition. Biomedical and environmental sciences : BES. vol 5. issue 1. 1992-06-23. PMID:1586462. |
these insecticides effected significant inhibition of brain acetylcholinesterase (ache) activity accompanied by a concurrent increase in acetylcholine (ach). |
1992-06-23 |
2023-08-11 |
Not clear |
| R N Khazipov, R A Giniatulli. [Effect of magnesium ions on the functional state of postsynaptic membrane by modulation of the level of non-quantal secretion of the mediator]. Neirofiziologiia = Neurophysiology. vol 24. issue 1. 1992-06-16. PMID:1584312. |
the role of non-quantal secretion (ns) of acetylcholine (ach) in shortening of miniature end-plate currents (mepc) after initial prolongation of mepc due to acetylcholinesterase (ache) inhibition was studied in the mouse diaphragm muscle under the voltage clamp conditions. |
1992-06-16 |
2023-08-11 |
mouse |