| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Babu, S M Somani, S N Dub. Effect of physostigmine and exercise on choline acetyltransferase and acetylcholinesterase activities in fast and slow muscles of rat. Pharmacology, biochemistry, and behavior. vol 45. issue 3. 1993-08-19. PMID:8332628. |
our results suggest that phy and exercise has significant effect on the synthetic (chat) and degradative (ache) enzymes of acetylcholine in active edl muscle. |
1993-08-19 |
2023-08-12 |
rat |
| S Itabashi, T Ohrui, K Sekizawa, Y Matsuzaki, H Sasak. Peripheral airway hyperresponsiveness in the choline-deficiently fed rat. Respiration physiology. vol 92. issue 2. 1993-08-06. PMID:8327793. |
rats fed with choline-deficient diets are known as a model of aging and learning impairments due to acetylcholine (ach) deficiency in the brain which may be associated with a decrease in acetylcholinesterase (ache; ec 3.1.1.7). |
1993-08-06 |
2023-08-12 |
rat |
| Y Kawato, M Sekiguchi, K Akahane, Y Tsutomi, Y Hirota, H Kuga, W Suzuki, H Hakusui, K Sat. Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. The Journal of pharmacy and pharmacology. vol 45. issue 5. 1993-07-22. PMID:8099964. |
in the present study, we investigated the activities of camptothecin derivatives in inhibiting acetylcholinesterase (ache) and in binding to muscarinic acetylcholine receptors (achr). |
1993-07-22 |
2023-08-12 |
rat |
| S Sasho, H Obase, S Ichikawa, T Kitazawa, H Nonaka, R Yoshizaki, A Ishii, K Shut. Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility. Journal of medicinal chemistry. vol 36. issue 5. 1993-06-24. PMID:8496937. |
ranitidine (1), the histamine h2-receptor antagonist, has been previously reported to increase gastric emptying and gastric motility by inhibition of acetylcholinesterase (ache) and enhancement of acetylcholine (ach) release. |
1993-06-24 |
2023-08-12 |
Not clear |
| N O Sjöstrand, S D Beckett, E Kling. Nervous regulation of the tone of the retractor penis muscle in the goat. Acta physiologica Scandinavica. vol 147. issue 4. 1993-06-17. PMID:8388153. |
the noradrenaline (na) and acetylcholine (ach) content of the rp was determined, and histochemistry for adrenergic and acetylcholinesterase (ache) positive nerves was performed. |
1993-06-17 |
2023-08-12 |
Not clear |
| J Salamoun, J Remie. Indirect detection of anti-acetylcholinesterase compounds in microcolumn liquid chromatography using packed bed reactor with immobilized human red blood cell acetylcholinesterase and choline oxidase. Journal of pharmaceutical and biomedical analysis. vol 10. issue 10-12. 1993-05-07. PMID:1298399. |
a home-made packed bed microbioreactor system containing immobilized enzyme acetylcholinesterase (ache) in human red blood cell membrane and choline oxidase (cho) from alcaligenes was used for the post-column conversion of acetylcholine to hydrogen peroxide which was detected by an electrochemical detector. |
1993-05-07 |
2023-08-11 |
human |
| T N Nagaraja, T Desiraj. Effects of chronic consumption of metanil yellow by developing and adult rats on brain regional levels of noradrenaline, dopamine and serotonin, on acetylcholine esterase activity and on operant conditioning. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 31. issue 1. 1993-04-06. PMID:8095244. |
regional levels of noradrenaline, dopamine and serotonin, activity of acetylcholine esterase (ache), and operant conditioning with food reward were assessed in rats fed, metanil yellow and in controls. |
1993-04-06 |
2023-08-12 |
rat |
| K K Kunjilwar, J Behar. Effect of amplitude-modulated radio frequency radiation on cholinergic system of developing rats. Brain research. vol 601. issue 1-2. 1993-03-17. PMID:8431780. |
decrease in acetylcholine esterase (ache) activity was independent of carrier wave frequencies. |
1993-03-17 |
2023-08-12 |
rat |
| G H Sterling, P H Doukas, C Jackson, R Caccese, K J O'Neill, J J O'Neil. 3-Carbamyl-N-allylquinuclidinium bromide. Effects on cholinergic activity and protection against soman. Biochemical pharmacology. vol 45. issue 2. 1993-03-16. PMID:8435096. |
the results demonstrate that reversible inhibition of ache with suppression of acetylcholine synthesis into a single compound, cab, enhances the protection against organophosphates. |
1993-03-16 |
2023-08-12 |
Not clear |
| A Ricci, M Mancini, P Strocchi, S Bongrani, E Bronzett. Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: sensitivity to treatment with the monoamine oxidase-B inhibitor L-deprenyl. Drugs under experimental and clinical research. vol 18. issue 5. 1993-03-04. PMID:1490432. |
administration of ethylcholine mustard aziridinium (af64a) and of the monoamine oxidase (mao)-b inhibitor l-deprenyl on the acetylcholine (ach) biosynthetic enzyme choline acetyltransferase (chat), on the ach catabolic enzyme acetylcholinesterase (ache) and on the density of ach muscarinic m-1 and m-2 receptor sites. |
1993-03-04 |
2023-08-11 |
rat |
| G Lallement, P Carpentier, A Collet, D Baubichon, I Pernot-Marino, G Blanche. Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures. Neurotoxicology. vol 13. issue 3. 1993-02-03. PMID:1475060. |
extracellular acetylcholine (ach) levels were determined, by intracranial microdialysis, in medial septum, amygdala and hippocampus (ca1, ca3, dentate gyrus) of rats during seizures induced by systemic administration of soman (pinacolyl methylphosphonofluoridate), a potent inhibitor of acetylcholinesterase (ache). |
1993-02-03 |
2023-08-11 |
rat |
| R Gábriel, D Buda. Seasonal variations in acetylcholine content and the levels of cholinergic enzymes in the alimentary tract and heart of Rana esculenta L. Journal of the autonomic nervous system. vol 40. issue 3. 1993-01-12. PMID:1460236. |
seasonal variations in acetylcholine content and the levels of cholinergic enzymes in the alimentary tract and heart of rana esculenta l. the acetylcholine (ach) content and the relative levels of choline-acetyltransferase (chat) and acetylcholinesterase (ache) were measured in the stomach and intestinal musculature and in the heart muscles of frogs (rana esculenta l.) during hibernation (january-stage 1), low activity (april-stage 2) and high activity period (july-stage 3). |
1993-01-12 |
2023-08-11 |
Not clear |
| A Kinoshita, K Yamada, T Mushiroi, T Hayakaw. Cholinergic deafferentation prevents delayed neuronal death of the hippocampal CA1 pyramidal neurons after transient forebrain ischaemia. Neurological research. vol 14. issue 4. 1993-01-07. PMID:1360631. |
the relation between ca1 neurons, fimbria-fornix and cholinergic neurons of the basal forebrain was examined with the aid of acetylcholine esterase (ache) staining, woelcke's staining and immunohistochemistry of choline-acetyl transferase (chat). |
1993-01-07 |
2023-08-11 |
Not clear |
| M M el-Etri, W T Nickell, M Ennis, K A Skau, M T Shiple. Brain norepinephrine reductions in soman-intoxicated rats: association with convulsions and AChE inhibition, time course, and relation to other monoamines. Experimental neurology. vol 118. issue 2. 1992-12-22. PMID:1426125. |
although a primary cause of these symptoms is the excess of acetylcholine which follows acetylcholinesterase (ache) inhibition, centrally acting muscarinic blockers, such as atropine, alleviate, but do not block, the convulsive actions of soman. |
1992-12-22 |
2023-08-11 |
human |
| R A Giniatullin, R N Khazipov, T I Oranskai. [Non-quantal secretion of a mediator as factor determining consequences of acetylcholinesterase inhibition]. Biulleten' eksperimental'noi biologii i meditsiny. vol 114. issue 7. 1992-12-01. PMID:1421312. |
the mechanism of shortening mepc decay phase after initial prolongation due to acetylcholinesterase inhibition by armine and neostigmine was studied by use of two-electrode voltage-clamp at the mice diaphragm factors which switch off non-quantal secretion of acetylcholine from the nerve (acute denervation in vitro, ouabain, high concentration of magnesium ions) only slightly reduced the prolongation of mepc caused by ache inhibition. |
1992-12-01 |
2023-08-11 |
mouse |
| J Sirviö, P J Riekkine. Brain and cerebrospinal fluid cholinesterases in Alzheimer's disease, Parkinson's disease and aging. A critical review of clinical and experimental studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. 1992-11-17. PMID:1388703. |
acetylcholinesterase (ache), an enzyme responsible for the break-down of acetylcholine, is found both in cholinergic and non-cholinergic neurons in the central nervous system. |
1992-11-17 |
2023-08-11 |
Not clear |
| J Sirviö, P J Riekkine. Brain and cerebrospinal fluid cholinesterases in Alzheimer's disease, Parkinson's disease and aging. A critical review of clinical and experimental studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. 1992-11-17. PMID:1388703. |
in addition to its role in the catabolism of acetylcholine, ache have other functions in brain, e.g. |
1992-11-17 |
2023-08-11 |
Not clear |
| A Shafferman, B Velan, A Ordentlich, C Kronman, H Grosfeld, M Leitner, Y Flashner, S Cohen, D Barak, N Arie. Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center. The EMBO journal. vol 11. issue 10. 1992-11-02. PMID:1396557. |
we propose that binding of acetylcholine, on the surface of ache, may trigger sequence of conformational changes extending from the peripheral anionic site through w286 to d74, at the entrance of the 'gorge', and down to the catalytic center (through y341 to f338 and y337). |
1992-11-02 |
2023-08-11 |
human |
| Iu V Burov, T N Robakidze, A E Voroni. [A comparative study on the effects of amiridin on learning and memory of old rats during passive avoidance test]. Biulleten' eksperimental'noi biologii i meditsiny. vol 113. issue 1. 1992-10-30. PMID:1391861. |
the activity of acetylcholine esterase (ache) from homogenates of old rat cortex was reduced as compared with that of young rats. |
1992-10-30 |
2023-08-11 |
rat |
| E E Tyrala, S V Mathews, G S Ra. Effect of intrauterine exposure to cocaine on acetylcholinesterase in primary cultures of fetal mouse brain cells. Neurotoxicology and teratology. vol 14. issue 4. 1992-10-15. PMID:1522827. |
the effect of in utero exposure to cocaine on the developmental pattern of acetylcholinesterase (ache), a major regulator of the central nervous system neurotransmitter acetylcholine, was studied in fetal brain cell cultures collected from mice on gestational day 15 after maternal exposure to cocaine from gestational days 6-14. |
1992-10-15 |
2023-08-11 |
mouse |