| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Badiul Bhuiyan, Ferid Murad, Michael E Fan. The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell communication and signaling : CCS. vol 4. 2007-08-01. PMID:16686954. |
the human placenta, a non-neuronal tissue, contains an active cholinergic system comprised of acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase (ache), and high affinity muscarinic receptors. |
2007-08-01 |
2023-08-12 |
human |
| E Hagforse. The cutaneous non-neuronal cholinergic system and smoking related dermatoses: studies of the psoriasis variant palmoplantar pustulosis. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17341425. |
with immunohistochemistry the ach synthesizing enzyme choline acetyltransferase (chat) and the ach-degrading enzyme acetylcholinesterase (ache) were found to be strongly expressed in the gland and duct as were the alpha-3 and alpha-7 nicotinic acetylcholine receptors (nachrs). |
2007-08-01 |
2023-08-12 |
human |
| E Hagforse. The cutaneous non-neuronal cholinergic system and smoking related dermatoses: studies of the psoriasis variant palmoplantar pustulosis. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17341425. |
in involved ppp skin there was a massive infiltration of granulocytes expressing chat and alpha-3 nachr, and mast cells expressing ache indicating a role for acetylcholine in inflammation. |
2007-08-01 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Alexander Koehler, Ignaz Wessler, Paul G Laye. Expression and possible functions of the cholinergic system in a murine embryonic stem cell line. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17459421. |
we have demonstrated that embryonic stem cells express ach, acetylcholine receptors, choline acetyltransferase (chat), acetyl- and butyryl-cholinesterase (ache and bche). |
2007-08-01 |
2023-08-12 |
mouse |
| b' Emmanuelle Girard, V\\xc3\\xa9ronique Bernard, Jasmina Minic, Arnaud Chatonnet, Eric Krejci, Jordi Molg\\xc3\\xb. Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17467011.' |
at the neuromuscular junction (nmj) acetylcholinesterase (ache) and butyrylcholinesterase (bche) can hydrolyze acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
mouse |
| Malathi Srivatsa. An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation. vol 1. issue 8. 2007-08-01. PMID:17597908. |
the enzyme acetylcholinesterase (ache) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
human |
| Maibritt B Andersen, Thomas Werge, Anders Fink-Jense. The acetylcholinesterase inhibitor galantamine inhibits d-amphetamine-induced psychotic-like behavior in Cebus monkeys. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17374745. |
centrally acting selective muscarinic receptor agonists are currently not available for clinical use, but acetylcholinesterase (ache) inhibitors, which indirectly stimulate achr by blocking the breakdown of acetylcholine by ache, are widely used in the clinic against alzheimer's disease. |
2007-07-30 |
2023-08-12 |
monkey |
| D Majumdar, Szczepan Roszak, Jerzy Leszczynsk. Probing the acetylcholinesterase inhibition of sarin: a comparative interaction study of the inhibitor and acetylcholine with a model enzyme cavity. The journal of physical chemistry. B. vol 110. issue 27. 2007-07-27. PMID:16821887. |
the calculated interaction energies have been compared with those of acetylcholine and the same model ache cavity. |
2007-07-27 |
2023-08-12 |
Not clear |
| D Majumdar, Szczepan Roszak, Jerzy Leszczynsk. Probing the acetylcholinesterase inhibition of sarin: a comparative interaction study of the inhibitor and acetylcholine with a model enzyme cavity. The journal of physical chemistry. B. vol 110. issue 27. 2007-07-27. PMID:16821887. |
the ache...sarin and ache...acetylcholine (ach) structures have been optimized using dft based two-layer oniom hybrid calculations. |
2007-07-27 |
2023-08-12 |
Not clear |
| Julia Roensch, Milita Crisby, Agneta Nordberg, Yan Xiao, Lan-Jiang Zhang, Zhi-Zhong Gua. Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells. Neurochemistry international. vol 50. issue 6. 2007-07-26. PMID:17412455. |
in order to reveal the neuroprotective effects of statins that could be of interest for the prevention and treatment of alzheimer's disease (ad), we investigated the expression of nicotinic acetylcholine receptors (nachrs) detected by rt-pcr, the activity of acetylcholinesterase (ache) and butyrylcholinesterase (buche) by colorimetric determination, and the levels of the alpha-form of secreted beta-amyloid precursor protein (alphaapps) by western blotting in neuroblastoma (sh-sy5y) cells exposed to lovastatin, atorvastatin, rosuvastatin and simvastatin, respectively. |
2007-07-26 |
2023-08-12 |
Not clear |
| Daquan Gao, Chang-Guo Zha. Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases. The journal of physical chemistry. B. vol 109. issue 48. 2007-07-18. PMID:16854005. |
molecular dynamics (md) simulations and hydrogen bonding energy (hbe) calculations have been performed on the prereactive enzyme-substrate complexes (es), transition states (ts1), and intermediates (int1) for acetylcholinesterase (ache)-catalyzed hydrolysis of acetylcholine (ach), butyrylcholinesterase (bche)-catalyzed hydrolysis of ach, and bche-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. |
2007-07-18 |
2023-08-12 |
human |
| C Eggers, B Szelies, B Bauer, K Wienhard, H Schröder, K Herholz, W-D Heis. Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness. European journal of neurology. vol 14. issue 6. 2007-07-10. PMID:17539952. |
positron emission tomography with 11c-n-methyl-4-piperidyl-acetate (mp4a) was applied in eight healthy volunteers and two patients with mild alzheimer's disease (ad) to assess acetylcholine esterase (ache) activity in magnetic resonance imaging-identified brainstem nuclei. |
2007-07-10 |
2023-08-12 |
human |
| Jul Lea Shamy, Cindy A Buckmaster, David G Amaral, Michael E Calhoun, Peter R Rap. Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys. The Journal of comparative neurology. vol 502. issue 2. 2007-06-26. PMID:17348008. |
alternate histological sections were processed for the visualization of somatostatin and vesicular acetylcholine transporter (vacht) immunoreactivity and acetylcholinesterase histochemistry (ache). |
2007-06-26 |
2023-08-12 |
rat |
| Hideaki Nakajima, Kenzo Uchida, Shigeru Kobayashi, Tomoo Inukai, Yukiko Horiuchi, Takafumi Yayama, Ryuichiro Sato, Hisatoshi Bab. Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene. Journal of neurotrauma. vol 24. issue 4. 2007-06-06. PMID:17439352. |
adv-bdnf transfection was associated with increased numbers of intact neurons as confirmed by nissl, cholineacetyltransferase (chat), and acetylcholine esterase (ache) staining especially from 2 weeks after injury, compared with the adv-lacz injected rats. |
2007-06-06 |
2023-08-12 |
rat |
| Pulok K Mukherjee, Venkatesan Kumar, Mainak Mal, Peter J Houghto. Acetylcholinesterase inhibitors from plants. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 14. issue 4. 2007-05-31. PMID:17346955. |
inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as alzheimer's disease, senile dementia, ataxia and myasthenia gravis. |
2007-05-31 |
2023-08-12 |
Not clear |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Kristin Huse Haug, Trond Myhrer, Frode Fonnu. The combination of donepezil and procyclidine protects against soman-induced seizures in rats. Toxicology and applied pharmacology. vol 220. issue 2. 2007-05-14. PMID:17289099. |
six hours after soman exposure cerebral ache activity and acetylcholine (ach) concentration was 5% and 188% of control, respectively. |
2007-05-14 |
2023-08-12 |
rat |
| Anatoly S Loukianov, Tatiana K Syomina, Aleksander M Korole. Conformational changes in proteins in vitro as a means of predicting the acute toxicities of chemicals. Alternatives to laboratory animals : ATLA. vol 35. issue 1. 2007-05-10. PMID:17411361. |
experimental data are presented on ovalbumin denaturation (od, ec10) and human acetylcholine esterase (ache) inhibition (ic50) in vitro, following exposure to the chemicals used in the international multicentre evaluation of in vitro cytotoxicity (meic) programme. |
2007-05-10 |
2023-08-12 |
human |
| Hiroshi Fukuda, Nobuyuki Okamur. [Introduction to and general remarks on molecular imaging]. Brain and nerve = Shinkei kenkyu no shinpo. vol 59. issue 3. 2007-05-01. PMID:17370645. |
11c-mp4p (n-methlpiperidyl-4-propionate), is a probe for the measurement of acetylcholine esterase (ache) activity in the human brain by pet. |
2007-05-01 |
2023-08-12 |
mouse |
| Timothy C Marrs, Paul Rice, J Allister Val. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicological reviews. vol 25. issue 4. 2007-04-17. PMID:17288500. |
nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (ache), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. |
2007-04-17 |
2023-08-12 |
Not clear |