| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Fernanda Montenegro, Francisco Ruiz-Espejo, Francisco Javier Campoy, Encarnación Muñoz-Delgado, María Páez de la Cadena, Juan Cabezas-Herrera, Cecilio J Vida. Acetyl- and butyrylcholinesterase activities decrease in human colon adenocarcinoma. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192624. |
apart from the hydrolysis of acetylcholine (ach), acetyl- (ache) and butyrylcholinesterase (bche), through noncatalytic mechanisms, intervene in hematopoiesis, morphogenesis, and neurogenesis (layer and willbold, 1995; soreq and seidman, 2001). |
2007-02-23 |
2023-08-12 |
human |
| Maria-Ximena Silveyra, Maria-Salud García-Ayllón, Miguel Calero, Javier Sáez-Valer. Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192630. |
the potential importance of these variants is increased by the possibility that ache has roles other than acetylcholine hydrolysis. |
2007-02-23 |
2023-08-12 |
Not clear |
| b' Emmanuelle Girard, V\\xc3\\xa9ronique Bernard, Shelley Camp, Palmer Taylor, Eric Krejci, Jordi Molg\\xc3\\xb. Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192646.' |
at the vertebrate skeletal neuromuscular junction (nmj), two closely related enzymes can hydrolyze acetylcholine (ach): acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2007-02-23 |
2023-08-12 |
mouse |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Laura Paleari, Sonya Trombino, Carla Falugi, Lorenzo Gallus, Sebastiano Carlone, Cristiano Angelini, Kristina Sepcic, Tom Turk, Marco Faimali, Douglas M Noonan, Adriana Albin. Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors. International journal of oncology. vol 29. issue 6. 2007-02-22. PMID:17088975. |
cholino-acetyltransferase (chat), vesicular acetylcholine transporter (vacht) and acetylcholinesterase (ache) were observed in nsclc tumor biopsies and in nsclc cell lines. |
2007-02-22 |
2023-08-12 |
mouse |
| Itamar Willner, Bilha Willner, Eugenii Kat. Biomolecule-nanoparticle hybrid systems for bioelectronic applications. Bioelectrochemistry (Amsterdam, Netherlands). vol 70. issue 1. 2007-02-20. PMID:16750941. |
a hybrid system consisting of acetylcholine esterase (ache)/cds-nps is immobilized in a monolayer configuration on an electrode. |
2007-02-20 |
2023-08-12 |
Not clear |
| Björn Schilström, Vladimir B Ivanov, Charlotte Wiker, Torgny H Svensso. Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 1. 2007-02-09. PMID:16641937. |
galantamine is an allosteric modulator of nicotinic acetylcholine receptors (nachrs) and, at higher doses, an acetylcholine esterase (ache) inhibitor. |
2007-02-09 |
2023-08-12 |
rat |
| Jun-ichi Anza. [Use of biosensors for detecting organophosphorus agents]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 126. issue 12. 2007-02-07. PMID:17139155. |
acetylcholine esterase (ache)-immobilized electrodes have been used for detecting ache inhibitors including organophosphorus and carbamate pesticides. |
2007-02-07 |
2023-08-12 |
Not clear |
| Saharudin Haron, Asim K Ra. Optical biodetection of cadmium and lead ions in water. Medical engineering & physics. vol 28. issue 10. 2007-01-30. PMID:17018258. |
the catalytic activities of urease and acetylcholine esterase (ache) were inhibited by the presence of cadmium (cd(2+)) and lead (pb(2+)) ions. |
2007-01-30 |
2023-08-12 |
Not clear |
| Gabriel Zimmerman, Hermona Sore. Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and tissue research. vol 326. issue 2. 2007-01-23. PMID:16802134. |
this unique termination mechanism makes acetylcholinesterase (ache), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling. |
2007-01-23 |
2023-08-12 |
Not clear |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Aviad Hai, Deborah Ben-Haim, Nina Korbakov, Ariel Cohen, Joseph Shappir, Ruthi Oren, Micha E Spira, Shlomo Yitzchai. Acetylcholinesterase-ISFET based system for the detection of acetylcholine and acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 22. issue 5. 2007-01-17. PMID:16529923. |
a bioelectronic hybrid system for the detection of acetylcholine esterase (ache) catalytic activity was assembled by way of immobilizing the enzyme to the gate surface of an ion-sensitive field-effect transistor (isfet). |
2007-01-17 |
2023-08-12 |
Not clear |
| Tsao-Jen Lin, Kuang-Tse Huang, Chia-Yu Li. Determination of organophosphorous pesticides by a novel biosensor based on localized surface plasmon resonance. Biosensors & bioelectronics. vol 22. issue 4. 2007-01-17. PMID:16769211. |
the underlying mechanism is that paraoxon prevents acetylcholine chloride (ach) reacting with ache by destroying the oh bond of serine in ache. |
2007-01-17 |
2023-08-12 |
Not clear |
| Martin J Hoogduijn, Zoltan Rakonczay, Paul G Geneve. The effects of anticholinergic insecticides on human mesenchymal stem cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 94. issue 2. 2007-01-09. PMID:16960032. |
organophosphate (op) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (ache). |
2007-01-09 |
2023-08-12 |
human |
| Carlos H T P da Silva, Vanessa Leiria Campo, Ivone Carvalho, Carlton A Taf. Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. Journal of molecular graphics & modelling. vol 25. issue 2. 2007-01-08. PMID:16413803. |
it is achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-01-08 |
2023-08-12 |
human |
| Patrik Danielson, Håkan Alfredson, Sture Forsgre. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microscopy research and technique. vol 69. issue 10. 2006-12-29. PMID:16830327. |
antibodies against the m(2) receptor, choline acetyltransferase (chat), and vesicular acetylcholine transporter (vacht) were applied, and staining for demonstration of activity of acetylcholinesterase (ache) was also utilized. |
2006-12-29 |
2023-08-12 |
human |
| Davut Alptekin, Hüsnü Umit Lüleyap, Levent Yilmaz, Hakan Demirhindi, Yüksel Gökel, Ayfer Pazarbaşi, Mehmet Dokur, Mülkiye Kasap, Halil Kasa. The sister-chromatid exchange and acetylcholine esterase enzyme levels among patients with insecticide intoxication in the Cukurova region, Turkey. Acta medica Okayama. vol 60. issue 2. 2006-12-28. PMID:16680189. |
acetylcholine esterase (pseudocholinesterase) enzyme (ache), sister-chromatid exchanges (sce), the mitotic index (mi), and the replication index (ri) were evaluated. |
2006-12-28 |
2023-08-12 |
Not clear |
| Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, Pascale Marcho. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16837465. |
hydrolysis of acetylcholine catalyzed by acetylcholinesterase (ache), one of the most efficient enzymes in nature, occurs at the base of a deep and narrow active center gorge. |
2006-11-27 |
2023-08-12 |
mouse |
| Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, Pascale Marcho. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16837465. |
complementary crystal structures of mouse ache and an inactive mouse ache mutant with a substituted catalytic serine (s203a), in various complexes with four substrates (acetylcholine, acetylthiocholine, succinyldicholine, and butyrylthiocholine), two non-hydrolyzable substrate analogues (m-(n,n,n-trimethylammonio)-trifluoroacetophenone and 4-ketoamyltrimethylammonium), and one reaction product (choline) were solved in the 2.05-2.65-a resolution range. |
2006-11-27 |
2023-08-12 |
mouse |
| Ai-Ling Fu, Zhao-Hui Dong, Man-Ji Su. Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16872586. |
there was also an increase in acetylcholinesterase (ache) activity and a reduction in the choline acetyltransferase (chat) activity and acetylcholine (ach) levels. |
2006-10-31 |
2023-08-12 |
mouse |