| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengli Hu, Huiying Zhang, Huaqing Lin, Chunhui Deng, Xiangmin Zhan. Enzyme inhibitor screening by electrospray mass spectrometry with immobilized enzyme on magnetic silica microspheres. Journal of the American Society for Mass Spectrometry. vol 19. issue 6. 2008-07-10. PMID:18396060. |
ache activity was monitored by biochemical assay that is based on mixing of ache immobilized microspheres and model substrate acetylcholine, separating and detecting the product through esi-ms. |
2008-07-10 |
2023-08-12 |
Not clear |
| Gabriel Zimmerman, Marleisje Njunting, Sebastian Ivens, Else A Tolner, Elsa Tolner, Christoph J Behrens, Miriam Gross, Hermona Soreq, Uwe Heinemann, Alon Friedma. Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. The European journal of neuroscience. vol 27. issue 4. 2008-07-08. PMID:18333967. |
we confirmed that while the total activity of the acetylcholine (ach)-hydrolysing enzyme, acetylcholinesterase (ache) was not altered, epileptic rats showed alternative splicing of ache pre-mrna transcripts, accompanied by a shift from membrane-bound ache tetramers to soluble monomers. |
2008-07-08 |
2023-08-12 |
rat |
| Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Francesco Menichin. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Current medicinal chemistry. vol 15. issue 12. 2008-06-30. PMID:18473814. |
ad and other forms of dementia could be treated by the use of agents which restore the level of acetylcholine through inhibition of both two major forms of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2008-06-30 |
2023-08-12 |
Not clear |
| Scott D Bembenek, John M Keith, Michael A Letavic, Richard Apodaca, Ann J Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L Miller, Timothy W Lovenberg, Nicholas I Carruther. Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249544. |
however, whereas an ache inhibitor will impart its effect everywhere, a histamine h(3) antagonist will raise acetylcholine levels mostly in the brain as its mode of action will primarily be on the central nervous system. |
2008-06-13 |
2023-08-12 |
Not clear |
| Hiroaki Fukunishi, Reiji Teramoto, Jiro Shimad. Hidden active information in a random compound library: extraction using a pseudo-structure-activity relationship model. Journal of chemical information and modeling. vol 48. issue 3. 2008-06-03. PMID:18278890. |
from tests for four functionally different targets, estrogen receptor antagonist (er), thymidine kinase (tk), thrombin, and acetylcholine esterase (ache), using five scoring functions, we obtained three conclusions: (1) the psar models significantly gave higher percentages of known ligands found than random sampling, and these results are sufficient to support our hypothesis; (2) the psar models gave higher percentages of known ligands found than normal scoring by scoring function, and these results demonstrate the practical usefulness of the psar model; and (3) the psar model can assess compounds failed in the docking simulation. |
2008-06-03 |
2023-08-12 |
Not clear |
| Jere R Virta, Tuula Tolvanen, Kjell Någren, Anna Brück, Anne Roivainen, Juha O Rinn. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 3. 2008-05-16. PMID:18287260. |
the neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2008-05-16 |
2023-08-12 |
human |
| M David, H B Shivakumar, H Ramesh, S R Marigoudar, V R Nai. Hepatotoxic potential of Malathion in the freshwater teleost, Cirrhinus mrigala (Hamilton). Journal of basic and clinical physiology and pharmacology. vol 18. issue 4. 2008-05-12. PMID:18380172. |
an increase in free amino acids, protease activity, and acetylcholine (ach) levels, in contrast to decrement in total, structural, and soluble proteins, and acetylcholine esterase (ache) activity were observed at 5 and 15 days of exposure, but on day 25 of exposure, all values reached near normalcy. |
2008-05-12 |
2023-08-12 |
Not clear |
| Reiji Teramoto, Hiroaki Fukunish. Consensus scoring with feature selection for structure-based virtual screening. Journal of chemical information and modeling. vol 48. issue 2. 2008-05-05. PMID:18229906. |
we evaluated the enrichments of five scoring functions (f-score, d-score, pmf, g-score, and chemscore), fscs, and rcs (rank-by-rank consensus scoring) for four different target proteins: acetylcholine esterase (ache), thrombin (thrombin), phosphodiesterase 5 (pde5), and peroxisome proliferator-activated receptor gamma (ppargamma). |
2008-05-05 |
2023-08-12 |
Not clear |
| Sun-Ha Choi, Jong-Moon Hur, Eun-Ju Yang, Mira Jun, Hyo-Jun Park, Kyung-Bok Lee, Eunho Moon, Kyung-Sik Son. Beta-secretase (BACE1) inhibitors from Perilla frutescens var. acuta. Archives of pharmacal research. vol 31. issue 2. 2008-05-01. PMID:18365688. |
they were less inhibitory against other enzymes such as alpha-secretase (tace), acetylcholine esterase (ache), chymotrypsin, and elastase, indicating that they were relatively specific inhibitors of bace1. |
2008-05-01 |
2023-08-12 |
Not clear |
| Dongren Yang, Angela Howard, Donald Bruun, Mispa Ajua-Alemanj, Cecile Pickart, Pamela J Lei. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and applied pharmacology. vol 228. issue 1. 2008-04-28. PMID:18076960. |
a primary role of acetylcholinesterase (ache) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. |
2008-04-28 |
2023-08-12 |
mouse |
| Glynis Johnson, Chrisna Swart, Samuel W Moor. Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain. The Biochemical journal. vol 411. issue 3. 2008-04-25. PMID:18215127. |
although the primary function of ache (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth and amyloidosis. |
2008-04-25 |
2023-08-12 |
mouse |
| Shravan K Singh, Deep C Kaushal, P Kalpana Murthy, Nuzhat A Kausha. Partial purification and characterization of acetylcholinesterase isozymes from adult bovine filarial parasite Setaria cervi. Indian journal of biochemistry & biophysics. vol 44. issue 5. 2008-04-08. PMID:18341214. |
both isozymes preferentially utilized acetylcholine iodide as substrate and were strongly inhibited by the true ache inhibitor (bw284c51), suggesting that they were true ache. |
2008-04-08 |
2023-08-12 |
human |
| Hitoshi Shinoto. [Imaging of brain acetylcholinesterase activity in dementias and extrapyramidal disorders]. Rinsho shinkeigaku = Clinical neurology. vol 47. issue 11. 2008-04-04. PMID:18210807. |
carbon-11 labeled n-methylpiperidin-4-yl acetate ([11c]mp4a) and carbon-11 labeled n-methylpiperidin-4-yl propionate ([11c]mp4p) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (ache) activity in vivo in humans. |
2008-04-04 |
2023-08-12 |
Not clear |
| O N Schuvailo, S V Dzyadevych, A V El'skaya, S Gautier-Sauvigné, E Csöregi, R Cespuglio, A P Soldatki. Carbon fibre-based microbiosensors for in vivo measurements of acetylcholine and choline. Biosensors & bioelectronics. vol 21. issue 1. 2008-03-05. PMID:15967355. |
this electrode was also modified through the co-immobilisation of acetylcholinesterase (ache) and/or choline oxidase (chox) in a bovine serum albumin (bsa) membrane for the development of a sensor for in vivo measurements of acetylcholine and choline. |
2008-03-05 |
2023-08-12 |
cattle |
| Atsunori Nakao, David J Kaczorowski, Brian S Zuckerbraun, Jing Lei, Gaetano Faleo, Kentaro Deguchi, Kenneth R McCurry, Timothy R Billiar, Shinichi Kann. Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and biophysical research communications. vol 367. issue 3. 2008-03-04. PMID:18174021. |
galantamine, a reversible inhibitor of acetylcholine esterase (ache), is a novel drug treatment for mild to moderate alzheimer's disease and vascular dementia. |
2008-03-04 |
2023-08-12 |
rat |
| Alexandra A Anderson, Dmitry S Ushakov, Michael A Ferenczi, Ryoichi Mori, Paul Martin, Jane L Saffel. Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17948252. |
acetylcholinesterase (ache) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. |
2008-02-19 |
2023-08-12 |
mouse |
| Martina Zimmermann, Sven Grösgen, Martin S Westwell, Susan A Greenfiel. Selective enhancement of the activity of C-terminally truncated, but not intact, acetylcholinesterase. Journal of neurochemistry. vol 104. issue 1. 2008-02-18. PMID:17986217. |
the enzyme is involved in the terminal breakdown of the neurotransmitter acetylcholine, but non-enzymatic roles have also been described for the entire ache molecule and its isolated c-terminal sequences. |
2008-02-18 |
2023-08-12 |
cattle |
| Y C Zhou, Benzhuo Lu, Gary A Huber, Michael J Holst, J Andrew McCammo. Continuum simulations of acetylcholine consumption by acetylcholinesterase: a Poisson-Nernst-Planck approach. The journal of physical chemistry. B. vol 112. issue 2. 2008-02-15. PMID:18052268. |
the poisson-nernst-planck (pnp) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ach) with acetylcholinesterase (ache) enzymes. |
2008-02-15 |
2023-08-12 |
Not clear |
| Mohamed-Bassem Ashour, Didair A Ragheb, El-Sayed A El-Sheikh, El-Adarosy A Gomaa, Shizuo G Kamita, Bruce D Hammoc. Biosafety of recombinant and wild type nucleopolyhedroviruses as bioinsecticides. International journal of environmental research and public health. vol 4. issue 2. 2008-02-08. PMID:17617674. |
no marked changes in acetylcholine esterase (ache) activity were found. |
2008-02-08 |
2023-08-12 |
rat |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
the main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited ache. |
2008-02-04 |
2023-08-12 |
Not clear |