| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
many drugs currently used for the treatment of the ad are based on the improvement of cholinergic neurotransmission achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-09-18 |
2023-08-12 |
Not clear |
| Dan Grisaru, Ran Keidar, Letizia Schreiber, Joseph B Lessing, Varda Deutsc. The effect of the readthrough acetylcholinesterase variant (AChE-R) on uterine muscle and leiomyomas. Molecular human reproduction. vol 13. issue 5. 2007-09-13. PMID:17350961. |
acetylcholine signaling and acetylcholinesterase (ache) function(s) are pivotal elements in muscle development. |
2007-09-13 |
2023-08-12 |
human |
| J B Matthews, O Lazari, A J Davidson, S Warren, M E Selkir. A tryptophan amphiphilic tetramerization domain-containing acetylcholinesterase from the bovine lungworm, Dictyocaulus viviparus. Parasitology. vol 133. issue Pt 3. 2007-09-10. PMID:16719958. |
acetylcholine (ach) is one of an array of neurotransmitters used by invertebrates and, analogous to vertebrate nervous systems, acetylcholinesterase (ache) regulates synaptic levels of this transmitter. |
2007-09-10 |
2023-08-12 |
cattle |
| b' Nevenka Kopjar, Davor Zeljezi\\xc4\\x87, Ana Luci\\xc4\\x87 Vrdoljak, Bozica Radi\\xc4\\x87, Snjezana Rami\\xc4\\x87, Mirta Mili\\xc4\\x87, Marija Gamulin, Vesna Pavlica, Aleksandra Fuci\\xc4\\x8. Irinotecan toxicity to human blood cells in vitro: relationship between various biomarkers. Basic & clinical pharmacology & toxicology. vol 100. issue 6. 2007-09-07. PMID:17516995.' |
irinotecan was found to be strong inhibitor of the acetylcholine hydrolysis and to cause a continuous decrease of catalytic activity of ache. |
2007-09-07 |
2023-08-12 |
human |
| Kamil Kuca, Jirí Cabal, Daniel Jun, Jirí Kassa, Lucie Bartosová, Gabriela Kunesová, Vlastimil Dohna. Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601804. |
nerve agent poisoning is conventionally treated using a combination of a cholinolytic drug (atropine mostly) to counteract the accumulation of acetylcholine at muscarinic receptors and ache reactivators (pralidoxime or obidoxime) to reactivate inhibited ache. |
2007-08-28 |
2023-08-12 |
Not clear |
| Haris Carageorgiou, Constantinos Pantos, Apostolos Zarros, Vasileios Stolakis, Iordanis Mourouzis, Dennis Cokkinos, Stylianos Tsakiri. Changes in acetylcholinesterase, Na+,K+-ATPase, and Mg2+-ATPase activities in the frontal cortex and the hippocampus of hyper- and hypothyroid adult rats. Metabolism: clinical and experimental. vol 56. issue 8. 2007-08-23. PMID:17618957. |
the th-reduced na+,k+-atpase activity may increase the synaptic acetylcholine release and, thus, modulate ache activity. |
2007-08-23 |
2023-08-12 |
rat |
| Gottipolu R Reddy, Bhuvaneswari C Devi, Chellu S Chett. Developmental lead neurotoxicity: alterations in brain cholinergic system. Neurotoxicology. vol 28. issue 2. 2007-08-21. PMID:16678265. |
in this study, we have further examined in detail, the alterations in ache activity and acetylcholine (ach) levels in different brain regions using histochemical and spectrophotometric methods. |
2007-08-21 |
2023-08-12 |
rat |
| Kazuaki Katakawa, Akiko Nozoe, Noriyuki Kogure, Mariko Kitajima, Masakiyo Hosokawa, Hiromitsu Takayam. Fawcettimine-related alkaloids from Lycopodium serratum. Journal of natural products. vol 70. issue 6. 2007-08-06. PMID:17503851. |
some alkaloids isolated in this and previous studies (1, 2, 5, and 10) were assayed for acetylcholine esterase (ache) inhibitory activity. |
2007-08-06 |
2023-08-12 |
Not clear |
| Md Badiul Bhuiyan, Ferid Murad, Michael E Fan. The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell communication and signaling : CCS. vol 4. 2007-08-01. PMID:16686954. |
the human placenta, a non-neuronal tissue, contains an active cholinergic system comprised of acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase (ache), and high affinity muscarinic receptors. |
2007-08-01 |
2023-08-12 |
human |
| E Hagforse. The cutaneous non-neuronal cholinergic system and smoking related dermatoses: studies of the psoriasis variant palmoplantar pustulosis. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17341425. |
with immunohistochemistry the ach synthesizing enzyme choline acetyltransferase (chat) and the ach-degrading enzyme acetylcholinesterase (ache) were found to be strongly expressed in the gland and duct as were the alpha-3 and alpha-7 nicotinic acetylcholine receptors (nachrs). |
2007-08-01 |
2023-08-12 |
human |
| E Hagforse. The cutaneous non-neuronal cholinergic system and smoking related dermatoses: studies of the psoriasis variant palmoplantar pustulosis. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17341425. |
in involved ppp skin there was a massive infiltration of granulocytes expressing chat and alpha-3 nachr, and mast cells expressing ache indicating a role for acetylcholine in inflammation. |
2007-08-01 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Alexander Koehler, Ignaz Wessler, Paul G Laye. Expression and possible functions of the cholinergic system in a murine embryonic stem cell line. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17459421. |
we have demonstrated that embryonic stem cells express ach, acetylcholine receptors, choline acetyltransferase (chat), acetyl- and butyryl-cholinesterase (ache and bche). |
2007-08-01 |
2023-08-12 |
mouse |
| b' Emmanuelle Girard, V\\xc3\\xa9ronique Bernard, Jasmina Minic, Arnaud Chatonnet, Eric Krejci, Jordi Molg\\xc3\\xb. Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17467011.' |
at the neuromuscular junction (nmj) acetylcholinesterase (ache) and butyrylcholinesterase (bche) can hydrolyze acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
mouse |
| Malathi Srivatsa. An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation. vol 1. issue 8. 2007-08-01. PMID:17597908. |
the enzyme acetylcholinesterase (ache) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
human |
| Maibritt B Andersen, Thomas Werge, Anders Fink-Jense. The acetylcholinesterase inhibitor galantamine inhibits d-amphetamine-induced psychotic-like behavior in Cebus monkeys. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17374745. |
centrally acting selective muscarinic receptor agonists are currently not available for clinical use, but acetylcholinesterase (ache) inhibitors, which indirectly stimulate achr by blocking the breakdown of acetylcholine by ache, are widely used in the clinic against alzheimer's disease. |
2007-07-30 |
2023-08-12 |
monkey |
| D Majumdar, Szczepan Roszak, Jerzy Leszczynsk. Probing the acetylcholinesterase inhibition of sarin: a comparative interaction study of the inhibitor and acetylcholine with a model enzyme cavity. The journal of physical chemistry. B. vol 110. issue 27. 2007-07-27. PMID:16821887. |
the calculated interaction energies have been compared with those of acetylcholine and the same model ache cavity. |
2007-07-27 |
2023-08-12 |
Not clear |
| D Majumdar, Szczepan Roszak, Jerzy Leszczynsk. Probing the acetylcholinesterase inhibition of sarin: a comparative interaction study of the inhibitor and acetylcholine with a model enzyme cavity. The journal of physical chemistry. B. vol 110. issue 27. 2007-07-27. PMID:16821887. |
the ache...sarin and ache...acetylcholine (ach) structures have been optimized using dft based two-layer oniom hybrid calculations. |
2007-07-27 |
2023-08-12 |
Not clear |
| Julia Roensch, Milita Crisby, Agneta Nordberg, Yan Xiao, Lan-Jiang Zhang, Zhi-Zhong Gua. Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells. Neurochemistry international. vol 50. issue 6. 2007-07-26. PMID:17412455. |
in order to reveal the neuroprotective effects of statins that could be of interest for the prevention and treatment of alzheimer's disease (ad), we investigated the expression of nicotinic acetylcholine receptors (nachrs) detected by rt-pcr, the activity of acetylcholinesterase (ache) and butyrylcholinesterase (buche) by colorimetric determination, and the levels of the alpha-form of secreted beta-amyloid precursor protein (alphaapps) by western blotting in neuroblastoma (sh-sy5y) cells exposed to lovastatin, atorvastatin, rosuvastatin and simvastatin, respectively. |
2007-07-26 |
2023-08-12 |
Not clear |