| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Yano, K Koda, Y Ago, H Kobayashi, T Kawasaki, K Takuma, T Matsud. Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice. British journal of pharmacology. vol 156. issue 1. 2009-05-18. PMID:19133998. |
galantamine, a weak acetylcholine esterase (ache) inhibitor and allosteric potentiator of nicotinic ach receptors (nachrs), improves apomorphine-induced deficits in prepulse inhibition (ppi), sensory information-processing deficits, via a nachr-independent mechanism. |
2009-05-18 |
2023-08-12 |
mouse |
| Kazufumi Hirano, Thomas M Piers, Kirsten L Searle, Neil D Miller, A Richard Rutter, Paul F Chapma. Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease. Life sciences. vol 84. issue 15-16. 2009-05-01. PMID:19302808. |
brain microdialysis studies demonstrated that 5-ht(6) antagonists enhance not only cholinergic but also monoaminergic neurotransmission, a property that may differentiate from acetylcholine esterase (ache) inhibitors such as donepezil. |
2009-05-01 |
2023-08-12 |
rat |
| E Dere, A Zlomuzica, D Viggiano, L A Ruocco, T Watanabe, A G Sadile, J P Huston, M A De Souza-Silv. Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum. Neuroscience. vol 157. issue 3. 2009-04-14. PMID:18926883. |
in order to relate possible behavioral deficits to neurobiological changes, we examined h1r-ko and wild-type (wt) mice in terms of acetylcholine esterase (ache) activity in subregions of the hippocampus and ache and tyrosine hydroxylase (th) expression in the striatum. |
2009-04-14 |
2023-08-12 |
mouse |
| B P Paudya. Organophosphorus poisoning. JNMA; journal of the Nepal Medical Association. vol 47. issue 172. 2009-04-14. PMID:19079407. |
the toxicity of these op pesticides is due to the irreversible inhibition of acetylcholinesterase (ache) enzyme leading to accumulation of acetylcholine and subsequent over-activation of cholinergic receptors in various parts of the body. |
2009-04-14 |
2023-08-12 |
Not clear |
| Shu-Zhi Zhong, Qing-Hua Ge, Rong Qu, Qiao Li, Shi-Ping M. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. Journal of the neurological sciences. vol 277. issue 1-2. 2009-04-02. PMID:19007942. |
paeonol increased acetylcholine (ach) and glutathione (gsh) levels, restored superoxide dismutase (sod) and na(+), k(+)-adenosine triphosphatase (na(+), k(+)-atpase) activities, but decreased cholinesterase ache activity and malondialdehyde (mda) level in d-gal-treated mice. |
2009-04-02 |
2023-08-12 |
mouse |
| M J Fernandez-Cabezudo, S Azimullah, S M Nurulain, M Mechkarska, D E Lorke, M Y Hasan, G A Petroianu, B K Al-Ramad. The organophosphate paraoxon has no demonstrable effect on the murine immune system following subchronic low dose exposure. International journal of immunopathology and pharmacology. vol 21. issue 4. 2009-03-30. PMID:19144274. |
desulphuration of parathion by liver enzymes or sunlight results in the formation of paraoxon which inhibits acetylcholine esterase (ache) activity. |
2009-03-30 |
2023-08-12 |
mouse |
| Gürdal Orhan, Ilkay Orhan, Neşe Subutay-Oztekin, Fikri Ak, Bilge Sene. Contemporary anticholinesterase pharmaceuticals of natural origin and their synthetic analogues for the treatment of Alzheimer's disease. Recent patents on CNS drug discovery. vol 4. issue 1. 2009-03-17. PMID:19149713. |
therefore, the most important therapeutic approach has emerged as inhibition of acetylcholinesterase (ache), which is the key enzyme in the breakdown of acetylcholine. |
2009-03-17 |
2023-08-12 |
Not clear |
| Martina Zimmermann, Martin S Westwell, Susan A Greenfiel. Impact of detergents on the activity of acetylcholinesterase and on the effectiveness of its inhibitors. Biological chemistry. vol 390. issue 1. 2009-03-12. PMID:19007306. |
acetylcholinesterase (ache) plays a central role in the development of alzheimer's disease: ache inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. |
2009-03-12 |
2023-08-12 |
Not clear |
| H Kalonia, M Bishnoi, A Kuma. Possible mechanism involved in sleep deprivation-induced memory dysfunction. Methods and findings in experimental and clinical pharmacology. vol 30. issue 7. 2009-02-23. PMID:18985181. |
in addition, increased levels of acetylcholinesterase (ache; the enzyme responsible for the degradation of acetylcholine) and reduction in norepinephrine and dopamine levels were seen in 72-h sleep-deprived animals. |
2009-02-23 |
2023-08-12 |
rat |
| María-Salud García-Ayllón, Omar Cauli, María-Ximena Silveyra, Regina Rodrigo, Asunción Candela, Antonio Compañ, Rodrigo Jover, Miguel Pérez-Mateo, Salvador Martínez, Vicente Felipo, Javier Sáez-Valer. Brain cholinergic impairment in liver failure. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18772221. |
a selective increase of tetrameric ache, the major ache species involved in hydrolysis of acetylcholine in the brain, was detected in both cirrhotic humans and bdl rats. |
2008-12-12 |
2023-08-12 |
human |
| María-Salud García-Ayllón, Omar Cauli, María-Ximena Silveyra, Regina Rodrigo, Asunción Candela, Antonio Compañ, Rodrigo Jover, Miguel Pérez-Mateo, Salvador Martínez, Vicente Felipo, Javier Sáez-Valer. Brain cholinergic impairment in liver failure. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18772221. |
increased ache in bdl cirrhotic rats leads to a pronounced decrease (~50-60%) in the levels of acetylcholine. |
2008-12-12 |
2023-08-12 |
human |
| Jennifer M Bui, J Andrew McCammo. Intrinsic conformational flexibility of acetylcholinesterase. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18452905. |
to understand the dynamical properties of acetylcholinesterase (ache) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (md) trajectories of ache in the presence and absence of its inhibitors [j.m. |
2008-12-10 |
2023-08-12 |
Not clear |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Christelle Bertrand, Beatrice Bonafos, Maud Tremblay, Arnaud Ferry, Arnaud Chatonne. Effect of fluoxetine on neuromuscular function in acetylcholinesterase (AChE) knockout mice. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18550043. |
the slow channel myasthenic syndrome (slow-channel-cms) results in a marked prolongation of channel opening in stimulated receptors (nachr) and the end plate acetylcholinesterase (ache) deficiency congenital myasthenic syndrome (colq-cms) results in an increased action of acetylcholine (ach) at the synapse. |
2008-12-10 |
2023-08-12 |
mouse |
| Brian R Coleman, Ruthie H Ratcliffe, Samuel A Oguntayo, Xuerong Shi, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18588864. |
the toxicity of organophosphorous (op) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (ache), which leads to excessive accumulation of acetylcholine (ach) and is followed by the release of excitatory amino acids (eaa). |
2008-12-10 |
2023-08-12 |
rat |
| Michal Alon, Fishel Alon, Ralf Nauen, Shai Mori. Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associated with a point mutation in an ace1-type acetylcholinesterase and overexpression of carboxylesterase. Insect biochemistry and molecular biology. vol 38. issue 10. 2008-12-10. PMID:18721883. |
organophosphate (op) insecticides are inhibitors of the enzyme acetylcholinesterase (ache), which terminates nerve impulses by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2008-12-10 |
2023-08-12 |
Not clear |
| Hong Zhang, Ting Han, Lei Zhang, Cheng-Hao Yu, De-Guang Wan, Khalid Rahman, Lu-Ping Qin, Cheng Pen. Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 15. issue 8. 2008-11-03. PMID:18289838. |
the levels of cortical acetylcholine esterase (ache) activity and hippocampal neurotransmitters in aged mice given tenuifolin (0.02, 0.04, 0.08 g/kgd(-1), for 15 d) were also investigated, and increased levels of norepinephrine (ne), dopamine (da), decreased activity of ache were found. |
2008-11-03 |
2023-08-12 |
mouse |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
acetylcholinesterase (ache), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. |
2008-09-26 |
2023-08-12 |
Not clear |
| Christophe Minier, Joëlle Forget-Leray, Anne Bjørnstad, Lionel Camu. Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider crab, Hyasaraneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl phthalate. Marine pollution bulletin. vol 56. issue 8. 2008-09-25. PMID:18599090. |
all compounds significantly affected muscle acetylcholine esterase (ache) activity (p<0.05, n=10) with 50 microg/l dpa having the strongest effect by lowering the value to 37% of control. |
2008-09-25 |
2023-08-12 |
spider |
| J Berger, S Valdez, B Puschner, C M Leutenegger, I A Gardner, J E Madiga. Effects of oral tetrachlorvinphos fly control (Equitrol) administration in horses: physiological and behavioural findings. Veterinary research communications. vol 32. issue 1. 2008-09-17. PMID:17522960. |
tcvp exerts its effect by inhibiting the enzyme cholinesterase (che) leading to the accumulation of the neurotransmitter acetylcholine (ache) in synapses of the central and peripheral nervous systems. |
2008-09-17 |
2023-08-12 |
Not clear |