| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Christelle Bertrand, Beatrice Bonafos, Maud Tremblay, Arnaud Ferry, Arnaud Chatonne. Effect of fluoxetine on neuromuscular function in acetylcholinesterase (AChE) knockout mice. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18550043. |
the slow channel myasthenic syndrome (slow-channel-cms) results in a marked prolongation of channel opening in stimulated receptors (nachr) and the end plate acetylcholinesterase (ache) deficiency congenital myasthenic syndrome (colq-cms) results in an increased action of acetylcholine (ach) at the synapse. |
2008-12-10 |
2023-08-12 |
mouse |
| Brian R Coleman, Ruthie H Ratcliffe, Samuel A Oguntayo, Xuerong Shi, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18588864. |
the toxicity of organophosphorous (op) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (ache), which leads to excessive accumulation of acetylcholine (ach) and is followed by the release of excitatory amino acids (eaa). |
2008-12-10 |
2023-08-12 |
rat |
| Michal Alon, Fishel Alon, Ralf Nauen, Shai Mori. Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associated with a point mutation in an ace1-type acetylcholinesterase and overexpression of carboxylesterase. Insect biochemistry and molecular biology. vol 38. issue 10. 2008-12-10. PMID:18721883. |
organophosphate (op) insecticides are inhibitors of the enzyme acetylcholinesterase (ache), which terminates nerve impulses by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2008-12-10 |
2023-08-12 |
Not clear |
| Hong Zhang, Ting Han, Lei Zhang, Cheng-Hao Yu, De-Guang Wan, Khalid Rahman, Lu-Ping Qin, Cheng Pen. Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 15. issue 8. 2008-11-03. PMID:18289838. |
the levels of cortical acetylcholine esterase (ache) activity and hippocampal neurotransmitters in aged mice given tenuifolin (0.02, 0.04, 0.08 g/kgd(-1), for 15 d) were also investigated, and increased levels of norepinephrine (ne), dopamine (da), decreased activity of ache were found. |
2008-11-03 |
2023-08-12 |
mouse |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
acetylcholinesterase (ache), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. |
2008-09-26 |
2023-08-12 |
Not clear |
| Christophe Minier, Joëlle Forget-Leray, Anne Bjørnstad, Lionel Camu. Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider crab, Hyasaraneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl phthalate. Marine pollution bulletin. vol 56. issue 8. 2008-09-25. PMID:18599090. |
all compounds significantly affected muscle acetylcholine esterase (ache) activity (p<0.05, n=10) with 50 microg/l dpa having the strongest effect by lowering the value to 37% of control. |
2008-09-25 |
2023-08-12 |
spider |
| J Berger, S Valdez, B Puschner, C M Leutenegger, I A Gardner, J E Madiga. Effects of oral tetrachlorvinphos fly control (Equitrol) administration in horses: physiological and behavioural findings. Veterinary research communications. vol 32. issue 1. 2008-09-17. PMID:17522960. |
tcvp exerts its effect by inhibiting the enzyme cholinesterase (che) leading to the accumulation of the neurotransmitter acetylcholine (ache) in synapses of the central and peripheral nervous systems. |
2008-09-17 |
2023-08-12 |
Not clear |
| Xiang-Qiang Chen, Miao He, Qiang Cai, Shi-Kun Zhu, Han-Chang Sh. [Detecting organophosphorus pesticide in water environment using an enzyme biosensor]. Huan jing ke xue= Huanjing kexue. vol 27. issue 8. 2008-09-02. PMID:17111624. |
based on a screen printed carbon electrode which contained a sensitive film prepared by crosslinking acetylcholine esterase (ache) with glutaraldehyde on the surface of working electrode, an amperometric enzyme biosensor was taken on the determination of organophosphorus (op) pesticide in water environment. |
2008-09-02 |
2023-08-12 |
Not clear |
| J Venkateswara Rao, Ghousia Begum, R Pallela, P K Usman, R Nageswara Ra. Changes in behavior and brain acetylcholinesterase activity in mosquito fish, Gambusia affinis in response to the sub-lethal exposure to chlorpyrifos. International journal of environmental research and public health. vol 2. issue 3-4. 2008-08-29. PMID:16819104. |
the alteration in locomotor behavior of fish may be due to an accumulation of acetylcholine (ach), a neurotransmitter at synaptic junctions, due to the inhibition of ache enzyme activity (40 to 55%) in brain and also bioaccumulation of the toxicant in different parts of fish. |
2008-08-29 |
2023-08-12 |
Not clear |
| K Dutta, D Bhattacharyay, A Mukherjee, S J Setford, A P F Turner, P Sarka. Detection of pesticide by polymeric enzyme electrodes. Ecotoxicology and environmental safety. vol 69. issue 3. 2008-08-11. PMID:17328951. |
screen-printed electrodes (spes) containing immobilized acetylcholine esterase (ache) enzyme were used for the electrochemical determination of organophosphorous (op) and carbamate pesticides. |
2008-08-11 |
2023-08-12 |
Not clear |
| K Dutta, D Bhattacharyay, A Mukherjee, S J Setford, A P F Turner, P Sarka. Detection of pesticide by polymeric enzyme electrodes. Ecotoxicology and environmental safety. vol 69. issue 3. 2008-08-11. PMID:17328951. |
the extent of ache deactivation by the pesticide was determined in the presence of acetylcholine (achcl) substrate. |
2008-08-11 |
2023-08-12 |
Not clear |
| Wei Zhao, Si-Xin Sun, Jing-Juan Xu, Hong-Yuan Chen, Xiao-Jian Cao, Xiao-Hong Gua. Electrochemical identification of the property of peripheral nerve fiber based on a biocompatible polymer film via in situ incorporating gold nanoparticles. Analytical chemistry. vol 80. issue 10. 2008-08-11. PMID:18363334. |
moreover the adsorption sites of ache would not be blocked by bovine serum albumin (bsa) which provides a good platform for the quantitative amperometric determination of ache via the oxidation of the enzymatically generated h 2o 2 in the bienzyme system in the presence of acetylcholine. |
2008-08-11 |
2023-08-12 |
cattle |
| Chiara Giuliano, Vinay Parikh, Josh R Ward, Christian Chiamulera, Martin Sarte. Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites? Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18346819. |
previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (chox) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ach) and its hydrolysis by endogenous acetylcholinesterase (ache). |
2008-08-08 |
2023-08-12 |
Not clear |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
5-hydroxytryptamine (5-ht4) receptor agonists increase gastrointestinal (gi) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (ache) to inactive metabolites. |
2008-08-06 |
2023-08-12 |
human |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18023504. |
mice deficient for acetylcholinesterase (ache) have strongly increased extracellular levels of acetylcholine (ach) in the dorsal hippocampus [hartmann, j., kiewert, c., duysen, e.g., lockridge, o., greig, n.h., klein, j., 2007. |
2008-07-28 |
2023-08-12 |
mouse |
| Doaa A Ghareeb, Hend M Husse. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neuroscience letters. vol 436. issue 1. 2008-07-22. PMID:18378083. |
the alterations of both ache forms observed in diabetic state could be attributed to hyperglycemia and lipid peroxidation that triggered brain dysfunction by disturbing the neurotransmitter acetylcholine level. |
2008-07-22 |
2023-08-12 |
rat |
| Kosuke Yamamoto, Suguru Oguri, Yoshie S Momonok. Characterization of trimeric acetylcholinesterase from a legume plant, Macroptilium atropurpureum Urb. Planta. vol 227. issue 4. 2008-07-21. PMID:18046576. |
similar to electric eel ache, both plant aches hydrolyzed acetylthiocholine (or acetylcholine) and propionylthiocholine (or propionylcholine), but not butyrylthiocholine (or butyrylcholine), and their specificity constant was highest against acetylcholine. |
2008-07-21 |
2023-08-12 |
Not clear |
| A I Skorinkin, A R Shaihutdinova, F Vyskoci. Model of concentration changes across the synaptic cleft during a single quantum release. General physiology and biophysics. vol 27. issue 1. 2008-07-18. PMID:18436979. |
one outcome of the present model is that the variable part of ache activity is zero at the moment of acetylcholine (ach) release and then increases. |
2008-07-18 |
2023-08-12 |
Not clear |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |