| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Glynis Johnson, Chrisna Swart, Samuel W Moor. Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain. The Biochemical journal. vol 411. issue 3. 2008-04-25. PMID:18215127. |
although the primary function of ache (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth and amyloidosis. |
2008-04-25 |
2023-08-12 |
mouse |
| Shravan K Singh, Deep C Kaushal, P Kalpana Murthy, Nuzhat A Kausha. Partial purification and characterization of acetylcholinesterase isozymes from adult bovine filarial parasite Setaria cervi. Indian journal of biochemistry & biophysics. vol 44. issue 5. 2008-04-08. PMID:18341214. |
both isozymes preferentially utilized acetylcholine iodide as substrate and were strongly inhibited by the true ache inhibitor (bw284c51), suggesting that they were true ache. |
2008-04-08 |
2023-08-12 |
human |
| Hitoshi Shinoto. [Imaging of brain acetylcholinesterase activity in dementias and extrapyramidal disorders]. Rinsho shinkeigaku = Clinical neurology. vol 47. issue 11. 2008-04-04. PMID:18210807. |
carbon-11 labeled n-methylpiperidin-4-yl acetate ([11c]mp4a) and carbon-11 labeled n-methylpiperidin-4-yl propionate ([11c]mp4p) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (ache) activity in vivo in humans. |
2008-04-04 |
2023-08-12 |
Not clear |
| O N Schuvailo, S V Dzyadevych, A V El'skaya, S Gautier-Sauvigné, E Csöregi, R Cespuglio, A P Soldatki. Carbon fibre-based microbiosensors for in vivo measurements of acetylcholine and choline. Biosensors & bioelectronics. vol 21. issue 1. 2008-03-05. PMID:15967355. |
this electrode was also modified through the co-immobilisation of acetylcholinesterase (ache) and/or choline oxidase (chox) in a bovine serum albumin (bsa) membrane for the development of a sensor for in vivo measurements of acetylcholine and choline. |
2008-03-05 |
2023-08-12 |
cattle |
| Atsunori Nakao, David J Kaczorowski, Brian S Zuckerbraun, Jing Lei, Gaetano Faleo, Kentaro Deguchi, Kenneth R McCurry, Timothy R Billiar, Shinichi Kann. Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and biophysical research communications. vol 367. issue 3. 2008-03-04. PMID:18174021. |
galantamine, a reversible inhibitor of acetylcholine esterase (ache), is a novel drug treatment for mild to moderate alzheimer's disease and vascular dementia. |
2008-03-04 |
2023-08-12 |
rat |
| Alexandra A Anderson, Dmitry S Ushakov, Michael A Ferenczi, Ryoichi Mori, Paul Martin, Jane L Saffel. Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17948252. |
acetylcholinesterase (ache) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. |
2008-02-19 |
2023-08-12 |
mouse |
| Martina Zimmermann, Sven Grösgen, Martin S Westwell, Susan A Greenfiel. Selective enhancement of the activity of C-terminally truncated, but not intact, acetylcholinesterase. Journal of neurochemistry. vol 104. issue 1. 2008-02-18. PMID:17986217. |
the enzyme is involved in the terminal breakdown of the neurotransmitter acetylcholine, but non-enzymatic roles have also been described for the entire ache molecule and its isolated c-terminal sequences. |
2008-02-18 |
2023-08-12 |
cattle |
| Y C Zhou, Benzhuo Lu, Gary A Huber, Michael J Holst, J Andrew McCammo. Continuum simulations of acetylcholine consumption by acetylcholinesterase: a Poisson-Nernst-Planck approach. The journal of physical chemistry. B. vol 112. issue 2. 2008-02-15. PMID:18052268. |
the poisson-nernst-planck (pnp) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ach) with acetylcholinesterase (ache) enzymes. |
2008-02-15 |
2023-08-12 |
Not clear |
| Mohamed-Bassem Ashour, Didair A Ragheb, El-Sayed A El-Sheikh, El-Adarosy A Gomaa, Shizuo G Kamita, Bruce D Hammoc. Biosafety of recombinant and wild type nucleopolyhedroviruses as bioinsecticides. International journal of environmental research and public health. vol 4. issue 2. 2008-02-08. PMID:17617674. |
no marked changes in acetylcholine esterase (ache) activity were found. |
2008-02-08 |
2023-08-12 |
rat |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
the main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited ache. |
2008-02-04 |
2023-08-12 |
Not clear |
| Junichi Kusafuka, Hiroyuki Kobayashi, Katsumi Miyahara, Geoffrey J Lane, Noriyoshi Sueyoshi, Atsuyuki Yamatak. Does abnormal expression of acetylcholine receptors in Hirschsprung's disease induce acetylcholine esterase positive nerve fibres? Asian journal of surgery. vol 30. issue 4. 2008-01-08. PMID:17962128. |
the purpose of the present study was to investigate the distribution of alpha-btx-sensitive nachr in hirschsprung's disease (hd) to understand the histopathological features of hd, especially the increase in acetylcholine esterase (ache) positive nerve fibres. |
2008-01-08 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Donia, Larry B Goldstein, Sarah Bullman, T Tu, Wasi A Khan, Ankelika M Dechkovskaia, Ali A Abdel-Rahma. Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. Journal of toxicology and environmental health. Part A. vol 71. issue 2. 2008-01-03. PMID:18080902. |
on postnatal day (pnd) 30, all male and female offspring were evaluated for (a) acetylcholinesterase (ache) and butyrylcholinesterase (buche) activity, (b) ligand binding for nicotinic acetylcholine receptors (nachr) and muscarinic acetylcholine receptors (m2 machr), (c) sensorimotor performance (inclined plane, beam-walking, and forepaw grip), and (d) pathological alterations in the brain (using cresyl violet and glial fibrillary acidic protein [gfap] immunostaining). |
2008-01-03 |
2023-08-12 |
human |
| Tatsuya Kikuchi, Toshimitsu Okamura, Kiyoshi Fukushi, Kazuhiro Takahashi, Jun Toyohara, Maki Okada, Ming-Rong Zhang, Toshiaki Iri. Cerebral acetylcholinesterase imaging: development of the radioprobes. Current topics in medicinal chemistry. vol 7. issue 18. 2007-12-18. PMID:17979787. |
the other approach is measuring cerebral ache activity with radiolabeled acetylcholine analogue substrates. |
2007-12-18 |
2023-08-12 |
Not clear |
| Ingrid Walz, Wolfgang Schwac. Cutinase inhibition by means of insecticidal organophosphates and carbamates. 3. Oxidation of phosphorothionates by chloroperoxidase from Caldariomyces fumago. Journal of agricultural and food chemistry. vol 55. issue 20. 2007-12-12. PMID:17824663. |
this type of enzymatic oxidation is easier to perform and more efficient, as compared to bromine or n-bromosuccinimide, used for acetylcholine esterase (ache) assay in water analyses, but is insufficient for complex matrices such as plant sample extracts. |
2007-12-12 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Reiji Teramoto, Hiroaki Fukunish. Supervised scoring models with docked ligand conformations for structure-based virtual screening. Journal of chemical information and modeling. vol 47. issue 5. 2007-11-06. PMID:17685604. |
we applied ssm to the flexx scoring function, that is, f-score, with five different target proteins: thymidine kinase (tk), estrogen receptor (er), acetylcholine esterase (ache), phosphodiesterase 5 (pde5), and peroxisome proliferator-activated receptor gamma (ppargamma). |
2007-11-06 |
2023-08-12 |
Not clear |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |
| Geetu Raheja, Kiran Dip Gil. Altered cholinergic metabolism and muscarinic receptor linked second messenger pathways after chronic exposure to dichlorvos in rat brain. Toxicology and industrial health. vol 23. issue 1. 2007-10-31. PMID:17722737. |
activity of the synthesizing enzyme of acetylcholine (ach) ie, choline acetyltransferase, was found to be significantly increased and the activity of hydrolyzing enzyme, acetyl cholinesterase (ache), was inhibited in all the three brain regions studied. |
2007-10-31 |
2023-08-12 |
rat |
| Yoshihito X Fujii, Ayako Tashiro, Kumiko Arimoto, Hirofumi Fujigaya, Yasuhiro Moriwaki, Hidemi Misawa, Takeshi Fujii, Minoru Matsui, Tadashi Kasahara, Koichiro Kawashim. Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice. Journal of neuroimmunology. vol 188. issue 1-2. 2007-10-19. PMID:17586055. |
immunological activation of t cells enhances synthesis of acetylcholine (ach) and transcription of choline acetyltransferase (chat), m5 muscarinic ach receptor (machr) and acetylcholinesterase (ache). |
2007-10-19 |
2023-08-12 |
mouse |
| Prabhu Venkataraman, Raju Muthuvel, Gunasekaran Krishnamoorthy, Arumugam Arunkumar, Muthusami Sridhar, Narasimhan Srinivasan, Karundevi Balasubramanian, Maria Michael Aruldhas, Jagadeesan Arunakara. PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. Neurotoxicology. vol 28. issue 3. 2007-10-18. PMID:17141323. |
hydrogen peroxide (h(2)o(2)), lipid peroxidation (lpo) and acetylcholine esterase activity (ache) were determined. |
2007-10-18 |
2023-08-12 |
rat |