| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L B Pagliosa, S C Monteiro, K B Silva, J P de Andrade, J Dutilh, J Bastida, M Cammarota, J A S Zuanazz. Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19969445. |
the treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache). |
2010-12-03 |
2023-08-12 |
Not clear |
| Hanaa A Hassan, Hani S Hafez, Fawzia E Zegheba. Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 7. 2010-11-30. PMID:20457208. |
serum and brain homogenates of the rats received nano2 (80 mg/kg body weight) for 3 months exhibited significant decrease in acetylcholine esterase (ache) activity as well as the levels of phospholipids, total protein and the endogenous antioxidant system (glutathione; gsh and superoxide dismutase; sod). |
2010-11-30 |
2023-08-12 |
rat |
| Clarisse B S Roepcke, Susanne B Muench, Holger Schulze, Till T Bachmann, Till Bachmann, Rolf D Schmid, Bernhard Haue. Analysis of phosphorothionate pesticides using a chloroperoxidase pretreatment and acetylcholinesterase biosensor detection. Journal of agricultural and food chemistry. vol 58. issue 15. 2010-11-22. PMID:20614938. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the nervous system. |
2010-11-22 |
2023-08-12 |
Not clear |
| V B Prozorovskiĭ, L V Pavlova, I M Suslova, A V Sazonova, N I Shchemelev. [Bizerine: new anticholinesterase drug with selective gastrointestinal action]. Eksperimental'naia i klinicheskaia farmakologiia. vol 73. issue 8. 2010-11-16. PMID:20919551. |
bizerine-oxalate of hexamethylene-bic-[n-methylcarbamic acid-3-(2-dimethylaminomethyl)pyridyl ether] exhibits the properties of acetylcholine esterase (ache) inhibitor, being comparable in this respect in in vitro tests to aminostigmine. |
2010-11-16 |
2023-08-12 |
mouse |
| Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M G Berg, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein, Hermona Sore. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.). vol 16. issue 7-8. 2010-11-08. PMID:20464061. |
previous studies implicated acetylcholinesterase (ache) involvement in stroke, and circulating ache activity reflects inflammatory response, since acetylcholine suppresses inflammation. |
2010-11-08 |
2023-08-12 |
Not clear |
| Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M G Berg, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein, Hermona Sore. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.). vol 16. issue 7-8. 2010-11-08. PMID:20464061. |
our study sought diagnostic values of ache and cholinergic status (cs, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. |
2010-11-08 |
2023-08-12 |
Not clear |
| Can-Jun Ruan, Zhan Li, Li Zhang, Di-Hua Chen, Guan-Hua Du, Lan Su. Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by Abeta(25-35) in, hypercholesterolemic rats. Brain research bulletin. vol 82. issue 5-6. 2010-11-01. PMID:20451590. |
to further explore the mechanism of s3, the activities of superoxide dismutase (sod), glutathione peroxidase (gsh-px), choline acetyl transferase (chat), acetylcholine esterase (ache) and the contents of malondialdehyde (mda) in hippocampus were analyzed by spectrophotometric method. |
2010-11-01 |
2023-08-12 |
rat |
| Umadevi Subramanian, Sharmila Poongavanam, A J Vanisre. Studies on the neuroprotective role of Piper longum in C6 glioma induced rats. Investigational new drugs. vol 28. issue 5. 2010-10-21. PMID:19730792. |
from the study, the glioma induced animals showed an increased level of lipid peroxides (lpo), tissue marker enzymes lactate dehydrogenase (ldh), creatine kinase (ck), 5'nucleotidase (5'nd) and acetylcholine esterase (ache). |
2010-10-21 |
2023-08-12 |
human |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| C S Yadav, V Kumar, S G Suke, R S Ahmed, P K Mediratta, B D Banerje. Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera. Indian journal of biochemistry & biophysics. vol 47. issue 2. 2010-09-17. PMID:20521626. |
blood and brain acetylcholine esterase (ache) activity was also assessed. |
2010-09-17 |
2023-08-12 |
rat |
| Can-Jun Ruan, Li Zhang, Di-Hua Chen, Zhan Li, Guan-Hua Du, Lan Su. Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Abeta(25-35) both in vitro and in vivo. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20346380. |
at the same time, the decreased superoxide dismutase (sod) and choline acetyl transferase (chat) were markedly increased, and the increased acetylcholine esterase (ache) activity was significantly decreased in hippocampus and cortex. |
2010-09-13 |
2023-08-12 |
mouse |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia. Experimental brain research. vol 203. issue 3. 2010-09-03. PMID:20458473. |
cholinergic markers like acetylcholine (ach) and acetyl cholinesterase (ache) were evaluated from cortex and hippocampus. |
2010-09-03 |
2023-08-12 |
rat |
| Peter Eyer, Franz Worek, Horst Thiermann, Michael Eddlesto. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:19883634. |
it is generally accepted that inhibition of acetylcholinesterase (ache) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. |
2010-09-01 |
2023-08-12 |
mouse |
| Suzana Berend, Bozica Radić, Kamil Kuca, Ana Lucić Vrdolja. The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138854. |
inhibition of ache results in accumulation of acetylcholine (ach) at the synaptic cleft of the cholinergic neurons, leading to overstimulation of cholinergic receptors. |
2010-09-01 |
2023-08-12 |
mouse |
| Julian R Haigh, Michael Adler, James P Apland, Sharad S Deshpande, Charles B Barham, Patrick Desmond, Irwin Koplovitz, David E Lenz, Richard K Gordo. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20144889. |
organophosphate (op) chemical warfare agents such as gd exert their toxic effects by inhibiting acetylcholinesterase (ache) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). |
2010-09-01 |
2023-08-12 |
marmoset |
| Séverine M Sigoillot, Francine Bourgeois, Claire Lega. Cholinesterases regulation in the absence of ColQ. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20153305. |
one of these molecules is acetylcholinesterase (ache) that regulates acetylcholine levels. |
2010-09-01 |
2023-08-12 |
Not clear |
| Heidi Q Xie, K Wing Leung, Vicky P Chen, Gallant K L Chan, Sherry L Xu, Ava J Y Guo, Kevin Y Zhu, Ken Y Z Zheng, Cathy W Bi, Janis Y X Zhan, Wallace K P Chan, Roy C Y Choi, Karl W K Tsi. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20178777. |
acetylcholinesterase (ache), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. |
2010-09-01 |
2023-08-12 |
Not clear |
| Kelvin Kin-Kwan Wong, Jacky Chi-Ki Ngo, Sijie Liu, Huang-Quan Lin, Chun Hu, Pang-Chui Shaw, David Chi-Cheong Wa. Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20350537. |
current therapeutic intervention for ad is primarily based on the inhibition of brain acetylcholinesterase (ache) to restore the brain acetylcholine level. |
2010-09-01 |
2023-08-12 |
human |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Ramesh Halappa, Muniswamy Davi. In vivo inhibition of acetylcholinesterase activity in functionally different tissues of the freshwater fish, Cyprinus carpio, under chlorpyrifos exposure. Drug metabolism and drug interactions. vol 24. issue 2-4. 2010-07-08. PMID:20408496. |
depression of ache activity suggested decreased cholinergic transmission and consequent accumulation of acetylcholine (ach). |
2010-07-08 |
2023-08-12 |
Not clear |