| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
we are currently probing the mechanism(s) of ache shedding, and whether this process and its apparent association with α7 nicotinic acetylcholine receptors and metabolism of the alzheimer's amyloid precursor protein is determined by its association with lipid raft domains either in normal or pathological situations. |
2011-03-30 |
2023-08-12 |
rat |
| Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-Nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshim. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20219155. |
galantamine, a drug used to treat alzheimer's disease, inhibits acetylcholinesterase (ache) and allosterically modulates nicotinic acetylcholine receptors (nachrs) resulting in stimulation of catecholamine neurotransmission. |
2011-03-18 |
2023-08-12 |
mouse |
| Yingjun Zhao, Xiaoying Wang, Tao Wang, Xin Hu, Xin Hui, Mingxia Yan, Qiang Gao, Taoyang Chen, Jinjun Li, Ming Yao, Dafang Wan, Jianren Gu, Jia Fan, Xianghuo H. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology (Baltimore, Md.). vol 53. issue 2. 2011-03-18. PMID:21274871. |
further study showed that ache suppressed cell proliferation via its enzymatic activity of acetylcholine catalysis and degradation. |
2011-03-18 |
2023-08-12 |
human |
| Shaik Firdoz, Fang Ma, Xiuli Yue, Zhifei Dai, Anil Kumar, Bin Jian. A novel amperometric biosensor based on single walled carbon nanotubes with acetylcholine esterase for the detection of carbaryl pesticide in water. Talanta. vol 83. issue 1. 2011-03-10. PMID:21035674. |
amperometric biosensor is fabricated for the detection of carbaryl based on single walled carbon nanotubes (swcnts) and acetylcholine esterase (ache). |
2011-03-10 |
2023-08-12 |
Not clear |
| F A Gbor. Brain and hypophyseal acetylcholinesterase activity of pubertal boars fed dietary fumonisin B1. Journal of animal physiology and animal nutrition. vol 94. issue 5. 2011-03-02. PMID:20546069. |
the effects of dietary fumonisin b(1) (fb(1)) on regional brain and hypophyseal activities of ache (ec 3117), the enzyme which catalyses the hydrolysis of acetylcholine, were studied using 24 male large white weanling pigs divided into four groups. |
2011-03-02 |
2023-08-12 |
Not clear |
| Qiong Wang, Li-Hua Sun, William Jia, Xin-Min Liu, Hai-Xia Dang, Wen-Li Mai, Ning Wang, Andre Steinmetz, Yu-Qin Wang, Chang-Jiang X. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564503. |
after 6 and 12 mg/kg of rg1 and rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (sd) and the morris water maze (mwm) tests, the acetylcholinesterase (ache) activity, acetylcholine (ach) content and serotonin (5-ht) level in the hippocampus were analysed after sd and mwm tests. |
2011-02-17 |
2023-08-12 |
mouse |
| Mohga M Badran, Maha Abdel Hakeem, Suzan M Abuel-Maaty, Afaf El-Malah, Rania M Abdel Sala. Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease. Archiv der Pharmazie. vol 343. issue 10. 2011-02-14. PMID:20925094. |
the newly synthesized compounds have been tested for their ability to inhibit acetylcholine esterase (ache) activity using tacrine as standard drug. |
2011-02-14 |
2023-08-12 |
Not clear |
| Carles Galdeano, Elisabet Viayna, Pau Arroyo, Axel Bidon-Chanal, J Ramón Blas, Diego Muñoz-Torrero, F Javier Luqu. Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents. Current pharmaceutical design. vol 16. issue 25. 2011-02-08. PMID:20698824. |
some dual binding site ache inhibitors take on added value a significant ability to additionally inhibit the enzymes butyrylcholinesterase and bace-1, involved in the co-regulation of the hydrolysis of the neurotransmitter acetylcholine and in aβ formation, respectively. |
2011-02-08 |
2023-08-12 |
Not clear |
| Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Chetan Bhutada, Santosh Tawari, Pankaj Dixit, Dharmendra Mundhad. Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats. Neurobiology of learning and memory. vol 94. issue 3. 2011-01-27. PMID:20620214. |
diabetes-related cognitive dysfunction is a consequence of changes within the central nervous system that are secondary to chronic hyperglycemia, oxidative stress, and cholinergic dysfunction, and probably therefore anti-diabetics, anti-oxidants, and acetylcholine esterase (ache) inhibitors were found to have beneficial effects in animal models. |
2011-01-27 |
2023-08-12 |
rat |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| M Kalogiannis, S L Grupke, P E Potter, J G Edwards, R M Chemelli, Y Y Kisanuki, M Yanagisawa, C S Leonar. Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576035. |
mrna for choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht) and the high-affinity choline transporter (cht1) but not acetylcholinesterase (ache) was significantly higher in samples from dko than wild-type (wt) mice. |
2011-01-13 |
2023-08-12 |
mouse |
| Yi Wang, Yun Tang, Ling-ling Xu, Xiao-ping Dia. [Ecotoxicolgical effects of albendazole on Eisenia fetida]. Ying yong sheng tai xue bao = The journal of applied ecology. vol 20. issue 9. 2010-12-23. PMID:20030157. |
by using artificial soil test, the effects of different concentration albendozole on eisenia foetida's growth, survival, reproduction, and activities of superoxide dismutase (sod), glutathione-sulfurtransferase (gst-s) and acetylcholine esterase (ache) were studied. |
2010-12-23 |
2023-08-12 |
Not clear |
| L B Pagliosa, S C Monteiro, K B Silva, J P de Andrade, J Dutilh, J Bastida, M Cammarota, J A S Zuanazz. Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19969445. |
the treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache). |
2010-12-03 |
2023-08-12 |
Not clear |
| Hanaa A Hassan, Hani S Hafez, Fawzia E Zegheba. Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 7. 2010-11-30. PMID:20457208. |
serum and brain homogenates of the rats received nano2 (80 mg/kg body weight) for 3 months exhibited significant decrease in acetylcholine esterase (ache) activity as well as the levels of phospholipids, total protein and the endogenous antioxidant system (glutathione; gsh and superoxide dismutase; sod). |
2010-11-30 |
2023-08-12 |
rat |
| Clarisse B S Roepcke, Susanne B Muench, Holger Schulze, Till T Bachmann, Till Bachmann, Rolf D Schmid, Bernhard Haue. Analysis of phosphorothionate pesticides using a chloroperoxidase pretreatment and acetylcholinesterase biosensor detection. Journal of agricultural and food chemistry. vol 58. issue 15. 2010-11-22. PMID:20614938. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the nervous system. |
2010-11-22 |
2023-08-12 |
Not clear |
| V B Prozorovskiĭ, L V Pavlova, I M Suslova, A V Sazonova, N I Shchemelev. [Bizerine: new anticholinesterase drug with selective gastrointestinal action]. Eksperimental'naia i klinicheskaia farmakologiia. vol 73. issue 8. 2010-11-16. PMID:20919551. |
bizerine-oxalate of hexamethylene-bic-[n-methylcarbamic acid-3-(2-dimethylaminomethyl)pyridyl ether] exhibits the properties of acetylcholine esterase (ache) inhibitor, being comparable in this respect in in vitro tests to aminostigmine. |
2010-11-16 |
2023-08-12 |
mouse |
| Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M G Berg, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein, Hermona Sore. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.). vol 16. issue 7-8. 2010-11-08. PMID:20464061. |
previous studies implicated acetylcholinesterase (ache) involvement in stroke, and circulating ache activity reflects inflammatory response, since acetylcholine suppresses inflammation. |
2010-11-08 |
2023-08-12 |
Not clear |
| Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M G Berg, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein, Hermona Sore. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.). vol 16. issue 7-8. 2010-11-08. PMID:20464061. |
our study sought diagnostic values of ache and cholinergic status (cs, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. |
2010-11-08 |
2023-08-12 |
Not clear |
| Can-Jun Ruan, Zhan Li, Li Zhang, Di-Hua Chen, Guan-Hua Du, Lan Su. Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by Abeta(25-35) in, hypercholesterolemic rats. Brain research bulletin. vol 82. issue 5-6. 2010-11-01. PMID:20451590. |
to further explore the mechanism of s3, the activities of superoxide dismutase (sod), glutathione peroxidase (gsh-px), choline acetyl transferase (chat), acetylcholine esterase (ache) and the contents of malondialdehyde (mda) in hippocampus were analyzed by spectrophotometric method. |
2010-11-01 |
2023-08-12 |
rat |
| Umadevi Subramanian, Sharmila Poongavanam, A J Vanisre. Studies on the neuroprotective role of Piper longum in C6 glioma induced rats. Investigational new drugs. vol 28. issue 5. 2010-10-21. PMID:19730792. |
from the study, the glioma induced animals showed an increased level of lipid peroxides (lpo), tissue marker enzymes lactate dehydrogenase (ldh), creatine kinase (ck), 5'nucleotidase (5'nd) and acetylcholine esterase (ache). |
2010-10-21 |
2023-08-12 |
human |