| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shihua Hou, Zhongmin Ou, Qiang Chen, Baoyan W. Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Biosensors & bioelectronics. vol 33. issue 1. 2012-06-21. PMID:22230694. |
a novel acetylcholinesterase (ache)/choline oxidase (chox) bienzyme amperometric acetylcholine biosensor based on gold nanoparticles (aunps) and multi-walled carbon nanotubes (mwcnts) has been successfully developed by self-assembly process in combination of sol-gel technique. |
2012-06-21 |
2023-08-12 |
Not clear |
| Yonglin Gao, Chunmei Li, Jungang Yin, Jingyu Shen, Hongtao Wang, Yuzhen Wu, Haizhu Ji. Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats. Environmental toxicology and pharmacology. vol 33. issue 2. 2012-06-12. PMID:22301160. |
furthermore, fucoidan reversed the decreased activity of choline acetyl transferase (chat), superoxide dismutase (sod), glutathione peroxidase (gsh-px) and content of acetylcholine (ach), as well as the increased activity of acetylcholine esterase (ache) and content of malondialdehyde (mda) in hippocampal tissue of aβ-injected rats. |
2012-06-12 |
2023-08-12 |
rat |
| Amy C Halliday, Susan A Greenfiel. From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933122. |
acetylcholinesterase (ache), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ach). |
2012-06-08 |
2023-08-12 |
Not clear |
| T F Holth, K E Tollefse. Acetylcholine esterase inhibitors in effluents from oil production platforms in the North Sea. Aquatic toxicology (Amsterdam, Netherlands). vol 112-113. 2012-06-08. PMID:22115844. |
inhibition of acetylcholine esterase (ache) activity is a biomarker for the exposure to neurotoxic compounds such as organophosphates and is intimately associated with the toxicity of several pesticides. |
2012-06-08 |
2023-08-12 |
Not clear |
| Haley E Speed, Cory A Blaiss, Ahleum Kim, Michael E Haws, Neal R Melvin, Michael Jennings, Amelia J Eisch, Craig M Powel. Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 1. 2012-06-06. PMID:21948870. |
agricultural and household organophosphorus (op) pesticides inhibit acetylcholinesterase (ache), resulting in increased acetylcholine (ach) in the central nervous system. |
2012-06-06 |
2023-08-12 |
mouse |
| Mauricio Valenzuela-Harrington, Irene Castillo, Corín Díaz, Inés Alés, Antonio Rodríguez-Moren. Dimethoate accelerates the extinction of eyeblink conditioning in mice. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22182529. |
these compounds decrease acetylcholine esterase (ache) activity, thereby provoking an accumulation of the neurotransmitter acetylcholine at synapses and resulting in the over-stimulation of acetylcholine receptors. |
2012-06-04 |
2023-08-12 |
mouse |
| Guiling He, Yang Sun, Fei L. RNA interference of two acetylcholinesterase genes in Plutella xylostella reveals their different functions. Archives of insect biochemistry and physiology. vol 79. issue 2. 2012-05-29. PMID:22392769. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme with a typical function of degrading the neurotransmitter acetylcholine. |
2012-05-29 |
2023-08-12 |
Not clear |
| Ying-hua Shu, Hong-hui Ma, Yan Du, Jian-wu Wan. [Effects of Bt corn straw insecticidal proteins on enzyme activities of Eisenia fetida]. Ying yong sheng tai xue bao = The journal of applied ecology. vol 22. issue 8. 2012-05-24. PMID:22097378. |
in this study, the straws of bt corn and its near-isogenic non-bt line were added into soil with an application rate of 5% and 7.5% to breed eisenia fetida, and the total protein content and the activities of acetylcholine esterase (ache), glutathione peroxidase (gsh-px), catalase (cat), and superoxide dismutase (sod) in e. fetida were determined after 7 and 14 days. |
2012-05-24 |
2023-08-12 |
cat |
| A Sherin, J Anu, K T Peeyush, S Smijin, M Anitha, B T Roshni, C S Paulos. Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. vol 202. 2012-05-18. PMID:22155651. |
expression of cholinergic enzymes; acetylcholine esterase (ache) and choline acetyltransferase (chat) upregulated and downregulated, respectively, in diabetic group, which was further exacerbated by hypoglycemia. |
2012-05-18 |
2023-08-12 |
rat |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Shinji Sato, Kam Ming Ko, Tetsuya Konish. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free radical research. vol 45. issue 8. 2012-05-16. PMID:21615274. |
at the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (pat) and morris water maze (mwm) with concomitant increase of acetylcholinesterase (ache) activity and decreased acetylcholine levels. |
2012-05-16 |
2023-08-12 |
mouse |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Shinji Sato, Kam Ming Ko, Tetsuya Konish. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free radical research. vol 45. issue 8. 2012-05-16. PMID:21615274. |
further, the scopolamine-induced increase in ache activity was significantly suppressed and the level of acetylcholine was maintained as normal by sch b treatment. |
2012-05-16 |
2023-08-12 |
mouse |
| Nejat Gacar, Oguz Mutlu, Tijen Utkan, Ipek Komsuoglu Celikyurt, Semil Selcen Gocmez, Güner Ula. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacology, biochemistry, and behavior. vol 99. issue 3. 2012-05-16. PMID:21624386. |
resveratrol (3,5,4-trihydroxy-trans-stilbene), which is found in grapes and red wine has been shown to protect neuronal cells with its antioxidant activity, improve memory function in dementia and reverse acetylcholine esterase (ache) activity. |
2012-05-16 |
2023-08-12 |
rat |
| Shuzhen Liao, Yanan Qiao, Wenting Han, Zhaoxia Xie, Zhaoyang Wu, Guoli Shen, Ruqin Y. Acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor. Analytical chemistry. vol 84. issue 1. 2012-05-01. PMID:22148672. |
a novel acetylcholinesterase (ache) liquid crystal (lc) biosensor based on enzymatic growth of gold nanoparticles (au nps) has been developed for amplified detection of acetylcholine (ach) and ache inhibitor. |
2012-05-01 |
2023-08-12 |
Not clear |
| Joseph S Zakhari, Isao Kinoyama, Mark S Hixon, Antonia Di Mola, Daniel Globisch, Kim D Jand. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization. Bioorganic & medicinal chemistry. vol 19. issue 21. 2012-04-26. PMID:21975066. |
the carbamate prodrug is intended to be a slowly reversible inhibitor of acetylcholinesterase (ache) along the lines of the stigmines thereby allowing increased persistence of released acetylcholine within the synaptic cleft. |
2012-04-26 |
2023-08-12 |
Not clear |
| Joseph S Zakhari, Isao Kinoyama, Mark S Hixon, Antonia Di Mola, Daniel Globisch, Kim D Jand. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization. Bioorganic & medicinal chemistry. vol 19. issue 21. 2012-04-26. PMID:21975066. |
as a secondary activity, cleavage of the carbamate prodrug by ache will afford the localized release of 3,4-dap, which in turn, will enhance the pre-synaptic release of additional acetylcholine. |
2012-04-26 |
2023-08-12 |
Not clear |
| Manojkumar Valiyaveettil, Yonas Alamneh, Samuel Oguntayo, Yanling Wei, Ying Wang, Peethambaran Arun, Madhusoodana P Nambia. Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22079491. |
acetylcholinesterase (ache) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (tbi). |
2012-04-24 |
2023-08-12 |
mouse |
| Doaa A Ghareeb, Hani S Hafez, Hend M Hussien, Nihal F Kabap. Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. Metabolic brain disease. vol 26. issue 4. 2012-04-12. PMID:21881966. |
acetylcholine esterase (ache), monoamine oxidase (mao), prooxidant/ antioxidants status, atpase, lipid profile and glucose level were estimated spectrophotometrically while inflammatory markers; interleukin 6 and tumor necrosis factor alpha (il6 and tnf-α) and insulin were assessed by elisa technique. |
2012-04-12 |
2023-08-12 |
rat |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| A Barelli, P M Soave, M Del Vicario, R Barell. New experimental Oximes in the management of organophosphorus pesticides poisoning. Minerva anestesiologica. vol 77. issue 12. 2012-04-04. PMID:21799476. |
the main toxic mechanism of opcs is the inhibition of the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), resulting in accumulation of acetylcholine (ach) at the synapse with cholinergic crisis and possible death. |
2012-04-04 |
2023-08-12 |
Not clear |
| A Zlomuzica, D Viggiano, J Degen, S Binder, L A Ruocco, A G Sadile, K Willecke, J P Huston, E Der. Behavioral alterations and changes in Ca/calmodulin kinase II levels in the striatum of connexin36 deficient mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21889545. |
additionally, we examined the effects of cx36 deficiency on acetylcholine esterase (ache) activity and calcium calmodulin kinase ii alpha (camkii) protein levels in the striatum. |
2012-02-09 |
2023-08-12 |
mouse |