| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Liu, Yan Li, Junyan Liu, Chunhui Deng, Xiangmin Zhan. High throughput enzyme inhibitor screening by functionalized magnetic carbonaceous microspheres and graphene oxide-based MALDI-TOF-MS. Journal of the American Society for Mass Spectrometry. vol 22. issue 12. 2012-02-07. PMID:21952774. |
the efficiency of immobilized ache was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized mc microspheres with model substrate acetylcholine (ach), and subsequent quantitative determination of substrate ach and product choline using graphene oxide-based maldi-tof-ms with no background inference. |
2012-02-07 |
2023-08-12 |
Not clear |
| Kasim Abass Askar, A Caleb Kudi, A John Mood. Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography. Applied biochemistry and biotechnology. vol 165. issue 1. 2012-02-02. PMID:21499785. |
the purpose of this study was to develop a protocol for the purification of acetylcholinesterase (ache, acetylcholine acetylhydrolase, e.c.3.1.1.7) enzyme and to extend a purification method for further enzyme characterization. |
2012-02-02 |
2023-08-12 |
Not clear |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Yinyin Xia, Shuqun Cheng, Junlin He, Xueqing Liu, Yan Tang, Haiyan Yuan, Lijun He, Tao Lu, Baijie Tu, Yingxiong Wan. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21216261. |
b[a]p treatment decreased the levels of malondialdehyde (mda), nitric oxide (no), nitric oxide synthase (nos), superoxide dismutase (sod), acetylcholine (ach), choline acetyltransferase (chat), and increased the activity of acetylcholinesterase (ache). |
2012-01-25 |
2023-08-12 |
rat |
| Yushan Wang, Lidong Liu, Tracy Weiss, Christine Stewart, John Mikle. Effect of acute soman exposure on GABA(A) receptors in rat hippocampal slices and cultured hippocampal neurons. Neurotoxicity research. vol 20. issue 4. 2012-01-25. PMID:21643853. |
the effect of soman on gaba(a)r endocytosis was not due to inhibition of acetylcholinesterase (ache) because (1) the acetylcholine muscarinic receptor antagonist atropine did not block soman-induced gaba(a)r endocytosis; and (2) physostigmine, at concentrations that completely inhibit ache activity, did not cause gaba(a)r endocytosis. |
2012-01-25 |
2023-08-12 |
rat |
| Vijayasree Vayalanellore Giridharan, Rajarajan Amirthalingam Thandavarayan, Tetsuya Konish. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom. Food & function. vol 2. issue 6. 2012-01-24. PMID:21779570. |
to elucidate the mechanism of the cognitive enhancing activity of mec, the activities of acetylcholinesterase (ache), anti-oxidant enzymes, the levels of acetylcholine (ach) and nitrite of mice brain homogenates were evaluated. |
2012-01-24 |
2023-08-12 |
mouse |
| Jiefang Sun, Lei Guo, Yi Bao, Jianwei Xi. A simple, label-free AuNPs-based colorimetric ultrasensitive detection of nerve agents and highly toxic organophosphate pesticide. Biosensors & bioelectronics. vol 28. issue 1. 2012-01-23. PMID:21803563. |
here, a simple label-free colorimetric sensing method for organophosphate (op) nerve agents and pesticide based on catalytic reaction of acetylcholine esterase (ache) and the aggregation of lipoic acid (la) capped aunps has been established, which is highly sensitive with a limit of detection (lod) lowered to pm level. |
2012-01-23 |
2023-08-12 |
Not clear |
| Ryan Walsh, Kenneth Rockwood, Earl Martin, Sultan Darves. Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram. Biochimica et biophysica acta. vol 1810. issue 12. 2012-01-23. PMID:21872646. |
in ad brain, ache is diminished while buche is not, suggesting buche inhibition may be important in raising acetylcholine levels. |
2012-01-23 |
2023-08-12 |
human |
| Ludise Malkova, Alan P Kozikowski, Karen Gal. The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21185313. |
huperzine a is a reversible acetylcholinesterase (ache) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. |
2012-01-18 |
2023-08-12 |
human |
| Evert-Jan Kooi, Marloes Prins, Natasha Bajic, Jeroen A M Beliën, Wouter H Gerritsen, Jack van Horssen, Eleonora Aronica, Anne-Marie van Dam, Jeroen J M Hoozemans, Paul T Francis, Paul van der Valk, Jeroen J G Geurt. Cholinergic imbalance in the multiple sclerosis hippocampus. Acta neuropathologica. vol 122. issue 3. 2012-01-10. PMID:21691765. |
in ms hippocampus, activity and protein expression of choline acetyltransferase (chat), the acetylcholine synthesizing enzyme, was decreased, while the activity and protein expression of acetylcholinesterase (ache), the acetylcholine degrading enzyme, was found to be unaltered. |
2012-01-10 |
2023-08-12 |
Not clear |
| Michael Adler, Richard E Sweeney, Tracey A Hamilton, Oksana Lockridge, Ellen G Duysen, Angela L Purcell, Sharad S Deshpand. Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice. Cellular and molecular neurobiology. vol 31. issue 6. 2011-11-30. PMID:21538119. |
electrophysiological and ultrastructural studies were performed on phrenic nerve-hemidiaphragm preparations isolated from wild-type and acetylcholinesterase (ache) knockout (ko) mice to determine the compensatory mechanisms manifested by the neuromuscular junction to excess acetylcholine (ach). |
2011-11-30 |
2023-08-12 |
mouse |
| S Asha Devi, C S Shiva Shankar Reddy, M V V Subramanya. Peroxyl-induced oxidative stress in aging erythrocytes of rat. Biogerontology. vol 12. issue 4. 2011-11-21. PMID:21359656. |
membrane integrity in terms of hemolysis was negatively related to acetylcholine esterase (ache) activity with the extent of reduction under os being higher in the old erythrocyte than in the young. |
2011-11-21 |
2023-08-12 |
rat |
| Norifumi Shioda, Yui Yamamoto, Feng Han, Shigeki Moriguchi, Kohji Fukunag. [Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 131. issue 4. 2011-11-15. PMID:21467789. |
using this attractive obx mice model, we discovered a novel cognitive enhancer, spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3h)-one (zset1446/st101), that is a new azaindolizinone derivative without inhibitory action on acetylcholine esterase (ache). |
2011-11-15 |
2023-08-12 |
mouse |
| Pamela D Moore, Anita K Patlolla, Paul B Tchounwo. Cytogenetic evaluation of malathion-induced toxicity in Sprague-Dawley rats. Mutation research. vol 725. issue 1-2. 2011-11-15. PMID:21835262. |
its toxicity has been attributed primarily to the accumulation of acetylcholine (ach) at nerve junctions, due to the inhibition of acetylcholinesterase (ache), and consequently overstimulation of the nicotinic and muscarinic receptors. |
2011-11-15 |
2023-08-12 |
rat |
| Roberta Annicchiarico, Alessia Federici, Carla Pettenati, Carlo Caltagiron. Rivastigmine in Alzheimer's disease: Cognitive function and quality of life. Therapeutics and clinical risk management. vol 3. issue 6. 2011-11-10. PMID:18516265. |
rivastigmine is a dual inhibitor of both acetylcholine esterase (ache) and butyrylcholinesterase (buche), enzymes involved in the hydrolysis of acetylcholine. |
2011-11-10 |
2023-08-12 |
Not clear |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Vicky P Chen, Wilson K W Luk, Wallace K B Chan, K Wing Leung, Ava J Y Guo, Gallant K L Chan, Sherry L Xu, Roy C Y Choi, Karl W K Tsi. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22046147. |
acetylcholinesterase (ache) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. |
2011-11-10 |
2023-08-12 |
chicken |
| Alexandre P Atkinson, Evelyne Baguet, Nicolas Galland, Jean-Yves Le Questel, Aurélien Planchat, Jérôme Grato. Structural features and hydrogen-bond properties of galanthamine and codeine: an experimental and theoretical study. Chemistry (Weinheim an der Bergstrasse, Germany). vol 17. issue 41. 2011-11-07. PMID:21887829. |
an analysis of the interactions that occur between the two ligands and acetylcholine esterase (ache) suggests significant differences with trp84, a key component of the ache catalytic active site. |
2011-11-07 |
2023-08-12 |
Not clear |
| Tanja Klein-Rodewald, Thomas Seeger, Mathias Dutschmann, Franz Worek, Michael Mörsche. Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat. Toxicology letters. vol 206. issue 1. 2011-10-28. PMID:21767620. |
the impact of organophosphorus compound (op) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (ache) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. |
2011-10-28 |
2023-08-12 |
rat |
| Vinicius Barreto da Silva, Peterson de Andrade, Daniel Fábio Kawano, Pedro Alves Bezerra Morais, Jonathan Resende de Almeida, Ivone Carvalho, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silv. In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity. Future medicinal chemistry. vol 3. issue 8. 2011-10-12. PMID:21707398. |
one pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (ache) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. |
2011-10-12 |
2023-08-12 |
Not clear |