| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Sherin, J Anu, K T Peeyush, S Smijin, M Anitha, B T Roshni, C S Paulos. Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. vol 202. 2012-05-18. PMID:22155651. |
expression of cholinergic enzymes; acetylcholine esterase (ache) and choline acetyltransferase (chat) upregulated and downregulated, respectively, in diabetic group, which was further exacerbated by hypoglycemia. |
2012-05-18 |
2023-08-12 |
rat |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Shinji Sato, Kam Ming Ko, Tetsuya Konish. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free radical research. vol 45. issue 8. 2012-05-16. PMID:21615274. |
at the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (pat) and morris water maze (mwm) with concomitant increase of acetylcholinesterase (ache) activity and decreased acetylcholine levels. |
2012-05-16 |
2023-08-12 |
mouse |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Shinji Sato, Kam Ming Ko, Tetsuya Konish. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free radical research. vol 45. issue 8. 2012-05-16. PMID:21615274. |
further, the scopolamine-induced increase in ache activity was significantly suppressed and the level of acetylcholine was maintained as normal by sch b treatment. |
2012-05-16 |
2023-08-12 |
mouse |
| Nejat Gacar, Oguz Mutlu, Tijen Utkan, Ipek Komsuoglu Celikyurt, Semil Selcen Gocmez, Güner Ula. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacology, biochemistry, and behavior. vol 99. issue 3. 2012-05-16. PMID:21624386. |
resveratrol (3,5,4-trihydroxy-trans-stilbene), which is found in grapes and red wine has been shown to protect neuronal cells with its antioxidant activity, improve memory function in dementia and reverse acetylcholine esterase (ache) activity. |
2012-05-16 |
2023-08-12 |
rat |
| Shuzhen Liao, Yanan Qiao, Wenting Han, Zhaoxia Xie, Zhaoyang Wu, Guoli Shen, Ruqin Y. Acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor. Analytical chemistry. vol 84. issue 1. 2012-05-01. PMID:22148672. |
a novel acetylcholinesterase (ache) liquid crystal (lc) biosensor based on enzymatic growth of gold nanoparticles (au nps) has been developed for amplified detection of acetylcholine (ach) and ache inhibitor. |
2012-05-01 |
2023-08-12 |
Not clear |
| Joseph S Zakhari, Isao Kinoyama, Mark S Hixon, Antonia Di Mola, Daniel Globisch, Kim D Jand. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization. Bioorganic & medicinal chemistry. vol 19. issue 21. 2012-04-26. PMID:21975066. |
the carbamate prodrug is intended to be a slowly reversible inhibitor of acetylcholinesterase (ache) along the lines of the stigmines thereby allowing increased persistence of released acetylcholine within the synaptic cleft. |
2012-04-26 |
2023-08-12 |
Not clear |
| Joseph S Zakhari, Isao Kinoyama, Mark S Hixon, Antonia Di Mola, Daniel Globisch, Kim D Jand. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization. Bioorganic & medicinal chemistry. vol 19. issue 21. 2012-04-26. PMID:21975066. |
as a secondary activity, cleavage of the carbamate prodrug by ache will afford the localized release of 3,4-dap, which in turn, will enhance the pre-synaptic release of additional acetylcholine. |
2012-04-26 |
2023-08-12 |
Not clear |
| Manojkumar Valiyaveettil, Yonas Alamneh, Samuel Oguntayo, Yanling Wei, Ying Wang, Peethambaran Arun, Madhusoodana P Nambia. Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22079491. |
acetylcholinesterase (ache) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (tbi). |
2012-04-24 |
2023-08-12 |
mouse |
| Doaa A Ghareeb, Hani S Hafez, Hend M Hussien, Nihal F Kabap. Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. Metabolic brain disease. vol 26. issue 4. 2012-04-12. PMID:21881966. |
acetylcholine esterase (ache), monoamine oxidase (mao), prooxidant/ antioxidants status, atpase, lipid profile and glucose level were estimated spectrophotometrically while inflammatory markers; interleukin 6 and tumor necrosis factor alpha (il6 and tnf-α) and insulin were assessed by elisa technique. |
2012-04-12 |
2023-08-12 |
rat |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| A Barelli, P M Soave, M Del Vicario, R Barell. New experimental Oximes in the management of organophosphorus pesticides poisoning. Minerva anestesiologica. vol 77. issue 12. 2012-04-04. PMID:21799476. |
the main toxic mechanism of opcs is the inhibition of the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), resulting in accumulation of acetylcholine (ach) at the synapse with cholinergic crisis and possible death. |
2012-04-04 |
2023-08-12 |
Not clear |
| A Zlomuzica, D Viggiano, J Degen, S Binder, L A Ruocco, A G Sadile, K Willecke, J P Huston, E Der. Behavioral alterations and changes in Ca/calmodulin kinase II levels in the striatum of connexin36 deficient mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21889545. |
additionally, we examined the effects of cx36 deficiency on acetylcholine esterase (ache) activity and calcium calmodulin kinase ii alpha (camkii) protein levels in the striatum. |
2012-02-09 |
2023-08-12 |
mouse |
| Yang Liu, Yan Li, Junyan Liu, Chunhui Deng, Xiangmin Zhan. High throughput enzyme inhibitor screening by functionalized magnetic carbonaceous microspheres and graphene oxide-based MALDI-TOF-MS. Journal of the American Society for Mass Spectrometry. vol 22. issue 12. 2012-02-07. PMID:21952774. |
the efficiency of immobilized ache was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized mc microspheres with model substrate acetylcholine (ach), and subsequent quantitative determination of substrate ach and product choline using graphene oxide-based maldi-tof-ms with no background inference. |
2012-02-07 |
2023-08-12 |
Not clear |
| Kasim Abass Askar, A Caleb Kudi, A John Mood. Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography. Applied biochemistry and biotechnology. vol 165. issue 1. 2012-02-02. PMID:21499785. |
the purpose of this study was to develop a protocol for the purification of acetylcholinesterase (ache, acetylcholine acetylhydrolase, e.c.3.1.1.7) enzyme and to extend a purification method for further enzyme characterization. |
2012-02-02 |
2023-08-12 |
Not clear |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Yinyin Xia, Shuqun Cheng, Junlin He, Xueqing Liu, Yan Tang, Haiyan Yuan, Lijun He, Tao Lu, Baijie Tu, Yingxiong Wan. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21216261. |
b[a]p treatment decreased the levels of malondialdehyde (mda), nitric oxide (no), nitric oxide synthase (nos), superoxide dismutase (sod), acetylcholine (ach), choline acetyltransferase (chat), and increased the activity of acetylcholinesterase (ache). |
2012-01-25 |
2023-08-12 |
rat |
| Yushan Wang, Lidong Liu, Tracy Weiss, Christine Stewart, John Mikle. Effect of acute soman exposure on GABA(A) receptors in rat hippocampal slices and cultured hippocampal neurons. Neurotoxicity research. vol 20. issue 4. 2012-01-25. PMID:21643853. |
the effect of soman on gaba(a)r endocytosis was not due to inhibition of acetylcholinesterase (ache) because (1) the acetylcholine muscarinic receptor antagonist atropine did not block soman-induced gaba(a)r endocytosis; and (2) physostigmine, at concentrations that completely inhibit ache activity, did not cause gaba(a)r endocytosis. |
2012-01-25 |
2023-08-12 |
rat |
| Vijayasree Vayalanellore Giridharan, Rajarajan Amirthalingam Thandavarayan, Tetsuya Konish. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom. Food & function. vol 2. issue 6. 2012-01-24. PMID:21779570. |
to elucidate the mechanism of the cognitive enhancing activity of mec, the activities of acetylcholinesterase (ache), anti-oxidant enzymes, the levels of acetylcholine (ach) and nitrite of mice brain homogenates were evaluated. |
2012-01-24 |
2023-08-12 |
mouse |
| Jiefang Sun, Lei Guo, Yi Bao, Jianwei Xi. A simple, label-free AuNPs-based colorimetric ultrasensitive detection of nerve agents and highly toxic organophosphate pesticide. Biosensors & bioelectronics. vol 28. issue 1. 2012-01-23. PMID:21803563. |
here, a simple label-free colorimetric sensing method for organophosphate (op) nerve agents and pesticide based on catalytic reaction of acetylcholine esterase (ache) and the aggregation of lipoic acid (la) capped aunps has been established, which is highly sensitive with a limit of detection (lod) lowered to pm level. |
2012-01-23 |
2023-08-12 |
Not clear |
| Ryan Walsh, Kenneth Rockwood, Earl Martin, Sultan Darves. Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram. Biochimica et biophysica acta. vol 1810. issue 12. 2012-01-23. PMID:21872646. |
in ad brain, ache is diminished while buche is not, suggesting buche inhibition may be important in raising acetylcholine levels. |
2012-01-23 |
2023-08-12 |
human |