| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Maja D Vitorovi\\xc4\\x87-Todorovi\\xc4\\x87, Franz Worek, Andrej Perdih, Sonja \\xc4\\x90 Bauk, Tamara B Vujatovi\\xc4\\x87, Ilija N Cvijeti\\xc4\\x8. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228470.' |
acetylcholinesterase (ache) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. |
2019-08-19 |
2023-08-13 |
human |
| Shaukat Ali, Can Zhang, Zeqing Wang, Xing-Min Wang, Jian-Hui Wu, Andrew G S Cuthbertson, Zhenfang Shao, Bao-Li Qi. Toxicological and biochemical basis of synergism between the entomopathogenic fungus Lecanicillium muscarium and the insecticide matrine against Bemisia tabaci (Gennadius). Scientific reports. vol 7. 2019-08-06. PMID:28425450. |
the strong synergistic effect is possibly related to the disturbance of acetylcholine balance and changes in ache activities of the whitefly as both matrine and l. muscarium target insect acetylcholine (ach) receptors which in turn effects ache production. |
2019-08-06 |
2023-08-13 |
cat |
| Géssica Perin, Nathieli B Bottari, Anielen D Silva, Antonise M Jaguezeski, Teane M A Gomes, Thalison F Lopes, Maria Rosa C Schetinger, Vera M Morsch, Aleksandro S Da Silv. Cholinesterase's activities of infected mice by Brucella ovis. Microbial pathogenesis. vol 132. 2019-08-06. PMID:31028864. |
the increase in ache and bche characterized a pro-inflammatory response, since these enzymes regulate levels of acetylcholine (ach) and butyrylcholine (busch), molecules with anti-inflammatory properties. |
2019-08-06 |
2023-08-13 |
mouse |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Priyapan Posri, Jittra Suthiwong, Pitchayakarn Takomthong, Chatchawan Wongsa, Chindawadee Chuenban, Chantana Boonyarat, Chavi Yenja. A new flavonoid from the leaves of Atalantia monophylla (L.) DC. Natural product research. vol 33. issue 8. 2019-07-22. PMID:29600742. |
focusing on alzheimer's disease, acetylcholine esterase (ache) inhibition and antioxidant activity were evaluated using the modified ellman's method and the abts scavenging assay, respectively. |
2019-07-22 |
2023-08-13 |
Not clear |
| Pengfei Zhang, Shengtao Xu, Zheying Zhu, Jinyi X. Multi-target design strategies for the improved treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 176. 2019-07-22. PMID:31103902. |
herein, we highlight nine major targets associated with ad, which are acetylcholine esterase (ache), beta-site amyloid precursor protein cleaving enzyme 1 (β-secretase, bace-1), glycogen synthase kinase 3 beta (gsk-3β), monoamine oxidases (maos), metal ions in the brain, n-methyl-d-aspartate (nmda) receptor, 5-hydroxytryptamine (5-ht) receptors, the third subtype of histamine receptor (h |
2019-07-22 |
2023-08-13 |
human |
| Miranda L Xu, Wilson K W Luk, Etta Y L Liu, Xiang P Kong, Qi Y Wu, Ying J Xia, Tina T X Dong, Karl W K Tsi. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31170385. |
acetylcholinesterase (ache) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of ache, i.e. |
2019-07-22 |
2023-08-13 |
Not clear |
| Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Le. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 4. 2019-07-17. PMID:30823604. |
acetylcholinesterase (ache) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. |
2019-07-17 |
2023-08-13 |
human |
| Shibaji Ghosh, Kalyanashis Jana, Bishwajit Gangul. Revealing the mechanistic pathway of cholinergic inhibition of Alzheimer's disease by donepezil: a metadynamics simulation study. Physical chemistry chemical physics : PCCP. vol 21. issue 25. 2019-07-10. PMID:31173012. |
we report for the first time, the inhibition mechanism of ache by the donepezil drug molecule for the hydrolysis of acetylcholine (ach) with docking and well-tempered metadynamics (wtmtd) simulations with a human acetylcholinesterase (hache) crystal structure (). |
2019-07-10 |
2023-08-13 |
human |
| Monica Janeczek, Tamar Gefen, Mehrnoosh Samimi, Garam Kim, Sandra Weintraub, Eileen Bigio, Emily Rogalski, M-Marsel Mesulam, Changiz Geul. Variations in Acetylcholinesterase Activity within Human Cortical Pyramidal Neurons Across Age and Cognitive Trajectories. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 4. 2019-06-26. PMID:28334147. |
conceivably, low levels of ache activity could enhance the impact of acetylcholine on pyramidal neurons to counterbalance other involutional factors that mediate the decline of memory capacity during average aging. |
2019-06-26 |
2023-08-13 |
human |
| Ashok Iyaswamy, Ananth Kumar Kammella, Citarasu Thavasimuthu, Wankhar Wankupar, Wankhar Dapkupar, Sambantham Shanmugam, Ravindran Rajan, Sheeladevi Rathinasam. Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR-CaMKII-ERK/CREB signalling on consumption of aspartame in rat model. Journal of food and drug analysis. vol 26. issue 2. 2019-06-26. PMID:29567262. |
the animals showed a marked decrease in learning, spatial working and spatial recognition memory deficit in the morris water maze and y-maze performance task which could have resulted due to reduced hippocampal acetylcholine esterase (ache) activity. |
2019-06-26 |
2023-08-13 |
human |
| Miranda L Xu, Wilson K W Luk, Cathy W C Bi, Etta Y L Liu, Kevin Q Y Wu, Ping Yao, Tina T X Dong, Karl W K Tsi. Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast. Journal of neurochemistry. vol 146. issue 4. 2019-06-26. PMID:29675901. |
acetylcholinesterase (ache; ec 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. |
2019-06-26 |
2023-08-13 |
Not clear |
| Levent Cavas, Gamze Topcam, Cevher Gundogdu-Hizliates, Yavuz Ergu. Neural Network Modeling of AChE Inhibition by New Carbazole-Bearing Oxazolones. Interdisciplinary sciences, computational life sciences. vol 11. issue 1. 2019-06-25. PMID:29236214. |
acetylcholine esterase (ache) is one of the targeted enzymes in the therapy of important neurodegenerative diseases such as alzheimer's disease. |
2019-06-25 |
2023-08-13 |
Not clear |
| Agung Nugroho, Jong-Hyuk Park, Jae Sue Choi, Kyoung-Sik Park, Joon-Pyo Hong, Hee-Juhn Par. Structure determination and quantification of a new flavone glycoside with anti-acetylcholinesterase activity from the herbs of Elsholtzia ciliata. Natural product research. vol 33. issue 6. 2019-06-20. PMID:29224362. |
acetylcholinesterase (ache) inhibition activity was assayed to find anti-alzheimer's activity, since this enzyme increases the concentration of acetylcholine (ach), a neurotransmitter, responsible for brain's memory. |
2019-06-20 |
2023-08-13 |
Not clear |
| Mamangam Subaraja, Arambakkam Janardhanam Vanisre. Aberrant neurotransmissional mRNAs in cerebral ganglions of rotenone-exposed Lumbricus terrestris exhibiting motor dysfunction and altered cognitive behavior. Environmental science and pollution research international. vol 26. issue 14. 2019-06-19. PMID:30868461. |
gaba, cholinergic receptor, serotonin transporter (sert), acetylcholine esterase (ache), and dopamine-β-hydroxylase that are well known for their involvement in neuromuscular junctions were investigated by qrt-pcr. |
2019-06-19 |
2023-08-13 |
Not clear |
| Snezana Agatonovic-Kustrin, Ella Kustrin, Vladimir Gegechkori, David W Morto. High-Performance Thin-Layer Chromatography Hyphenated with Microchemical and Biochemical Derivatizations in Bioactivity Profiling of Marine Species. Marine drugs. vol 17. issue 3. 2019-06-17. PMID:30832418. |
high-performance thin-layer chromatography (hptlc) hyphenated with microchemical (dpph•, p-anisaldehyde, and fast blue b) and biochemical (α-amylase and acetylcholine esterase (ache) enzymatic) derivatizations was used to evaluate antioxidant activity, presence of phytosterols and phenolic lipids, α-amylase and ache inhibitory activities of extract components. |
2019-06-17 |
2023-08-13 |
Not clear |
| Rami B Kassab, Maha S Lokman, Ehab A Essaw. Neurochemical alterations following the exposure to di-n-butyl phthalate in rats. Metabolic brain disease. vol 34. issue 1. 2019-06-06. PMID:30446882. |
in addition, the levels of norepinephrine (ne), dopamine (da) and acetylcholine esterase (ache) activity were decreased. |
2019-06-06 |
2023-08-13 |
rat |
| Jing Zhao, Dejun Hao, Liubin Xiao, Yongan Tan, Yiping Jiang, Lixin Bai, Kai Wan. Molecular and functional properties of two Spodoptera exigua acetylcholinesterase genes. Archives of insect biochemistry and physiology. vol 101. issue 3. 2019-06-06. PMID:31033012. |
acetylcholinesterase (ache) is a vital enzyme that hydrolyzes acetylcholine. |
2019-06-06 |
2023-08-13 |
Not clear |
| Hassan M Albishri, Deia Abd El-Had. Hyphenation of enzyme/graphene oxide-ionic liquid/glassy carbon biosensors with anodic differential pulse stripping voltammetry for reliable determination of choline and acetylcholine in human serum. Talanta. vol 200. 2019-06-06. PMID:31036163. |
in the current work, sensitive and selective biosensors composed of choline oxidase (cho) and/or acetylcholine esterase (ache) on graphene oxide-ionic liquid (go-il)/ glassy carbon electrode (gce) hyphenated with anodic differential pulse stripping voltammetry (adpsv) were firstly established for the determination of ach and ch in human serum samples. |
2019-06-06 |
2023-08-13 |
human |
| Zafer Sahin, Merve Ertas, Ceysu Bender, Emre F Bülbül, Barkin Berk, Sevde N Biltekin, Leyla Yurttaş, Şeref Demiraya. Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors. Drug development research. vol 79. issue 8. 2019-06-05. PMID:30343499. |
hit, lead & candidate discovery after acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (ache). |
2019-06-05 |
2023-08-13 |
Not clear |