| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Zahra Ouardi, Hammou Anarghou, Hafsa Malqui, Nabila Ouasmi, Mohammed Chigr, Mohamed Najimi, Fatiha Chig. Gestational and Lactational Exposure to Malathion Affects Antioxidant Status and Neurobehavior in Mice Pups and Offspring. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:30637616. |
in the present work, we investigated the effect of an organophosphate pesticide, i.e., malathion, administrated peri- and postnatally on the antioxidant system as well as on acetylcholine esterase (ache) activity in the brains of mice pups during the three postnatal weeks. |
2020-01-21 |
2023-08-13 |
mouse |
| Jinal B Thakkar, Shweta Gupta, C Ratna Prabh. Acetylcholine esterase enzyme doped multiwalled carbon nanotubes for the detection of organophosphorus pesticide using cyclic voltammetry. International journal of biological macromolecules. vol 137. 2020-01-15. PMID:31247229. |
use of immobilized acetylcholine esterase (ache) for detecting organophosphorus pesticides in water sources and body fluids can bring down the detection costs dramatically. |
2020-01-15 |
2023-08-13 |
Not clear |
| Fikret Türkan, Parham Taslimi, Fatma Zerrin Salta. Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease. Journal of biochemical and molecular toxicology. vol 33. issue 8. 2020-01-13. PMID:30974029. |
in this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (ache), α-glycosidase, α-amylase, and butyrylcholinesterase (bche). |
2020-01-13 |
2023-08-13 |
Not clear |
| Sina Parvaz, Reza Taheri-Ledari, Mir Saeed Esmaeili, Mahboubeh Rabbani, Ali Malek. A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators. Life sciences. vol 240. 2020-01-13. PMID:31760098. |
one of the most important categories of these hydrophilic medications, are reactivators for acetyl cholinesterase (ache) enzyme that facilitates the breakdown of acetylcholine (as a neurotransmitter). |
2020-01-13 |
2023-08-13 |
Not clear |
| Eunjin Sohn, Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Joo-Hwan Kim, Soo-Jin Jeon. Nutrients. vol 11. issue 6. 2019-12-30. PMID:31141948. |
acetylcholine (ach) levels and acetylcholinesterase (ache) activity were measured via an enzyme-linked immunosorbent assay (elisa). |
2019-12-30 |
2023-08-13 |
mouse |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Pamela T Wong, Somnath Bhattacharjee, Jayme Cannon, Shengzhuang Tang, Kelly Yang, Sierra Bowden, Victoria Varnau, Jessica J O'Konek, Seok Ki Cho. Reactivity and mechanism of α-nucleophile scaffolds as catalytic organophosphate scavengers. Organic & biomolecular chemistry. vol 17. issue 16. 2019-12-02. PMID:30942252. |
in addition to op reactivity, several compounds in the pam class displayed a dual mode of activity, as they retained the ability to reactivate pox-inhibited acetylcholine esterase (ache). |
2019-12-02 |
2023-08-13 |
Not clear |
| Yifan Chen, Gang Cheng, Rongfeng Hu, Shengqi Chen, Wenjie Lu, Song Gao, Hongmei Xia, Bin Wang, Chaojie Sun, Xiangjiang Nie, Qiang Shen, Wenyou Fan. A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study. AAPS PharmSciTech. vol 20. issue 7. 2019-12-02. PMID:31485857. |
huperzine a (hup a), extracted from the chinese medicinal plant huperzia serrata, is a reversible and highly selective second-generation acetylcholine esterase (ache) inhibitor for treating alzheimer's disease (ad), but it suffers from low bioavailability in the brain. |
2019-12-02 |
2023-08-13 |
Not clear |
| Zrinka Kovarik, Jarosław Kalisiak, Nikolina Maček Hrvat, Maja Katalinić, Tamara Zorbaz, Suzana Žunec, Carol Green, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Chemistry (Weinheim an der Bergstrasse, Germany). vol 25. issue 16. 2019-11-26. PMID:30458057. |
acetylcholinesterase (ache), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (ops), such as nerve agents and pesticides, can be reactivated by oximes. |
2019-11-26 |
2023-08-13 |
mouse |
| Burgin, Szczupa. Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site The Journal of experimental biology. vol 201 (Pt 12). 2019-11-20. PMID:9600872. |
the results suggest the existence of a basal level of acetylcholine (ach) release in the leech ganglion that is powerfully counteracted by endogenous ache activity. |
2019-11-20 |
2023-08-12 |
Not clear |
| J Kuchinka, Monika Chrzanowska, T Kude. Adrenergic and cholinergic innervation of the atrioventricular valves in chinchilla (Chinchilla laniger). Folia morphologica. vol 76. issue 4. 2019-11-20. PMID:28553858. |
the dissected valves were stained entirely using the modified histochemical acetylcholine esterase technique (ache) and the spg-de la torre method. |
2019-11-20 |
2023-08-13 |
Not clear |
| Noam Cohen, Einat Toister, Yonatan Lati, Meni Girshengorn, Lilach Levin, Lea Silberstein, Dror Seliktar, Eyal Epstei. Cell encapsulation utilizing PEG-fibrinogen hydrogel supports viability and enhances productivity under stress conditions. Cytotechnology. vol 70. issue 3. 2019-11-20. PMID:29468479. |
here, we utilized a uniquely fabricated semi-synthetic 3d polyethylene glycol-fibrinogen (peg-fb) hydrogel scaffold, which exhibits both high stability and high bioactivity, to encapsulate hek293 cells for the production of human recombinant acetylcholine esterase (ache). |
2019-11-20 |
2023-08-13 |
human |
| Masahiro Tabuchi, Keiko Fujikura, Sakae Inou. Histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele Hynobius nigrescens. Journal of morphology. vol 207. issue 1. 2019-11-20. PMID:29865493. |
the development and structure of neuromuscular junctions (n-m-js) in stylopodia of forelimbs of larvae and adults of hynobius nigrescens were histochemically investigated for acetylcholine receptors (achrs) and acetylcholinesterase (ache) activity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yulong Lin, Yalin Wang, Jie Lv, Nannan Wang, Jing Wang, Meng L. Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity. International journal of nanomedicine. vol 14. 2019-11-01. PMID:31440049. |
design and synthesis of ache inhibitors that increase the cholinergic transmission by blocking the degradation of acetylcholine can serve as a strategy for the treatment of ache-associated disease. |
2019-11-01 |
2023-08-13 |
Not clear |
| Jean-Marie Graïc, Livio Corain, Antonella Peruffo, Bruno Cozzi, Dick F Swaa. The bovine anterior hypothalamus: Characterization of the vasopressin-oxytocin containing nucleus and changes in relation to sexual differentiation. The Journal of comparative neurology. vol 526. issue 17. 2019-10-28. PMID:30255945. |
in an effort to systematically describe the neurochemical anatomy of the bovine anterior hypothalamus, we used a series of immunocytochemical markers such as acetylcholine esterase (ache), arginine-vasopressin (avp), calbindin (calb), galanin (gal), neuropeptide-y (npy), oxytocin (oxt), somatostatin (sst), and vasoactive intestinal peptide (vip). |
2019-10-28 |
2023-08-13 |
cattle |
| Eng Leng Saw, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of molecular and cellular cardiology. vol 125. 2019-10-28. PMID:30343172. |
the existence of cardiac nncs has been confirmed by the presence of cholinergic markers in the cardiomyocytes, which are crucial for synthesis (choline acetyltransferase, chat), storage (vesicular acetylcholine transporter, vacht), reuptake of choline for synthesis (high-affinity choline transporter, cht1) and degradation (acetylcholinesterase, ache) of acetylcholine (ach). |
2019-10-28 |
2023-08-13 |
Not clear |
| Shan Huang, Jiandong Yao, Xu Chu, Yi Liu, Qi Xiao, Yue Zhan. One-Step Facile Synthesis of Nitrogen-Doped Carbon Dots: A Ratiometric Fluorescent Probe for Evaluation of Acetylcholinesterase Activity and Detection of Organophosphorus Pesticides in Tap Water and Food. Journal of agricultural and food chemistry. vol 67. issue 40. 2019-10-21. PMID:31532667. |
upon the addition of ache and choline oxidase, acetylcholine was catalyzed to produce choline that was further oxidized to produce h |
2019-10-21 |
2023-08-13 |
human |
| Kishwar Sultana, Muhammad Kashif Zahoor, Muhammad Sagheer, - Farha. Efficacy of Chrozophora plicata and Trianthema portuclacastrum weed plant extracts against Trogoderma granarium Everts under laboratory conditions. Pakistan journal of pharmaceutical sciences. vol 32. issue 1. 2019-10-15. PMID:30772803. |
a decrease in the activity of acetylcholine esterase (ache), acid phosphatase (acp), alkaline phosphatase (akp), α-carboxyl and β-carboxyl was also found. |
2019-10-15 |
2023-08-13 |
Not clear |
| C David Andersson, Nicolas Martinez, Dominik Zeller, Anders Allgardsson, Michael M Koza, Bernhard Frick, Fredrik Ekström, Judith Peters, Anna Linusso. Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering. The journal of physical chemistry. B. vol 122. issue 36. 2019-10-11. PMID:30110543. |
the enzyme acetylcholinesterase (ache) is essential in humans and animals because it catalyzes the breakdown of the nerve-signaling substance acetylcholine. |
2019-10-11 |
2023-08-13 |
Not clear |
| Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Yusang Choi, Young Ju Lee, Sungbaek Seo, Jin Tae Hong, Dae Youn Hwan. Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model. Molecules (Basel, Switzerland). vol 24. issue 5. 2019-10-07. PMID:30836659. |
furthermore, significant improvements were observed in the acetylcholinesterase (ache) activity and acetylcholine receptors' (achrs) downstream signaling pathway after treatment of spia. |
2019-10-07 |
2023-08-13 |
mouse |