| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin B Temeyer, Kristie G Schlechte, Pia U Olafson, Barbara S Drolet, Jason P Tidwell, Weste L A Osbrink, Allan T Showler, Aaron D Gross, Adalberto A Pérez de Leó. Association of Salivary Cholinesterase With Arthropod Vectors of Disease. Journal of medical entomology. vol 57. issue 6. 2021-01-27. PMID:32459332. |
acetylcholinesterase (ache) was previously reported to be present in saliva of the southern cattle tick, rhipicephalus (boophilus) microplus (canestrini), with proposed potential functions to 1) reduce acetylcholine toxicity during rapid engorgement, 2) modulate host immune responses, and 3) to influence pathogen transmission and establishment in the host. |
2021-01-27 |
2023-08-13 |
cattle |
| Samar S Elblehi, Omnia I El Euony, Yasser S El-Saye. Apoptosis and astrogliosis perturbations and expression of regulatory inflammatory factors and neurotransmitters in acrylamide-induced neurotoxicity under ω3 fatty acids protection in rats. Neurotoxicology. vol 76. 2021-01-20. PMID:31647937. |
moreover, it reduced neurotransmitters (acetylcholine, gaba, serotonin and noradrenaline levels) and increased ache activity in brain tissues. |
2021-01-20 |
2023-08-13 |
rat |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
in 1-day-old embryos, we show that spinal motoneurons express presynaptic cholinergic genes including choline acetyltransferase (chata), vesicular acetylcholine transporters (vachta, vachtb), high-affinity choline transporter (hacta) and acetylcholinesterase (ache), while nicotinic acetylcholine receptor (nachr) subunits are mainly expressed in interneurons. |
2021-01-19 |
2023-08-13 |
zebrafish |
| Dan Wu, Shuyu Zhang, Na Sun, Beiwei Zhu, Songyi Li. Neuroprotective Function of a Novel Hexapeptide QMDDQ from Shrimp via Activation of the PKA/CREB/BNDF Signaling Pathway and Its Structure-Activity Relationship. Journal of agricultural and food chemistry. vol 68. issue 24. 2021-01-13. PMID:32452680. |
biochemical results revealed that both peptides exhibited neuroprotective effects by increasing acetylcholine (ach) content and inhibiting acetylcholinesterase (ache) activity in pc12 cells; qmddq was more active than kmddq. |
2021-01-13 |
2023-08-13 |
mouse |
| Tao Li, Jason Berberich, Endalkachew Sahle-Demessie, Eunice Varughes. A disposable acetylcholine esterase sensor for As(III) determination in groundwater matrix based on 4-acetoxyphenol hydrolysis. Analytical methods : advancing methods and applications. vol 11. issue 40. 2021-01-10. PMID:32021658. |
to address this issue, an inhibition-based acetylcholine esterase (ache) sensor was developed to determine as(iii) in groundwater. |
2021-01-10 |
2023-08-13 |
Not clear |
| Ehsan H Abu Zeid, Bouthaina A Khalifa, Enas N Said, Ahmed H Arisha, Rasha M Red. Neurobehavioral and immune-toxic impairments induced by organic methyl mercury dietary exposure in Nile tilapia Oreochromis niloticus. Aquatic toxicology (Amsterdam, Netherlands). vol 230. 2021-01-04. PMID:33264694. |
mehg significantly decreased brain acetylcholine esterase (ache) and serum immunoglobulin m (igm) levels in all the exposed groups. |
2021-01-04 |
2023-08-13 |
Not clear |
| Piyoosh Sharma, Manish Kumar Tripathi, Sushant Kumar Shrivastav. Cholinesterase as a Target for Drug Development in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2089. 2020-12-29. PMID:31773661. |
herein, we describe the role of acetylcholine sterase (ache) and related hypothesis in ad along with the pharmacological and chemical aspects of the available cholinesterase inhibitors. |
2020-12-29 |
2023-08-13 |
Not clear |
| Alaa Alachkar, Sheikh Azimullah, Mohamed Lotfy, Ernest Adeghate, Shreesh K Ojha, Rami Beiram, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats. Molecules (Basel, Switzerland). vol 25. issue 7. 2020-12-28. PMID:32235506. |
were evaluated on the course of kindling development, kindling-induced memory deficit, oxidative stress levels (glutathione (gsh), malondialdehyde (mda), catalase (cat), and superoxide dismutase (sod)), various brain neurotransmitters (histamine (ha), acetylcholine (ach), γ-aminobutyric acid (gaba)), and glutamate (glu), acetylcholine esterase (ache) activity, and c-fos protein expression in pentylenetetrazole (ptz, 40 mg/kg) kindled rats. |
2020-12-28 |
2023-08-13 |
rat |
| Ewa Baranowska-Wójcik, Dominik Szwajgier, Anna Winiarska-Miecza. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. vol 12. issue 3. 2020-12-21. PMID:32155927. |
acetylcholinesterase (ache) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. |
2020-12-21 |
2023-08-13 |
Not clear |
| Xiangping Chen, Wei Guo, Lei Lei, Yongyong Guo, Lihua Yang, Jian Han, Bingsheng Zho. Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish. Environmental pollution (Barking, Essex : 1987). vol 268. issue Pt B. 2020-12-18. PMID:33120153. |
furthermore, hbb and pbb significantly inhibited ache activities, accompanied by increased contents of acetylcholine and decreased choline in larvae. |
2020-12-18 |
2023-08-13 |
zebrafish |
| Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Gani. Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration. Cellular and molecular neurobiology. vol 40. issue 3. 2020-12-07. PMID:31584139. |
we explicate the role of key neuroproteomic drug targets notably aβ, tau, alpha synuclein, prions, secretases, acetylcholinesterase (ache), lrrk2, molecular chaperones, a2a receptors, muscarinic acetylcholine receptors (machr), n-methyl-d-aspartate receptor (nmdar), glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) and mitochondrial/oxidative stress-related proteins for combating neurodegeneration and associated cognitive and motor impairment. |
2020-12-07 |
2023-08-13 |
Not clear |
| Ye Lu, Min Wei, Chenchen Wang, Wei Wei, Yong Li. Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and d-amino acids. Nanoscale. vol 12. issue 8. 2020-12-04. PMID:32053129. |
under the catalysis of acetylcholinesterase (ache) and choline oxidase (cho), h2o2 was produced by using acetylcholine chloride (ach) as a substrate, which was sensitive to the proposed cl system. |
2020-12-04 |
2023-08-13 |
human |
| J B Greer, J T Magnuson, K Hester, M Giroux, C Pope, T Anderson, J Liu, V Dang, N D Denslow, D Schlen. Effects of Chlorpyrifos on Cholinesterase and Serine Lipase Activities and Lipid Metabolism in Brains of Rainbow Trout (Oncorhynchus mykiss). Toxicological sciences : an official journal of the Society of Toxicology. 2020-11-01. PMID:31359069. |
chlorpyrifos is an organophosphorus insecticide that elicits acute toxicity through inhibition of acetylcholinesterase (ache), leading to acetylcholine accumulation and prolonged stimulation of cholinergic receptors throughout the central and peripheral nervous systems. |
2020-11-01 |
2023-08-13 |
Not clear |
| Si Chen, Zhengdong Lin, Kai-Leng Tan, Risheng Chen, Wenfang Su, Haishan Zhao, Qiwen Tan, Wen Ta. Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice. Frontiers in psychiatry. vol 11. 2020-10-22. PMID:33061920. |
butyrylcholinesterase (bche) efficiently hydrolyzes acetylcholine (ach) at high concentrations when acetylcholinesterase (ache) is substrate-inhibited. |
2020-10-22 |
2023-08-13 |
mouse |
| Ramachandra S Naik, Tatyana Belinskaya, C R Vinayaka, Ashima Saxen. Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish between acetylcholinesterases from ruminant and non-ruminant species. Chemico-biological interactions. vol 330. 2020-10-14. PMID:32795450. |
while ache regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions, bche in plasma has been suggested to be involved in detoxifying toxic compounds. |
2020-10-14 |
2023-08-13 |
mouse |
| Johannes H Erasmus, Victor Wepener, Milen Nachev, Sonja Zimmermann, Wynand Malherbe, Bernd Sures, Nico J Smi. The role of fish helminth parasites in monitoring metal pollution in aquatic ecosystems: a case study in the world's most productive platinum mining region. Parasitology research. vol 119. issue 9. 2020-10-07. PMID:32683559. |
therefore, the aims of the present study were (1) to determine the accumulation of a variety of metals (cadmium (cd), chromium (cr), copper (cu), nickel (ni), lead (pb), platinum (pt), and zinc (zn)) in helminth fish parasites compared with their hosts from a reference site and an impoundment impacted by pt mining activities; (2) to assess whether there is a difference between bioaccumulation of metals in infected and uninfected hosts, as well as between hosts with different infection intensities; and (3) to compare the biomarker responses (acetylcholine esterase activity (ache), metallothionein content (mt), catalase activity (cat), reduced glutathione content (gsh), malondialdehyde content (mda), protein carbonyls induction (pc), superoxide dismutase activity (sod), and cellular energy allocation (cea)) between infected and uninfected hosts. |
2020-10-07 |
2023-08-13 |
cat |
| Suman Chowdhury, Shivani, Suresh Kuma. In vitro anti-acetylcholinesterase activity of an aqueous extract of Unicaria tomentosa and in silico study of its active constituents. Bioinformation. vol 12. issue 3. 2020-10-01. PMID:28149044. |
enzyme acetylcholinesterase (ache) is responsible for destruction of acetylcholine (ach) in the brain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jaymie R Voorhees, Diane S Rohlman, Pamela J Lein, Andrew A Piepe. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28149268. |
these compounds potently inhibit acetylcholinesterase (ache), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high op levels can cause cholinergic crisis in humans and animals. |
2020-10-01 |
2023-08-13 |
Not clear |
| Abd El-Hamid Mohamed Elwy, Ghada Tab. Impact of tramadol and morphine abuse on the activities of acetylcholine esterase, Na+/K+-ATPase and related parameters in cerebral cortices of male adult rats. Electronic physician. vol 9. issue 3. 2020-10-01. PMID:28461881. |
to determine the effect of the most commonly abused drugs (tramadol and morphine), on acetylcholine esterase (ache), na |
2020-10-01 |
2023-08-13 |
rat |