| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ewa Baranowska-Wójcik, Dominik Szwajgier, Anna Winiarska-Miecza. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. vol 12. issue 3. 2020-12-21. PMID:32155927. |
acetylcholinesterase (ache) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. |
2020-12-21 |
2023-08-13 |
Not clear |
| Xiangping Chen, Wei Guo, Lei Lei, Yongyong Guo, Lihua Yang, Jian Han, Bingsheng Zho. Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish. Environmental pollution (Barking, Essex : 1987). vol 268. issue Pt B. 2020-12-18. PMID:33120153. |
furthermore, hbb and pbb significantly inhibited ache activities, accompanied by increased contents of acetylcholine and decreased choline in larvae. |
2020-12-18 |
2023-08-13 |
zebrafish |
| Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Gani. Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration. Cellular and molecular neurobiology. vol 40. issue 3. 2020-12-07. PMID:31584139. |
we explicate the role of key neuroproteomic drug targets notably aβ, tau, alpha synuclein, prions, secretases, acetylcholinesterase (ache), lrrk2, molecular chaperones, a2a receptors, muscarinic acetylcholine receptors (machr), n-methyl-d-aspartate receptor (nmdar), glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) and mitochondrial/oxidative stress-related proteins for combating neurodegeneration and associated cognitive and motor impairment. |
2020-12-07 |
2023-08-13 |
Not clear |
| Ye Lu, Min Wei, Chenchen Wang, Wei Wei, Yong Li. Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and d-amino acids. Nanoscale. vol 12. issue 8. 2020-12-04. PMID:32053129. |
under the catalysis of acetylcholinesterase (ache) and choline oxidase (cho), h2o2 was produced by using acetylcholine chloride (ach) as a substrate, which was sensitive to the proposed cl system. |
2020-12-04 |
2023-08-13 |
human |
| J B Greer, J T Magnuson, K Hester, M Giroux, C Pope, T Anderson, J Liu, V Dang, N D Denslow, D Schlen. Effects of Chlorpyrifos on Cholinesterase and Serine Lipase Activities and Lipid Metabolism in Brains of Rainbow Trout (Oncorhynchus mykiss). Toxicological sciences : an official journal of the Society of Toxicology. 2020-11-01. PMID:31359069. |
chlorpyrifos is an organophosphorus insecticide that elicits acute toxicity through inhibition of acetylcholinesterase (ache), leading to acetylcholine accumulation and prolonged stimulation of cholinergic receptors throughout the central and peripheral nervous systems. |
2020-11-01 |
2023-08-13 |
Not clear |
| Si Chen, Zhengdong Lin, Kai-Leng Tan, Risheng Chen, Wenfang Su, Haishan Zhao, Qiwen Tan, Wen Ta. Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice. Frontiers in psychiatry. vol 11. 2020-10-22. PMID:33061920. |
butyrylcholinesterase (bche) efficiently hydrolyzes acetylcholine (ach) at high concentrations when acetylcholinesterase (ache) is substrate-inhibited. |
2020-10-22 |
2023-08-13 |
mouse |
| Ramachandra S Naik, Tatyana Belinskaya, C R Vinayaka, Ashima Saxen. Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish between acetylcholinesterases from ruminant and non-ruminant species. Chemico-biological interactions. vol 330. 2020-10-14. PMID:32795450. |
while ache regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions, bche in plasma has been suggested to be involved in detoxifying toxic compounds. |
2020-10-14 |
2023-08-13 |
mouse |
| Johannes H Erasmus, Victor Wepener, Milen Nachev, Sonja Zimmermann, Wynand Malherbe, Bernd Sures, Nico J Smi. The role of fish helminth parasites in monitoring metal pollution in aquatic ecosystems: a case study in the world's most productive platinum mining region. Parasitology research. vol 119. issue 9. 2020-10-07. PMID:32683559. |
therefore, the aims of the present study were (1) to determine the accumulation of a variety of metals (cadmium (cd), chromium (cr), copper (cu), nickel (ni), lead (pb), platinum (pt), and zinc (zn)) in helminth fish parasites compared with their hosts from a reference site and an impoundment impacted by pt mining activities; (2) to assess whether there is a difference between bioaccumulation of metals in infected and uninfected hosts, as well as between hosts with different infection intensities; and (3) to compare the biomarker responses (acetylcholine esterase activity (ache), metallothionein content (mt), catalase activity (cat), reduced glutathione content (gsh), malondialdehyde content (mda), protein carbonyls induction (pc), superoxide dismutase activity (sod), and cellular energy allocation (cea)) between infected and uninfected hosts. |
2020-10-07 |
2023-08-13 |
cat |
| Suman Chowdhury, Shivani, Suresh Kuma. In vitro anti-acetylcholinesterase activity of an aqueous extract of Unicaria tomentosa and in silico study of its active constituents. Bioinformation. vol 12. issue 3. 2020-10-01. PMID:28149044. |
enzyme acetylcholinesterase (ache) is responsible for destruction of acetylcholine (ach) in the brain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jaymie R Voorhees, Diane S Rohlman, Pamela J Lein, Andrew A Piepe. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28149268. |
these compounds potently inhibit acetylcholinesterase (ache), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high op levels can cause cholinergic crisis in humans and animals. |
2020-10-01 |
2023-08-13 |
Not clear |
| Abd El-Hamid Mohamed Elwy, Ghada Tab. Impact of tramadol and morphine abuse on the activities of acetylcholine esterase, Na+/K+-ATPase and related parameters in cerebral cortices of male adult rats. Electronic physician. vol 9. issue 3. 2020-10-01. PMID:28461881. |
to determine the effect of the most commonly abused drugs (tramadol and morphine), on acetylcholine esterase (ache), na |
2020-10-01 |
2023-08-13 |
rat |
| Ryan J Yoder, Qinggeng Zhuang, Jeremy M Beck, Andrew Franjesevic, Travis G Blanton, Sydney Sillart, Tyler Secor, Leah Guerra, Jason D Brown, Carolyn Reid, Craig A McElroy, Özlem Doğan Ekici, Christopher S Callam, Christopher M Hada. Study of ACS medicinal chemistry letters. vol 8. issue 6. 2020-10-01. PMID:28626522. |
the aged ache is unable to hydrolyze acetylcholine, resulting in accumulation of the neurotransmitter in the central nervous system (cns) and elsewhere. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wenwen Lian, Hao Jia, Lvjie Xu, Wei Zhou, De Kang, Ailin Liu, Guanhua D. Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29276489. |
the acetylcholine level and ache activity were not altered by d-galactose but were slightly affected by dl0410 in the brain. |
2020-10-01 |
2023-08-13 |
mouse |
| Etta Y L Liu, Miranda L Xu, Yan Jin, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29535608. |
in parallel, the expression of tetrameric form of proline-rich membrane anchor (prima)-linked acetyl-cholinesterase (g4 ache), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein prima. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| Mohd Babu Khan, Bhagath Kumar Palaka, Tuleshwori Devi Sapam, Naidu Subbarao, Dinakara Rao Ampasal. Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in the context of Alzheimer's disease. Bioinformation. vol 14. issue 8. 2020-10-01. PMID:30310249. |
an ache enzyme is a member of hydrolase family is activated by acetylcholine (ach), so, targeting the ache enzyme with the potential inhibitor may block the binding of the ach. |
2020-10-01 |
2023-08-13 |
Not clear |
| Azadeh Karami, Maria Eriksdotter, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Taher Darreh-Shor. CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer's Disease. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31680850. |
currently, three of four ad drugs act by inhibiting the acetylcholine (ach) degrading enzyme, acetylcholinesterase (ache). |
2020-10-01 |
2023-08-13 |
Not clear |
| Zahiruddin Othman, Rahimah Zakaria, Nik Hazlina Nik Hussain, Asma' Hassan, Nazlahshaniza Shafin, Badriya Al-Rahbi, Asma Hayati Ahma. Potential Role of Honey in Learning and Memory. Medical sciences (Basel, Switzerland). vol 3. issue 2. 2020-09-30. PMID:29083387. |
these studies show that tualang honey improves morphology of memory-related brain areas, reduces brain oxidative stress, increases brain-derived neurotrophic factor (bdnf) and acetylcholine (ach) concentrations, and reduces acetylcholinesterase (ache) in the brain homogenates. |
2020-09-30 |
2023-08-13 |
human |
| Edna Blotnick-Rubin, Lili Angliste. Fine Localization of Acetylcholinesterase in the Synaptic Cleft of the Vertebrate Neuromuscular Junction. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29725289. |
this localization pattern of ache is suggested to ensure full hydrolysis of acetylcholine (ach) bouncing off receptors, thus eliminating its unnecessary detrimental reattachment. |
2020-09-30 |
2023-08-13 |
mouse |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
the serum samples were further analyzed for biomarkers such as 8-hydroxydeoxyguanosine (8-ohdg), 4-hydroxynonenal (4-hne), tumor necrosis factor-alpha (tnf-α), cyclooxygenase-2 (cox-2), matrix metalloproteinase-8 (mmp-8), isoprostanes-2 alpha (isop-2α), and acetylcholine esterase (ache) using conventional enzyme linked immunosorbent assay (elisa) method. |
2020-09-30 |
2023-08-13 |
rat |