| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jayeong Hwang, Kumju Youn, Gyutae Lim, Jinhyuk Lee, Dong Hyun Kim, Mira Ju. Discovery of Natural Inhibitors of Cholinesterases from Nutrients. vol 13. issue 1. 2021-04-27. PMID:33477276. |
the loss of cognitive functions is mostly characterized by the rapid hydrolysis of acetylcholine by cholinesterases including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2021-04-27 |
2023-08-13 |
Not clear |
| Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Nipon Chattipakorn, Siriporn C Chattipakor. Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 1. 2021-04-13. PMID:32956775. |
donepezil, a well-known acetylcholine esterase (ache) inhibitor, has been proven to exert neuroprotective effects against several neurodegenerative diseases. |
2021-04-13 |
2023-08-13 |
rat |
| Anand Kumar Chaudhari, Vipin Kumar Singh, Akash Kedia, Somenath Das, Nawal Kishore Dube. Essential oils and their bioactive compounds as eco-friendly novel green pesticides for management of storage insect pests: prospects and retrospects. Environmental science and pollution research international. vol 28. issue 15. 2021-04-07. PMID:33609244. |
data collected from scientific articles show that these eos and their bioactive compounds exhibited insecticidal activity via fumigant, contact, repellent, antifeedant, ovicidal, oviposition deterrent and larvicidal activity, and by inhibiting/altering important neurotransmitters such as acetylcholine esterase (ache) and octopamine or neurotransmitter inhibitor γ-amino butyric acid (gaba), as well as by altering the enzymatic [superoxide dismutase (sod), catalase (cat), peroxidases (pox), glutathione-s-transferase (gst) and glutathione reductase (gr)] and non-enzymatic [glutathione (gsh)] antioxidant defence systems. |
2021-04-07 |
2023-08-13 |
cat |
| Laura Montali, Maria Maddalena Calabretta, Antonia Lopreside, Marcello D'Elia, Massimo Guardigli, Elisa Michelin. Multienzyme chemiluminescent foldable biosensor for on-site detection of acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 162. 2021-04-05. PMID:32452394. |
the rapid hydrolysis of acetylcholine (ach), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (ache) is fundamental for the termination of ach impulse transmission. |
2021-04-05 |
2023-08-13 |
human |
| Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L Jayaraj, David Reiner, Shreesh K Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. The Dual-Active Histamine H International journal of molecular sciences. vol 21. issue 11. 2021-03-31. PMID:32503208. |
the enzyme acetylcholine esterase (ache) is involved in the metabolism of brain ach. |
2021-03-31 |
2023-08-13 |
Not clear |
| Soomaayeh Heysieattalab, Leila Sadegh. Effects of Delphinidin on Pathophysiological Signs of Nucleus Basalis of Meynert Lesioned Rats as Animal Model of Alzheimer Disease. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32297026. |
it could also interact with catalytic site of ache enzyme and inhibits acetylcholine hydrolysis in in vitro and in vivo conditions. |
2021-03-29 |
2023-08-13 |
rat |
| Alexandre A de Castro, Letícia C Assis, Flávia V Soares, Kamil Kuca, Daniel A Polisel, Elaine F F da Cunha, Teodorico C Ramalh. Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019). Biomolecules. vol 10. issue 3. 2021-03-17. PMID:32178264. |
within the most outstanding reactivators, the substances denominated oximes stand out, showing good performance for reactivating ache and restoring the normal synaptic acetylcholine (ach) levels. |
2021-03-17 |
2023-08-13 |
Not clear |
| Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The inefficacy of donepezil on glycated-AChE inhibition: Binding affinity, complex stability and mechanism. International journal of biological macromolecules. vol 160. 2021-03-17. PMID:32454110. |
it is suggested that glycation of lysine residues on the structure of ache could change the conformation of the active site (trp-86 and his-447) in a way that the orientation of acetylcholine interrupted. |
2021-03-17 |
2023-08-13 |
Not clear |
| Wei Sun, Peidong Liu, Chunzhi Tang, Lei A. Melamine Disrupts Acetylcholine-Mediated Neural Information Flow in the Hippocampal CA3-CA1 Pathway. Frontiers in behavioral neuroscience. vol 15. 2021-03-10. PMID:33679339. |
the levels of acetylcholine (ach) and its esterolytic protease, acetylcholinesterase (ache), were detected in the hippocampus (hpc) following the behavioral test. |
2021-03-10 |
2023-08-13 |
rat |
| Qiyun Wu, Yiteng Xia, Kun Dai, Panzhu Bai, Kenneth K L Kwan, Maggie S S Guo, Tina T X Dong, Karl W K Tsi. Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32519787. |
the expression levels of choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular acetylcholine transporter (vacht), and synaptophysin, were upregulated during differentiation of keratinocytes. |
2021-03-01 |
2023-08-13 |
human |
| Agnieszka Zagórska, Anna Jaromi. Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-01. PMID:32717806. |
herein, we highlight major targets associated with ad, ranging from acetylcholine esterase (ache), beta-site amyloid precursor protein cleaving enzyme 1 (bace-1), glycogen synthase kinase 3 beta (gsk-3β), |
2021-03-01 |
2023-08-13 |
Not clear |
| Xiaohe Luo, Marianne Lauwers, Paul G Layer, Chunyi We. Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. Frontiers in cell and developmental biology. vol 8. 2021-02-16. PMID:33585459. |
acetylcholinesterase (ache), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. |
2021-02-16 |
2023-08-13 |
Not clear |
| Omowumi T Kayode, Damilare E Rotimi, Tomilola D Olaolu, Oluyomi Stephen Adeyem. Ketogenic diet improves and restores redox status and biochemical indices in monosodium glutamate-induced rat testicular toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-11. PMID:32434144. |
in the pre-treatment, the administration of msg resulted in a significant (p < 0.05) decrease in the testis-body weight ratio, alkaline phosphatase (alp), acetylcholine esterase (ache), cholesterol, triglycerides (tg), nitric oxide (no), glycogen, protein and antioxidant enzymes in the testis. |
2021-02-11 |
2023-08-13 |
rat |
| Sukesh Narayan Sinha, Kumpati Rajesh Kumar, Ramakrishna Ungarala, Dileshwar Kumar, Abhijeet Deshpande, K Vasudev, Naveen Kumar Boiroju, Amrisha Singh, R Pandu Naik, Sunil Pokharaka. Toxicokinetic analysis of commonly used pesticides using data on acute poisoning cases from Hyderabad, South India. Chemosphere. vol 268. 2021-02-10. PMID:33485672. |
organophosphorus pesticides (ops) interfere with the activity of acetylcholinesterase (ache), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (ach) accumulation at the synapses and myoneural junctions. |
2021-02-10 |
2023-08-13 |
human |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tomoyo Horio, Aisa Ozawa, Junichi Kamiie, Motoharu Sakau. Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury. The Journal of veterinary medical science. vol 82. issue 6. 2021-02-02. PMID:32321871. |
acetylcholine (ach), a neurotransmitter synthesized and hydrolyzed by choline acetyltransferase (chat) and acetylcholinesterase (ache), respectively, in the central nervous system, has the potential to regulate glial cells' states, i.e., non-reactive and reactive states. |
2021-02-02 |
2023-08-13 |
mouse |
| Engy Medhat, Laila Rashed, Marwa Abdelgwad, Basma Emad Aboulhoda, Mohamed Mansour Khalifa, Shimaa Saad El-Di. Exercise enhances the effectiveness of vitamin D therapy in rats with Alzheimer's disease: emphasis on oxidative stress and inflammation. Metabolic brain disease. vol 35. issue 1. 2021-01-29. PMID:31691146. |
the following parameters were assessed in rat brain tissues: acetylcholine esterase (ache) activity, levels of amyloid β 42 and tau proteins, dopamine brain neurotransmitter, bdnf and ngf by elisa. |
2021-01-29 |
2023-08-13 |
rat |
| Ghadha Ibrahim Foua. Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32124160. |
moreover, hypercholesterolemia resulted in decreased acetylcholine (ach) levels and increased acetylcholine-esterase (ache) activity, along with an increment of tumor necrosis factor and amyloid-β 42. |
2021-01-29 |
2023-08-13 |
rat |
| Walaa M S Ahmed, Naglaa M Abdel-Azeem, Marwa A Ibrahim, Nermeen A Helmy, Abeer M Rad. Neuromodulatory effect of cinnamon oil on behavioural disturbance, CYP1A1, iNOStranscripts and neurochemical alterations induced by deltamethrin in rat brain. Ecotoxicology and environmental safety. vol 209. 2021-01-29. PMID:33385678. |
rat behaviour, brain acetylcholine esterase (ache), serotonin, oxidative stress profile were assessed. |
2021-01-29 |
2023-08-13 |
rat |
| Edward J Okello, Joshua Mathe. Comparative Kinetics of Acetyl- and Butyryl-Cholinesterase Inhibition by Green Tea Catechins|Relevance to the Symptomatic Treatment of Alzheimer's Disease. Nutrients. vol 12. issue 4. 2021-01-27. PMID:32326457. |
acetyl-cholinesterase (ache) and butyryl-cholinesterase (buche) are attractive therapeutic targets in the treatment of ad since inhibition of these enzymes can be used to restore synaptic concentrations of acetylcholine. |
2021-01-27 |
2023-08-13 |
Not clear |