| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Wang, Amit Fischer, Avner Ehrlich, Yaakov Nahmias, Itamar Willne. Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin. Chemical science. vol 11. issue 17. 2021-06-15. PMID:34122910. |
the enzymes glucose oxidase (gox), acetylcholine esterase (ache) and urease that drive biocatalytic transformations to alter ph, are integrated into ph-responsive dna-based hydrogels. |
2021-06-15 |
2023-08-13 |
Not clear |
| Asmaa F Khafaga, Sara E El-Kazaz, Ahmed E Noreldi. Boswellia serrata suppress fipronil-induced neuronal necrosis and neurobehavioral alterations via promoted inhibition of oxidative/inflammatory/apoptotic pathways. The Science of the total environment. vol 785. 2021-06-10. PMID:33933775. |
conversely, significant (p > 0.05) up regulation of catalase (cat), glutathione peroxidase (gsh-px), gamma-aminobutyric acid (gaba), and acetylcholine esterase (ache) has reported in bse-co-treated groups. |
2021-06-10 |
2023-08-13 |
rat |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Dan Wu, Xiaomeng Xu, Na Sun, Dongmei Li, Beiwei Zhu, Songyi Li. AGLPM and QMDDQ peptides exert a synergistic action on memory improvement against scopolamine-induced amnesiac mice. Food & function. vol 11. issue 12. 2021-06-07. PMID:33242042. |
furthermore, combination treatment with qmddq and aglpm could significantly reduce the acetylcholinesterase (ache) level and increase the acetylcholine (ach) level in the hippocampus, and noticeably improve the pathological morphology of the neuron cells in hippocampal regions ca1 and ca2 and dentate gyrus (dg). |
2021-06-07 |
2023-08-13 |
mouse |
| Shani Vaknine, Hermona Sore. Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors. Neuropharmacology. vol 168. 2021-05-27. PMID:32143069. |
acetylcholinesterase (ache) inhibitors modulate acetylcholine hydrolysis and hence play a key role in determining the cholinergic tone and in implementing its impact on the cholinergic blockade of inflammatory processes. |
2021-05-27 |
2023-08-13 |
mouse |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
therefore, the aim of this work was to evaluate the activity of ache, acetylcholine (ach) concentration, and the expression of nicotinic ach receptors (nachr) and muscarinic ach receptors (machr) in spleen mononuclear cells (smnc) of nile tilapia (o. niloticus) exposed in vitro to diazoxon, a diazinon metabolite. |
2021-05-17 |
2023-08-13 |
Not clear |
| Unnati N Ahir, Trupti K Vyas, Kelvin D Gandhi, Priti R Faldu, Kamlesh G Pate. In Vitro Efficacy for Chlorpyrifos Degradation by Novel Isolate Tistrella sp. AUC10 Isolated from Chlorpyrifos Contaminated Field. Current microbiology. vol 77. issue 9. 2021-05-14. PMID:32361846. |
organophosphate pesticides have acute neurotoxicity because they suppress acetylcholine esterase (ache) which regulates the enzyme of neurotransmitters by reducing acetylcholine concentration at synaptic junctions. |
2021-05-14 |
2023-08-13 |
Not clear |
| Unnati N Ahir, Trupti K Vyas, Kelvin D Gandhi, Priti R Faldu, Kamlesh G Pate. In Vitro Efficacy for Chlorpyrifos Degradation by Novel Isolate Tistrella sp. AUC10 Isolated from Chlorpyrifos Contaminated Field. Current microbiology. vol 77. issue 9. 2021-05-14. PMID:32361846. |
on exposure to op, ache is inactivated and leads to accumulation of acetylcholine in the junction. |
2021-05-14 |
2023-08-13 |
Not clear |
| M D Fernández-Ramos, A L Ogunneye, N A A Babarinde, M M Erenas, L F Capitán-Vallve. Bioactive microfluidic paper device for pesticide determination in waters. Talanta. vol 218. 2021-05-14. PMID:32797872. |
the assay strip is composed of a paper support (1 × 17.6 mm) onto which acetylcholine esterase (ache) and acetylcholine chloride (achcl) are deposited, in such a way that there is a small hole between them that ensures that they only come into contact in the reaction zone when they are carried by a solution of the sample by lateral flow to the reaction zone containing bromocresol purple (bcp) as the ph indicator, immobilized by sol-gel. |
2021-05-14 |
2023-08-13 |
Not clear |
| Qiaoting Yang, Qian Li, Haiyin Li, Feng L. pH-Response Quantum Dots with Orange-Red Emission for Monitoring the Residue, Distribution, and Variation of an Organophosphorus Pesticide in an Agricultural Crop. Journal of agricultural and food chemistry. vol 69. issue 9. 2021-05-14. PMID:33635638. |
ache catalyzed hydrolysis of acetylcholine (ach) into ch |
2021-05-14 |
2023-08-13 |
Not clear |
| Kristy L Meads, Thaddeus P Thomas, Jeffrey L Langston, Todd M Myers, Tsung-Ming Shi. Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats. Toxicology and applied pharmacology. vol 416. 2021-05-10. PMID:33631229. |
soman, an organophosphorus (op) compound, disrupts nervous system function through inactivation of acetylcholinesterase (ache), the enzyme that breaks down acetylcholine at synapses. |
2021-05-10 |
2023-08-13 |
rat |
| Uğur Güller, Şükrü Önalan, Muhammed Arabacı, Boran Karataş, Muhterem Yaşar, Ömer İrfan Küfrevioğl. Effects of different LED light spectra on rainbow trout (Oncorhynchus mykiss): in vivo evaluation of the antioxidant status. Fish physiology and biochemistry. vol 46. issue 6. 2021-05-07. PMID:32860607. |
in the current study, it was intended to examine in rainbow trout how cultivating under different wavelengths affects the antioxidant enzymes and acetylcholine esterase (ache) activity, because its activity is associated with oxidative stress, and also the determination of which light is suitable for fish welfare was aimed. |
2021-05-07 |
2023-08-13 |
cat |
| Jayeong Hwang, Kumju Youn, Gyutae Lim, Jinhyuk Lee, Dong Hyun Kim, Mira Ju. Discovery of Natural Inhibitors of Cholinesterases from Nutrients. vol 13. issue 1. 2021-04-27. PMID:33477276. |
the loss of cognitive functions is mostly characterized by the rapid hydrolysis of acetylcholine by cholinesterases including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2021-04-27 |
2023-08-13 |
Not clear |
| Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Nipon Chattipakorn, Siriporn C Chattipakor. Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 1. 2021-04-13. PMID:32956775. |
donepezil, a well-known acetylcholine esterase (ache) inhibitor, has been proven to exert neuroprotective effects against several neurodegenerative diseases. |
2021-04-13 |
2023-08-13 |
rat |
| Anand Kumar Chaudhari, Vipin Kumar Singh, Akash Kedia, Somenath Das, Nawal Kishore Dube. Essential oils and their bioactive compounds as eco-friendly novel green pesticides for management of storage insect pests: prospects and retrospects. Environmental science and pollution research international. vol 28. issue 15. 2021-04-07. PMID:33609244. |
data collected from scientific articles show that these eos and their bioactive compounds exhibited insecticidal activity via fumigant, contact, repellent, antifeedant, ovicidal, oviposition deterrent and larvicidal activity, and by inhibiting/altering important neurotransmitters such as acetylcholine esterase (ache) and octopamine or neurotransmitter inhibitor γ-amino butyric acid (gaba), as well as by altering the enzymatic [superoxide dismutase (sod), catalase (cat), peroxidases (pox), glutathione-s-transferase (gst) and glutathione reductase (gr)] and non-enzymatic [glutathione (gsh)] antioxidant defence systems. |
2021-04-07 |
2023-08-13 |
cat |
| Laura Montali, Maria Maddalena Calabretta, Antonia Lopreside, Marcello D'Elia, Massimo Guardigli, Elisa Michelin. Multienzyme chemiluminescent foldable biosensor for on-site detection of acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 162. 2021-04-05. PMID:32452394. |
the rapid hydrolysis of acetylcholine (ach), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (ache) is fundamental for the termination of ach impulse transmission. |
2021-04-05 |
2023-08-13 |
human |
| Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L Jayaraj, David Reiner, Shreesh K Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. The Dual-Active Histamine H International journal of molecular sciences. vol 21. issue 11. 2021-03-31. PMID:32503208. |
the enzyme acetylcholine esterase (ache) is involved in the metabolism of brain ach. |
2021-03-31 |
2023-08-13 |
Not clear |
| Soomaayeh Heysieattalab, Leila Sadegh. Effects of Delphinidin on Pathophysiological Signs of Nucleus Basalis of Meynert Lesioned Rats as Animal Model of Alzheimer Disease. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32297026. |
it could also interact with catalytic site of ache enzyme and inhibits acetylcholine hydrolysis in in vitro and in vivo conditions. |
2021-03-29 |
2023-08-13 |
rat |
| Alexandre A de Castro, Letícia C Assis, Flávia V Soares, Kamil Kuca, Daniel A Polisel, Elaine F F da Cunha, Teodorico C Ramalh. Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019). Biomolecules. vol 10. issue 3. 2021-03-17. PMID:32178264. |
within the most outstanding reactivators, the substances denominated oximes stand out, showing good performance for reactivating ache and restoring the normal synaptic acetylcholine (ach) levels. |
2021-03-17 |
2023-08-13 |
Not clear |